| Frazier Life Sciences Management, L.P. | 6.8M | $536.7M | — | Held |
| JANUS HENDERSON GROUP PLC | 6.07M | $479.1M | — | Held |
| BlackRock, Inc. | 7.67M | $298.3M | — | Held |
| Vanguard | 2.6M | $205.1M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 70M | $180.7M | — | Held |
| State Street | 2.14M | $169.4M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 2.09M | $165.4M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 29.9M | $127.2M | — | Held |
| BVF INC/IL | 1.5M | $118.1M | — | Held |
| Citadel | 19.3M | $114M | — | Held |
| NOVO HOLDINGS A/S | 1.26M | $99.8M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 1.24M | $97.8M | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 1.24M | $97.6M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.06M | $84M | — | Held |
| READYSTATE ASSET MANAGEMENT LP | 30.4M | $78.6M | — | Held |
| D. E. Shaw & Co., Inc. | 948.2K | $74.9M | — | Held |
| TENOR CAPITAL MANAGEMENT Co., L.P. | 28.6M | $74.2M | — | Held |
| Clearbridge Investments, LLC | 866K | $68.4M | — | Held |
| Fidelity | 6.7M | $66.7M | — | Held |
| MACKAY SHIELDS LLC | 25.5M | $66M | — | Held |
| Polar Capital Holdings Plc | 793.6K | $62.7M | — | Held |
| CAPSTONE INVESTMENT ADVISORS, LLC | 24M | $62M | — | Held |
| Rock Springs Capital Management LP | 762.3K | $60.2M | — | Held |
| GOLDMAN SACHS GROUP INC | 724.3K | $57.2M | — | Held |
| BANK OF AMERICA CORP /DE/ | 721.5K | $56.4M | $20.5M | Added$27.2M |
| FRANKLIN RESOURCES INC | 2.53M | $56.2M | — | Held |
| Polar Asset Management Partners Inc. | 21.4M | $55.3M | $3.86M | Added$3.86M |
| Pictet Asset Management Holding SA | 577.3K | $45.6M | — | Held |
| Soleus Capital Management, L.P. | 573.6K | $45.3M | — | Held |
| Candriam S.C.A. | 569.6K | $45M | — | Held |
| Woodline Partners LP | 567.9K | $44.9M | — | Held |
| Bank of New York Mellon Corp | 565.6K | $44.7M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 521.7K | $41.2M | — | Held |
| LOOMIS SAYLES & CO L P | 515K | $40.7M | — | Held |
| Nuveen, LLC | 503K | $39.7M | — | Held |
| Point72 Asset Management, L.P. | 9.6M | $39.4M | — | Held |
| FEDERATED HERMES, INC. | 482K | $38.1M | — | Held |
| First Turn Management, LLC | 481.6K | $38M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 467.5K | $36.9M | — | Held |
| Renaissance Technologies | 439.1K | $34.7M | — | Held |
| MORGAN STANLEY | 625.7K | $34.1M | −$4.99M | Cut−$15.3M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 421.8K | $33.3M | — | Held |
| BOONE CAPITAL MANAGEMENT LLC | 421.2K | $33.3M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 409.3K | $32.3M | — | Held |
| TimesSquare Capital Management, LLC | 395.8K | $31.3M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 388.5K | $30.7M | — | Held |
| NORTHERN TRUST CORP | 374.9K | $29.6M | — | Held |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 372.5K | $29.4M | — | Held |
| NEXT CENTURY GROWTH INVESTORS LLC | 368K | $29.1M | — | Held |
| EMERALD ADVISERS, LLC | 367.1K | $29M | — | Held |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 336.7K | $26.6M | — | Held |
| UBS Group AG | 321.5K | $25.3M | — | Held |
| Patient Square Capital LP | 298.7K | $23.6M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 297.9K | $23.5M | — | Held |
| Nicholas Investment Partners, LP | 2.46M | $22.7M | — | Held |
| Balyasny Asset Management L.P. | 285.9K | $22.6M | — | Held |
| Penn Capital Management Company, LLC | 281.9K | $22.3M | — | Held |
| Hood River Capital Management LLC | 280K | $22.1M | — | Held |
| AMERIPRISE FINANCIAL INC | 271.5K | $21.4M | — | Held |
| NORGES BANK | 263.2K | $20.8M | — | New |
| PERCEPTIVE ADVISORS LLC | 259.5K | $20.5M | — | Held |
| Erste Asset Management GmbH | 250K | $19.8M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 246.4K | $19.5M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 244.3K | $19.3M | — | Held |
| EMERALD MUTUAL FUND ADVISERS TRUST | 242.3K | $19.1M | — | Held |
| TWO SIGMA ADVISERS, LP | 232.1K | $18.3M | — | Held |
| NAN FUNG TRINITY (HK) LTD | 227.5K | $18M | — | Held |
| Logos Global Management LP | 225K | $17.8M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 217.6K | $17.2M | — | Held |
| Russell Investments Group, Ltd. | 209.2K | $16.5M | — | Held |
| Aequim Alternative Investments LP | 6M | $15.5M | — | Held |
| DEUTSCHE BANK AG\ | 186.7K | $14.7M | — | Held |
| SEGALL BRYANT & HAMILL, LLC | 185K | $14.6M | — | Held |
| Voleon Capital Management LP | 173.1K | $13.7M | — | Held |
| Squarepoint Ops LLC | 172.4K | $13.6M | — | Held |
| Legal & General Group Plc | 168.4K | $13.3M | — | Held |
| RICE HALL JAMES & ASSOCIATES, LLC | 164.4K | $13M | — | Held |
| Palo Alto Investors LP | 156.4K | $12.4M | — | Held |
| BARCLAYS PLC | 515.1K | $12.2M | $1.87M | Added$2.85M |
| CITIGROUP INC | 261K | $11.8M | — | Held |
| Invesco Ltd. | 2.56M | $11.6M | — | Held |
| PDT Partners, LLC | 145.4K | $11.5M | — | Held |
| FIRST TRUST ADVISORS LP | 137.7K | $10.9M | — | Held |
| JPMORGAN CHASE & CO | 1.31M | $10.8M | — | Held |
| SSI INVESTMENT MANAGEMENT LLC | 4.12M | $10.6M | — | Held |
| Ensign Peak Advisors, Inc | 134K | $10.6M | — | Held |
| WELLS FARGO & COMPANY/MN | 639.4K | $10.5M | — | Held |
| Highlander Partners, L.P. | 123K | $9.71M | — | Held |
| BANK OF MONTREAL /CAN/ | 2.06M | $9.7M | — | Held |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 111.3K | $8.79M | — | Held |
| Qube Research & Technologies Ltd | 109K | $8.61M | — | Held |
| Rhenman & Partners Asset Management AB | 106.3K | $8.39M | — | Held |
| MARSHALL WACE, LLP | 102.7K | $8.11M | — | Held |
| Hennion & Walsh Asset Management, Inc. | 98.3K | $7.76M | — | Held |
| ARISTEIA CAPITAL, L.L.C. | 3M | $7.75M | — | Held |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 90.1K | $7.11M | — | Held |
| Atle Fund Management AB | 89.7K | $7.08M | — | Held |
| Swiss National Bank | 74.3K | $5.87M | — | Held |
| Rafferty Asset Management, LLC | 72.9K | $5.76M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 72.2K | $5.7M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 67.7K | $5.35M | — | Held |
| Vestal Point Capital, LP | 66K | $5.21M | — | Held |
| Linden Advisors LP | 2M | $5.17M | — | Held |
| CAPITAL FUND MANAGEMENT S.A. | 62.3K | $4.92M | — | Held |
| TCG Crossover Management, LLC | 62K | $4.9M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 59.2K | $4.68M | — | Held |
| SEI INVESTMENTS CO | 274.1K | $4.23M | — | Held |
| Jump Financial, LLC | 53.3K | $4.21M | — | Held |
| F/m Investments LLC | 53.1K | $4.19M | — | Held |
| RHUMBLINE ADVISERS | 50.8K | $4.01M | — | Held |
| Secure Asset Management, LLC | 50.4K | $3.98M | — | Held |
| PRUDENTIAL FINANCIAL INC | 50.1K | $3.96M | — | Held |
| Informed Momentum Co LLC | 48.1K | $3.8M | — | Held |
| Hillsdale Investment Management Inc. | 47.6K | $3.76M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 46.2K | $3.65M | — | Held |
| CenterBook Partners LP | 45.4K | $3.58M | — | Held |
| ADVENT CAPITAL MANAGEMENT /DE/ | 1.38M | $3.57M | — | Held |
| Legato Capital Management LLC | 44.1K | $3.49M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 43.5K | $3.43M | — | Held |
| ALPS ADVISORS INC | 42.1K | $3.33M | — | Held |
| XTX Topco Ltd | 40.2K | $3.18M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36.4K | $2.88M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 387.1K | $2.84M | — | Held |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 1.1M | $2.84M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 34.1K | $2.69M | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 33.7K | $2.66M | — | Held |
