| FARALLON CAPITAL MANAGEMENT LLC | 13.1M | $115.7M | $4.95M | Added$25.4M |
| TCG Crossover Management, LLC | 12.8M | $113.1M | — | Held |
| Boxer Capital Management, LLC | 10.9M | $96.4M | $4.49M | Added$14.3M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 10.6M | $94M | — | Held |
| Woodline Partners LP | 10.1M | $89.2M | — | Held |
| BlackRock, Inc. | 8.54M | $75.7M | — | Held |
| Siren, L.L.C. | 8.17M | $72.3M | — | Held |
| TRV GP IV, LLC | 7.87M | $69.8M | — | Held |
| Nextech Invest, Ltd. | 7.27M | $64.4M | — | Held |
| Vanguard | 6.75M | $59.8M | — | Held |
| State Street | 6.22M | $55.1M | — | Held |
| Balyasny Asset Management L.P. | 5.28M | $46.8M | — | Held |
| GOLDMAN SACHS GROUP INC | 4.94M | $43.8M | — | Held |
| Logos Global Management LP | 4.2M | $37.2M | — | Held |
| Bellevue Group AG | 3.93M | $34.8M | — | Held |
| Caligan Partners LP | 3.73M | $33M | — | Held |
| Nantahala Capital Management, LLC | 3.57M | $31.7M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2.91M | $25.8M | — | Held |
| Fidelity | 2.87M | $25.4M | — | Held |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2.66M | $23.6M | — | Held |
| JANUS HENDERSON GROUP PLC | 2.64M | $23.5M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 2.55M | $22.6M | — | Held |
| Deep Track Capital, LP | 2.45M | $21.7M | — | Held |
| Vivo Capital, LLC | 2.15M | $19.1M | — | Held |
| Point72 Asset Management, L.P. | 1.97M | $17.5M | — | Held |
| RTW INVESTMENTS, LP | 1.49M | $13.2M | — | Held |
| MORGAN STANLEY | 1.42M | $12.6M | $115.8K | Added$10.5M |
| FRANKLIN RESOURCES INC | 1.4M | $12.4M | — | Held |
| D. E. Shaw & Co., Inc. | 1.03M | $9.09M | — | Held |
| Affinity Asset Advisors, LLC | 1M | $8.86M | — | Held |
| UBS Group AG | 990.5K | $8.78M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 957.3K | $8.48M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 841K | $7.45M | — | Held |
| NORTHERN TRUST CORP | 803.2K | $7.12M | — | Held |
| Candriam S.C.A. | 708.8K | $6.28M | — | Held |
| ArrowMark Colorado Holdings LLC | 708.4K | $6.28M | — | Held |
| Bain Capital Life Sciences Investors, LLC | 653.5K | $5.79M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 593K | $5.25M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 544.6K | $4.82M | — | Held |
| PERCEPTIVE ADVISORS LLC | 513K | $4.55M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 487.1K | $4.32M | — | Held |
| BANK OF AMERICA CORP /DE/ | 478.1K | $4.24M | $71.5K | Added$2.93M |
| Rock Springs Capital Management LP | 386.9K | $3.43M | — | Held |
| BARCLAYS PLC | 368.2K | $3.26M | $168.2K | Added$190.4K |
| Mass General Brigham, Inc | 354.2K | $3.14M | — | Held |
| Bank of New York Mellon Corp | 343.8K | $3.05M | — | Held |
| MARSHALL WACE, LLP | 329.2K | $2.92M | — | Held |
| Qube Research & Technologies Ltd | 318.7K | $2.82M | — | Held |
| Nuveen, LLC | 300.4K | $2.66M | — | Held |
| GREAT LAKES ADVISORS, LLC | 294.3K | $2.61M | — | Held |
| ACUTA CAPITAL PARTNERS, LLC | 282.7K | $2.51M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 255.1K | $2.26M | — | Held |
| CONGRESS ASSET MANAGEMENT CO | 234.6K | $2.08M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 233.9K | $2.07M | — | Held |
| Rafferty Asset Management, LLC | 226.6K | $2.01M | — | Held |
| Seven Fleet Capital Management LP | 215.2K | $1.91M | — | Held |
| Integral Health Asset Management, LLC | 200K | $1.77M | — | Held |
