| Fidelity | 8.92M | $399.8M | — | Held |
| Avoro Capital Advisors LLC | 5.42M | $243.1M | — | Held |
| BlackRock, Inc. | 5.1M | $228.6M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 4.76M | $213.6M | — | Held |
| Driehaus Capital Management LLC | 4.54M | $203.4M | — | Held |
| JANUS HENDERSON GROUP PLC | 4.08M | $183.1M | — | Held |
| Capital International Investors | 3.41M | $153.1M | — | Held |
| Polar Capital Holdings Plc | 2.47M | $110.5M | — | Held |
| BRAIDWELL LP | 1.83M | $81.8M | — | Held |
| Commodore Capital LP | 1.8M | $80.7M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 1.59M | $71.4M | — | Held |
| JPMORGAN CHASE & CO | 1.49M | $67M | — | Held |
| State Street | 1.49M | $66.9M | — | Held |
| Citadel | 1.32M | $59.2M | — | Held |
| JENNISON ASSOCIATES LLC | 1.29M | $57.9M | — | Held |
| Holocene Advisors, LP | 1.28M | $57.5M | — | Held |
| Affinity Asset Advisors, LLC | 1.25M | $56M | — | Held |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1.23M | $55M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 952.7K | $42.7M | — | Held |
| Siren, L.L.C. | 812.8K | $36.4M | — | Held |
| First Turn Management, LLC | 799.7K | $35.8M | — | Held |
| Rock Springs Capital Management LP | 787.8K | $35.3M | — | Held |
| FRANKLIN RESOURCES INC | 758.1K | $34M | — | Held |
| Aberdeen Group plc | 750.3K | $33.6M | — | Held |
| GOLDMAN SACHS GROUP INC | 696K | $31.2M | — | Held |
| Fiera Capital Corp | 686.1K | $30.7M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 685.1K | $30.7M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 680.5K | $30.5M | — | Held |
| FEDERATED HERMES, INC. | 672.2K | $30.1M | — | Held |
| Vanguard | 664.6K | $29.8M | — | Held |
| Capital World Investors | 655.7K | $29.4M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 635.1K | $28.5M | — | Held |
| Pictet Asset Management Holding SA | 626K | $28M | — | Held |
| LOOMIS SAYLES & CO L P | 612K | $27.4M | — | Held |
| BARCLAYS PLC | 601K | $26.9M | $519.8K | Added$22.5M |
| Vestal Point Capital, LP | 600K | $26.9M | — | Held |
| Trails Edge Capital Partners, LP | 597.1K | $26.8M | — | Held |
| Caligan Partners LP | 549.7K | $24.6M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 542K | $24.3M | — | Held |
| TimesSquare Capital Management, LLC | 532.7K | $23.9M | — | Held |
| MPM BIOIMPACT LLC | 485.6K | $21.8M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 452.1K | $20.3M | — | Held |
| ORBIMED ADVISORS LLC | 447.2K | $20M | — | Held |
| NORTHERN TRUST CORP | 438.7K | $19.7M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 436.7K | $19.6M | — | Held |
| Candriam S.C.A. | 417.4K | $18.7M | — | Held |
| Bank of New York Mellon Corp | 387.2K | $17.4M | — | Held |
| BAKER BROS. ADVISORS LP | 370.2K | $16.6M | — | Held |
| Deep Track Capital, LP | 366.4K | $16.4M | — | Held |
| STEMPOINT CAPITAL LP | 348.6K | $15.6M | — | Held |
| MORGAN STANLEY | 294.3K | $13.2M | $1.37M | Cut−$1.53M |
| DAFNA Capital Management LLC | 287.9K | $12.9M | — | Held |
| DNB Asset Management AS | 272.8K | $12.2M | — | Held |
| TWO SIGMA ADVISERS, LP | 259.3K | $11.6M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 254K | $11.4M | $358.8K | Added$8.3M |
| Nicholas Investment Partners, LP | 243K | $10.9M | — | Held |
| Iron Triangle Partners LP | 233.7K | $10.5M | — | Held |
| Eversept Partners, LP | 231.4K | $10.4M | — | Held |
| NAN FUNG TRINITY (HK) LTD | 227K | $10.2M | — | Held |
| BANK OF AMERICA CORP /DE/ | 221.4K | $9.92M | $929.8K | Added$1.93M |
| Nuveen, LLC | 216.2K | $9.69M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 205.6K | $9.21M | — | Held |
| ADAR1 Capital Management, LLC | 204K | $9.14M | — | Held |
