| Fidelity | 8.93M | $694.7M | — | Held |
| BAKER BROS. ADVISORS LP | 8.66M | $673.6M | — | Held |
| Avoro Capital Advisors LLC | 7.47M | $581.6M | — | Held |
| Vanguard | 6.27M | $487.7M | — | Held |
| BVF INC/IL | 5.5M | $428.2M | — | Held |
| BlackRock, Inc. | 5M | $389.4M | — | Held |
| Atlas Venture Life Science Advisors, LLC | 4.66M | $362.6M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 4.41M | $343.4M | — | Held |
| Siren, L.L.C. | 3.29M | $255.7M | — | Held |
| State Street | 2.21M | $171.9M | — | Held |
| Capital Research Global Investors | 1.56M | $121.4M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.42M | $110.3M | — | Held |
| Driehaus Capital Management LLC | 1.07M | $83.2M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 952.1K | $74.1M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 912.5K | $71M | — | Held |
| Merck & Co., Inc. | 772.2K | $60.1M | — | Held |
| FEDERATED HERMES, INC. | 763.9K | $59.4M | — | Held |
| Holocene Advisors, LP | 761.2K | $59.2M | — | Held |
| Commodore Capital LP | 750K | $58.4M | — | Held |
| GOLDMAN SACHS GROUP INC | 740.3K | $57.6M | — | Held |
| UBS Group AG | 737K | $57.3M | — | Held |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 636K | $49.5M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 626.4K | $48.7M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 624K | $48.6M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 561.2K | $43.7M | — | Held |
| Octagon Capital Advisors LP | 535K | $41.6M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 497K | $38.7M | — | Held |
| Rock Springs Capital Management LP | 496.9K | $38.7M | — | Held |
| JENNISON ASSOCIATES LLC | 496.7K | $38.6M | — | Held |
| Pictet Asset Management Holding SA | 483.2K | $37.8M | — | Held |
| NORTHERN TRUST CORP | 467K | $36.3M | — | Held |
| BRAIDWELL LP | 454.3K | $35.3M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 430K | $33.5M | — | Held |
| TWO SIGMA ADVISERS, LP | 373.8K | $29.1M | — | Held |
| Alyeska Investment Group, L.P. | 371.9K | $28.9M | — | Held |
| FRANKLIN RESOURCES INC | 354.6K | $27.6M | — | Held |
| BANK OF AMERICA CORP /DE/ | 339K | $26.4M | $3.95M | Added$15.8M |
| Boxer Capital Management, LLC | 329.1K | $25.6M | $6.77M | Added$7.55M |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 289.4K | $22.5M | — | Held |
| Nextech Invest, Ltd. | 278.9K | $21.7M | — | Held |
| MORGAN STANLEY | 274K | $21.3M | $5.81M | Cut−$62.1K |
| TWO SIGMA INVESTMENTS, LP | 265.5K | $20.7M | — | Held |
| RTW INVESTMENTS, LP | 240K | $18.7M | — | Held |
| GILDER GAGNON HOWE & CO LLC | 239.9K | $18.7M | — | Held |
| Deer Management Co. LLC | 230.8K | $18M | — | Held |
| TD Asset Management Inc | 221.2K | $17.2M | — | Held |
| First Turn Management, LLC | 206.4K | $16.1M | — | Held |
| Woodline Partners LP | 203.6K | $15.8M | — | Held |
| Candriam S.C.A. | 201.7K | $15.7M | — | Held |
| Polar Capital Holdings Plc | 200.9K | $15.6M | — | Held |
| Bank of New York Mellon Corp | 192.7K | $15M | — | Held |
| TimesSquare Capital Management, LLC | 189.9K | $14.8M | — | Held |
| Point72 Asset Management, L.P. | 173.1K | $13.5M | — | Held |
| Citadel | 159.9K | $12.4M | — | Held |
| Squarepoint Ops LLC | 159.4K | $12.4M | — | Held |
| Foresite Capital Management VI LLC | 146.3K | $11.4M | — | Held |
| BARCLAYS PLC | 140.5K | $10.9M | $2.98M | Added$2.15M |
| Patient Square Capital LP | 139K | $10.8M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 135.9K | $10.6M | — | Held |
| Eagle Health Investments LP | 136.3K | $10.6M | — | Held |
| JPMORGAN CHASE & CO | 131.4K | $10.2M | — | Held |
| Logos Global Management LP | 130K | $10.1M | — | Held |
| Nuveen, LLC | 125K | $9.73M | — | Held |
| Invesco Ltd. | 116.7K | $9.08M | — | Held |
| WCM INVESTMENT MANAGEMENT, LLC | 105.2K | $8.22M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 105.6K | $8.21M | — | Held |
| Monashee Investment Management LLC | 100K | $7.78M | — | Held |
| Ensign Peak Advisors, Inc | 95K | $7.4M | — | Held |
| Swiss National Bank | 94.2K | $7.33M | — | Held |
| ARMISTICE CAPITAL, LLC | 81.2K | $6.32M | — | Held |
| DEUTSCHE BANK AG\ | 79.8K | $6.21M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 75K | $5.84M | — | Held |
| Yiheng Capital Management, L.P. | 73.4K | $5.71M | — | Held |
| RHUMBLINE ADVISERS | 72.3K | $5.63M | — | Held |
| PERCEPTIVE ADVISORS LLC | 69.9K | $5.44M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 67.1K | $5.22M | — | Held |
| WELLS FARGO & COMPANY/MN | 66.5K | $5.17M | — | Held |
| ALPS ADVISORS INC | 64.7K | $5.04M | — | Held |
| FIRST TRUST ADVISORS LP | 58.9K | $4.58M | — | Held |
| Rafferty Asset Management, LLC | 58.7K | $4.56M | — | Held |
| NEUBERGER BERMAN GROUP LLC | 58.5K | $4.55M | — | Held |
| Informed Momentum Co LLC | 56.5K | $4.39M | — | Held |
| Nicholas Investment Partners, LP | 55.8K | $4.34M | — | Held |
| Verition Fund Management LLC | 54.3K | $4.23M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 52.7K | $4.11M | — | Held |
| COMERICA BANK | 49.8K | $3.88M | — | Held |
| Russell Investments Group, Ltd. | 46K | $3.58M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45.7K | $3.56M | — | Held |
| Legal & General Group Plc | 43.4K | $3.38M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40.8K | $3.17M | — | Held |
| DARK FOREST CAPITAL MANAGEMENT LP | 39.2K | $3.05M | — | Held |
| Moody Aldrich Partners LLC | 38.5K | $3M | — | Held |
| MARSHALL WACE, LLP | 38K | $2.96M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 36.4K | $2.83M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 34.6K | $2.69M | — | Held |
| State of New Jersey Common Pension Fund D | 33.5K | $2.61M | — | Held |
| Sio Capital Management, LLC | 32.2K | $2.51M | — | Held |
| MetLife Investment Management, LLC | 31.4K | $2.44M | — | Held |
| Nan Fung Group Holdings Ltd | 30.9K | $2.4M | — | Held |
| SEVEN GRAND MANAGERS, LLC | 30K | $2.33M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 28.9K | $2.25M | — | Held |
| Erste Asset Management GmbH | 27K | $2.17M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 26.5K | $2.06M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 25.6K | $1.99M | — | Held |
| Rockefeller Capital Management L.P. | 25.5K | $1.99M | — | Held |
| Trexquant Investment LP | 24.7K | $1.92M | — | Held |
| China Universal Asset Management Co., Ltd. | 24.5K | $1.91M | — | Held |
| XTX Topco Ltd | 24.1K | $1.88M | — | Held |
| PROFUND ADVISORS LLC | 22.2K | $1.73M | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 21.5K | $1.67M | — | Held |
| JANUS HENDERSON GROUP PLC | 21.1K | $1.64M | — | Held |
| Man Group plc | 20K | $1.56M | — | Held |
| BAMCO INC /NY/ | 20K | $1.56M | — | Held |
| AJU IB Investment Co., Ltd. | 19.6K | $1.53M | — | Held |
| Walleye Capital LLC | 19.2K | $1.49M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 18.6K | $1.45M | — | Held |
| NORGES BANK | 16.5K | $1.29M | $834.4K | Cut−$73K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15.6K | $1.22M | — | Held |
| B. Metzler seel. Sohn & Co. AG | 15.6K | $1.21M | — | Held |
| Police & Firemen's Retirement System of New Jersey | 15K | $1.17M | — | Held |
| Maven Securities LTD | 15K | $1.17M | — | Held |
| Creative Planning | 13.8K | $1.07M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 13.8K | $1.07M | — | Held |
| ProShare Advisors LLC | 13.5K | $1.05M | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 13.3K | $1.03M | — | Held |
