| Frazier Life Sciences Management, L.P. | 12.5M | $206.8M | — | Held |
| Medicxi Ventures Management (Jersey) Ltd | 7.46M | $123.8M | — | Held |
| Invesco Ltd. | 3.92M | $65M | — | Held |
| BlackRock, Inc. | 3.56M | $59M | — | Held |
| Carlyle Group Inc. | 3.5M | $58M | — | Held |
| Vanguard | 3.18M | $52.7M | — | Held |
| Ensign Peak Advisors, Inc | 2.35M | $39M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 2.08M | $34.5M | — | Held |
| NEA Management Company, LLC | 1.96M | $32.5M | — | Held |
| 683 Capital Management, LLC | 1.78M | $29.6M | — | Held |
| Catalys Pacific, LLC | 1.43M | $23.7M | — | Held |
| WASATCH ADVISORS LP | 1.33M | $22.1M | — | Held |
| State Street | 1.15M | $19.1M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.07M | $17.8M | — | Held |
| Propel Bio Management, LLC | 740.9K | $12.3M | — | Held |
| Catalio Capital Management, LP | 699K | $11.6M | — | Held |
| Divisadero Street Capital Management, LP | 662.3K | $11M | — | Held |
| MOORE CAPITAL MANAGEMENT, LP | 600K | $9.95M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 549.2K | $9.11M | — | Held |
| SummitTX Capital, L.P. | 517.8K | $8.59M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 397.9K | $6.6M | — | Held |
| NEXT CENTURY GROWTH INVESTORS LLC | 393.8K | $6.53M | — | Held |
| GOLDMAN SACHS GROUP INC | 392K | $6.5M | — | Held |
| JANE STREET GROUP, LLC | 384.8K | $6.38M | — | Held |
| NORTHERN TRUST CORP | 356.5K | $5.91M | — | Held |
| Simplify Asset Management Inc. | 321.9K | $5.34M | — | Held |
| Citadel | 311.3K | $5.16M | — | Held |
| UBS Group AG | 304.4K | $5.05M | — | Held |
| StepStone Group LP | 422.1K | $4.97M | — | Held |
| JPMORGAN CHASE & CO | 296.7K | $4.92M | — | Held |
| Brevan Howard Capital Management LP | 277K | $4.6M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 268K | $4.45M | — | Held |
| D. E. Shaw & Co., Inc. | 261.1K | $4.33M | — | Held |
| BANK OF AMERICA CORP /DE/ | 259K | $4.3M | $1.2M | Added$1.36M |
| Balyasny Asset Management L.P. | 207.1K | $3.44M | — | Held |
| Avidity Partners Management LP | 206.1K | $3.42M | — | Held |
| Birchview Capital, LP | 195K | $3.24M | — | Held |
| NewEdge Advisors, LLC | 200.8K | $3.16M | — | Held |
| Woodline Partners LP | 187.3K | $3.11M | — | Held |
| AMERIPRISE FINANCIAL INC | 185.7K | $3.08M | — | Held |
| CAXTON ASSOCIATES LLP | 182K | $3.02M | — | Held |
| HUSSMAN STRATEGIC ADVISORS, INC. | 147K | $2.44M | — | Held |
| GILDER GAGNON HOWE & CO LLC | 145.2K | $2.41M | — | Held |
| Trexquant Investment LP | 136.8K | $2.27M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 134.5K | $2.23M | — | Held |
| Bank of New York Mellon Corp | 123K | $2.04M | — | Held |
| MORGAN STANLEY | 117.8K | $1.95M | $567.7K | Cut−$1.05M |
| Campbell & CO Investment Adviser LLC | 115.3K | $1.91M | — | Held |
| Hennion & Walsh Asset Management, Inc. | 115K | $1.91M | — | Held |
| Nuveen, LLC | 108.8K | $1.81M | — | Held |
| GROUP ONE TRADING LLC | 103.7K | $1.72M | — | Held |
| VARCOV Co. | 86.8K | $1.44M | — | Held |
| BARCLAYS PLC | 84.9K | $1.41M | $409K | Cut−$102.9K |
| Swiss National Bank | 84K | $1.39M | — | Held |
| Creative Planning | 80.8K | $1.34M | — | Held |
| WELLS FARGO & COMPANY/MN | 68K | $1.13M | — | Held |
| Penn Mutual Asset Management | 62.8K | $1.04M | $302.7K | Added$302.7K |
| DARK FOREST CAPITAL MANAGEMENT LP | 62.2K | $1.03M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 57.8K | $958.6K | — | Held |
| Icahn Capital | 54.4K | $903.3K | — | Held |
| RHUMBLINE ADVISERS | 52.1K | $864.2K | — | Held |
| STIFEL FINANCIAL CORP | 51.7K | $857.1K | — | Held |
| Stratos Wealth Partners, LTD. | 50.3K | $834.5K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 49.4K | $819.4K | — | Held |
| Virtus Investment Advisers, LLC | 46.9K | $778.7K | — | Held |
| Engineers Gate Manager LP | 44.3K | $734.2K | — | Held |
| ADAR1 Capital Management, LLC | 42.9K | $711.7K | — | Held |
| Southeast Asset Advisors, LLC | 42.9K | $711.3K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 41.8K | $692.7K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40.1K | $666K | — | Held |
| XTX Topco Ltd | 39.4K | $653.6K | — | Held |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 34.7K | $575.7K | — | Held |
| Legal & General Group Plc | 34.2K | $568.2K | — | Held |
| DEUTSCHE BANK AG\ | 33.4K | $553.8K | — | Held |
| Schonfeld Strategic Advisors LLC | 30.9K | $513.4K | — | Held |
| COMMONWEALTH EQUITY SERVICES, LLC | 30.9K | $513.3K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 30.6K | $508.2K | — | Held |
| Y-Intercept (Hong Kong) Ltd | 30.5K | $505.8K | — | Held |
| Occidental Asset Management, LLC | 29.9K | $496.4K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 28.6K | $473.7K | $137.6K | Added$72.5K |
| CITIGROUP INC | 28.5K | $472.1K | — | Held |
| AlphaQuest LLC | 28.3K | $468.7K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 33.4K | $444.9K | — | Held |
| MetLife Investment Management, LLC | 25.8K | $428.8K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 24.4K | $404.6K | — | Held |
| ROYAL BANK OF CANADA | 22.6K | $374K | — | Held |
| ExodusPoint Capital Management, LP | 22.4K | $371.6K | — | Held |
| Summit Financial Wealth Advisors, LLC | 22.1K | $367.4K | — | Held |
| Jain Global LLC | 21.7K | $360.6K | — | Held |
| JANUS HENDERSON GROUP PLC | 21.5K | $356.6K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 20.5K | $339.9K | — | Held |
| Kera Capital Partners, Inc. | 24.3K | $331.6K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19.9K | $330K | — | Held |
| INSPIRION WEALTH ADVISORS, LLC | 19.8K | $328.7K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 19.1K | $316.1K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18.5K | $306.3K | — | Held |
| Jump Financial, LLC | 17.4K | $288.8K | — | Held |
| Bridgefront Capital, LLC | 17K | $281.7K | — | Held |
| Fiduciary Trust Co | 16K | $266.1K | — | Held |
| PROFUND ADVISORS LLC | 15.6K | $258.2K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 15.3K | $253.6K | — | Held |
| Baader Bank Aktiengesellschaft | 15K | $248.8K | — | Held |
| Pathstone Holdings, LLC | 14.9K | $247.2K | — | Held |
| Private Advisor Group, LLC | 14.6K | $241.9K | — | Held |
| KLP KAPITALFORVALTNING AS | 14K | $232.3K | — | Held |
| Rafferty Asset Management, LLC | 13.9K | $229.9K | — | Held |
| Persistent Asset Partners Ltd | 12.9K | $214.3K | — | New |
| Scientech Research LLC | 12.9K | $213.7K | — | Held |
| Graham Capital Management, L.P. | 12.9K | $213.5K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12.4K | $206.3K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 11.9K | $197.8K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 11.9K | $196.9K | — | Held |
| China Universal Asset Management Co., Ltd. | 11.6K | $192.3K | — | Held |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 11.5K | $190.3K | — | Held |
