| Fidelity | 8.1M | $72.9M | −$136.5M | Cut−$131.2M |
| ORBIMED ADVISORS LLC | 5.69M | $51.2M | −$103.3M | Cut−$103.3M |
| BlackRock, Inc. | 3.37M | $30.3M | −$60.7M | Cut−$60.5M |
| Decheng Capital LLC | 2.72M | $24.5M | −$49.5M | Cut−$60.8M |
| ENAVATE SCIENCES GP, LLC | 2.46M | $22.1M | −$44.6M | Cut−$44.6M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.87M | $16.9M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 1M | $9.01M | −$845K | Added$7.74M |
| FEDERATED HERMES, INC. | 979.8K | $8.82M | −$8.75K | Added$8.8M |
| GEODE CAPITAL MANAGEMENT, LLC | 950.6K | $8.56M | −$15.5M | Cut−$14.6M |
| MILLENNIUM MANAGEMENT LLC | 937.3K | $8.44M | −$9.39M | Cut−$5.61M |
| SEB Asset Management AB | 878.5K | $7.91M | — | Held |
| Bain Capital Life Sciences Investors, LLC | 867.2K | $7.8M | −$15.7M | Cut−$28.3M |
| Woodline Partners LP | 831.5K | $7.48M | −$13.8M | Cut−$13.2M |
| D. E. Shaw & Co., Inc. | 820.5K | $7.38M | −$491.7K | Added$6.65M |
| Parkman Healthcare Partners LLC | 786.8K | $7.08M | −$14.3M | Cut−$15.6M |
| SAMSARA BIOCAPITAL, LLC | 736K | $6.62M | −$13.4M | Cut−$13.4M |
| Pictet Asset Management Holding SA | 733.4K | $6.6M | −$13.3M | Cut−$14.4M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 727.7K | $6.55M | — | Held |
| State Street | 705.4K | $6.35M | −$12.8M | Cut−$29.5M |
| HSBC HOLDINGS PLC | 640.3K | $5.76M | — | New |
| Qube Research & Technologies Ltd | 619.3K | $5.57M | — | New |
| MORGAN STANLEY | 552.6K | $4.97M | −$2.22M | Added$1.66M |
| JPMORGAN CHASE & CO | 463K | $4.07M | −$2.03M | Added$1.07M |
| Nantahala Capital Management, LLC | 400K | $3.6M | −$7.26M | Cut−$9.84M |
| Altshuler Shaham Ltd | 380.1K | $3.42M | −$6.9M | Cut−$33M |
| SPHERA FUNDS MANAGEMENT LTD. | 358K | $3.22M | — | New |
| Propel Bio Management, LLC | 341.8K | $3.1M | — | New |
| WELLINGTON MANAGEMENT GROUP LLP | 342.4K | $3.08M | −$6.21M | Cut−$21.2M |
| Jump Financial, LLC | 319.4K | $2.87M | — | New |
| GOLDMAN SACHS GROUP INC | 316.6K | $2.85M | −$5.75M | Cut−$6.2M |
| Alyeska Investment Group, L.P. | 298.3K | $2.68M | −$5.41M | Cut−$5.41M |
| NORTHERN TRUST CORP | 261K | $2.35M | −$4.3M | Cut−$4.08M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 257.7K | $2.32M | −$4.68M | Cut−$5.42M |
| Prosight Management, LP | 241.1K | $2.17M | — | New |
| UBS Group AG | 231.3K | $2.08M | −$4.2M | Cut−$47M |
| VANGUARD FIDUCIARY TRUST CO | 224.2K | $2.02M | — | Held |
| XTX Topco Ltd | 209.3K | $1.88M | −$273.9K | Added$1.47M |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 185.1K | $1.67M | — | New |
| TCG Crossover Management, LLC | 181.1K | $1.63M | −$3.29M | Cut−$18.6M |
| DEUTSCHE BANK AG\ | 180.9K | $1.63M | −$2.32M | Cut−$1.84M |
| Point72 Asset Management, L.P. | 178.2K | $1.6M | — | New |
| Trexquant Investment LP | 176.7K | $1.59M | −$563.5K | Added$746.9K |
| Schonfeld Strategic Advisors LLC | 161.3K | $1.45M | −$2.1M | Cut−$1.69M |
| Boxer Capital Management, LLC | 150K | $1.35M | −$2.72M | Cut−$2.72M |
| BNP PARIBAS FINANCIAL MARKETS | 126K | $1.13M | −$90.3K | Added$998.9K |
| ALLIANCEBERNSTEIN L.P. | 31K | $841.9K | $0 | Held |
