| BVF INC/IL | 1.25M | $31.2M | — | New |
| Affinity Asset Advisors, LLC | 1.07M | $26.6M | $9.98M | Added$18M |
| SAMSARA BIOCAPITAL, LLC | 1.06M | $26.5M | $2.73M | Added$24.1M |
| Kynam Capital Management, LP | 872.6K | $21.7M | $6.4M | Added$16.2M |
| ORBIMED ADVISORS LLC | 801.1K | $20M | — | New |
| VANGUARD CAPITAL MANAGEMENT LLC | 720.4K | $17.9M | — | Held |
| PERCEPTIVE ADVISORS LLC | 715.3K | $17.8M | — | New |
| RA CAPITAL MANAGEMENT, L.P. | 715.3K | $17.8M | — | New |
| EVENTIDE ASSET MANAGEMENT, LLC | 715.3K | $17.8M | — | New |
| Point72 Asset Management, L.P. | 692.1K | $17.2M | $2.39M | Added$15.2M |
| ADAR1 Capital Management, LLC | 524.4K | $13.1M | $894.8K | Added$12.3M |
| Velan Capital Investment Management LP | 512.2K | $12.8M | $4.16M | Added$9.15M |
| Balyasny Asset Management L.P. | 465.8K | $11.6M | $3.07M | Added$8.94M |
| Woodline Partners LP | 457.4K | $11.4M | — | New |
| UBS Group AG | 392.9K | $9.79M | $105K | Added$9.7M |
| Merck & Co., Inc. | 272.4K | $6.78M | $3.63M | Added$3.63M |
| ACUTA CAPITAL PARTNERS, LLC | 269.4K | $6.71M | $899.8K | Added$5.93M |
| BlackRock, Inc. | 232.7K | $5.8M | $1.57M | Added$4.44M |
| KVP Capital Advisors, LP | 226.6K | $5.64M | — | New |
| MARSHALL WACE, LLP | 222.6K | $5.55M | $1.14M | Added$4.56M |
| MILLENNIUM MANAGEMENT LLC | 210.4K | $5.24M | $2.81M | Added$402K |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200K | $4.98M | $2.67M | Added$2.67M |
| Opaleye Management Inc. | 190.7K | $4.75M | $2.54M | Added$2.54M |
| GEODE CAPITAL MANAGEMENT, LLC | 171.4K | $4.27M | $1.12M | Added$3.3M |
| Citadel | 117.5K | $2.93M | $428K | Added$2.56M |
| Renaissance Technologies | 97.8K | $2.44M | $1.3M | Added$1.02M |
| VANGUARD FIDUCIARY TRUST CO | 94.8K | $2.36M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84.9K | $2.11M | — | New |
| Eversept Partners, LP | 73.2K | $1.82M | $976K | Cut−$417.2K |
| BURKEHILL GLOBAL MANAGEMENT, LP | 71.5K | $1.78M | — | New |
| TWO SIGMA INVESTMENTS, LP | 65.2K | $1.62M | $620.2K | Added$1.09M |
| State Street | 52.1K | $1.3M | $457.1K | Added$901.8K |
| Fisher Asset Management, LLC | 35.3K | $879.2K | $470.8K | Added$470.7K |
| Trexquant Investment LP | 34.3K | $855.5K | — | New |
| NORTHERN TRUST CORP | 33.2K | $826.2K | $191.8K | Added$659.8K |
| JANE STREET GROUP, LLC | 27.8K | $691.5K | $306.1K | Added$426K |
| GOLDMAN SACHS GROUP INC | 27.2K | $677.2K | $209K | Added$495.9K |
| STEMPOINT CAPITAL LP | 23.3K | $580.3K | — | New |
| BANK OF AMERICA CORP /DE/ | 18.9K | $470.1K | $56.2K | Added$421.4K |
| CITIGROUP INC | 18.8K | $469.4K | $13.9K | Added$457.4K |
| Brevan Howard Capital Management LP | 18.8K | $468.1K | — | New |
| AJU IB Investment Co., Ltd. | 17.5K | $435.9K | $233.4K | Added$233.4K |
| Invesco Ltd. | 17.2K | $427.6K | $226.4K | Added$231.2K |
| RBF Capital, LLC | 15.3K | $380.4K | $203.7K | Added$203.7K |
| Hudson Bay Capital Management LP | 14.8K | $367.9K | — | New |
| Sigma Planning Corp | 12.5K | $311.9K | — | New |
| Jump Financial, LLC | 12.4K | $308.5K | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10.6K | $263.5K | — | New |
| MORGAN STANLEY | 10.5K | $262.3K | $140.5K | Added$78.1K |
| OMERS ADMINISTRATION Corp | 8.7K | $216.7K | $116.1K | Added$89.2K |
| Icahn Capital | 8.61K | $214.4K | $114.8K | Added$5.7K |
| XTX Topco Ltd | 8.2K | $204.3K | — | New |
| Persistent Asset Partners Ltd | 7.41K | $184.6K | — | New |
| State of Tennessee, Department of Treasury | 7.4K | $184.3K | $73.7K | Added$73.7K |
| Vanguard Global Advisers, LLC | 7.18K | $178.9K | — | Held |
| OSAIC HOLDINGS, INC. | 1.28K | $31.9K | $17.1K | Added$16.4K |
| Fidelity | 1.05K | $26.2K | $14K | Added$13.3K |
| CWM, LLC | 983 | $24.5K | $24.5K | Added$24.5K |
| Owl Creek Wealth Partners LLC | 491 | $12.2K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 335.8K | $8.36K | $4.48K | Added$4.46K |
| Physician Wealth Advisors, Inc. | 182 | $4.53K | $2.43K | Added$2.43K |
| BARCLAYS PLC | 139 | $3.46K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 111 | $2.77K | $1.48K | Added$1.48K |
| SIMPLEX TRADING, LLC | 62 | $1.54K | — | New |
| PNC Financial Services Group, Inc. | 62 | $1.54K | $827 | Added$827 |
| Fortitude Family Office, LLC | 56 | $1.4K | $747 | Added$747 |
| Bogart Wealth, LLC | 50 | $1.25K | $667 | Added$667 |
| Parallel Advisors, LLC | 47 | $1.17K | $627 | Added$627 |
| NISA INVESTMENT ADVISORS, LLC | 44 | $1.1K | $587 | Added$587 |
| GSA CAPITAL PARTNERS LLP | 25.8K | $643 | $344 | Cut−$388 |
| HighMark Wealth Management LLC | 23 | $572 | $306 | Added$306 |
| EverSource Wealth Advisors, LLC | 19 | $473 | $253 | Added$114 |
| Advisory Services Network, LLC | 15 | $374 | — | New |
| Arax Advisory Partners | 41 | $75 | −$30 | Added$40 |
| FIFTH THIRD BANCORP | 2 | $50 | — | New |
| FNY Investment Advisers, LLC | 1K | $24 | $13 | Added$13 |
| Avion Wealth | 72 | $1 | $1 | Added$1 |
| ROYAL BANK OF CANADA | 12 | $0 | $0 | Held |