| RA CAPITAL MANAGEMENT, L.P. | 23.6M | $129.6M | — | Held |
| Avoro Capital Advisors LLC | 21.7M | $119.3M | — | Held |
| BlackRock, Inc. | 18.6M | $102.5M | — | Held |
| MORGAN STANLEY | 18.1M | $99.4M | $40.3M | Added$36.3M |
| RTW INVESTMENTS, LP | 16.4M | $90.2M | — | Held |
| Vestal Point Capital, LP | 13.8M | $75.6M | — | Held |
| GOLDMAN SACHS GROUP INC | 13.7M | $75.3M | — | Held |
| Fidelity | 13.5M | $74.4M | — | Held |
| Vanguard | 13.3M | $73M | — | Held |
| State Street | 10.8M | $59.3M | — | Held |
| Siren, L.L.C. | 10.1M | $55.7M | — | Held |
| Octagon Capital Advisors LP | 8.86M | $48.7M | — | Held |
| Polar Capital Holdings Plc | 7.93M | $43.6M | — | Held |
| BARCLAYS PLC | 5.54M | $30.5M | $11.5M | Added$13.6M |
| GEODE CAPITAL MANAGEMENT, LLC | 5.39M | $29.6M | — | Held |
| D. E. Shaw & Co., Inc. | 4.01M | $22.1M | — | Held |
| BAKER BROS. ADVISORS LP | 4M | $22M | — | Held |
| Point72 Asset Management, L.P. | 3.87M | $21.3M | — | Held |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 3.72M | $20.5M | — | Held |
| Affinity Asset Advisors, LLC | 3.3M | $18.1M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 3.18M | $17.5M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2.72M | $15M | — | Held |
| ADAR1 Capital Management, LLC | 2.5M | $13.7M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.9M | $10.5M | — | Held |
| Citadel | 1.85M | $10.2M | — | Held |
| NORGES BANK | 1.84M | $10.1M | — | New |
| B Group, Inc. | 1.8M | $9.9M | — | Held |
| Casdin Capital, LLC | 1.5M | $8.25M | — | Held |
| Invesco Ltd. | 1.33M | $7.33M | — | Held |
| GordonMD Global Investments LP | 1.33M | $7.32M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.33M | $7.3M | — | Held |
| RICE HALL JAMES & ASSOCIATES, LLC | 1.27M | $6.99M | — | Held |
| NORTHERN TRUST CORP | 1.24M | $6.81M | — | Held |
| Palo Alto Investors LP | 1.18M | $6.51M | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.15M | $6.34M | $2.57M | Added$2.06M |
| Aberdeen Group plc | 1.02M | $5.62M | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 980.8K | $5.39M | — | Held |
| Informed Momentum Co LLC | 823.8K | $4.53M | — | Held |
| Quantum Private Wealth, LLC | 819.7K | $4.51M | — | Held |
| JPMORGAN CHASE & CO | 774.4K | $4.26M | — | Held |
| Sands Capital Alternatives, LLC | 724.9K | $3.99M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 711.2K | $3.91M | — | Held |
| Granahan Investment Management, LLC | 704K | $3.87M | — | Held |
| Bank of New York Mellon Corp | 624.4K | $3.43M | — | Held |
| Nuveen, LLC | 545.3K | $3M | — | Held |
| Woodline Partners LP | 500K | $2.75M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 490.5K | $2.7M | — | Held |
| Squarepoint Ops LLC | 471.6K | $2.59M | — | Held |
| Ally Bridge Group (NY) LLC | 457.1K | $2.51M | — | Held |
| ACUTA CAPITAL PARTNERS, LLC | 454.8K | $2.5M | — | Held |
| UBS Group AG | 383K | $2.11M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 368.1K | $2.02M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 351.1K | $1.93M | — | Held |
| Rafferty Asset Management, LLC | 344.8K | $1.9M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 309.5K | $1.7M | — | Held |
| Hennion & Walsh Asset Management, Inc. | 308.5K | $1.7M | — | Held |
| WELLS FARGO & COMPANY/MN | 305.1K | $1.68M | — | Held |
| Capricorn Fund Managers Ltd | 300K | $1.65M | — | Held |
| Focus Partners Wealth | 295.5K | $1.63M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 288.5K | $1.59M | — | Held |
| Ensign Peak Advisors, Inc | 275.1K | $1.51M | — | Held |
| Swiss National Bank | 268.8K | $1.48M | — | Held |
| ORACLE INVESTMENT MANAGEMENT INC | 265K | $1.46M | — | Held |
| NOMURA HOLDINGS INC | 259.3K | $1.43M | — | Held |
| RHUMBLINE ADVISERS | 257.4K | $1.42M | — | Held |
