| BlackRock, Inc. | 3.79M | $310.4M | — | Held |
| RTW INVESTMENTS, LP | 3.34M | $273.1M | — | Held |
| Deep Track Capital, LP | 3M | $246M | — | Held |
| Paradigm Biocapital Advisors LP | 2.56M | $209.8M | — | Held |
| Vanguard | 2.4M | $196.5M | — | Held |
| JENNISON ASSOCIATES LLC | 2.23M | $182.6M | — | Held |
| MORGAN STANLEY | 2.04M | $167.1M | $42.9M | Added$53.4M |
| JANUS HENDERSON GROUP PLC | 1.93M | $158.1M | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 1.19M | $97.3M | — | Held |
| Driehaus Capital Management LLC | 1.17M | $96M | — | Held |
| Assenagon Asset Management S.A. | 1.13M | $92.3M | — | Held |
| Invesco Ltd. | 1.01M | $82.9M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 947.8K | $77.6M | — | Held |
| State Street | 929.1K | $76.1M | — | Held |
| BANK OF AMERICA CORP /DE/ | 758.1K | $62.1M | $12M | Added$30.2M |
| Frazier Life Sciences Management, L.P. | 728.6K | $59.7M | — | Held |
| Fidelity | 647.1K | $53M | — | Held |
| D. E. Shaw & Co., Inc. | 615.2K | $50.4M | — | Held |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 584.7K | $47.9M | — | Held |
| TORONTO DOMINION BANK | 510.3K | $41.8M | — | Held |
| Clearbridge Investments, LLC | 506.1K | $41.4M | — | Held |
| Ensign Peak Advisors, Inc | 474.1K | $38.8M | — | Held |
| LOOMIS SAYLES & CO L P | 441.9K | $36.2M | — | Held |
| Artisan Partners Limited Partnership | 436.6K | $35.7M | — | Held |
| Qube Research & Technologies Ltd | 401.2K | $32.9M | — | Held |
| GOLDMAN SACHS GROUP INC | 378.7K | $31M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 356.1K | $29.2M | — | Held |
| NORTHERN TRUST CORP | 342.5K | $28M | — | Held |
| FRANKLIN RESOURCES INC | 337K | $27.6M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 333.1K | $27.3M | — | Held |
| TimesSquare Capital Management, LLC | 332.4K | $27.2M | — | Held |
| MPM BIOIMPACT LLC | 328.9K | $26.9M | — | Held |
| Nuveen, LLC | 322.5K | $26.4M | — | Held |
| Rock Springs Capital Management LP | 260.3K | $21.3M | — | Held |
| Cormorant Asset Management, LP | 250K | $20.5M | — | Held |
| Integral Health Asset Management, LLC | 200K | $16.4M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 173.3K | $14.2M | — | Held |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 161.8K | $13.3M | — | Held |
| ORBIMED ADVISORS LLC | 154.4K | $12.6M | — | Held |
| Russell Investments Group, Ltd. | 153.8K | $12.6M | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 151.1K | $12.4M | — | Held |
| Allspring Global Investments Holdings, LLC | 130.4K | $10.5M | — | Held |
| Jump Financial, LLC | 128.1K | $10.5M | — | Held |
| WELLS FARGO & COMPANY/MN | 119.1K | $9.75M | — | Held |
| Jefferies Financial Group Inc. | 118.8K | $9.73M | — | Held |
| DEUTSCHE BANK AG\ | 118.2K | $9.68M | — | Held |
| NORGES BANK | 117.6K | $9.63M | $3.59M | Cut−$10.5M |
| MILLENNIUM MANAGEMENT LLC | 117K | $9.58M | — | Held |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 114.5K | $9.37M | — | Held |
| FIRST TRUST ADVISORS LP | 111.8K | $9.15M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 109.9K | $9M | — | Held |
| Bank of New York Mellon Corp | 107.8K | $8.82M | — | Held |
| Woodline Partners LP | 100.2K | $8.2M | — | Held |
| Sands Capital Alternatives, LLC | 85K | $6.96M | — | Held |
| BARCLAYS PLC | 80.8K | $6.61M | $1.81M | Added$1.14M |
| Squadron Capital Management LLC | 80K | $6.55M | — | Held |
| Voleon Capital Management LP | 77.4K | $6.34M | — | Held |
| Informed Momentum Co LLC | 72.9K | $5.97M | — | Held |
| COMMONWEALTH EQUITY SERVICES, LLC | 68.3K | $5.59M | — | Held |
| UBS Group AG | 66.9K | $5.48M | — | Held |
