| Opaleye Management Inc. | 930K | $6.84M | — | Held |
| Affinity Asset Advisors, LLC | 889.6K | $6.55M | — | Held |
| Vanguard | 559.6K | $4.12M | — | Held |
| Ikarian Capital, LLC | 544.6K | $4.01M | — | Held |
| Soleus Capital Management, L.P. | 440K | $3.24M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 421.3K | $3.1M | — | Held |
| Davidson Kempner Capital Management LP | 310K | $2.28M | — | New |
| BRAIDWELL LP | 303.4K | $2.23M | — | Held |
| Exome Asset Management LLC | 295.5K | $2.18M | — | Held |
| AMERIPRISE FINANCIAL INC | 276.9K | $2.04M | — | Held |
| Boxer Capital Management, LLC | 252.5K | $1.86M | — | New |
| BlackRock, Inc. | 247.6K | $1.82M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 187.7K | $1.38M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 148.8K | $1.1M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147.7K | $1.09M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 144.6K | $1.06M | — | Held |
| Catalio Capital Management, LP | 143K | $1.05M | — | Held |
| Avidity Partners Management LP | 134.6K | $990.4K | — | Held |
| MARSHALL WACE, LLP | 128.5K | $945.4K | — | Held |
| GROUP ONE TRADING LLC | 102.4K | $753.8K | — | Held |
| Walleye Capital LLC | 95.7K | $704.1K | — | Held |
| TWO SIGMA ADVISERS, LP | 89.7K | $660.4K | — | Held |
| UBS Group AG | 88.5K | $651K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 65.9K | $484.8K | — | Held |
| Context Capital Management, LLC | 63K | $463.6K | — | Held |
| Renaissance Technologies | 59.9K | $441K | — | Held |
| Quadrature Capital Ltd | 59.7K | $439.5K | — | Held |
| State Street | 58.9K | $433.8K | — | Held |
| ROYAL BANK OF CANADA | 58K | $427K | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 57.2K | $421.1K | — | Held |
| Jump Financial, LLC | 53.8K | $396.1K | — | Held |
| DAFNA Capital Management LLC | 51K | $375.4K | — | Held |
| ADAR1 Capital Management, LLC | 50K | $368K | — | Held |
| BANK OF AMERICA CORP /DE/ | 48.1K | $353.9K | $77 | Added$353.3K |
| Trexquant Investment LP | 41.7K | $307.2K | — | Held |
| SILVERBACK ASSET MANAGEMENT LLC | 40K | $294.4K | — | Held |
| JANE STREET GROUP, LLC | 35.5K | $261.5K | — | Held |
| SIMPLEX TRADING, LLC | 32.9K | $241.9K | — | Held |
| Citadel | 31.7K | $233.4K | — | Held |
| NORTHERN TRUST CORP | 29K | $213.6K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 28.7K | $211.4K | — | Held |
| Baird Financial Group, Inc. | 28K | $206K | — | Held |
| Persistent Asset Partners Ltd | 18.3K | $134.8K | — | New |
| TUDOR INVESTMENT CORP ET AL | 12.9K | $95.1K | — | New |
| XTX Topco Ltd | 11.9K | $87.6K | — | Held |
| Bank of New York Mellon Corp | 11.1K | $81.6K | — | Held |
| MORGAN STANLEY | 8.86K | $65.2K | $7.26K | Cut−$103.3K |
| BARCLAYS PLC | 4.11K | $30.2K | $3.37K | Added$3.37K |
| TD Waterhouse Canada Inc. | 3.2K | $23.5K | — | Held |
| JPMORGAN CHASE & CO | 1.74K | $12.8K | — | Held |
| T. Rowe Price Investment Management, Inc. | 1.49M | $11K | — | Held |
| Corient Private Wealth LLC | 10K | $10K | — | Held |
| Rockefeller Capital Management L.P. | 733 | $5.39K | — | Held |
| Fidelity | 679 | $5K | — | Held |
| Aspect Partners, LLC | 391 | $2.88K | — | Held |
| OSAIC HOLDINGS, INC. | 282 | $2.08K | — | Held |
| Quent Capital, LLC | 235 | $1.73K | — | Held |
| MB, LEVIS & ASSOCIATES, LLC | 100 | $736 | — | Held |
| C WorldWide Group Holding A/S | 100K | $736 | — | Held |
| HARBOUR INVESTMENTS, INC. | 85 | $626 | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 82 | $604 | — | Held |
| SBI Securities Co., Ltd. | 74 | $545 | — | Held |
| Activest Wealth Management | 66 | $486 | — | Held |
| Allworth Financial LP | 26 | $192 | $21 | Added$21 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10.9K | $81 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 3.73K | $27 | — | Held |
| West Branch Capital LLC | 3 | $23 | — | Held |
| CIBC Private Wealth Group LLC | 3 | $22 | — | Held |
| CITIGROUP INC | 1 | $7 | — | Held |