| TRV GP VI, LLC | 194.2K | $1.72M | — | Held |
| Fisher Asset Management, LLC | 187.7K | $1.66M | — | Held |
| Invesco Ltd. | 177.6K | $1.57M | — | Held |
| Squarepoint Ops LLC | 173.9K | $1.54M | — | Held |
| Citadel | 151.9K | $1.35M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 144.4K | $1.28M | — | Held |
| ADAR1 Capital Management, LLC | 140K | $1.24M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 129.5K | $1.15M | — | Held |
| RHUMBLINE ADVISERS | 129.1K | $1.14M | — | Held |
| Verition Fund Management LLC | 121.8K | $1.08M | — | Held |
| WELLS FARGO & COMPANY/MN | 121.2K | $1.07M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 106.5K | $943.5K | — | Held |
| Trexquant Investment LP | 105.3K | $932.7K | — | Held |
| Swiss National Bank | 87.8K | $777.9K | — | Held |
| PROFUND ADVISORS LLC | 83.8K | $742.1K | — | Held |
| Icahn Capital | 82.2K | $728.6K | — | Held |
| DEUTSCHE BANK AG\ | 74.2K | $657.4K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 68.3K | $604.7K | $24.6K | Added$154.7K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 62.6K | $551.9K | — | Held |
| MetLife Investment Management, LLC | 59.7K | $528.9K | — | Held |
| Y-Intercept (Hong Kong) Ltd | 59.3K | $525.7K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 64.2K | $512K | — | Held |
| JPMORGAN CHASE & CO | 56.8K | $503.6K | — | Held |
| SEI INVESTMENTS CO | 53.9K | $477.8K | — | Held |
| Graham Capital Management, L.P. | 51.3K | $454.7K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 50.4K | $446.5K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48.2K | $427.1K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 47.8K | $423.6K | — | Held |
| SmartHarvest Portfolios, LLC | 46.1K | $408.6K | — | Held |
| Creative Planning | 41.9K | $371.3K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 41.5K | $367.3K | — | Held |
| Legal & General Group Plc | 39.4K | $349.4K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 38.9K | $345K | — | Held |
| XTX Topco Ltd | 37.8K | $335.2K | — | Held |
| CITIGROUP INC | 36.2K | $321.1K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35.2K | $312K | — | Held |
| Philadelphia Financial Management of San Francisco, LLC | 33.3K | $295K | — | Held |
| ExodusPoint Capital Management, LP | 32.9K | $291.5K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32.3K | $286.6K | — | Held |
| Engineers Gate Manager LP | 30.6K | $271.1K | — | Held |
| VARCOV Co. | 29.5K | $261.2K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 29.3K | $259.9K | — | Held |
| Virtus Investment Advisers, LLC | 28.5K | $252.1K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 28.3K | $250.7K | — | Held |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 28K | $248.3K | — | Held |
| EverSource Wealth Advisors, LLC | 25.6K | $227.2K | — | Held |
| ProShare Advisors LLC | 25.4K | $224.9K | — | Held |
| CANTOR FITZGERALD, L. P. | 25K | $221.5K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 24.6K | $217.7K | — | Held |
| Quantinno Capital Management LP | 22.3K | $197.9K | — | Held |
| Mitsubishi UFJ Asset Management Co., Ltd. | 21.9K | $195.3K | — | Held |
| China Universal Asset Management Co., Ltd. | 21.9K | $194.4K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 21.5K | $190.5K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 20.4K | $180.8K | — | Held |
| AXQ CAPITAL, LP | 20.3K | $179.6K | — | Held |
| Tower Research Capital LLC (TRC) | 19.7K | $174.9K | — | Held |
| Bridgefront Capital, LLC | 19.5K | $172.6K | — | Held |
| BANK OF MONTREAL /CAN/ | 16.5K | $146.1K | — | Held |
| Atria Investments, Inc | 14.8K | $131.3K | — | Held |
| Entropy Technologies, LP | 14.8K | $131.1K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12.8K | $113.2K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 12.3K | $108.7K | — | Held |
| LPL Financial LLC | 12K | $106.3K | — | Held |
| Pinnacle Wealth Planning Services, Inc. | 10.8K | $95.5K | — | Held |
| Corient Private Wealth LLC | 10.5K | $93.3K | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 10.5K | $92.7K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 10.2K | $90.4K | — | Held |
| Soleus Capital Management, L.P. | 10K | $88.6K | — | Held |
| Russell Investments Group, Ltd. | 9.79K | $86.8K | — | Held |
| KLP KAPITALFORVALTNING AS | 9.7K | $85.9K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 9.56K | $84.7K | — | Held |
| Ameritas Investment Partners, Inc. | 8.63K | $76.5K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 6.54K | $58K | — | Held |
| Sterling Capital Management LLC | 6.13K | $54.3K | — | Held |
| ANTIPODES PARTNERS Ltd | 4.51K | $40K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4.47K | $39.6K | — | Held |
| Global Retirement Partners, LLC | 4K | $35.5K | — | Held |
| ROYAL BANK OF CANADA | 3.68K | $32K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 2.65K | $23.4K | — | Held |
| COMERICA BANK | 2.16K | $19.1K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 1.74K | $15.4K | — | Held |
| TFC Financial Management, Inc. | 1.3K | $11.5K | — | Held |
| Rockefeller Capital Management L.P. | 887 | $7.86K | — | Held |
| BESSEMER GROUP INC | 708.4K | $6.28K | — | Held |
| OSAIC HOLDINGS, INC. | 692 | $6.13K | — | Held |
| Optiver Holding B.V. | 576 | $5.1K | — | Held |
| GAMMA Investing LLC | 477 | $4.23K | — | Held |
| T. Rowe Price Investment Management, Inc. | 446.2K | $3.95K | — | Held |
| AlphaQuest LLC | 375 | $3.32K | — | Held |
| FEDERATED HERMES, INC. | 362 | $3.21K | — | Held |
| Farther Finance Advisors, LLC | 355 | $3.15K | — | Held |
| Caitong International Asset Management Co., Ltd | 320 | $2.83K | — | Held |
| FLAGSHIP HARBOR ADVISORS, LLC | 300 | $2.66K | — | New |
| IFP Advisors, Inc | 233 | $2.06K | $107 | Added$107 |
| PNC Financial Services Group, Inc. | 212 | $1.88K | — | Held |
| WPG Advisers, LLC | 159 | $1.41K | — | Held |
| GSA CAPITAL PARTNERS LLP | 118.6K | $1.05K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 58.4K | $518 | — | Held |
| DekaBank Deutsche Girozentrale | 60K | $502 | — | Held |
| Allworth Financial LP | 45 | $399 | $17 | Added$79 |
| Clearstead Advisors, LLC | 45 | $399 | — | Held |
| Janney Montgomery Scott LLC | 36K | $319 | — | Held |
| Larson Financial Group LLC | 34 | $301 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 26 | $230 | — | Held |
| SG Americas Securities, LLC | 22K | $195 | — | Held |
| SBI Securities Co., Ltd. | 19 | $168 | — | Held |
| Arax Advisory Partners | 8 | $71 | — | Held |
| CWM, LLC | 4.83K | $43 | — | Held |
| Essential Partners LLC | 4 | $35 | — | New |
| AMALGAMATED BANK | 3.34K | $30 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1.02K | $9 | — | Held |
| Daiwa Securities Group Inc. | 355 | $3 | — | Held |
| Covestor Ltd | 32 | $0 | — | Held |