| SEI INVESTMENTS CO | 13.3K | $1.03M | — | Held |
| Knights of Columbus Asset Advisors LLC | 12.9K | $1M | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12.7K | $984.7K | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 12.5K | $974.4K | — | Held |
| Campbell & CO Investment Adviser LLC | 11.5K | $897.5K | — | Held |
| MILLENNIUM MANAGEMENT LLC | 11.2K | $874.8K | — | Held |
| CLOUGH CAPITAL PARTNERS L P | 10.9K | $850.1K | — | Held |
| Proficio Capital Partners LLC | 10.8K | $843.8K | — | Held |
| CITIGROUP INC | 10.5K | $817.5K | — | Held |
| GUGGENHEIM CAPITAL LLC | 10.3K | $802K | — | Held |
| KLP KAPITALFORVALTNING AS | 10.2K | $793.7K | — | Held |
| Legato Capital Management LLC | 9.53K | $741.8K | — | Held |
| Odyssean, LLC | 9.35K | $727.3K | — | Held |
| Icahn Capital | 9.34K | $726.7K | — | Held |
| Aigen Investment Management, LP | 9.1K | $707.9K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 8.8K | $684.6K | — | Held |
| HSBC HOLDINGS PLC | 7.62K | $596.6K | — | Held |
| Vident Advisory, LLC | 7.58K | $589.9K | — | Held |
| Scientech Research LLC | 7.38K | $574.2K | — | Held |
| HighVista Strategies LLC | 6.83K | $531.8K | — | Held |
| Keudell/Morrison Wealth Management | 6.6K | $513.5K | — | Held |
| GLENMEDE TRUST CO NA | 6.54K | $509.2K | — | Held |
| PSP Research LLC | 6.35K | $493.9K | — | Held |
| Vestmark Advisory Solutions, Inc. | 6.2K | $482.7K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6.16M | $479.3K | — | Held |
| AlphaQuest LLC | 5.98K | $465.6K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 5.9K | $459.1K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 5.84K | $454.2K | — | Held |
| Abel Hall, LLC | 5.84K | $454.1K | — | Held |
| LBP AM SA | 5.67K | $440.9K | — | Held |
| Allianz Asset Management GmbH | 5.5K | $428K | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 5.11K | $397.8K | — | Held |
| AlphaCentric Advisors LLC | 5.04K | $391.8K | — | Held |
| Edgestream Partners, L.P. | 4.96K | $386.2K | — | Held |
| Advisors Asset Management, Inc. | 4.94K | $384.5K | — | Held |
| Ameritas Investment Partners, Inc. | 4.66K | $362.8K | — | Held |
| XPONANCE LLC | 4.5K | $350.5K | — | Held |
| STRS OHIO | 3.9K | $303.5K | — | Held |
| CIBC WORLD MARKETS CORP | 3.73K | $290.4K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 3.65K | $283.7K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.5K | $272K | — | Held |
| MACKENZIE FINANCIAL CORP | 3.46K | $270.1K | — | Held |
| AMERIPRISE FINANCIAL INC | 3.43K | $266.6K | — | Held |
| PRUDENTIAL FINANCIAL INC | 3.41K | $265.3K | — | Held |
| Cetera Investment Advisers | 3.35K | $260.7K | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 3.33K | $259.3K | — | Held |
| Belvedere Trading LLC | 3.28K | $255.4K | — | Held |
| Private Advisor Group, LLC | 3.24K | $252K | — | Held |
| Virtus Investment Advisers, LLC | 2.97K | $230.8K | — | Held |
| CIBC Asset Management Inc | 2.94K | $228.7K | — | Held |
| Orion Porfolio Solutions, LLC | 2.87K | $223.2K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 2.82K | $219.3K | — | Held |
| DRIVE WEALTH MANAGEMENT, LLC | 2.8K | $217.6K | — | Held |
| Aquatic Capital Management LLC | 2.69K | $209.3K | — | Held |
| Perbak Capital Partners LLP | 2.64K | $205.3K | — | Held |
| Caitong International Asset Management Co., Ltd | 2.54K | $197.8K | — | Held |
| ROYAL BANK OF CANADA | 2.26K | $176K | — | Held |
| US BANCORP \DE\ | 2.24K | $174.3K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 1.97K | $120.9K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.41K | $109.9K | — | Held |
| OSAIC HOLDINGS, INC. | 1.38K | $107.5K | — | Held |
