| NEA Management Company, LLC | 24.5M | $133.6M | −$13.9M | Cut−$13.9M |
| Bain Capital Life Sciences Investors, LLC | 17.6M | $96.1M | −$10M | Cut−$10M |
| VR ADVISER, LLC | 13.7M | $75M | −$7.83M | Cut−$7.83M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 13.6M | $74.1M | −$7.73M | Cut−$7.73M |
| TCG Crossover Management, LLC | 12.4M | $67.5M | −$7.05M | Cut−$7.05M |
| BlackRock, Inc. | 11.3M | $61.6M | −$6.33M | Cut−$5.27M |
| Frazier Life Sciences Management, L.P. | 9.72M | $53.1M | −$5.54M | Cut−$6.39M |
| Polar Capital Holdings Plc | 9.54M | $52.1M | −$4.73M | Added$2.01M |
| VANGUARD CAPITAL MANAGEMENT LLC | 7.78M | $42.5M | — | Held |
| Nantahala Capital Management, LLC | 7.34M | $40.1M | −$4.19M | Cut−$4.19M |
| State Street | 6.71M | $36.6M | −$2.47M | Added$10.5M |
| RTW INVESTMENTS, LP | 5.95M | $32.5M | −$3.39M | Cut−$3.39M |
| MARSHALL WACE, LLP | 4.51M | $24.6M | −$2.57M | Cut−$2.85M |
| Woodline Partners LP | 4.25M | $23.2M | −$2.42M | Cut−$2.42M |
| GEODE CAPITAL MANAGEMENT, LLC | 3.59M | $19.6M | −$1.95M | Cut−$982.8K |
| Spruce Street Capital LP | 3.38M | $18.5M | −$1.37M | Added$3.93M |
| EMERALD ADVISERS, LLC | 3.37M | $18.4M | −$1.92M | Cut−$2.67M |
| Rosalind Advisors, Inc. | 3.2M | $17.5M | −$1.83M | Cut−$3.03M |
| WELLINGTON MANAGEMENT GROUP LLP | 2.71M | $14.8M | −$1.52M | Cut−$1.33M |
| Vestal Point Capital, LP | 2.6M | $14.2M | −$915.4K | Added$4.51M |
| Affinity Asset Advisors, LLC | 2.51M | $13.7M | −$1.43M | Cut−$3.15M |
| EMERALD MUTUAL FUND ADVISERS TRUST | 2.37M | $12.9M | −$1.35M | Cut−$1.52M |
| Pictet Asset Management Holding SA | 2.28M | $12.4M | — | New |
| D. E. Shaw & Co., Inc. | 2.11M | $11.5M | −$951.5K | Added$1.46M |
| NAN FUNG TRINITY (HK) LTD | 1.84M | $10.1M | −$962.4K | Cut−$122.4K |
| MORGAN STANLEY | 1.79M | $9.75M | −$1.02M | Cut−$4.34M |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1.59M | $8.66M | −$567.4K | Added$2.66M |
| ADAR1 Capital Management, LLC | 1.46M | $8M | −$801.1K | Cut−$478.5K |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.43M | $7.81M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1.38M | $7.51M | — | Held |
| Longaeva Partners L.P. | 1.27M | $6.96M | −$710.2K | Cut−$552.1K |
| NORTHERN TRUST CORP | 1.19M | $6.5M | −$614.2K | Cut−$711 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.14M | $6.23M | −$649.9K | Cut−$779.1K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1.05M | $5.75M | $5.74M | Added$5.74M |
| VANGUARD FIDUCIARY TRUST CO | 1M | $5.49M | — | Held |
| DEUTSCHE BANK AG\ | 848.4K | $4.63M | −$470.1K | Cut−$340.8K |
| Citadel | 798.7K | $4.36M | −$441.5K | Cut−$309.1K |
| VOYA INVESTMENT MANAGEMENT LLC | 756.8K | $4.13M | −$428.2K | Cut−$398.1K |
| SPHERA FUNDS MANAGEMENT LTD. | 739.2K | $4.04M | −$421.3K | Cut−$3.07M |
| Swedbank AB | 700K | $3.82M | −$399K | Cut−$1.3M |
| Renaissance Technologies | 652.7K | $3.56M | −$189.3K | Added$1.56M |
| F/m Investments LLC | 651K | $3.55M | −$371.1K | Cut−$538.7K |
| ORBIMED ADVISORS LLC | 635K | $3.47M | — | New |
| Moody Aldrich Partners LLC | 614.3K | $3.35M | — | New |
| Sio Capital Management, LLC | 613.9K | $3.35M | −$349.9K | Cut−$349.9K |