| ALPS ADVISORS INC | 224.9K | $1.24M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 218.2K | $1.2M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 195.8K | $1.08M | — | Held |
| STEMPOINT CAPITAL LP | 182.1K | $1M | — | Held |
| WEXFORD CAPITAL LP | 180.9K | $994.7K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 179.6K | $988K | — | Held |
| Palumbo Wealth Management LLC | 178K | $979K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 172.5K | $948.7K | — | Held |
| Renaissance Technologies | 171.1K | $941K | — | Held |
| Icahn Capital | 168.9K | $928.7K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 167.5K | $921.3K | — | Held |
| Seven Fleet Capital Management LP | 167.2K | $919.7K | — | Held |
| Privium Fund Management B.V. | 164.9K | $907K | — | Held |
| JANE STREET GROUP, LLC | 163.1K | $897.3K | — | Held |
| DEUTSCHE BANK AG\ | 160.8K | $884.3K | — | Held |
| POLEN CAPITAL MANAGEMENT LLC | 156.6K | $861.2K | — | Held |
| Chicago Partners Investment Group LLC | 166.5K | $776.1K | — | Held |
| TWO SIGMA ADVISERS, LP | 139.6K | $767.7K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 138.6K | $762.2K | — | Held |
| Legal & General Group Plc | 133.1K | $732.3K | — | Held |
| PROFUND ADVISORS LLC | 128.6K | $707.2K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125K | $687.4K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 122.6K | $677.7K | — | Held |
| MetLife Investment Management, LLC | 113.3K | $623K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 113.2K | $622.5K | — | Held |
| FRANKLIN RESOURCES INC | 108.4K | $596.2K | — | Held |
| PRUDENTIAL FINANCIAL INC | 86.7K | $477K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 71.1K | $390.9K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 68.9K | $378.9K | — | Held |
| JANUS HENDERSON GROUP PLC | 69K | $378.5K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 67.5K | $371.3K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 67.5K | $371.1K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67.1K | $369K | — | Held |
| RED REEF ADVISORS LLC | 66K | $362.7K | — | Held |
| Creative Planning | 63.2K | $347.8K | — | Held |
| CITIGROUP INC | 63K | $346.6K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 57.2K | $314.4K | — | Held |
| SummitTX Capital, L.P. | 56.6K | $311.3K | — | Held |
| COMMONWEALTH EQUITY SERVICES, LLC | 55.7K | $306.1K | — | Held |
| Mitsubishi UFJ Asset Management Co., Ltd. | 58K | $304.4K | — | Held |
| Abacus Wealth Partners, LLC | 55.2K | $303.5K | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 54.8K | $301.3K | — | Held |
| NBC SECURITIES, INC. | 53K | $291.3K | — | Held |
| ProShare Advisors LLC | 52.5K | $288.5K | — | Held |
| SEI INVESTMENTS CO | 47.9K | $263.2K | — | Held |
| Militia Capital Partners, LP | 46.5K | $255.8K | $103.7K | Added$37.3K |
| Virtus Investment Advisers, LLC | 45.9K | $252.7K | — | Held |
| Williams & Novak, LLC | 45K | $247.5K | — | Held |
| Redwood Wealth Management Group, LLC | 44.7K | $245.8K | — | Held |
| China Universal Asset Management Co., Ltd. | 44.6K | $245.5K | — | Held |
| GROUP ONE TRADING LLC | 44.2K | $243.1K | — | Held |
| FIRST MANHATTAN CO. LLC. | 43.5K | $239.3K | — | Held |
| Allianz Asset Management GmbH | 42.4K | $233.2K | — | Held |
| Balyasny Asset Management L.P. | 42.1K | $231.4K | — | Held |
| AXQ CAPITAL, LP | 37.8K | $207.9K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 37.7K | $207.2K | — | Held |
| J. Goldman & Co LP | 33.8K | $185.6K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 32.9K | $161.6K | — | Held |
| KLP KAPITALFORVALTNING AS | 29.3K | $161.2K | — | Held |
| Leonteq Securities AG | 28K | $154K | $62.4K | Added$62.4K |
| Allegheny Financial Group | 26.4K | $144.9K | — | Held |
| Caitong International Asset Management Co., Ltd | 25.6K | $140.7K | — | Held |
| Jefferies Financial Group Inc. | 25K | $137.5K | — | Held |
