| BAKER BROS. ADVISORS LP | 19.9M | $759.3M | $202.4M | Added$202.4M |
| BlackRock, Inc. | 3.94M | $150M | $40M | Added$39.4M |
| State Street | 2.25M | $85.8M | $17.6M | Added$37.4M |
| BRAIDWELL LP | 1.82M | $69.3M | $18.5M | Added$11.4M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.72M | $65.5M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.69M | $64.4M | $13.2M | Added$28M |
| RTW INVESTMENTS, LP | 1.49M | $56.7M | $15.1M | Added$15.1M |
| TCG Crossover Management, LLC | 1.45M | $55.1M | $14.7M | Added$14.7M |
| Boxer Capital Management, LLC | 1.36M | $51.9M | $11.5M | Added$20.1M |
| JANUS HENDERSON GROUP PLC | 1.33M | $50.5M | $10.2M | Added$22.6M |
| ICONIQ Capital, LLC | 1.27M | $48.3M | $12.9M | Added$12.9M |
| Ikarian Capital, LLC | 1.27M | $48.3M | $7.31M | Added$28.1M |
| GEODE CAPITAL MANAGEMENT, LLC | 1M | $38.1M | $9.12M | Added$13M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 991.9K | $37.8M | $10.1M | Added$9.21M |
| Citadel | 870.8K | $33.2M | $2.95M | Added$25.1M |
| Balyasny Asset Management L.P. | 726.5K | $27.7M | $2.67M | Added$20.3M |
| Board of Trustees of The Leland Stanford Junior University | 691.8K | $26.4M | $7.03M | Added$7.03M |
| Artisan Partners Limited Partnership | 690.3K | $26.3M | $7.01M | Added$2.93M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 575K | $21.9M | $5.84M | Cut−$29.6K |
| MORGAN STANLEY | 515.9K | $19.7M | $5.24M | Added$99.1K |
| Point72 Asset Management, L.P. | 459.7K | $17.5M | $4.67M | Cut−$43.1M |
| WELLINGTON MANAGEMENT GROUP LLP | 436.3K | $16.6M | $4.43M | Added$3.39M |
| NORTHERN TRUST CORP | 391.3K | $14.9M | $3.39M | Added$5.59M |
| Squadron Capital Management LLC | 380K | $14.5M | $2.96M | Added$6.33M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 365.1K | $13.9M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 349.8K | $13.3M | $3.46M | Added$3.81M |
| BOOTHBAY FUND MANAGEMENT, LLC | 328.7K | $12.5M | $1.76M | Added$7.69M |
| DIMENSIONAL FUND ADVISORS LP | 315.4K | $12M | $3.19M | Added$2.85M |
| Invesco Ltd. | 305.1K | $11.6M | $3.1M | Cut−$3.89M |
| BANK OF AMERICA CORP /DE/ | 300.4K | $11.4M | $2M | Added$5.95M |
| Renaissance Technologies | 294.3K | $11.2M | $2.99M | Added$1.16M |
| BOONE CAPITAL MANAGEMENT LLC | 281.3K | $10.7M | $2.86M | Cut−$3.36M |
| VANGUARD FIDUCIARY TRUST CO | 258.1K | $9.84M | — | Held |
| D. E. Shaw & Co., Inc. | 230K | $8.77M | $2.34M | Cut−$199.4K |
| FEDERATED HERMES, INC. | 210.2K | $8.01M | $2.14M | Added$1.18M |
| DIADEMA PARTNERS LP | 193K | $7.36M | — | New |
| Atom Investors LP | 190.8K | $7.27M | $1.94M | Added$1.47M |
| Fidelity | 183.9K | $7.01M | $1.87M | Added$1.44M |
| TD Asset Management Inc | 162.3K | $6.19M | $1.36M | Added$2.44M |
| UBS Group AG | 153.2K | $5.84M | $1.56M | Added$1.13M |
| Bruce & Co., Inc. | 145K | $5.53M | $1.47M | Added$914K |
| Trexquant Investment LP | 123.4K | $4.7M | $1.25M | Cut−$622.4K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 120.6K | $4.6M | $930.5K | Added$2.04M |
| SPHERA FUNDS MANAGEMENT LTD. | 114.8K | $4.38M | $1.17M | Cut−$531K |
| PFM Health Sciences, LP | 114.7K | $4.37M | — | New |
| Bank of New York Mellon Corp | 111.3K | $4.24M | $1.04M | Added$1.37M |
| Resolute Capital Asset Partners LLC | 100K | $3.81M | — | New |
| TWO SIGMA INVESTMENTS, LP | 99.5K | $3.79M | $525K | Added$2.35M |
| Nuveen, LLC | 95.3K | $3.63M | $742.1K | Added$1.59M |
| Informed Momentum Co LLC | 88.4K | $3.37M | — | New |
| Icahn Capital | 85.8K | $3.27M | $586.2K | Added$1.66M |
| RIA Advisory Group LLC | 84.7K | $3.23M | $860.3K | Added$55K |
| PRUDENTIAL FINANCIAL INC | 80.2K | $3.06M | $795.7K | Added$868K |
| WELLS FARGO & COMPANY/MN | 77.1K | $2.94M | $783.7K | Added$364.1K |
| Rafferty Asset Management, LLC | 71.5K | $2.73M | $604.7K | Added$1.06M |
| Harvest Investment Services, LLC | 71.3K | $2.72M | $629.7K | Added$986.8K |