| ExodusPoint Capital Management, LP | 91.4K | $822.9K | −$1.37M | Cut−$1.22M |
| AMERICAN CENTURY COMPANIES INC | 87.6K | $788.6K | −$1.59M | Cut−$1.59M |
| Bank of New York Mellon Corp | 81.4K | $732.4K | −$1.48M | Cut−$1.57M |
| DIMENSIONAL FUND ADVISORS LP | 80K | $719.5K | — | New |
| Simplify Asset Management Inc. | 77.8K | $700.1K | — | New |
| Nuveen, LLC | 75.5K | $679.8K | −$1.37M | Cut−$1.45M |
| EntryPoint Capital, LLC | 73.6K | $662.1K | — | New |
| Icahn Capital | 72.2K | $649.5K | −$553.6K | Cut−$178.6K |
| MARSHALL WACE, LLP | 66.8K | $600.9K | −$1.21M | Cut−$8.73M |
| Renaissance Technologies | 62.1K | $558.9K | −$297.7K | Added$113.6K |
| Quantinno Capital Management LP | 49.4K | $444.5K | −$279.8K | Added$26K |
| BANK OF AMERICA CORP /DE/ | 48.5K | $436.1K | −$879.5K | Cut−$1.91M |
| Swiss National Bank | 48.1K | $432.9K | −$482.8K | Cut−$289.3K |
| Squarepoint Ops LLC | 44.6K | $401.6K | — | New |
| ALPS ADVISORS INC | 44K | $395.9K | −$798.5K | Cut−$808.9K |
| STATE OF WISCONSIN INVESTMENT BOARD | 41.7K | $375K | — | New |
| RHUMBLINE ADVISERS | 41.2K | $370.8K | −$747.8K | Cut−$756.5K |
| Invesco Ltd. | 40.5K | $364.6K | −$735.3K | Cut−$4.07M |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39.7K | $356.9K | −$265.9K | Cut−$40.9K |
| ADAR1 Capital Management, LLC | 35K | $315K | — | New |
| Stonepine Capital Management, LLC | 35K | $315K | — | New |
| Aquatic Capital Management LLC | 31.5K | $283.4K | — | New |
| Bleakley Financial Group, LLC | 28.9K | $259.8K | — | New |
| AXQ CAPITAL, LP | 27.5K | $247.5K | — | New |
| Mariner, LLC | 27.3K | $245.8K | −$214.7K | Cut−$75.3K |
| TUDOR INVESTMENT CORP ET AL | 26.4K | $237.7K | — | New |
| MARTINGALE ASSET MANAGEMENT L P | 26.2K | $236K | — | New |
| VICTORY CAPITAL MANAGEMENT INC | 25.9K | $232.8K | — | New |
| BARCLAYS PLC | 24.7K | $222.5K | −$448.7K | Cut−$14M |
| DNB Asset Management AS | 23.5K | $211.6K | −$232.2K | Cut−$135.7K |
| Entropy Technologies, LP | 23.3K | $210K | — | New |
| DIADEMA PARTNERS LP | 21.6K | $194.5K | −$372.1K | Cut−$362.1K |
| Man Group plc | 21.2K | $190.4K | — | New |
| NISA INVESTMENT ADVISORS, LLC | 19.6K | $176K | −$7.26K | Added$165.2K |
| MetLife Investment Management, LLC | 19.4K | $174.4K | −$351.7K | Cut−$359.8K |
| WELLS FARGO & COMPANY/MN | 18.4K | $165.6K | −$334K | Cut−$833.3K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16K | $143.6K | −$289.7K | Cut−$1.37M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15.6K | $140.5K | −$283.6K | Cut−$334.8K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15.3K | $138K | −$184.2K | Cut−$137.4K |
| FRANKLIN RESOURCES INC | 14.6K | $131.3K | — | New |
| Vanguard Global Advisers, LLC | 13.1K | $117.5K | — | Held |
| Corient Private Wealth LLC | 12.2K | $109.4K | — | New |
| Creative Planning | 10.8K | $97.7K | −$196.9K | Cut−$221.3K |
| Virtus Investment Advisers, LLC | 10K | $90.4K | −$177.9K | Cut−$175.7K |
| Shay Capital LLC | 10K | $90K | — | New |
| STRS OHIO | 9.8K | $88.2K | −$177.9K | Cut−$177.9K |
| Legal & General Group Plc | 9.61K | $86.5K | −$174.4K | Cut−$285.7K |