| Icahn Capital | 32.5K | $2.57M | — | Held |
| Trails Edge Capital Partners, LP | 31.9K | $2.52M | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 31.7K | $2.5M | — | Held |
| Creative Planning | 31.5K | $2.49M | — | Held |
| ZACKS INVESTMENT MANAGEMENT | 30.4K | $2.4M | — | Held |
| Allianz Asset Management GmbH | 27.4K | $2.17M | — | Held |
| Faithward Advisors, LLC | 27.3K | $2.16M | — | Held |
| PROFUND ADVISORS LLC | 27.1K | $2.14M | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 27.9K | $2.01M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23.3K | $1.84M | — | Held |
| TD Asset Management Inc | 23.3K | $1.84M | — | Held |
| Sofinnova Investments, Inc. | 23.1K | $1.82M | — | Held |
| AGF MANAGEMENT LTD | 700K | $1.81M | — | Held |
| MetLife Investment Management, LLC | 22.7K | $1.8M | — | Held |
| Pathstone Holdings, LLC | 21.7K | $1.71M | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 20.5K | $1.62M | — | Held |
| ROYAL BANK OF CANADA | 20.2K | $1.59M | — | Held |
| MACKENZIE FINANCIAL CORP | 19.9K | $1.57M | — | Held |
| Knights of Columbus Asset Advisors LLC | 19.5K | $1.54M | — | Held |
| Golden State Equity Partners | 19.4K | $1.53M | — | Held |
| MARTINGALE ASSET MANAGEMENT L P | 18.2K | $1.44M | — | Held |
| OAK RIDGE INVESTMENTS LLC | 17.3K | $1.37M | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 17.2K | $1.36M | — | Held |
| Values First Advisors, Inc. | 16.4K | $1.3M | — | Held |
| SBI Okasan Asset Management Co.Ltd. | 16K | $1.28M | — | Held |
| COMMONWEALTH EQUITY SERVICES, LLC | 16.1K | $1.27M | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14.8K | $1.17M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 14.4K | $1.13M | — | Held |
| Fisher Asset Management, LLC | 14.1K | $1.11M | — | Held |
| POLEN CAPITAL MANAGEMENT LLC | 13.4K | $1.06M | — | Held |
| State of New Jersey Common Pension Fund D | 12.9K | $1.02M | — | Held |
| Engineers Gate Manager LP | 10.7K | $845K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 10.7K | $844.8K | — | Held |
| Virtus Investment Advisers, LLC | 10.5K | $830.4K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 10.5K | $829.6K | — | Held |
| Persistent Asset Partners Ltd | 10.2K | $804.8K | — | New |
| NOMURA HOLDINGS INC | 9.88K | $780.1K | — | Held |
| STRS OHIO | 9.8K | $774.1K | — | Held |
| ProShare Advisors LLC | 9.77K | $772K | — | Held |
| GUGGENHEIM CAPITAL LLC | 9.77K | $771.9K | — | Held |
| Odyssean, LLC | 9.28K | $732.8K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 9.27K | $732.6K | — | Held |
| OP Asset Management Ltd | 8.54K | $674.4K | — | New |
| China Universal Asset Management Co., Ltd. | 8.38K | $661.5K | — | Held |
| Verition Fund Management LLC | 8.25K | $651.7K | — | Held |
| KLP KAPITALFORVALTNING AS | 8K | $631.9K | — | Held |
| Kohlberg Kravis Roberts & Co. L.P. | 244K | $630.7K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 7.95K | $627.7K | — | Held |
| Graham Capital Management, L.P. | 7.18K | $567.1K | — | Held |
| PSP Research LLC | 6.85K | $541.4K | — | Held |
| Man Group plc | 6.84K | $540.4K | — | Held |
| AlphaQuest LLC | 6.55K | $517.5K | — | Held |
| GREAT LAKES ADVISORS, LLC | 6.46K | $510.7K | — | Held |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 6.45K | $509.5K | — | Held |
| Steward Partners Investment Advisory, LLC | 7.23K | $494.8K | — | Held |
| Jasper Ridge Partners, L.P. | 6.25K | $493.5K | — | Held |
| Cetera Investment Advisers | 6.17K | $487.4K | — | Held |
| Dana Investment Advisors, Inc. | 6.11K | $482.2K | — | Held |
| Reliant Investment Partners, LLC | 5.97K | $472K | — | Held |
| LAZARD ASSET MANAGEMENT LLC | 11.5M | $452.5K | — | Held |
| Freestone Grove Partners LP | 5.69K | $449.6K | — | Held |
