| Fidelity | 7.52M | $204.1M | — | Held |
| ORBIMED ADVISORS LLC | 5.69M | $154.6M | — | Held |
| BlackRock, Inc. | 3.34M | $90.8M | — | Held |
| Decheng Capital LLC | 3.14M | $85.3M | — | Held |
| NORGES BANK | 2.88M | $78.3M | $20.4M | Added$72.3M |
| ENAVATE SCIENCES GP, LLC | 2.46M | $66.8M | — | Held |
| Vanguard | 2.39M | $64.8M | — | Held |
| UBS Group AG | 1.81M | $49M | — | Held |
| JANUS HENDERSON GROUP PLC | 1.53M | $41.4M | — | Held |
| Altshuler Shaham Ltd | 1.34M | $36.4M | — | Held |
| Bain Capital Life Sciences Investors, LLC | 1.33M | $36.1M | — | Held |
| Omega Fund Management, LLC | 1.33M | $36M | — | Held |
| State Street | 1.32M | $35.8M | — | Held |
| VR ADVISER, LLC | 1.17M | $31.7M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 894.7K | $24.3M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 851.9K | $23.1M | — | Held |
| Parkman Healthcare Partners LLC | 834.6K | $22.7M | — | Held |
| Pictet Asset Management Holding SA | 773.1K | $21M | — | Held |
| Woodline Partners LP | 760.3K | $20.6M | — | Held |
| Integral Health Asset Management, LLC | 750K | $20.4M | — | Held |
| TCG Crossover Management, LLC | 743.9K | $20.2M | — | Held |
| SAMSARA BIOCAPITAL, LLC | 736K | $20M | — | Held |
| Vestal Point Capital, LP | 720K | $19.5M | — | Held |
| Siren, L.L.C. | 588.5K | $16M | — | Held |
| BARCLAYS PLC | 524.5K | $14.2M | $711.5K | Added$12.6M |
| MILLENNIUM MANAGEMENT LLC | 517.3K | $14M | — | Held |
| Nantahala Capital Management, LLC | 495K | $13.4M | — | Held |
| MARSHALL WACE, LLP | 343.8K | $9.33M | — | Held |
| GOLDMAN SACHS GROUP INC | 333.5K | $9.05M | — | Held |
| GREAT POINT PARTNERS LLC | 300K | $8.14M | — | Held |
| Alyeska Investment Group, L.P. | 298.3K | $8.1M | — | Held |
| JENNISON ASSOCIATES LLC | 288.8K | $7.84M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 284.9K | $7.74M | — | Held |
| NORTHERN TRUST CORP | 236.8K | $6.43M | — | Held |
| Squadron Capital Management LLC | 230.7K | $6.26M | — | Held |
| Invesco Ltd. | 163.2K | $4.43M | — | Held |
| Boxer Capital Management, LLC | 150K | $4.07M | — | New |
| DEUTSCHE BANK AG\ | 127.8K | $3.47M | — | Held |
| MORGAN STANLEY | 122.1K | $3.31M | $730K | Added$1.67M |
| SummitTX Capital, L.P. | 116.7K | $3.17M | — | Held |
| Schonfeld Strategic Advisors LLC | 115.8K | $3.14M | — | Held |
| JPMORGAN CHASE & CO | 110.3K | $2.99M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 87.8K | $2.38M | — | Held |
| BANK OF AMERICA CORP /DE/ | 86.4K | $2.35M | $462.6K | Added$1.3M |
| Bank of New York Mellon Corp | 84.9K | $2.3M | — | Held |
| Nuveen, LLC | 78.6K | $2.13M | — | Held |
| ExodusPoint Capital Management, LP | 75.4K | $2.05M | — | Held |
| Artia Global Partners LP | 68.7K | $1.86M | — | Held |
| Exome Asset Management LLC | 64.8K | $1.76M | — | Held |
| AMERIPRISE FINANCIAL INC | 56.6K | $1.54M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55.8K | $1.52M | — | Held |
| SEVEN GRAND MANAGERS, LLC | 50K | $1.36M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 46.6K | $1.26M | — | Held |
| ALPS ADVISORS INC | 44.4K | $1.2M | — | Held |
| RHUMBLINE ADVISERS | 41.5K | $1.13M | — | Held |
| Rafferty Asset Management, LLC | 38.7K | $1.05M | — | Held |
| WELLS FARGO & COMPANY/MN | 36.8K | $999K | — | Held |
| Trexquant Investment LP | 31K | $843K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 31K | $841.9K | — | Held |
| Icahn Capital | 30.5K | $828.2K | — | Held |
| D. E. Shaw & Co., Inc. | 27.1K | $735.5K | — | Held |
| Swiss National Bank | 26.6K | $722.2K | — | Held |
| DIADEMA PARTNERS LP | 20.5K | $556.6K | — | Held |
| MetLife Investment Management, LLC | 19.7K | $534.3K | — | Held |
| PSP Research LLC | 17.6K | $478.8K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17.5K | $475.3K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16.6K | $449.6K | — | Held |