| GordonMD Global Investments LP | 66.7K | $5.46M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 66.3K | $5.43M | — | Held |
| Lisanti Capital Growth, LLC | 64.3K | $5.27M | — | Held |
| Renaissance Technologies | 64.1K | $5.25M | — | Held |
| TD Asset Management Inc | 64K | $5.24M | — | Held |
| PDT Partners, LLC | 63K | $5.16M | — | Held |
| Swiss National Bank | 62.4K | $5.11M | — | Held |
| JPMORGAN CHASE & CO | 56.6K | $4.64M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55.3K | $4.54M | — | Held |
| Trexquant Investment LP | 54.5K | $4.47M | — | Held |
| HighVista Strategies LLC | 53.6K | $4.39M | — | Held |
| CITIGROUP INC | 52K | $4.26M | — | Held |
| ExodusPoint Capital Management, LP | 51.5K | $4.22M | — | Held |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 50K | $4.09M | — | Held |
| FEDERATED HERMES, INC. | 49.3K | $4.04M | — | Held |
| RHUMBLINE ADVISERS | 47.1K | $3.85M | — | Held |
| Baird Financial Group, Inc. | 46.9K | $3.84M | — | Held |
| SEI INVESTMENTS CO | 43.3K | $3.55M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 43.2K | $3.53M | — | Held |
| CAXTON ASSOCIATES LLP | 41K | $3.35M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 40.7K | $3.33M | — | Held |
| Walleye Capital LLC | 40.3K | $3.3M | — | Held |
| F/m Investments LLC | 39.2K | $3.21M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 38.1K | $3.12M | — | Held |
| Point72 Asset Management, L.P. | 37.6K | $3.08M | — | Held |
| Pictet Asset Management Holding SA | 37.6K | $3.08M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 36.1K | $2.96M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 35.6K | $2.92M | — | Held |
| ALPS ADVISORS INC | 34.8K | $2.85M | — | Held |
| Calamos Advisors LLC | 34.4K | $2.82M | — | Held |
| E. Ohman J:or Asset Management AB | 33.3K | $2.73M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 31.9K | $2.61M | — | Held |
| Ikarian Capital, LLC | 31.2K | $2.55M | — | Held |
| Legal & General Group Plc | 31.1K | $2.55M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30.2K | $2.47M | — | Held |
| Cinctive Capital Management LP | 28.8K | $2.36M | — | Held |
| PFM Health Sciences, LP | 27.3K | $2.24M | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 31.5K | $2.17M | — | Held |
| Icahn Capital | 25.9K | $2.12M | — | Held |
| Campbell & CO Investment Adviser LLC | 25.4K | $2.08M | — | Held |
| Ishara Investments LP | 24K | $1.97M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 23.4K | $1.91M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 22.7K | $1.86M | — | New |
| Capricorn Fund Managers Ltd | 22K | $1.8M | — | Held |
| Squarepoint Ops LLC | 21.8K | $1.79M | — | Held |
| MetLife Investment Management, LLC | 21.7K | $1.77M | — | Held |
| Engineers Gate Manager LP | 21K | $1.72M | — | Held |
| Schonfeld Strategic Advisors LLC | 20.7K | $1.69M | — | Held |
| JANE STREET GROUP, LLC | 20.5K | $1.68M | — | Held |
| AlphaQuest LLC | 19.2K | $1.57M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 19.1K | $1.56M | — | Held |
| XTX Topco Ltd | 18.4K | $1.51M | — | Held |
| D.A. DAVIDSON & CO. | 18.2K | $1.49M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18.2K | $1.49M | — | Held |
| Legato Capital Management LLC | 17.8K | $1.45M | — | Held |
| HUSSMAN STRATEGIC ADVISORS, INC. | 16.8K | $1.38M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 16.8K | $1.37M | — | Held |
| LPL Financial LLC | 15.3K | $1.25M | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 14.7K | $1.21M | — | Held |
| Creative Planning | 14K | $1.15M | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 13.8K | $1.13M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 13.6K | $1.12M | — | Held |