| KVP Capital Advisors, LP | 605.3K | $3.3M | −$345K | Cut−$345K |
| Integral Health Asset Management, LLC | 600K | $3.28M | — | New |
| UBS Group AG | 596.7K | $3.26M | −$115.6K | Added$2.03M |
| BANK OF AMERICA CORP /DE/ | 588.2K | $3.21M | −$241.4K | Added$657.3K |
| GOLDMAN SACHS GROUP INC | 580.1K | $3.17M | −$294.5K | Added$52K |
| Point72 Asset Management, L.P. | 463K | $2.53M | — | New |
| JANE STREET GROUP, LLC | 431K | $2.35M | −$245.7K | Cut−$1.17M |
| Eversept Partners, LP | 384.3K | $2.1M | −$97K | Added$1.07M |
| XTX Topco Ltd | 379.4K | $2.07M | −$14.1K | Added$1.92M |
| Sofinnova Investments, Inc. | 364.8K | $1.99M | −$173.7K | Added$153.8K |
| Nuveen, LLC | 343.6K | $1.88M | −$155.4K | Added$232K |
| Bank of New York Mellon Corp | 309.7K | $1.69M | −$176.5K | Cut−$195.7K |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 308K | $1.68M | — | New |
| Seven Fleet Capital Management LP | 295.7K | $1.61M | −$35.8K | Added$1.24M |
| HighVista Strategies LLC | 251K | $1.37M | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 240.6K | $1.31M | −$17.8K | Added$1.13M |
| Invesco Ltd. | 223K | $1.22M | −$127.1K | Cut−$2.93M |
| Walleye Capital LLC | 195.1K | $1.07M | −$85.5K | Added$160.1K |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 205.1K | $1.04M | — | New |
| Rafferty Asset Management, LLC | 189K | $1.03M | −$51.2K | Added$489.8K |
| Squarepoint Ops LLC | 170.8K | $932.7K | — | New |
| RHUMBLINE ADVISERS | 157.1K | $858K | −$87.1K | Cut−$63.2K |
| Aquatic Capital Management LLC | 153.1K | $836.2K | −$47.4K | Added$335.2K |
| ALLIANCEBERNSTEIN L.P. | 127K | $766.1K | $0 | Held |
| Swiss National Bank | 136.8K | $746.9K | — | New |
| Verdad Advisers, LP | 128.4K | $700.9K | — | New |
| Connor, Clark & Lunn Investment Management Ltd. | 122.9K | $670.8K | −$42.7K | Added$219.3K |
| Trexquant Investment LP | 114.2K | $623.5K | — | New |
| GLENMEDE TRUST CO NA | 105.3K | $574.8K | — | New |
| Vanguard Global Advisers, LLC | 91.7K | $500.7K | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 90K | $491.4K | −$58.5K | Cut−$58.5K |
| ENVESTNET ASSET MANAGEMENT INC | 88.7K | $484.4K | — | New |
| Qube Research & Technologies Ltd | 87.6K | $478.2K | — | New |
| WELLS FARGO & COMPANY/MN | 86.9K | $474.6K | −$49.5K | Cut−$536.3K |
| PROFUND ADVISORS LLC | 85K | $464K | −$20K | Added$252.1K |
| Optimize Financial Inc | 84.1K | $459.2K | — | New |
| Cresset Asset Management, LLC | 83.5K | $455.8K | −$47.5K | Cut−$46.7K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 81.3K | $438.4K | −$45.6K | Added$9.8K |
| JPMORGAN CHASE & CO | 80.7K | $407.6K | −$71.6K | Cut−$33K |
| EntryPoint Capital, LLC | 73.9K | $403.4K | −$23.2K | Added$157.9K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71.6K | $390.9K | −$40.8K | Cut−$2.89M |
| MetLife Investment Management, LLC | 69.4K | $379.2K | −$39.6K | Cut−$94.5K |
| Fidelity | 69K | $376.9K | −$15.9K | Added$209K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 68.2K | $372.2K | −$24.8K | Added$109.6K |
| FIFTH THIRD BANCORP | 66.4K | $362.7K | — | New |
| Susquehanna Portfolio Strategies, LLC | 60K | $327.5K | −$33.9K | Cut−$31.1K |
| Creative Planning | 59.8K | $326.7K | −$31.8K | Cut−$9.32K |
| Icahn Capital | 55.2K | $301.3K | — | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 52.7K | $287.8K | — | New |
| Sivia Capital Partners, LLC | 48.5K | $264.8K | −$27.6K | Cut−$27.7K |
| VARCOV Co. | 48.3K | $263.9K | — | New |
| Avidity Partners Management LP | 50K | $262K | — | New |
| VANGUARD ASSET MANAGEMENT, Ltd | 47.6K | $260.1K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 46.9K | $255.8K | — | New |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 46K | $251.2K | −$26.2K | Cut−$26.2K |
| JANUS HENDERSON GROUP PLC | 45.2K | $247K | — | New |
| TUDOR INVESTMENT CORP ET AL | 44.8K | $244.6K | — | New |
| SEI INVESTMENTS CO | 44.6K | $243.3K | −$8.38K | Added$154.7K |
| BANK OF MONTREAL /CAN/ | 43.4K | $236.8K | — | New |
| Police & Firemen's Retirement System of New Jersey | 40.6K | $221.9K | −$19.3K | Added$17.3K |
| Balyasny Asset Management L.P. | 40K | $218.5K | −$22.8K | Cut−$916.4K |
| nVerses Capital, LLC | 39.9K | $217.6K | — | New |
| Virtus Investment Advisers, LLC | 39.4K | $215.2K | −$21.9K | Cut−$16.7K |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 37.6K | $205.3K | −$12.3K | Added$75.6K |
| Brevan Howard Capital Management LP | 36.6K | $199.7K | −$20.9K | Cut−$51.4K |
| NEW YORK STATE COMMON RETIREMENT FUND | 36.6K | $199.6K | −$20.8K | Cut−$20.8K |
| China Universal Asset Management Co., Ltd. | 36.1K | $197.1K | −$18.9K | Cut−$2.78K |
| OSAIC HOLDINGS, INC. | 35.9K | $196.2K | −$18.6K | Cut−$892 |
| Magnetar Financial LLC | 34.6K | $188.7K | — | New |
| Brooklyn Investment Group | 33.7K | $183.8K | −$29.3K | Cut−$49.2K |
| Legal & General Group Plc | 33.6K | $183.5K | −$8.47K | Added$94K |
| STATE OF WISCONSIN INVESTMENT BOARD | 33.1K | $180.9K | — | New |
| INTECH INVESTMENT MANAGEMENT LLC | 33.1K | $180.5K | −$18.8K | Cut−$66.5K |
| CITIGROUP INC | 32.3K | $176.3K | −$11.7K | Added$52.1K |
| AXQ CAPITAL, LP | 32.2K | $175.6K | — | New |
| ProShare Advisors LLC | 30.3K | $165.7K | −$17.3K | Cut−$44.6K |
| BARCLAYS PLC | 27.9K | $152.2K | −$15.9K | Cut−$1.7M |
| Farther Finance Advisors, LLC | 26.9K | $150.1K | −$12.1K | Cut−$12.1K |
| Engineers Gate Manager LP | 27.4K | $149.8K | — | New |
| DARK FOREST CAPITAL MANAGEMENT LP | 27.2K | $148.4K | — | New |
| STRS OHIO | 26.5K | $144.7K | −$15.1K | Cut−$15.1K |
| Hudson Bay Capital Management LP | 26.5K | $144.7K | — | New |
| DIMENSIONAL FUND ADVISORS LP | 26.4K | $144.3K | −$15.1K | Cut−$881.6K |
| Orion Porfolio Solutions, LLC | 24.6K | $134.6K | — | New |
| E Fund Management Co., Ltd. | 23.8K | $129.7K | — | Held |
| State of New Jersey Common Pension Fund D | 23.6K | $129K | — | New |
| Vanguard Investments Australia, Ltd. | 23.5K | $128.1K | — | Held |
| Graham Capital Management, L.P. | 23.1K | $126.2K | −$13.2K | Cut−$211.5K |
| PRUDENTIAL FINANCIAL INC | 22.2K | $121.1K | — | New |
| Quadrature Capital Ltd | 21.3K | $116.5K | — | New |
| BROWN ADVISORY INC | 20.9K | $113.9K | −$11.9K | Cut−$11.9K |
| Tower Research Capital LLC (TRC) | 19.2K | $105.1K | −$1.18K | Added$92.6K |
| ARIZONA STATE RETIREMENT SYSTEM | 19K | $103.7K | — | New |
| Sanctuary Advisors, LLC | 16.9K | $92.1K | −$9.62K | Cut−$17.8K |
| Focus Partners Wealth | 15.6K | $85K | −$8.87K | Cut−$67.1K |
| OPPENHEIMER & CO INC | 15.5K | $84.6K | −$8.84K | Cut−$8.84K |
| INCEPTIONR LLC | 15.5K | $84.4K | — | New |
| KLP KAPITALFORVALTNING AS | 15.2K | $83K | — | New |
| US BANCORP \DE\ | 14.3K | $77.8K | — | New |
| CIBC Asset Management Inc | 14.1K | $76.9K | −$8.03K | Cut−$8.03K |
| TWO SIGMA INVESTMENTS, LP | 13.2K | $72.2K | — | New |
| Blueshift Asset Management, LLC | 13.2K | $71.9K | — | New |
| XPONANCE LLC | 12.7K | $69.6K | −$6.26K | Added$3.32K |
| VICTORY CAPITAL MANAGEMENT INC | 11.9K | $65K | −$6.79K | Cut−$6.89K |
| Schonfeld Strategic Advisors LLC | 11.5K | $63.1K | — | New |
| MML INVESTORS SERVICES, LLC | 11.5K | $63K | — | New |
| Ameritas Investment Partners, Inc. | 11.5K | $62.8K | −$6.55K | Cut−$6.55K |
| Russell Investments Group, Ltd. | 10.8K | $59K | −$6.15K | Cut−$8.89K |
| Mirae Asset Global Investments Co., Ltd. | 10.6K | $57.9K | −$5.64K | Cut−$1.67K |
| PRINCIPAL FINANCIAL GROUP INC | 10.4K | $56.6K | — | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7.92K | $43.2K | −$4.51K | Cut−$9.36K |
| GF FUND MANAGEMENT CO. LTD. | 4.55K | $24.8K | −$2.28K | Added$735 |
| 1620 INVESTMENT ADVISORS, INC. | 3K | $16.4K | −$1.71K | Cut−$1.71K |
| PNC Financial Services Group, Inc. | 1.52K | $8.33K | −$870 | Cut−$900 |
| NISA INVESTMENT ADVISORS, LLC | 1.47K | $8.04K | −$839 | Cut−$1.5K |
| Optiver Holding B.V. | 1.33K | $7.24K | −$380 | Added$3.22K |
| Sterling Capital Management LLC | 951 | $5.19K | −$528 | Cut−$386 |
| SIMPLEX TRADING, LLC | 926 | $5.05K | −$529 | Cut−$50.6K |
| ALGERT GLOBAL LLC | 864.6K | $4.72K | — | New |
| Larson Financial Group LLC | 816 | $4.46K | −$364 | Added$602 |
| CWM, LLC | 554 | $3.02K | $2.69K | Added$3.02K |
| ROYAL BANK OF CANADA | 504 | $3K | −$21 | Cut−$22K |
| Caitong International Asset Management Co., Ltd | 506 | $2.76K | −$288 | Cut−$236.3K |
| GROUP ONE TRADING LLC | 399 | $2.18K | — | New |
| Allworth Financial LP | 205 | $1.12K | −$96 | Added$112 |
| JONES FINANCIAL COMPANIES LLLP | 146 | $750 | −$130 | Cut−$130 |
| GAMMA Investing LLC | 136 | $743 | −$26 | Added$460 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 101.5K | $555 | −$40 | Added$135 |
| ROTHSCHILD INVESTMENT LLC | 100 | $546 | −$3 | Added$516 |
| GSA CAPITAL PARTNERS LLP | 93.7K | $512 | −$53 | Cut−$337 |
| SG Americas Securities, LLC | 57.4K | $313 | −$27 | Added$38 |
| TWIN PEAKS WEALTH ADVISORS, LLC | 30 | $164 | — | New |
| Sunbelt Securities, Inc. | 25 | $136 | −$15 | Cut−$15 |
| Root Financial Partners, LLC | 17 | $93 | — | New |
| EverSource Wealth Advisors, LLC | 12 | $66 | — | New |
| Stone House Investment Management, LLC | 8 | $44 | — | New |
| SBI Securities Co., Ltd. | 3 | $16 | −$2 | Cut−$2 |
| MAI Capital Management | 2 | $11 | −$2 | Cut−$2 |
| JNBA Financial Advisors | 1 | $6 | — | New |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | New |
| Covestor Ltd | 22 | $0 | — | New |