| China Universal Asset Management Co., Ltd. | 9.59K | $86.3K | −$159.8K | Cut−$152.8K |
| Police & Firemen's Retirement System of New Jersey | 9.46K | $85.1K | −$171.6K | Cut−$171.6K |
| VANGUARD ASSET MANAGEMENT, Ltd | 9.25K | $83.3K | — | Held |
| KLP KAPITALFORVALTNING AS | 5.9K | $53.1K | −$52.6K | Cut−$25.6K |
| Persistent Asset Partners Ltd | 5.5K | $49.5K | −$99.7K | Cut−$192.4K |
| CITIGROUP INC | 5.05K | $45.5K | −$91.7K | Cut−$143.2K |
| Vanguard Investments Australia, Ltd. | 4.1K | $36.9K | — | Held |
| CWM, LLC | 3.88K | $34.9K | $30.1K | Added$34.9K |
| Russell Investments Group, Ltd. | 3.65K | $32.8K | −$51.2K | Cut−$43.8K |
| Wellington Grp LLC | 3K | $27K | −$36.3K | Cut−$27.3K |
| Mirae Asset Global Investments Co., Ltd. | 2.82K | $25.4K | −$47.7K | Cut−$45.9K |
| Ameritas Investment Partners, Inc. | 2.74K | $24.7K | −$49.7K | Cut−$49.7K |
| Tower Research Capital LLC (TRC) | 1.43K | $12.8K | −$12.1K | Cut−$5.34K |
| GF FUND MANAGEMENT CO. LTD. | 1.2K | $10.8K | −$19.3K | Cut−$18K |
| Larson Financial Group LLC | 1.11K | $9.96K | −$254 | Added$9.58K |
| Sterling Capital Management LLC | 1.09K | $9.85K | −$19.9K | Cut−$42.3K |
| Versant Capital Management, Inc | 762 | $6.86K | −$10.1K | Cut−$8.29K |
| Rockefeller Capital Management L.P. | 738 | $6.64K | — | New |
| GAMMA Investing LLC | 715 | $6.43K | −$13K | Cut−$18K |
| Quantbot Technologies LP | 663 | $5.97K | — | New |
| US BANCORP \DE\ | 590 | $5.31K | −$9.91K | Cut−$9.51K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 588 | $5.29K | −$4.39K | Cut−$1.28K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 477 | $4.29K | — | New |
| Essential Partners LLC | 402 | $3.62K | −$1.76K | Added$984 |
| OSAIC HOLDINGS, INC. | 389 | $3.5K | −$91 | Added$3.37K |
| Allworth Financial LP | 263 | $2.37K | −$1.24K | Added$520 |
| EverSource Wealth Advisors, LLC | 222 | $2K | −$4.03K | Cut−$5.66K |
| MAI Capital Management | 171 | $1.54K | — | New |
| Torren Management, LLC | 162 | $1.46K | −$2.94K | Cut−$28.4K |
| NATIXIS | 120 | $1.08K | — | New |
| N.E.W. Advisory Services LLC | 120 | $1.08K | −$1.09K | Cut−$549 |
| NEW YORK STATE COMMON RETIREMENT FUND | 100 | $900 | −$1.81K | Cut−$316.8K |
| Wealth Preservation Advisors, LLC | 86 | $774 | — | New |
| Farther Finance Advisors, LLC | 81 | $754 | — | New |
| Arax Advisory Partners | 77 | $693 | −$36 | Added$639 |
| SIGNATUREFD, LLC | 66 | $594 | −$1.2K | Cut−$2.58K |
| ROTHSCHILD INVESTMENT LLC | 61 | $549 | −$18 | Added$522 |
| GSA CAPITAL PARTNERS LLP | 39.2K | $353 | — | New |
| Ameritas Advisory Services, LLC | 31 | $279 | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 26.4K | $238 | −$357 | Cut−$296 |
| Caitong International Asset Management Co., Ltd | 23 | $207 | — | New |
| Root Financial Partners, LLC | 20 | $180 | — | New |
| SJS Investment Consulting Inc. | 2 | $18 | — | New |
| Parallel Advisors, LLC | 2 | $18 | −$36 | Cut−$36 |
| IFP Advisors, Inc | 1 | $9 | −$18 | Cut−$18 |
| Freestone Grove Partners LP | 1 | $9 | — | New |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |
| Covestor Ltd | 4 | $0 | — | New |