| Entropy Technologies, LP | 11K | $182.5K | — | Held |
| AXQ CAPITAL, LP | 10.5K | $174.9K | — | Held |
| Allworth Financial LP | 10.4K | $173.4K | $50.4K | Cut−$67.3K |
| 9823 Capital, L.P. | 10.4K | $173K | — | Held |
| ProShare Advisors LLC | 10.4K | $172.2K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 9.79K | $162.4K | — | Held |
| Fidelity | 7.18K | $119.1K | — | Held |
| Russell Investments Group, Ltd. | 6.64K | $110.2K | — | Held |
| OSAIC HOLDINGS, INC. | 6.45K | $107K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 4.6K | $76.3K | — | Held |
| Ameritas Investment Partners, Inc. | 3.53K | $58.5K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.46K | $57.4K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 2.87K | $47.6K | — | Held |
| RiverPark Advisors, LLC | 2.81K | $46.6K | — | Held |
| Kestra Advisory Services, LLC | 2.27K | $37.7K | — | Held |
| HUNTINGTON NATIONAL BANK | 1.99K | $32.9K | — | Held |
| Sterling Capital Management LLC | 1.75K | $29K | — | Held |
| SIMPLEX TRADING, LLC | 1.6K | $26.5K | — | Held |
| PNC Financial Services Group, Inc. | 1.42K | $23.6K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.4K | $23.2K | — | Held |
| GW&K Investment Management, LLC | 1.31M | $21.7K | — | Held |
| Tower Research Capital LLC (TRC) | 1.1K | $18.2K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 1.07K | $17.8K | — | Held |
| C M BIDWELL & ASSOCIATES LTD | 853 | $14.2K | — | Held |
| Larson Financial Group LLC | 647 | $10.7K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 568 | $9.42K | — | Held |
| FEDERATED HERMES, INC. | 549 | $9.11K | — | Held |
| Quantbot Technologies LP | 535 | $8.88K | — | Held |
| MCF Advisors LLC | 446 | $7.4K | — | Held |
| Farther Finance Advisors, LLC | 342 | $5.67K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 320 | $5.31K | — | Held |
| GAMMA Investing LLC | 303 | $5.03K | — | Held |
| US BANCORP \DE\ | 277 | $4.59K | — | Held |
| Fortitude Family Office, LLC | 208 | $3.45K | — | Held |
| Optiver Holding B.V. | 198 | $3.29K | — | Held |
| Rockefeller Capital Management L.P. | 155 | $2.57K | — | Held |
| Parallel Advisors, LLC | 100 | $1.66K | — | Held |
| True Wealth Design, LLC | 95 | $1.58K | — | Held |
| GSA CAPITAL PARTNERS LLP | 82.6K | $1.37K | — | Held |
| SIGNATUREFD, LLC | 40 | $664 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 37.1K | $616 | — | Held |
| Caitong International Asset Management Co., Ltd | 28 | $465 | — | Held |
| HRT FINANCIAL LP | 27K | $448 | — | Held |
| Rachor Investment Advisory Services, LLC | 25 | $415 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 22.2K | $367 | — | Held |
| ELEVATION WEALTH PARTNERS, LLC | 20 | $332 | — | Held |
| SG Americas Securities, LLC | 16.5K | $274 | — | Held |
| Virtu Financial LLC | 15.5K | $258 | — | Held |
| CANADA LIFE ASSURANCE Co | 6.82K | $113 | — | Held |
| Essential Partners LLC | 6 | $100 | — | New |
| Arax Advisory Partners | 6 | $100 | — | Held |
| EverSource Wealth Advisors, LLC | 5 | $83 | — | Held |
| CWM, LLC | 2.01K | $33 | — | Held |
| AMALGAMATED BANK | 1.25K | $21 | — | Held |
| IFP Advisors, Inc | 1 | $17 | — | New |
| Strategic Wealth Advisors LLC | 1K | $16 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 604 | $10 | — | Held |
| Daiwa Securities Group Inc. | 260 | $4 | — | Held |
| Covestor Ltd | 16 | $0 | — | Held |