| Ethic Inc. | 22.7K | $125K | — | Held |
| Cetera Investment Advisers | 21.2K | $116.3K | — | Held |
| MANGROVE PARTNERS IM, LLC | 20.5K | $113K | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 20.2K | $111K | — | Held |
| Lee Financial Co | 20K | $110K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 19.8K | $109.1K | — | Held |
| SIMPLEX TRADING, LLC | 19.8K | $108.8K | — | Held |
| Pictet Asset Management Holding SA | 19.3K | $106.2K | — | Held |
| Scientech Research LLC | 18.2K | $100K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 18.1K | $99.8K | — | Held |
| Ameritas Investment Partners, Inc. | 17.7K | $97.2K | — | Held |
| XPONANCE LLC | 17.2K | $94.7K | — | Held |
| Russell Investments Group, Ltd. | 16.9K | $93.1K | — | Held |
| CAPTRUST FINANCIAL ADVISORS | 15.1K | $83.1K | — | Held |
| Legato Capital Management LLC | 15K | $82.6K | — | Held |
| CIBC WORLD MARKETS CORP | 14.6K | $80.4K | — | Held |
| BANK OF MONTREAL /CAN/ | 13.7K | $75.4K | — | Held |
| MACKENZIE FINANCIAL CORP | 13.3K | $75.2K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 13.3K | $73.2K | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 12.8K | $70.5K | — | Held |
| CIBC Asset Management Inc | 12K | $65.8K | — | Held |
| PANAGORA ASSET MANAGEMENT INC | 11.6K | $63.7K | — | Held |
| GUGGENHEIM CAPITAL LLC | 11.1K | $61.1K | — | Held |
| OPPENHEIMER ASSET MANAGEMENT INC. | 10.8K | $59.3K | — | Held |
| Capital Investment Advisors, LLC | 10K | $55K | — | Held |
| ST GERMAIN D J CO INC | 9.63K | $53K | — | Held |
| ROYAL BANK OF CANADA | 6.3K | $34K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 5.51K | $30.3K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 5.38K | $29.6K | — | Held |
| Rockefeller Capital Management L.P. | 5K | $27.5K | — | Held |
| Chung Wu Investment Group, LLC | 4K | $22K | — | Held |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 2K | $11K | — | Held |
| Sterling Capital Management LLC | 1.41K | $7.76K | — | Held |
| PNC Financial Services Group, Inc. | 1.05K | $5.8K | — | Held |
| Optiver Holding B.V. | 934 | $5.14K | — | Held |
| US BANCORP \DE\ | 912 | $5.02K | — | Held |
| SG Americas Securities, LLC | 781.5K | $4.3K | — | Held |
| Tower Research Capital LLC (TRC) | 475 | $2.61K | — | Held |
| HRT FINANCIAL LP | 409.3K | $2.25K | — | Held |
| Essential Partners LLC | 327 | $1.8K | $730 | Added$730 |
| Parallel Advisors, LLC | 280 | $1.54K | — | Held |
| OSAIC HOLDINGS, INC. | 277 | $1.53K | — | Held |
| GAMMA Investing LLC | 276 | $1.52K | — | Held |
| Sound Income Strategies, LLC | 325 | $1.48K | — | Held |
| Allworth Financial LP | 223 | $1.23K | $479 | Added$523 |
| GSA CAPITAL PARTNERS LLP | 208K | $1.14K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 121.8K | $670 | — | Held |
| EverSource Wealth Advisors, LLC | 91 | $501 | — | Held |
| Bare Financial Services, Inc | 85 | $468 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 70 | $385 | — | Held |
| SIGNATUREFD, LLC | 60 | $330 | — | Held |
| Farther Finance Advisors, LLC | 55 | $303 | — | Held |
| SageView Advisory Group, LLC | 49 | $270 | — | Held |
| True Wealth Design, LLC | 30 | $165 | — | Held |
| Cambridge Investment Research Advisors, Inc. | 22.1K | $121 | — | Held |
| Arax Advisory Partners | 21 | $116 | — | Held |
| Tradewinds Capital Management, LLC | 20 | $110 | — | Held |
| SBI Securities Co., Ltd. | 15 | $83 | — | Held |
| IFP Advisors, Inc | 14 | $77 | $31 | Added$31 |
| CWM, LLC | 13.1K | $72 | — | Held |
| ASSETMARK, INC | 8 | $44 | — | Held |
| MAI Capital Management | 8 | $44 | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 8 | $44 | — | Held |
| AMALGAMATED BANK | 6.94K | $38 | — | Held |
| Hughes Financial Services, LLC | 4 | $22 | — | Held |
| Capital Advisors, Ltd. LLC | 77 | $12 | — | Held |
| Daiwa Securities Group Inc. | 691 | $4 | — | Held |