| PERCEPTIVE ADVISORS LLC | 11.8M | $66.7M | — | Held |
| Bain Capital Life Sciences Investors, LLC | 7.91M | $44.6M | — | Held |
| Siren, L.L.C. | 7.69M | $43.4M | — | Held |
| Vestal Point Capital, LP | 5.82M | $32.8M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 5.81M | $32.8M | — | Held |
| BlackRock, Inc. | 4.87M | $27.5M | — | Held |
| Vanguard | 3.45M | $19.5M | — | Held |
| Citadel | 2.66M | $15M | — | Held |
| ARMISTICE CAPITAL, LLC | 2.61M | $14.7M | — | Held |
| Point72 Asset Management, L.P. | 2.42M | $13.6M | — | Held |
| Fidelity | 2.03M | $11.4M | — | Held |
| Redmile Group, LLC | 1.86M | $10.5M | — | Held |
| Alyeska Investment Group, L.P. | 1.68M | $9.49M | — | Held |
| Nantahala Capital Management, LLC | 1.6M | $9.04M | — | Held |
| FRANKLIN RESOURCES INC | 1.6M | $9.02M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.4M | $7.9M | — | Held |
| Monashee Investment Management LLC | 1.35M | $7.61M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.27M | $7.15M | — | Held |
| State Street | 1.09M | $6.13M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.01M | $5.68M | — | Held |
| Finepoint Capital LP | 961.3K | $5.42M | — | Held |
| UBS Group AG | 911.4K | $5.14M | — | Held |
| Birchview Capital, LP | 706K | $3.98M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 679.1K | $3.83M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 499.3K | $2.82M | — | Held |
| Parkman Healthcare Partners LLC | 418.4K | $2.36M | — | Held |
| Ally Bridge Group (NY) LLC | 413.6K | $2.33M | — | Held |
| NORTHERN TRUST CORP | 412.8K | $2.33M | — | Held |
| Nuveen, LLC | 395K | $2.23M | — | Held |
| MORGAN STANLEY | 394.3K | $2.22M | −$136.7K | Added$632.7K |
| Balyasny Asset Management L.P. | 360.9K | $2.04M | — | Held |
| BANK OF AMERICA CORP /DE/ | 344.3K | $1.94M | −$182.5K | Cut−$2.93M |
| Woodline Partners LP | 316.8K | $1.79M | — | Held |
| Boxer Capital Management, LLC | 300K | $1.69M | −$159K | Cut−$2.01M |
| PANAGORA ASSET MANAGEMENT INC | 226.8K | $1.28M | — | Held |
| JANE STREET GROUP, LLC | 213.4K | $1.2M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 199.4K | $1.12M | — | Held |
| Apis Capital Advisors, LLC | 196K | $1.11M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 185.7K | $1.05M | — | Held |
| Schonfeld Strategic Advisors LLC | 182.9K | $1.03M | — | Held |
| Knott David M Jr | 162.4K | $916.2K | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161.5K | $911.1K | — | Held |
| Ikarian Capital, LLC | 160.4K | $904.7K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 153.4K | $865.2K | — | Held |
| Invesco Ltd. | 152.1K | $858K | — | Held |
| Bank of New York Mellon Corp | 144.7K | $816.1K | — | Held |
| BARCLAYS PLC | 138.1K | $779.1K | −$73.2K | Cut−$202.6K |
| Icahn Capital | 132K | $744.2K | — | Held |
| D. E. Shaw & Co., Inc. | 128.3K | $723.4K | — | Held |
| MILLENNIUM MANAGEMENT LLC | 116.6K | $657.8K | — | Held |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 116.5K | $657.2K | — | Held |
| Fisher Asset Management, LLC | 103.5K | $583.6K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 97.3K | $548.9K | — | Held |
| Quantum Private Wealth, LLC | 94.2K | $531.5K | — | Held |
| RHUMBLINE ADVISERS | 82.6K | $465.7K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 81.8K | $461.5K | — | Held |
| WELLS FARGO & COMPANY/MN | 76.1K | $429.2K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 74.6K | $420.9K | — | Held |
| SIMPLEX TRADING, LLC | 60.5K | $341.4K | — | Held |
| Renaissance Technologies | 52.8K | $297.8K | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 52.8K | $297.8K | — | Held |
| Squarepoint Ops LLC | 50.1K | $282.3K | — | Held |
| DEUTSCHE BANK AG\ | 40K | $225.4K | — | Held |
| Y-Intercept (Hong Kong) Ltd | 36.1K | $203.9K | — | Held |
| XTX Topco Ltd | 35.6K | $201K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 34.5K | $194.5K | — | Held |
| MetLife Investment Management, LLC | 33.2K | $187.3K | — | Held |
| JPMORGAN CHASE & CO | 31.8K | $179.1K | — | Held |
| CIBC Private Wealth Group LLC | 30.6K | $172.6K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 30K | $169.2K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27.3K | $154.2K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 25K | $141K | — | Held |
| Creative Planning | 24.9K | $140.4K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 23.5K | $132.3K | — | Held |
| HSBC HOLDINGS PLC | 22.2K | $126.7K | — | Held |
| Lido Advisors, LLC | 20.2K | $124.5K | — | Held |
| AXQ CAPITAL, LP | 20.6K | $116.4K | — | Held |
| Jain Global LLC | 20.3K | $114.3K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18.3K | $102.9K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 17.4K | $98.1K | — | Held |
| ProShare Advisors LLC | 14.2K | $80.2K | — | Held |
| SEI INVESTMENTS CO | 13.1K | $73.8K | — | Held |
| China Universal Asset Management Co., Ltd. | 12.7K | $71.6K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 11.2K | $62.9K | — | Held |
| COMMONWEALTH EQUITY SERVICES, LLC | 10.9K | $61.2K | — | Held |
| Tower Research Capital LLC (TRC) | 10.7K | $60.2K | — | Held |
| MARTINGALE ASSET MANAGEMENT L P | 10.6K | $59.6K | — | Held |
| Russell Investments Group, Ltd. | 7.2K | $40.6K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 7.1K | $40K | — | Held |
| GROUP ONE TRADING LLC | 6.55K | $37K | — | Held |
| Legal & General Group Plc | 5.27K | $29.7K | — | Held |
| Steward Partners Investment Advisory, LLC | 4.96K | $27.9K | — | Held |
| Ameritas Investment Partners, Inc. | 4.93K | $27.8K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 4.84K | $27.3K | — | Held |
| ROYAL BANK OF CANADA | 4.3K | $24K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.79K | $21.4K | — | Held |
| Aquatic Capital Management LLC | 3.71K | $20.9K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.63K | $20.5K | — | Held |
| CITIGROUP INC | 3.51K | $19.8K | — | Held |
| Sterling Capital Management LLC | 3.4K | $19.2K | — | Held |
| OSAIC HOLDINGS, INC. | 2.02K | $11.4K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 1.6K | $9.05K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.53K | $8.63K | — | Held |
| SBI Securities Co., Ltd. | 756 | $4.26K | — | Held |
| PNC Financial Services Group, Inc. | 656 | $3.7K | — | Held |
| True Wealth Design, LLC | 582 | $3.28K | — | Held |
| Osbon Capital Management LLC | 501 | $2.83K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 499 | $2.81K | — | Held |
| Allworth Financial LP | 411 | $2.32K | −$217 | Cut−$217 |
| Rockefeller Capital Management L.P. | 344 | $1.94K | — | Held |
| Physician Wealth Advisors, Inc. | 312 | $1.76K | — | Held |
| Optiver Holding B.V. | 304 | $1.72K | — | Held |
| US BANCORP \DE\ | 300 | $1.69K | — | Held |
| IFP Advisors, Inc | 298 | $1.68K | −$158 | Cut−$158 |
| GAMMA Investing LLC | 242 | $1.36K | — | Held |
| Larson Financial Group LLC | 222 | $1.25K | — | Held |
| Parkside Financial Bank & Trust | 135 | $762 | — | Held |
| MAI Capital Management | 123 | $694 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35.1K | $198 | — | Held |
| SG Americas Securities, LLC | 20.9K | $118 | — | Held |
| HRT FINANCIAL LP | 14.9K | $84 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 4.95K | $27 | — | Held |
| CWM, LLC | 4.49K | $25 | — | Held |
| AMALGAMATED BANK | 1.85K | $10 | — | Held |
| HANTZ FINANCIAL SERVICES, INC. | 1K | $6 | — | Held |
| Daiwa Securities Group Inc. | 231 | $1 | — | Held |