| Caprock Group, LLC | 5.6K | $442.1K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 5.57K | $439.9K | — | Held |
| LPL Financial LLC | 5.21K | $411.8K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 5.21K | $411.1K | $29.6K | Cut−$1.62M |
| OPPENHEIMER ASSET MANAGEMENT INC. | 67.1K | $408.9K | — | Held |
| EntryPoint Capital, LLC | 5.15K | $406.8K | — | Held |
| NorthCrest Asset Manangement, LLC | 5.37K | $405.7K | — | Held |
| Palumbo Wealth Management LLC | 5.08K | $401.4K | — | Held |
| CONTRAVISORY INVESTMENT MANAGEMENT, INC. | 4.93K | $389.8K | — | Held |
| State of Wyoming | 4.69K | $370.2K | — | Held |
| VIRTUS ADVISERS, LLC | 22K | $362.4K | −$227.4K | Added$69.2K |
| Central Pacific Bank - Trust Division | 125K | $322.5K | — | Held |
| Swiss Life Asset Management Ltd | 4.05K | $320.1K | — | New |
| Tidal Investments LLC | 3.76K | $296.8K | — | Held |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 3.76K | $292.3K | — | Held |
| Ameritas Investment Partners, Inc. | 3.37K | $266.4K | — | Held |
| Ballentine Partners, LLC | 3.32K | $262.6K | — | Held |
| GLENMEDE TRUST CO NA | 3.31K | $261.9K | — | Held |
| Ares Systematic Credit Ltd | 100K | $259.1K | — | Held |
| XPONANCE LLC | 3.21K | $253.2K | — | Held |
| Quantinno Capital Management LP | 3.19K | $252.1K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 3.16K | $249.6K | — | Held |
| Atria Investments, Inc | 3.15K | $248.8K | — | Held |
| RWC Asset Management LLP | 3.13K | $247.6K | — | Held |
| NBC SECURITIES, INC. | 3.12K | $246.1K | — | Held |
| Brookwood Investment Group LLC | 3.1K | $244.9K | — | Held |
| Sumitomo Mitsui Trust Group, Inc. | 3.04K | $240K | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 3K | $237K | $17K | Added$17K |
| Concurrent Investment Advisors, LLC | 3K | $237K | — | Held |
| MQS Management LLC | 2.9K | $229.2K | — | Held |
| CIBC WORLD MARKETS CORP | 2.71K | $214.3K | — | Held |
| Avanza Fonder AB | 2.68K | $211.5K | — | Held |
| Forefront Analytics, LLC | 2.66K | $210.3K | — | Held |
| WETZEL INVESTMENT ADVISORS, INC. | 2.6K | $205.4K | — | Held |
| GLOBEFLEX CAPITAL L P | 2.26K | $178.2K | — | Held |
| Tower Research Capital LLC (TRC) | 2.16K | $170.5K | — | Held |
| HOLLENCREST CAPITAL MANAGEMENT | 1.89K | $149.1K | — | Held |
| RiverPark Advisors, LLC | 1.73K | $136.8K | — | Held |
| Rockefeller Capital Management L.P. | 1.68K | $132.9K | — | Held |
| OSAIC HOLDINGS, INC. | 1.58K | $124.6K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.42M | $112.2K | — | Held |
| PICTON MAHONEY ASSET MANAGEMENT | 1.42K | $112.2K | — | Held |
| EFG International AG | 1.35K | $107K | — | Held |
| Calamos Advisors LLC | 41K | $105.9K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.01K | $79.6K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 945 | $74.6K | — | Held |
| GROUP ONE TRADING LLC | 872 | $68.9K | — | Held |
| LORD, ABBETT & CO. LLC | 6.53M | $61.2K | — | Held |
| US BANCORP \DE\ | 745 | $58.8K | — | Held |
| Allworth Financial LP | 680 | $53.7K | $3.77K | Added$5.11K |
| COMERICA BANK | 675 | $53.3K | — | Held |
| STEPHENS INC /AR/ | 20K | $51.6K | — | Held |
| PNC Financial Services Group, Inc. | 612 | $48.3K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 477 | $37.7K | — | Held |
| EverSource Wealth Advisors, LLC | 450 | $35.5K | — | Held |
| Parallel Advisors, LLC | 447 | $35.3K | — | Held |
| MCF Advisors LLC | 436 | $34.4K | — | Held |
| CIBC Private Wealth Group LLC | 401 | $31.7K | — | Held |
| Eurizon Capital SGR S.p.A. | 400 | $31.5K | — | Held |
| Cullen/Frost Bankers, Inc. | 383 | $30.3K | — | Held |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 278 | $27.6K | — | Held |
| NewEdge Advisors, LLC | 10K | $25.8K | — | Held |
| Balboa Wealth Partners | 10K | $25.6K | — | Held |