| Renaissance Technologies | 16.4K | $445.3K | — | Held |
| Quantinno Capital Management LP | 15.4K | $418.5K | — | Held |
| XTX Topco Ltd | 15.1K | $409.7K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14.7K | $397.8K | — | Held |
| PROFUND ADVISORS LLC | 14.6K | $395.9K | — | Held |
| Graham Capital Management, L.P. | 13.7K | $372.3K | — | Held |
| Legal & General Group Plc | 13.7K | $372.2K | — | Held |
| Citadel | 13.4K | $364.4K | — | Held |
| DNB Asset Management AS | 12.8K | $347.3K | — | Held |
| Verition Fund Management LLC | 12K | $326.3K | — | Held |
| Mariner, LLC | 11.8K | $321.2K | — | Held |
| Creative Planning | 11.7K | $319K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 11.7K | $317.7K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 10.5K | $285.1K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 10.4K | $282.3K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10.1K | $275.5K | — | Held |
| Virtus Investment Advisers, LLC | 9.8K | $266.1K | — | Held |
| STRS OHIO | 9.8K | $266.1K | — | Held |
| VARCOV Co. | 9.62K | $261.2K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 9.46K | $256.7K | — | Held |
| Persistent Asset Partners Ltd | 8.91K | $241.8K | — | New |
| China Universal Asset Management Co., Ltd. | 8.81K | $239.1K | — | Held |
| ProShare Advisors LLC | 8.35K | $226.8K | — | Held |
| SEI INVESTMENTS CO | 8.09K | $219.6K | — | Held |
| CITIGROUP INC | 6.95K | $188.7K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 4.98K | $135.1K | — | Held |
| KLP KAPITALFORVALTNING AS | 2.9K | $78.7K | — | Held |
| Russell Investments Group, Ltd. | 2.82K | $76.6K | — | Held |
| Ameritas Investment Partners, Inc. | 2.74K | $74.4K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.63K | $71.3K | — | Held |
| Wellington Grp LLC | 2K | $54.3K | — | Held |
| Sterling Capital Management LLC | 1.92K | $52.1K | — | Held |
| Torren Management, LLC | 1.1K | $29.8K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.06K | $28.8K | — | Held |
| ROYAL BANK OF CANADA | 969 | $26K | — | Held |
| GAMMA Investing LLC | 900 | $24.4K | — | Held |
| Tower Research Capital LLC (TRC) | 669 | $18.2K | — | Held |
| Versant Capital Management, Inc | 558 | $15.2K | — | Held |
| US BANCORP \DE\ | 546 | $14.8K | — | Held |
| FEDERATED HERMES, INC. | 482 | $13.1K | — | Held |
| SIMPLEX TRADING, LLC | 466 | $12.7K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 400 | $10.9K | — | Held |
| EverSource Wealth Advisors, LLC | 282 | $7.66K | — | Held |
| Global Retirement Partners, LLC | 273 | $7.41K | — | Held |
| Aster Capital Management (DIFC) Ltd | 271 | $7.36K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 242 | $6.57K | — | Held |
| J.Safra Asset Management Corp | 128 | $3.48K | — | Held |
| SIGNATUREFD, LLC | 117 | $3.18K | — | Held |
| PNC Financial Services Group, Inc. | 106 | $2.88K | — | Held |
| Essential Partners LLC | 97 | $2.63K | $809 | Added$809 |
| Allworth Financial LP | 68 | $1.85K | $559 | Added$586 |
| N.E.W. Advisory Services LLC | 60 | $1.63K | — | Held |
| SageView Advisory Group, LLC | 30 | $815 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19.6K | $534 | — | Held |
| Sunbelt Securities, Inc. | 19 | $516 | — | Held |
| Larson Financial Group LLC | 14 | $380 | — | Held |
| Virtu Financial LLC | 12.2K | $332 | — | Held |
| SG Americas Securities, LLC | 5.52K | $150 | — | Held |
| OSAIC HOLDINGS, INC. | 5 | $136 | — | Held |
| CWM, LLC | 3.36K | $91 | — | Held |
| Parallel Advisors, LLC | 2 | $54 | — | Held |
| Arax Advisory Partners | 2 | $54 | — | Held |
| AMALGAMATED BANK | 1.03K | $28 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 1 | $27 | — | Held |
| IFP Advisors, Inc | 1 | $27 | $8 | Cut−$11 |
| Daiwa Securities Group Inc. | 180 | $5 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |