| Frazier Life Sciences Management, L.P. | 6.65M | $209.8M | — | Held |
| ORBIMED ADVISORS LLC | 3.94M | $124.1M | — | Held |
| NEA Management Company, LLC | 3.61M | $114M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 3.35M | $105.7M | — | Held |
| Deep Track Capital, LP | 3.25M | $102.5M | — | Held |
| BlackRock, Inc. | 2.92M | $92.1M | — | Held |
| NVP ASSOCIATES, LLC | 2.14M | $67.4M | — | Held |
| EcoR1 Capital, LLC | 2.12M | $67M | — | Held |
| Vanguard | 1.82M | $57.3M | — | Held |
| Driehaus Capital Management LLC | 1.41M | $44.4M | — | Held |
| Cormorant Asset Management, LP | 1.12M | $35.3M | — | Held |
| BRAIDWELL LP | 1.02M | $32.1M | — | Held |
| Woodline Partners LP | 1M | $31.5M | — | Held |
| Kynam Capital Management, LP | 934.8K | $29.5M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 890K | $28.1M | — | Held |
| Parkman Healthcare Partners LLC | 885.6K | $27.9M | — | Held |
| Citadel | 809.9K | $25.5M | — | Held |
| Point72 Asset Management, L.P. | 680.6K | $21.5M | — | Held |
| State Street | 672.7K | $21.2M | — | Held |
| D. E. Shaw & Co., Inc. | 671.8K | $21.2M | — | Held |
| TCG Crossover Management, LLC | 650K | $20.5M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 649.4K | $20.5M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 462K | $14.6M | — | Held |
| Soleus Capital Management, L.P. | 408.9K | $12.9M | — | Held |
| GOLDMAN SACHS GROUP INC | 331.9K | $10.5M | — | Held |
| Trails Edge Capital Partners, LP | 315.2K | $9.94M | — | Held |
| Rock Springs Capital Management LP | 282.6K | $8.91M | — | Held |
| UBS Group AG | 281.2K | $8.87M | — | Held |
| Opaleye Management Inc. | 260K | $8.2M | — | Held |
| Affinity Asset Advisors, LLC | 250K | $7.88M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 222.2K | $7.01M | — | Held |
| Goelzer Investment Management, Inc. | 221.7K | $6.99M | — | Held |
| Elmind Capital, LP | 211K | $6.65M | — | Held |
| NORTHERN TRUST CORP | 190.9K | $6.02M | — | Held |
| Schonfeld Strategic Advisors LLC | 167.1K | $5.27M | — | Held |
| DAFNA Capital Management LLC | 165.3K | $5.21M | — | Held |
| Tetragon Partners GP Ltd | 143.3K | $4.52M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 138.6K | $4.37M | — | Held |
| KVP Capital Advisors, LP | 121.5K | $3.83M | — | Held |
| Balyasny Asset Management L.P. | 119.7K | $3.78M | — | Held |
| TD Asset Management Inc | 101.5K | $3.2M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 100K | $3.15M | — | Held |
| JANE STREET GROUP, LLC | 86.6K | $2.73M | — | Held |
| PFM Health Sciences, LP | 79.3K | $2.5M | — | Held |
| STEMPOINT CAPITAL LP | 78.6K | $2.48M | — | Held |
| OSAIC HOLDINGS, INC. | 77.6K | $2.45M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76.5K | $2.41M | — | Held |
| Nuveen, LLC | 75.6K | $2.38M | — | Held |
| Bank of New York Mellon Corp | 75.3K | $2.37M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 73.7K | $2.28M | — | Held |
| Aaron Wealth Advisors LLC | 70K | $2.21M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69.6K | $2.15M | — | Held |
| MORGAN STANLEY | 59K | $1.86M | $629.9K | Added$1.08M |
| Verition Fund Management LLC | 57.6K | $1.82M | — | Held |
| ExodusPoint Capital Management, LP | 57K | $1.8M | — | Held |
| BARCLAYS PLC | 52.7K | $1.66M | $303.6K | Added$1.28M |
| Squarepoint Ops LLC | 46.7K | $1.47M | — | Held |
| PLATINUM INVESTMENT MANAGEMENT LTD | 43.6K | $1.38M | — | Held |
| BANK OF AMERICA CORP /DE/ | 37.9K | $1.2M | $373.7K | Added$729.4K |
| ALPS ADVISORS INC | 36.9K | $1.16M | — | Held |
| Creative Planning | 33.7K | $1.06M | — | Held |
| RHUMBLINE ADVISERS | 33.4K | $1.05M | — | Held |
| Renaissance Technologies | 32.6K | $1.03M | — | Held |
| WELLS FARGO & COMPANY/MN | 31.9K | $1.01M | — | Held |
| Icahn Capital | 31.4K | $990.6K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 27.9K | $880K | — | Held |
| Brevan Howard Capital Management LP | 25.7K | $809.4K | — | Held |
| Trexquant Investment LP | 24.3K | $765.4K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 23.8K | $751.3K | — | Held |
| Qube Research & Technologies Ltd | 23.2K | $732.1K | — | Held |
| Cerity Partners LLC | 21.3K | $672.5K | — | Held |
| Invesco Ltd. | 21.2K | $668.7K | — | Held |
| XTX Topco Ltd | 20.1K | $635.2K | — | Held |
| DEUTSCHE BANK AG\ | 20K | $631.7K | — | Held |
| Koa Wealth Management, LLC | 18.4K | $580.7K | — | Held |
| Seven Fleet Capital Management LP | 18.2K | $574K | — | Held |
| CITIGROUP INC | 16.4K | $517K | — | Held |
| MetLife Investment Management, LLC | 16K | $505.2K | — | Held |
| Fidelity | 15.7K | $496.6K | — | Held |
| China Universal Asset Management Co., Ltd. | 15.3K | $483.1K | — | Held |
| JPMORGAN CHASE & CO | 14.6K | $461.9K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13.3K | $418.2K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 12.2K | $385.9K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 11.6K | $365.9K | — | Held |
| Graham Capital Management, L.P. | 11.3K | $355K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 10K | $315.4K | — | Held |
| GROUP ONE TRADING LLC | 9.43K | $297.4K | — | Held |
| PROFUND ADVISORS LLC | 9.21K | $290.6K | — | Held |
| SIMPLEX TRADING, LLC | 8.93K | $281.5K | — | Held |
| Virtus Investment Advisers, LLC | 8.91K | $281K | — | Held |
| Rafferty Asset Management, LLC | 8.11K | $255.9K | — | Held |
| SEI INVESTMENTS CO | 7.66K | $241.5K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 7.52K | $237.2K | — | Held |
| ProShare Advisors LLC | 7.19K | $226.7K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 10.4K | $225.7K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 6.86K | $216.3K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 6.78K | $214K | — | Held |
| AXQ CAPITAL, LP | 6.46K | $203.8K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 4.3K | $135.6K | — | Held |
| Tower Research Capital LLC (TRC) | 3.42K | $107.7K | — | Held |
| Rockefeller Capital Management L.P. | 3K | $94.6K | — | Held |
| Russell Investments Group, Ltd. | 2.86K | $90.1K | — | Held |
| Legal & General Group Plc | 2.54K | $80.1K | — | Held |
| Ameritas Investment Partners, Inc. | 2.31K | $72.9K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.18K | $68.8K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.75K | $55.3K | — | Held |
| Sterling Capital Management LLC | 1.64K | $51.8K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 1.59K | $50.2K | — | Held |
| ROYAL BANK OF CANADA | 1.53K | $49K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 882 | $27.8K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 840.5K | $26.5K | — | Held |
| STRS OHIO | 700 | $22.1K | — | Held |
| US BANCORP \DE\ | 312 | $9.84K | — | Held |
| GAMMA Investing LLC | 299 | $9.43K | — | Held |
| Aster Capital Management (DIFC) Ltd | 265 | $8.36K | — | Held |
| PNC Financial Services Group, Inc. | 196 | $6.18K | — | Held |
| SIGNATUREFD, LLC | 179 | $5.65K | — | Held |
| Physician Wealth Advisors, Inc. | 109 | $3.44K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 100 | $3.15K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 80 | $2.52K | — | Held |
| Parallel Advisors, LLC | 61 | $1.92K | — | Held |
| Allworth Financial LP | 52 | $1.64K | $351 | Added$1.2K |
| ACADIAN ASSET MANAGEMENT LLC | 48.6K | $1.53K | — | Held |
| Cornerstone Financial Management LLC | 34 | $1.07K | — | Held |
| EverSource Wealth Advisors, LLC | 25 | $789 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 24 | $757 | — | Held |
| GSA CAPITAL PARTNERS LLP | 19.3K | $609 | — | Held |
| Global Retirement Partners, LLC | 19 | $599 | — | Held |
| Essential Partners LLC | 15 | $473 | $28 | Added$438 |
| Farther Finance Advisors, LLC | 10 | $315 | — | Held |
| SBI Securities Co., Ltd. | 9 | $284 | — | Held |
| SG Americas Securities, LLC | 4.76K | $150 | — | Held |
| True Wealth Design, LLC | 2 | $64 | — | Held |
| Cygnus Capital Advisors, LLC | 1.8K | $57 | — | Held |
| CWM, LLC | 1.78K | $56 | — | Held |
| IFP Advisors, Inc | 1 | $32 | — | New |
| AMALGAMATED BANK | 895 | $28 | — | Held |
| Daiwa Securities Group Inc. | 150 | $5 | — | Held |