| PERCEPTIVE ADVISORS LLC | 200.8K | $9M | — | Held |
| DEUTSCHE BANK AG\ | 190.2K | $8.53M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 189.1K | $8.47M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 186.7K | $8.37M | — | Held |
| NEXTBio Capital Management LP | 183.7K | $8.23M | — | Held |
| NEUBERGER BERMAN GROUP LLC | 178.7K | $8.01M | — | Held |
| PEREGRINE CAPITAL MANAGEMENT LLC | 174.9K | $7.84M | — | Held |
| Jain Global LLC | 173.9K | $7.79M | — | Held |
| MARSHALL WACE, LLP | 162.6K | $7.29M | — | Held |
| Foresite Capital Management IV, LLC | 160K | $7.17M | — | Held |
| Parkman Healthcare Partners LLC | 154.2K | $6.91M | — | Held |
| WELLS FARGO & COMPANY/MN | 152.3K | $6.83M | — | Held |
| MOORE CAPITAL MANAGEMENT, LP | 140K | $6.27M | — | Held |
| Rhenman & Partners Asset Management AB | 139K | $6.23M | — | Held |
| Patient Square Capital LP | 136.5K | $6.12M | — | Held |
| Redmile Group, LLC | 133.9K | $6M | — | Held |
| Assenagon Asset Management S.A. | 119.2K | $5.34M | — | Held |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 116.1K | $5.2M | — | Held |
| Man Group plc | 114.8K | $5.15M | — | Held |
| Swiss National Bank | 114K | $5.11M | — | Held |
| AMERIPRISE FINANCIAL INC | 109.5K | $4.91M | — | Held |
| Squadron Capital Management LLC | 105.6K | $4.73M | — | Held |
| Palo Alto Investors LP | 96.5K | $4.33M | — | Held |
| Verition Fund Management LLC | 93.8K | $4.2M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 93.5K | $4.19M | — | Held |
| Granahan Investment Management, LLC | 92.8K | $4.16M | — | Held |
| Atika Capital Management LLC | 92.5K | $4.15M | — | Held |
| RHUMBLINE ADVISERS | 90.1K | $4.04M | — | Held |
| ROYAL BANK OF CANADA | 89.8K | $4.02M | — | Held |
| Russell Investments Group, Ltd. | 86.2K | $3.86M | — | Held |
| Balyasny Asset Management L.P. | 84.4K | $3.78M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 83.3K | $3.73M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 81.2K | $3.58M | — | Held |
| LAZARD ASSET MANAGEMENT LLC | 78.7K | $3.53M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 73K | $3.27M | — | Held |
| Legal & General Group Plc | 70.3K | $3.15M | — | Held |
| ALPS ADVISORS INC | 63.3K | $2.84M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 60.9K | $2.73M | — | Held |
| Sofinnova Investments, Inc. | 59.9K | $2.68M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 56.6K | $2.54M | — | Held |
| UBS Group AG | 52.5K | $2.35M | — | Held |
| Invesco Ltd. | 50.9K | $2.28M | — | Held |
| Erste Asset Management GmbH | 50K | $2.22M | — | Held |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 48K | $2.15M | — | Held |
| SEI INVESTMENTS CO | 43.9K | $1.97M | — | Held |
| MetLife Investment Management, LLC | 42K | $1.88M | — | Held |
| Artia Global Partners LP | 40K | $1.79M | — | Held |
| TD Asset Management Inc | 38.1K | $1.71M | — | Held |
| Legato Capital Management LLC | 37K | $1.66M | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 35.8K | $1.6M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 35.7K | $1.6M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35.3K | $1.58M | — | Held |
| DARK FOREST CAPITAL MANAGEMENT LP | 33.5K | $1.5M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32.6K | $1.45M | — | Held |
| Jump Financial, LLC | 31K | $1.39M | — | Held |
| D. E. Shaw & Co., Inc. | 30.9K | $1.38M | — | Held |
| BAMCO INC /NY/ | 30K | $1.34M | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 25.8K | $1.16M | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 25.6K | $1.15M | — | Held |
| Lighthouse Investment Partners, LLC | 25K | $1.12M | — | Held |