| Baader Bank Aktiengesellschaft | 12K | $982.6K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 11.6K | $950.1K | — | Held |
| State of New Jersey Common Pension Fund D | 10.8K | $884.8K | — | Held |
| KEYBANK NATIONAL ASSOCIATION/OH | 10.7K | $876.5K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 10.4K | $849.8K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9.42K | $771.5K | — | Held |
| Entropy Technologies, LP | 9.4K | $769.3K | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 9.29K | $760.7K | — | Held |
| TWO SIGMA ADVISERS, LP | 9.1K | $745.1K | — | Held |
| Jain Global LLC | 9.1K | $744.8K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 9.05K | $741.4K | — | Held |
| ProShare Advisors LLC | 9.03K | $739.7K | — | Held |
| FORA Capital, LLC | 8.88K | $726.8K | — | Held |
| Vontobel Holding Ltd. | 8.84K | $724.1K | — | Held |
| OCCUDO QUANTITATIVE STRATEGIES LP | 8.76K | $716.9K | — | Held |
| AlphaCore Capital LLC | 8.75K | $716.5K | — | Held |
| AMERIPRISE FINANCIAL INC | 8.6K | $704.4K | — | Held |
| STRS OHIO | 8.4K | $687.8K | — | Held |
| Virtus Investment Advisers, LLC | 8.4K | $687.7K | — | Held |
| Odyssean, LLC | 7.63K | $624.3K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7.59K | $621.6K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 7.45K | $610K | — | Held |
| Quantbot Technologies LP | 7.1K | $581.5K | — | Held |
| China Universal Asset Management Co., Ltd. | 6.92K | $566.4K | — | Held |
| KLP KAPITALFORVALTNING AS | 6.9K | $565K | — | Held |
| Allianz Asset Management GmbH | 6.9K | $565K | — | Held |
| STIFEL FINANCIAL CORP | 6.8K | $557K | — | Held |
| PSP Research LLC | 6.52K | $533.8K | — | Held |
| WINTON GROUP Ltd | 6.45K | $527.8K | — | Held |
| Lighthouse Investment Partners, LLC | 6.22K | $509.2K | — | Held |
| Valmark Advisers, Inc. | 5.5K | $450.3K | — | Held |
| Dynamic Technology Lab Private Ltd | 5.16K | $423K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 4.66K | $381.9K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 4.5K | $368.9K | — | Held |
| Seven Fleet Capital Management LP | 4.5K | $368.5K | — | Held |
| Brevan Howard Capital Management LP | 4.46K | $365K | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 4.32K | $354K | — | Held |
| ROYAL BANK OF CANADA | 4.21K | $344K | — | Held |
| OPPENHEIMER & CO INC | 4.15K | $339.8K | — | Held |
| Valeo Financial Advisors, LLC | 3.92K | $320.6K | — | Held |
| PROFUND ADVISORS LLC | 3.83K | $313.6K | — | Held |
| GUGGENHEIM CAPITAL LLC | 3.67K | $300.8K | — | Held |
| HighTower Advisors, LLC | 3.62K | $296.7K | — | Held |
| West Wealth Group, LLC | 3.4K | $278.4K | — | Held |
| Ameritas Investment Partners, Inc. | 3.27K | $267.9K | — | Held |
| M&T Bank Corp | 3.12K | $255.4K | — | Held |
| XPONANCE LLC | 3.07K | $251.7K | — | Held |
| SIMPLEX TRADING, LLC | 3.01K | $246.7K | — | Held |
| Tower Research Capital LLC (TRC) | 2.92K | $239.3K | — | Held |
| Rafferty Asset Management, LLC | 2.88K | $235.4K | — | Held |
| Quantinno Capital Management LP | 2.75K | $224.8K | — | Held |
| J. Goldman & Co LP | 2.7K | $221K | — | Held |
| PRUDENTIAL FINANCIAL INC | 2.61K | $213.7K | — | Held |
| CIBC WORLD MARKETS CORP | 2.59K | $212.2K | — | Held |
| CIBC Private Wealth Group LLC | 2.5K | $204.7K | — | Held |
| MACKENZIE FINANCIAL CORP | 2.45K | $201.6K | — | Held |
| Pale Fire Capital SE | 2.45K | $200.8K | — | Held |
| Quarry LP | 2.4K | $196.5K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.06K | $168.9K | — | Held |
| Leonteq Securities AG | 2K | $163.8K | $44.9K | Cut−$222.5K |
