| BAKER BROS. ADVISORS LP | 19.9M | $556.9M | — | Held |
| BlackRock, Inc. | 3.95M | $110.6M | — | Held |
| Vanguard | 2.31M | $64.7M | — | Held |
| Point72 Asset Management, L.P. | 2.17M | $60.6M | — | Held |
| BRAIDWELL LP | 2.07M | $58M | — | Held |
| State Street | 1.73M | $48.4M | — | Held |
| RTW INVESTMENTS, LP | 1.49M | $41.6M | — | Held |
| TCG Crossover Management, LLC | 1.45M | $40.4M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.3M | $36.4M | — | Held |
| ICONIQ Capital, LLC | 1.27M | $35.4M | — | Held |
| Boxer Capital Management, LLC | 1.14M | $31.8M | $8.69M | Added$19.5M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.02M | $28.6M | — | Held |
| JANUS HENDERSON GROUP PLC | 1M | $27.9M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 897.7K | $25.1M | — | Held |
| PERCEPTIVE ADVISORS LLC | 848.9K | $23.7M | — | Held |
| Artisan Partners Limited Partnership | 836.5K | $23.4M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 785K | $21.9M | — | Held |
| Ikarian Capital, LLC | 719.8K | $20.1M | — | Held |
| MORGAN STANLEY | 699.8K | $19.6M | $7.51M | Added$8.96M |
| Board of Trustees of The Leland Stanford Junior University | 691.8K | $19.3M | — | Held |
| Invesco Ltd. | 555.1K | $15.5M | — | Held |
| BOONE CAPITAL MANAGEMENT LLC | 503.8K | $14.1M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 473.8K | $13.2M | — | Held |
| Renaissance Technologies | 359.8K | $10.1M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 340.7K | $9.52M | — | Held |
| NORTHERN TRUST CORP | 333.7K | $9.33M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 327.5K | $9.16M | — | Held |
| D. E. Shaw & Co., Inc. | 320.6K | $8.97M | — | Held |
| Squadron Capital Management LLC | 291.7K | $8.16M | — | Held |
| Citadel | 290.5K | $8.12M | — | Held |
| Jain Global LLC | 284.9K | $7.97M | — | Held |
| Balyasny Asset Management L.P. | 263.3K | $7.36M | — | Held |
| FEDERATED HERMES, INC. | 244.2K | $6.83M | — | Held |
| Atom Investors LP | 207.5K | $5.8M | — | Held |
| Fidelity | 199.2K | $5.57M | — | Held |
| BANK OF AMERICA CORP /DE/ | 196.7K | $5.5M | $2.28M | Added$439.9K |
| Trexquant Investment LP | 190.5K | $5.33M | — | Held |
| PANAGORA ASSET MANAGEMENT INC | 180.7K | $5.05M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 175.5K | $4.91M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 173.2K | $4.84M | — | Held |
| UBS Group AG | 168.6K | $4.71M | — | Held |
| Bruce & Co., Inc. | 165K | $4.61M | — | Held |
| TD Asset Management Inc | 133.9K | $3.74M | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 127.2K | $3.56M | — | Held |
| BARCLAYS PLC | 124.3K | $3.48M | $798K | Added$2.35M |
| RIA Advisory Group LLC | 113.5K | $3.17M | $1.32M | Added$462.9K |
| TWO SIGMA ADVISERS, LP | 103.1K | $2.88M | — | Held |
| Bank of New York Mellon Corp | 102.7K | $2.87M | — | Held |
| WELLS FARGO & COMPANY/MN | 92.1K | $2.58M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 91.5K | $2.56M | — | Held |
| OSAIC HOLDINGS, INC. | 83.4K | $2.33M | — | Held |
| PRUDENTIAL FINANCIAL INC | 78.3K | $2.19M | — | Held |
| Nuveen, LLC | 73K | $2.04M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 67.3K | $1.88M | — | Held |
| National Philanthropic Trust | 66.4K | $1.86M | $437.2K | Added$1.24M |
| Harvest Investment Services, LLC | 62K | $1.73M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 60.6K | $1.69M | — | Held |
| Soleus Capital Management, L.P. | 60K | $1.68M | — | Held |
| Rafferty Asset Management, LLC | 59.5K | $1.66M | — | Held |
| Icahn Capital | 57.7K | $1.61M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 51.7K | $1.44M | — | Held |
| NORGES BANK | 50K | $1.4M | — | New |
| VICTORY CAPITAL MANAGEMENT INC | 44K | $1.23M | — | Held |
| Campbell & CO Investment Adviser LLC | 43.4K | $1.21M | — | Held |
| RHUMBLINE ADVISERS | 43.2K | $1.21M | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 43.2K | $1.21M | — | Held |
| POLEN CAPITAL MANAGEMENT LLC | 41.3K | $1.16M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 38K | $1.06M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 36.8K | $1.03M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 36.7K | $1.03M | — | Held |
| DEUTSCHE BANK AG\ | 35.3K | $987.5K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 35.2K | $983.6K | — | Held |
| Russell Investments Group, Ltd. | 31.7K | $886.8K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 29.4K | $822.6K | — | Held |
| J. Goldman & Co LP | 28.9K | $809.4K | — | Held |
| Aries Wealth Management | 25K | $699K | — | Held |
| PROFUND ADVISORS LLC | 22.1K | $617.7K | — | Held |
| SEI INVESTMENTS CO | 20.7K | $577.8K | — | Held |
| AMERIPRISE FINANCIAL INC | 19.9K | $556.3K | — | Held |