| Quantinno Capital Management LP | 24.6K | $1.1M | — | Held |
| Rathbones Group PLC | 23.7K | $1.06M | — | Held |
| Cinctive Capital Management LP | 23.3K | $1.05M | — | Held |
| HighMark Wealth Management LLC | 23K | $1.03M | — | Held |
| Vestmark Advisory Solutions, Inc. | 21.9K | $980.8K | — | Held |
| XTX Topco Ltd | 21.5K | $963.5K | — | Held |
| ASSETMARK, INC | 21.3K | $953.3K | — | Held |
| Birchview Capital, LP | 21K | $941.2K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 20.1K | $902.1K | — | Held |
| State of New Jersey Common Pension Fund D | 19.7K | $884.7K | — | Held |
| Walleye Capital LLC | 19.6K | $877.9K | — | Held |
| Creative Planning | 19.2K | $860.5K | — | Held |
| STIFEL FINANCIAL CORP | 17.5K | $786.5K | — | Held |
| ProShare Advisors LLC | 17.3K | $774.4K | — | Held |
| Entropy Technologies, LP | 17K | $763.1K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 16.2K | $725.1K | — | Held |
| Campbell & CO Investment Adviser LLC | 16.1K | $721.8K | — | Held |
| Orion Porfolio Solutions, LLC | 14.4K | $645.7K | — | Held |
| SBI Okasan Asset Management Co.Ltd. | 14.4K | $638.4K | — | Held |
| J. Safra Sarasin Holding AG | 13.6K | $608.7K | — | Held |
| CIBC WORLD MARKET INC. | 13.5K | $603.3K | — | Held |
| China Universal Asset Management Co., Ltd. | 12.6K | $564.4K | — | Held |
| KLP KAPITALFORVALTNING AS | 12.3K | $551.3K | — | Held |
| PSP Research LLC | 11.7K | $523.4K | — | Held |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 11.3K | $505.5K | — | Held |
| Supplemental Annuity Collective Trust of NJ | 11K | $493K | — | Held |
| Knott David M Jr | 11K | $491.3K | — | Held |
| Elmwood Wealth Management, Inc. | 10.8K | $482.1K | — | Held |
| Marex Group plc | 10.6K | $473.2K | — | New |
| Allianz Asset Management GmbH | 9.4K | $421.3K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 8.63K | $386.9K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 8.32K | $372.9K | — | Held |
| ALTFEST L J & CO INC | 8.23K | $369K | — | Held |
| Advisors Asset Management, Inc. | 8.01K | $359.1K | — | Held |
| Neo Ivy Capital Management | 7.48K | $335.1K | — | Held |
| OXFORD ASSET MANAGEMENT LLP | 7.38K | $330.7K | — | New |
| CITIGROUP INC | 7.36K | $329.9K | — | Held |
| PenderFund Capital Management Ltd. | 6.85K | $307K | — | Held |
| Abel Hall, LLC | 6.76K | $302.8K | — | Held |
| PNC Financial Services Group, Inc. | 6.57K | $294.6K | — | Held |
| FIRST TRUST ADVISORS LP | 6.36K | $285.1K | — | Held |
| Ameritas Investment Partners, Inc. | 6.17K | $276.4K | — | Held |
| Virtus Investment Advisers, LLC | 6.04K | $270.6K | — | Held |
| LETSON INVESTMENT MANAGEMENT, INC. | 6K | $268.9K | — | Held |
| XPONANCE LLC | 5.97K | $267.8K | — | Held |
| Ensign Peak Advisors, Inc | 5.19K | $232.8K | — | Held |
| Magnetar Financial LLC | 5.15K | $231K | — | Held |
| Caprock Group, LLC | 5.07K | $227.2K | — | Held |
| EntryPoint Capital, LLC | 5.03K | $225.4K | — | Held |
| CIBC WORLD MARKETS CORP | 5.03K | $225.3K | — | Held |
| CITIZENS FINANCIAL GROUP INC/RI | 5K | $224.1K | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 5K | $224.1K | — | Held |
| MACKENZIE FINANCIAL CORP | 4.77K | $210.1K | — | Held |
| Whalen Wealth Management Inc. | 4.64K | $208K | — | Held |
| Amundi | 4.61K | $206.6K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 4.53K | $203.2K | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 4.49K | $201.2K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.75K | $168.3K | — | Held |
| Tower Research Capital LLC (TRC) | 3.23K | $144.9K | — | Held |
| Corient Private Wealth LLC | 25.1K | $143.4K | — | Held |
| IFP Advisors, Inc | 1.88K | $84.1K | $8.77K | Added$7.52K |
| GF FUND MANAGEMENT CO. LTD. | 1.52K | $68K | — | Held |
| State of Wyoming | 1.5K | $67.3K | — | Held |
| STRS OHIO | 1.3K | $58.3K | — | Held |
| Caitong International Asset Management Co., Ltd | 1.23K | $54.9K | — | Held |
| Clearstead Advisors, LLC | 1.22K | $54.5K | — | Held |
| Rockefeller Capital Management L.P. | 1.1K | $49.3K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1.06M | $47.5K | — | Held |
| Farther Finance Advisors, LLC | 1.06K | $47.4K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 924 | $41.4K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 862.3K | $38.6K | — | Held |
| DANSKE BANK A/S | 800 | $35.9K | $10.8K | Added$10.8K |
| Blue Trust, Inc. | 745 | $33.4K | — | Held |
| Kestra Advisory Services, LLC | 740 | $33.2K | — | Held |
| T. Rowe Price Investment Management, Inc. | 547.6K | $24.5K | — | Held |
| Sterling Capital Management LLC | 491 | $22K | — | Held |
| SIGNATUREFD, LLC | 473 | $21.2K | — | Held |
| OSAIC HOLDINGS, INC. | 319 | $14.3K | — | Held |
| Mitsubishi UFJ Asset Management Co., Ltd. | 276 | $12.3K | — | Held |
| GAMMA Investing LLC | 264 | $11.8K | — | Held |
| MAI Capital Management | 261 | $11.7K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 236 | $10.6K | — | Held |
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ | 235 | $10.5K | — | Held |
| EverSource Wealth Advisors, LLC | 212 | $9.5K | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 190 | $8.52K | — | Held |
| US BANCORP \DE\ | 175 | $7.84K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 150 | $6.72K | — | Held |
| Parallel Advisors, LLC | 147 | $6.59K | — | Held |
| HRT FINANCIAL LP | 129.8K | $5.82K | — | Held |
| ALGERT GLOBAL LLC | 123.2K | $5.52K | — | Held |
| Kemnay Advisory Services Inc. | 123 | $5.51K | — | Held |
| Allworth Financial LP | 116 | $5.2K | $543 | Added$141 |
| ROTHSCHILD INVESTMENT LLC | 111 | $4.97K | — | Held |
| Bell Investment Advisors, Inc | 100 | $4.48K | — | Held |
| J.Safra Asset Management Corp | 87 | $3.9K | — | Held |
| Rossby Financial, LCC | 47 | $2.11K | — | Held |
| DekaBank Deutsche Girozentrale | 39K | $1.82K | — | Held |
| Cape Investment Advisory, Inc. | 39 | $1.75K | $182 | Added$182 |
| Aster Capital Management (DIFC) Ltd | 36 | $1.61K | — | Held |
| CVA Family Office, LLC | 33 | $1.48K | — | Held |
| Parkside Financial Bank & Trust | 30 | $1.34K | — | Held |
| Handelsbanken Fonder AB | 29.8K | $1.34K | — | Held |
| Arax Advisory Partners | 27 | $1.21K | — | Held |
| CoreCap Advisors, LLC | 17 | $762 | — | Held |
| Park Place Capital Corp | 16 | $717 | — | Held |
| Smartleaf Asset Management LLC | 16 | $706 | — | Held |
| Physician Wealth Advisors, Inc. | 13 | $583 | — | Held |
| MassMutual Private Wealth & Trust, FSB | 11 | $493 | — | Held |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 10.6K | $477 | — | Held |
| HARBOR CAPITAL ADVISORS, INC. | 10.1K | $451 | — | Held |
| SG Americas Securities, LLC | 7.08K | $317 | — | Held |
| CANADA LIFE ASSURANCE Co | 7.02K | $315 | — | Held |
| TLS Advisors LLC | 18.9K | $307 | — | Held |
| Thrivent Financial for Lutherans | 5.58K | $250 | — | Held |
| TD PRIVATE CLIENT WEALTH LLC | 3 | $134 | — | Held |
| KBC Group NV | 2.78K | $125 | $9 | Added$50 |
| AMALGAMATED BANK | 2.39K | $107 | — | Held |
| Larson Financial Group LLC | 2 | $90 | — | Held |
| SBI Securities Co., Ltd. | 1 | $45 | — | Held |
| CWM, LLC | 366 | $16 | — | Held |
| Covestor Ltd | 247 | $11 | — | Held |
| Daiwa Securities Group Inc. | 229 | $10 | — | Held |
| Motiv8 Investments LLC | 40 | $2 | — | Held |
| HANTZ FINANCIAL SERVICES, INC. | 25 | $1 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |