| Fidelity | 5.6M | $177.8M | — | Held |
| RTW INVESTMENTS, LP | 5.55M | $176.1M | — | Held |
| Lynx1 Capital Management LP | 5.4M | $171.5M | — | Held |
| BlackRock, Inc. | 5.21M | $165.4M | — | Held |
| Redmile Group, LLC | 4.03M | $128M | — | Held |
| MORGAN STANLEY | 3.55M | $112.6M | $29.1M | Added$29.4M |
| BAKER BROS. ADVISORS LP | 3.34M | $105.9M | — | Held |
| TORONTO DOMINION BANK | 3.17M | $100.7M | — | Held |
| Vanguard | 3.15M | $100M | — | Held |
| State Street | 2.5M | $79.3M | — | Held |
| BVF INC/IL | 2.27M | $71.9M | — | Held |
| Siren, L.L.C. | 2.25M | $71.3M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1.82M | $57.9M | — | Held |
| JANUS HENDERSON GROUP PLC | 1.45M | $46M | — | Held |
| Polar Capital Holdings Plc | 1.27M | $40.3M | — | Held |
| Assenagon Asset Management S.A. | 1.23M | $39M | — | Held |
| Point72 Asset Management, L.P. | 1.22M | $38.8M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.17M | $37M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.14M | $36.3M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 827.1K | $26.3M | — | Held |
| MPM BIOIMPACT LLC | 770.3K | $24.4M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 735.8K | $23.4M | — | Held |
| Opaleye Management Inc. | 695K | $22.1M | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 500K | $15.9M | — | Held |
| Candriam S.C.A. | 446.7K | $14.2M | — | Held |
| Parkman Healthcare Partners LLC | 430.2K | $13.7M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 410.9K | $13M | — | Held |
| NORTHERN TRUST CORP | 403.2K | $12.8M | — | Held |
| Erste Asset Management GmbH | 396K | $12.6M | — | Held |
| JPMORGAN CHASE & CO | 277.9K | $8.82M | — | Held |
| Birchview Capital, LP | 260K | $8.25M | — | Held |
| Invesco Ltd. | 259.5K | $8.24M | — | Held |
| BAILLIE GIFFORD & CO | 246.9K | $7.84M | — | Held |
| Rhenman & Partners Asset Management AB | 216K | $6.86M | — | Held |
| BANK OF AMERICA CORP /DE/ | 206.2K | $6.54M | $1.7M | Added$681.5K |
| Granahan Investment Management, LLC | 191.4K | $6.07M | — | Held |
| UBS Group AG | 169.7K | $5.39M | — | Held |
| FIRST TRUST ADVISORS LP | 162.7K | $5.16M | — | Held |
| BARCLAYS PLC | 150.9K | $4.79M | $887.6K | Added$2.26M |
| Bank of New York Mellon Corp | 140.8K | $4.47M | — | Held |
| FRANKLIN RESOURCES INC | 132.2K | $4.2M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 126.3K | $4.01M | — | Held |
| GILDER GAGNON HOWE & CO LLC | 122.4K | $3.89M | — | Held |
| Informed Momentum Co LLC | 117.8K | $3.74M | — | Held |
| HighVista Strategies LLC | 115.5K | $3.67M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 115.1K | $3.65M | — | Held |
| DAFNA Capital Management LLC | 108.9K | $3.46M | — | Held |
| Nuveen, LLC | 104.3K | $3.31M | — | Held |
| Rafferty Asset Management, LLC | 90.2K | $2.86M | — | Held |
| Quantedge Capital Pte Ltd | 87.2K | $2.77M | — | Held |
| Swiss National Bank | 75.7K | $2.4M | — | Held |
| Alyeska Investment Group, L.P. | 75K | $2.38M | — | Held |
| Palo Alto Investors LP | 72K | $2.29M | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 70.3K | $2.23M | — | Held |
| JANE STREET GROUP, LLC | 67.1K | $2.13M | — | Held |
| ALPS ADVISORS INC | 66.5K | $2.11M | — | Held |
| Schonfeld Strategic Advisors LLC | 63.1K | $2M | — | Held |
| HUSSMAN STRATEGIC ADVISORS, INC. | 63K | $2M | — | Held |
| RHUMBLINE ADVISERS | 62.4K | $1.98M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 57.2K | $1.82M | — | Held |
| Privium Fund Management B.V. | 55K | $1.75M | — | Held |
| Woodline Partners LP | 50.1K | $1.59M | — | Held |
| D. E. Shaw & Co., Inc. | 49.9K | $1.58M | — | Held |
| WELLS FARGO & COMPANY/MN | 49.6K | $1.57M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46K | $1.46M | — | Held |
| NOMURA HOLDINGS INC | 44.4K | $1.41M | — | Held |
| Creative Planning | 41.7K | $1.32M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 41.1K | $1.31M | — | Held |
| PLATINUM INVESTMENT MANAGEMENT LTD | 40.8K | $1.3M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 40.6K | $1.29M | — | Held |
| Kennondale Capital Management LLC | 38.7K | $1.23M | — | Held |
| Harvest Investment Services, LLC | 38.3K | $1.22M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37.1K | $1.18M | — | Held |
| Legal & General Group Plc | 36.4K | $1.15M | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 35.2K | $1.12M | — | Held |
| DEUTSCHE BANK AG\ | 33.4K | $1.06M | — | Held |
| PROFUND ADVISORS LLC | 33.4K | $1.06M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32.5K | $1.03M | — | Held |
| Icahn Capital | 29.5K | $935.3K | — | Held |
| READYSTATE ASSET MANAGEMENT LP | 29.1K | $922.3K | — | Held |
| Cresset Asset Management, LLC | 26.3K | $835.6K | $216.9K | Added$207.3K |
| MetLife Investment Management, LLC | 25.3K | $803.7K | — | Held |
| Allspring Global Investments Holdings, LLC | 24.5K | $755.9K | — | Held |
| AMERIPRISE FINANCIAL INC | 21.1K | $669K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 19.3K | $612.9K | — | New |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 19.1K | $606.3K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 18.7K | $592K | — | Held |
| DIADEMA PARTNERS LP | 17.2K | $545.3K | — | Held |
| SEI INVESTMENTS CO | 16.6K | $527.9K | — | Held |
| PSP Research LLC | 16.6K | $527.6K | — | Held |
| AVIVA PLC | 15.9K | $503.7K | — | Held |
| Citadel | 15.9K | $503.1K | — | Held |
| AlphaQuest LLC | 15K | $477.2K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 15K | $477.2K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 14.8K | $470.4K | — | Held |
| SIMPLEX TRADING, LLC | 14.3K | $453.3K | — | Held |
| CITIGROUP INC | 13.6K | $431.8K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13.6K | $430.1K | — | Held |
| Campbell & CO Investment Adviser LLC | 13K | $412.5K | — | Held |
| China Universal Asset Management Co., Ltd. | 12.9K | $409.7K | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 12.9K | $408.7K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 12.5K | $397.9K | — | Held |
| Entropy Technologies, LP | 11.8K | $373.4K | — | Held |
| CAPITAL FUND MANAGEMENT S.A. | 11.7K | $371.9K | — | Held |
| Quantinno Capital Management LP | 11.1K | $351.9K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 10.9K | $347.1K | — | Held |
| Dorsey & Whitney Trust CO LLC | 10.8K | $343.3K | — | Held |
| ProShare Advisors LLC | 10.7K | $340.3K | — | Held |
| NewEdge Advisors, LLC | 10.4K | $330.2K | — | Held |
| OSAIC HOLDINGS, INC. | 10.3K | $325.7K | — | Held |
| Balyasny Asset Management L.P. | 9.34K | $296.5K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 9.21K | $291.8K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9.13K | $289.8K | — | Held |
| BANK OF MONTREAL /CAN/ | 9.05K | $287.4K | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 9K | $285.7K | — | New |
| Tidal Investments LLC | 8.36K | $265.2K | — | Held |
| Virtus Investment Advisers, LLC | 8.21K | $260.7K | — | Held |
| KLP KAPITALFORVALTNING AS | 8.2K | $260.3K | — | Held |
| Dynamic Technology Lab Private Ltd | 8.05K | $256K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 7.76K | $246.3K | — | Held |
| LPL Financial LLC | 7.38K | $234.2K | — | Held |
| STRS OHIO | 7K | $222.2K | — | Held |
| J. Goldman & Co LP | 6.83K | $216.7K | — | Held |
| Swiss Life Asset Management Ltd | 6.8K | $215.8K | — | New |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 6.55K | $207.9K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 6.37K | $202.2K | — | Held |
| Persistent Asset Partners Ltd | 4.58K | $145.2K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 4.26K | $135.1K | — | Held |
| GROUP ONE TRADING LLC | 4.11K | $130.5K | — | Held |
| Ameritas Investment Partners, Inc. | 3.75K | $119K | — | Held |
| Russell Investments Group, Ltd. | 3.62K | $114.8K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.78K | $88.1K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 2.57K | $81.6K | — | Held |
| Generali Investments, Management Co LLC | 2.47K | $78.4K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 2.44K | $77.3K | — | Held |
| CFG Wealth Management Services, Inc. | 2.23K | $70.8K | — | Held |
| ROYAL BANK OF CANADA | 1.62K | $52K | — | Held |
| Versant Capital Management, Inc | 1.59K | $50.5K | — | Held |
| HARBOUR INVESTMENTS, INC. | 1.19K | $37.6K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.12K | $35.6K | — | Held |
| State of Wyoming | 1.11K | $35.2K | — | Held |
| GAMMA Investing LLC | 830 | $26.3K | — | Held |
| Kestra Advisory Services, LLC | 818 | $26K | — | Held |
| Tower Research Capital LLC (TRC) | 630 | $20K | — | Held |
| EverSource Wealth Advisors, LLC | 622 | $19.7K | — | Held |
| Stone House Investment Management, LLC | 500 | $15.9K | — | Held |
| MONTAG A & ASSOCIATES INC | 440 | $14K | — | Held |
| Wilmington Savings Fund Society, FSB | 400 | $12.7K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 372.3K | $11.8K | — | Held |
| Sterling Capital Management LLC | 298 | $9.46K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 293 | $9.3K | — | Held |
| US BANCORP \DE\ | 244 | $7.75K | — | Held |
| Prestige Wealth Management Group LLC | 200 | $6.35K | — | New |
| Smartleaf Asset Management LLC | 155 | $4.93K | — | Held |
| Optiver Holding B.V. | 142 | $4.51K | — | Held |
| Rockefeller Capital Management L.P. | 98 | $3.11K | — | Held |
| J.Safra Asset Management Corp | 97 | $3.08K | — | Held |
| Larson Financial Group LLC | 92 | $2.92K | — | Held |
| Penserra Capital Management LLC | 88.5K | $2.81K | — | Held |
| Quantbot Technologies LP | 88 | $2.79K | — | Held |
| SIGNATUREFD, LLC | 83 | $2.63K | — | Held |
| PNC Financial Services Group, Inc. | 44 | $1.4K | — | Held |
| Rachor Investment Advisory Services, LLC | 40 | $1.27K | — | Held |
| Global Retirement Partners, LLC | 35 | $1.11K | — | Held |
| SG Americas Securities, LLC | 25.8K | $820 | — | Held |
| Arax Advisory Partners | 21 | $667 | — | Held |
| Farther Finance Advisors, LLC | 18 | $571 | — | Held |
| CANADA LIFE ASSURANCE Co | 14.8K | $469 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 14.1K | $447 | — | Held |
| Parallel Advisors, LLC | 13 | $413 | — | Held |
| Vestcor Inc | 10.2K | $323 | — | Held |
| GSA CAPITAL PARTNERS LLP | 7.08K | $225 | — | Held |
| Allworth Financial LP | 7 | $223 | $17 | Added$176 |
| Root Financial Partners, LLC | 7 | $222 | — | Held |
| IFP Advisors, Inc | 5 | $159 | $41 | Added$41 |
| SBI Securities Co., Ltd. | 5 | $159 | — | Held |
| True Wealth Design, LLC | 4 | $127 | — | Held |
| Cygnus Capital Advisors, LLC | 3K | $95 | — | Held |
| AMALGAMATED BANK | 1.41K | $45 | — | Held |
| VALLEY NATIONAL ADVISERS INC | 750 | $23 | — | Held |
| CWM, LLC | 565 | $18 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 476 | $15 | — | Held |
| Daiwa Securities Group Inc. | 175 | $6 | — | Held |