| FRANKLIN RESOURCES INC | 19.5K | $546K | — | Held |
| MetLife Investment Management, LLC | 19.4K | $543.2K | — | Held |
| PSP Research LLC | 19.4K | $542.9K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18.7K | $521.9K | — | Held |
| LPL Financial LLC | 18.4K | $514.4K | — | Held |
| JPMORGAN CHASE & CO | 17.9K | $500.6K | — | Held |
| Brevan Howard Capital Management LP | 17.2K | $481.1K | — | Held |
| Artia Global Partners LP | 17K | $475.9K | — | Held |
| CITIGROUP INC | 16.6K | $464.6K | — | Held |
| Cerity Partners LLC | 16.4K | $459.8K | — | Held |
| Headlands Technologies LLC | 16.3K | $455.1K | — | Held |
| Continuum Advisory, LLC | 14.9K | $415.3K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 14.8K | $414.1K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 13.9K | $389.7K | — | Held |
| Dynamic Technology Lab Private Ltd | 13.6K | $379K | — | Held |
| Jefferies Financial Group Inc. | 13.1K | $367.2K | — | Held |
| Virtus Investment Advisers, LLC | 11.2K | $312.4K | — | Held |
| Brooklyn Investment Group | 10.6K | $306.2K | — | Held |
| Creative Planning | 10.8K | $301.6K | — | Held |
| Scientech Research LLC | 10.3K | $288.8K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 9.72K | $271.9K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 9.1K | $254.4K | — | Held |
| ROYAL BANK OF CANADA | 8.74K | $245K | — | Held |
| China Universal Asset Management Co., Ltd. | 8.64K | $241.7K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 8.55K | $239.1K | — | Held |
| Quantinno Capital Management LP | 8.44K | $235.9K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 8.41K | $235.1K | — | Held |
| ProShare Advisors LLC | 8.33K | $232.9K | — | Held |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 8.23K | $230.3K | — | Held |
| Belvedere Trading LLC | 8.04K | $224.7K | — | Held |
| DIVERSIFIED TRUST CO | 7.85K | $219.5K | — | Held |
| CIBC WORLD MARKET INC. | 7.37K | $206.1K | — | Held |
| SIMPLEX TRADING, LLC | 6.13K | $171.5K | — | Held |
| Aster Capital Management (DIFC) Ltd | 4.25K | $118.9K | — | Held |
| GROUP ONE TRADING LLC | 3.85K | $107.7K | — | Held |
| STRS OHIO | 3.1K | $86.7K | — | Held |
| Legal & General Group Plc | 2.92K | $81.6K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.58K | $72.1K | — | Held |
| Ameritas Investment Partners, Inc. | 2.57K | $71.8K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 2.3K | $64.3K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2.02K | $56.3K | — | Held |
| US BANCORP \DE\ | 1.93K | $54.1K | — | Held |
| Sterling Capital Management LLC | 1.89K | $52.8K | — | Held |
| PNC Financial Services Group, Inc. | 1.23K | $34.4K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.17M | $32.7K | — | Held |
| Farther Finance Advisors, LLC | 1.14K | $31.8K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.04K | $29.1K | — | Held |
| Activest Wealth Management | 1K | $28K | — | Held |
| EverSource Wealth Advisors, LLC | 991 | $27.7K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 709.8K | $19.8K | — | Held |
| GAMMA Investing LLC | 708 | $19.8K | — | Held |
| Spire Wealth Management | 633 | $17.7K | — | Held |
| Physician Wealth Advisors, Inc. | 599 | $16.7K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 569 | $15.9K | — | Held |
| POM Investment Strategies, LLC | 500 | $14K | — | Held |
| Tower Research Capital LLC (TRC) | 435 | $12.2K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 420 | $11.7K | — | Held |
| T. Rowe Price Investment Management, Inc. | 409.1K | $11.4K | — | Held |
| Allworth Financial LP | 354 | $9.9K | $23 | Added$9.87K |
| AlphaQuest LLC | 210 | $5.87K | — | Held |
| Cornerstone Planning Group LLC | 210 | $5.47K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 193 | $5.4K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 182 | $3.83K | — | Held |
| FINANCIAL CONSULATE, INC | 30 | $839 | — | Held |
| SG Americas Securities, LLC | 24.1K | $675 | — | Held |
| Wealth Watch Advisors, INC | 15 | $419 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 14 | $391 | — | Held |
| True Wealth Design, LLC | 13 | $364 | — | Held |
| Global Retirement Partners, LLC | 10 | $280 | — | Held |
| Cambridge Investment Research Advisors, Inc. | 9.6K | $268 | — | Held |
| ALGERT GLOBAL LLC | 9.39K | $263 | — | Held |
| IFP Advisors, Inc | 6 | $168 | $70 | Added$70 |
| MAI Capital Management | 5 | $140 | — | Held |
| Essential Partners LLC | 4 | $112 | — | New |
| CWM, LLC | 3.13K | $88 | — | Held |
| AMALGAMATED BANK | 1.03K | $29 | — | Held |
| CIBC Private Wealth Group LLC | 1 | $28 | — | Held |
| Avion Wealth | 411 | $11 | — | Held |
| Daiwa Securities Group Inc. | 177 | $5 | — | Held |