| 1620 INVESTMENT ADVISORS, INC. | 1.81K | $148K | — | Held |
| OSAIC HOLDINGS, INC. | 1.54K | $126.3K | — | Held |
| Rockefeller Capital Management L.P. | 1.28K | $105.1K | — | Held |
| Truvestments Capital LLC | 909 | $74.4K | — | Held |
| LORD, ABBETT & CO. LLC | 855.6K | $70.1K | — | Held |
| COMERICA BANK | 855 | $70K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 833 | $68.2K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 518.8K | $42.5K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 406 | $33.2K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 347 | $28.4K | — | Held |
| GAMMA Investing LLC | 340 | $27.8K | — | Held |
| MAI Capital Management | 285 | $23.3K | — | Held |
| Sterling Capital Management LLC | 253 | $20.7K | — | Held |
| Parallel Advisors, LLC | 209 | $17.1K | — | Held |
| Optiver Holding B.V. | 189 | $15.5K | — | Held |
| PNC Financial Services Group, Inc. | 152 | $12.4K | — | Held |
| Spire Wealth Management | 143 | $11.7K | — | Held |
| Arax Advisory Partners | 132 | $10.8K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 110 | $9.01K | — | Held |
| Accent Capital Management, LLC | 85 | $6.96K | — | Held |
| PRIVATE TRUST CO NA | 84 | $6.88K | — | Held |
| Global Retirement Partners, LLC | 73 | $5.98K | — | Held |
| Steward Partners Investment Advisory, LLC | 69 | $5.65K | — | Held |
| Kemnay Advisory Services Inc. | 62 | $5.08K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 60 | $4.91K | — | Held |
| Allworth Financial LP | 55 | $4.5K | $740 | Added$2.54K |
| ALGERT GLOBAL LLC | 46K | $3.77K | — | Held |
| LRI Investments, LLC | 42 | $3.41K | — | Held |
| Smartleaf Asset Management LLC | 37 | $3.05K | — | Held |
| EverSource Wealth Advisors, LLC | 30 | $2.46K | — | Held |
| Penserra Capital Management LLC | 29.4K | $2.41K | — | Held |
| Essential Partners LLC | 26 | $2.13K | $584 | Added$584 |
| HRT FINANCIAL LP | 24.8K | $2.03K | — | Held |
| Farther Finance Advisors, LLC | 23 | $1.88K | — | Held |
| HARBOR CAPITAL ADVISORS, INC. | 21.7K | $1.78K | — | Held |
| US BANCORP \DE\ | 18 | $1.47K | — | Held |
| WPG Advisers, LLC | 17 | $1.39K | — | Held |
| Parkside Financial Bank & Trust | 16 | $1.31K | — | Held |
| Cambridge Investment Research Advisors, Inc. | 15.2K | $1.24K | — | Held |
| ASSETMARK, INC | 14 | $1.15K | — | Held |
| Handelsbanken Fonder AB | 13.8K | $1.13K | — | Held |
| SG Americas Securities, LLC | 13.5K | $1.11K | — | Held |
| Janney Montgomery Scott LLC | 12.9K | $1.05K | — | Held |
| Bell Investment Advisors, Inc | 11 | $901 | — | Held |
| True Wealth Design, LLC | 11 | $901 | — | Held |
| SIGNATUREFD, LLC | 7 | $573 | — | Held |
| Breakwater Investment Management | 6 | $492 | — | Held |
| QUADRANT CAPITAL GROUP LLC | 6 | $492 | — | Held |
| Bare Financial Services, Inc | 6 | $491 | — | Held |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 4.48K | $367 | — | Held |
| GSA CAPITAL PARTNERS LLP | 3.61K | $296 | — | Held |
| Versant Capital Management, Inc | 3 | $246 | — | Held |
| THOROUGHBRED FINANCIAL SERVICES, LLC | 2.73K | $223 | — | Held |
| SBI Securities Co., Ltd. | 2 | $164 | — | Held |
| Turning Point Benefit Group, Inc. | 2 | $163 | — | Held |
| KBC Group NV | 1.3K | $106 | $29 | Added$29 |
| AMALGAMATED BANK | 1.23K | $101 | — | Held |
| HUNTINGTON NATIONAL BANK | 1 | $82 | — | Held |
| IFP Advisors, Inc | 1 | $82 | $23 | Added$23 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 433 | $35 | — | Held |
| CWM, LLC | 403 | $33 | — | Held |
| Daiwa Securities Group Inc. | 137 | $11 | — | Held |
| BESSEMER GROUP INC | 48 | $4 | — | Held |
| Covestor Ltd | 25 | $2 | — | Held |