| Tower Research Capital LLC (TRC) | 1.26K | $98.2K | — | Held |
| Larson Financial Group LLC | 1.06K | $82.8K | — | Held |
| MAI Capital Management | 924 | $71.9K | — | Held |
| PNC Financial Services Group, Inc. | 822 | $64K | — | Held |
| T. Rowe Price Investment Management, Inc. | 629.7K | $49K | — | Held |
| Smartleaf Asset Management LLC | 535 | $41.8K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 499 | $38.8K | — | Held |
| Sterling Capital Management LLC | 371 | $28.9K | — | Held |
| GAMMA Investing LLC | 298 | $23.2K | — | Held |
| SBI Securities Co., Ltd. | 286 | $22.3K | — | Held |
| EverSource Wealth Advisors, LLC | 277 | $21.6K | — | Held |
| Kestra Advisory Services, LLC | 276 | $21.5K | — | Held |
| Truvestments Capital LLC | 274 | $21.3K | — | Held |
| Optiver Holding B.V. | 236 | $18.4K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 221 | $17.2K | — | Held |
| IFP Advisors, Inc | 185 | $14.4K | $3.92K | Added$3.92K |
| Kemnay Advisory Services Inc. | 183 | $14.2K | — | Held |
| WHITTIER TRUST CO | 183 | $13.4K | — | Held |
| Farther Finance Advisors, LLC | 165 | $12.8K | — | Held |
| Inspire Investing, LLC | 165 | $12.8K | — | Held |
| Accent Capital Management, LLC | 150 | $11.7K | — | Held |
| SIGNATUREFD, LLC | 140 | $10.9K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 99 | $7.7K | — | Held |
| Root Financial Partners, LLC | 84 | $6.54K | — | Held |
| EASTERN BANK | 74 | $5.76K | — | Held |
| Parkside Financial Bank & Trust | 68 | $5.29K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 64.8K | $5.04K | — | Held |
| Bare Financial Services, Inc | 50 | $3.89K | — | Held |
| Quantbot Technologies LP | 48 | $3.73K | — | Held |
| Allworth Financial LP | 44 | $3.42K | $933 | Added$933 |
| Arax Advisory Partners | 37 | $2.88K | — | Held |
| SJS Investment Consulting Inc. | 34 | $2.65K | — | Held |
| Manchester Capital Management LLC | 31 | $2.41K | — | Held |
| HARBOR CAPITAL ADVISORS, INC. | 30.6K | $2.38K | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 28 | $2.18K | — | Held |
| Virtu Financial LLC | 27.3K | $2.12K | — | Held |
| Torren Management, LLC | 24 | $1.87K | — | Held |
| SG Americas Securities, LLC | 22.7K | $1.77K | — | Held |
| Fortitude Family Office, LLC | 21 | $1.63K | — | Held |
| Parallel Advisors, LLC | 20 | $1.56K | — | Held |
| Keating Financial Advisory Services, Inc. | 19 | $1.48K | — | Held |
| HRT FINANCIAL LP | 18.2K | $1.41K | — | Held |
| Handelsbanken Fonder AB | 18K | $1.4K | — | Held |
| JFS WEALTH ADVISORS, LLC | 16 | $1.25K | — | Held |
| Global Retirement Partners, LLC | 15 | $1.17K | — | Held |
| Rachor Investment Advisory Services, LLC | 14 | $1.09K | — | Held |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 13K | $1.01K | — | Held |
| TD PRIVATE CLIENT WEALTH LLC | 12 | $934 | — | Held |
| DekaBank Deutsche Girozentrale | 23.6K | $878 | — | Held |
| Cambridge Investment Research Advisors, Inc. | 6.5K | $506 | — | Held |
| DiNuzzo Private Wealth, Inc. | 6 | $467 | — | Held |
| Bell Investment Advisors, Inc | 6 | $467 | — | Held |
| ASSETMARK, INC | 6 | $467 | — | Held |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 4.67K | $364 | — | Held |
| CANADA LIFE ASSURANCE Co | 3.93K | $306 | — | Held |
| Rialto Wealth Management, LLC | 3 | $234 | — | Held |
| MOSAIC FINANCIAL GROUP, LLC | 2.89K | $225 | — | Held |
| HFM Investment Advisors, LLC | 2 | $156 | — | Held |
| AMALGAMATED BANK | 1.77K | $138 | — | Held |
| KBC Group NV | 1.72K | $134 | $37 | Added$37 |
| ACADIAN ASSET MANAGEMENT LLC | 1.38K | $107 | — | Held |
| Bay Harbor Wealth Management, LLC | 1 | $77 | — | Held |
| BESSEMER GROUP INC | 950 | $74 | — | Held |
| Dunhill Financial, LLC | 1 | $62 | — | Held |