| Squarepoint Ops LLC | 71.1K | $2.71M | — | New |
| JPMORGAN CHASE & CO | 79.7K | $2.68M | $102.1K | Added$2.18M |
| NEW YORK STATE COMMON RETIREMENT FUND | 69.9K | $2.66M | $683.4K | Added$782.5K |
| National Philanthropic Trust | 66.4K | $2.53M | $674.6K | Added$674.6K |
| Jefferies Financial Group Inc. | 66.3K | $2.53M | $133.4K | Added$2.16M |
| AMERIPRISE FINANCIAL INC | 65.5K | $2.5M | $202.1K | Added$1.94M |
| Maven Securities LTD | 59K | $2.25M | — | New |
| Swiss National Bank | 57.4K | $2.19M | — | New |
| Jain Global LLC | 52.6K | $2M | $534.1K | Cut−$5.96M |
| Persistent Asset Partners Ltd | 51.3K | $1.96M | — | New |
| STATE OF WISCONSIN INVESTMENT BOARD | 49.3K | $1.88M | $373.6K | Added$849.5K |
| FRED ALGER MANAGEMENT, LLC | 48.4K | $1.84M | — | New |
| RHUMBLINE ADVISERS | 48K | $1.83M | $439.4K | Added$619.1K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 43.8K | $1.67M | $1.96K | Added$1.66M |
| HighVista Strategies LLC | 43.6K | $1.66M | — | New |
| POLEN CAPITAL MANAGEMENT LLC | 41.4K | $1.58M | $420K | Added$420.5K |
| DEUTSCHE BANK AG\ | 41.3K | $1.57M | $358.8K | Added$585.5K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 40.9K | $1.56M | $415.9K | Cut−$2M |
| VICTORY CAPITAL MANAGEMENT INC | 37.6K | $1.43M | $382.4K | Added$203.2K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34.2K | $1.3M | $347.7K | Added$278K |
| PROFUND ADVISORS LLC | 31.8K | $1.21M | $224.5K | Added$596.2K |
| Vanguard Global Advisers, LLC | 30.6K | $1.17M | — | Held |
| PANAGORA ASSET MANAGEMENT INC | 29.7K | $1.13M | $301.9K | Cut−$3.92M |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29.4K | $1.12M | $20.5K | Added$1.06M |
| FRANKLIN RESOURCES INC | 29.3K | $1.12M | $198.4K | Added$572.7K |
| BNP PARIBAS FINANCIAL MARKETS | 29.1K | $1.11M | $85.4K | Added$875.2K |
| ALLIANCEBERNSTEIN L.P. | 38.5K | $1.08M | −$0 | Added$92.3K |
| Aries Wealth Management | 25K | $953K | $254K | Added$254K |
| Walleye Capital LLC | 23.6K | $898.6K | — | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22.8K | $847.8K | $171.2K | Added$325.9K |
| Schonfeld Strategic Advisors LLC | 22.2K | $844.4K | — | New |
| Headlands Technologies LLC | 20.6K | $785K | $165.4K | Added$329.9K |
| MetLife Investment Management, LLC | 20.4K | $776.2K | $197.4K | Added$233.1K |
| Legal & General Group Plc | 20.2K | $769K | $29.6K | Added$687.4K |
| SIMPLEX TRADING, LLC | 19.8K | $753.1K | $62.3K | Added$581.6K |
| VANGUARD ASSET MANAGEMENT, Ltd | 19.2K | $730.9K | — | Held |
| Russell Investments Group, Ltd. | 18.6K | $710.2K | $189.3K | Cut−$176.7K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18.2K | $693.8K | $184.9K | Cut−$514.1K |
| XTX Topco Ltd | 18K | $685.3K | — | New |
| Optimize Financial Inc | 17.8K | $679.6K | — | New |
| Artia Global Partners LP | 17K | $648.8K | $172.9K | Added$172.9K |
| Palumbo Wealth Management LLC | 15.3K | $583.4K | — | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15.1K | $575.7K | $98.8K | Added$303.9K |
| Vanguard Personalized Indexing Management, LLC | 15K | $571.3K | $150.5K | Added$157.2K |
| Cerity Partners LLC | 14.9K | $566.8K | $151.1K | Added$107K |
| Continuum Advisory, LLC | 14.9K | $566.2K | $150.9K | Added$150.9K |
| MILLENNIUM MANAGEMENT LLC | 14.3K | $543.9K | $145K | Cut−$1.15M |
| Campbell & CO Investment Adviser LLC | 13.2K | $503.9K | $134.3K | Cut−$708.7K |
| Engineers Gate Manager LP | 12K | $458.1K | — | New |
| LPL Financial LLC | 12K | $456.1K | $121.6K | Cut−$58.4K |
| Virtus Investment Advisers, LLC | 11.5K | $436.5K | $113.5K | Added$124.1K |
| Quantinno Capital Management LP | 11.4K | $434.4K | $85.7K | Added$198.5K |
| BARCLAYS PLC | 11.3K | $430.9K | $114.9K | Cut−$3.05M |
| INTECH INVESTMENT MANAGEMENT LLC | 11K | $418.3K | $111.5K | Added$28.5K |
| Police & Firemen's Retirement System of New Jersey | 10.9K | $413.6K | $92.4K | Added$159.3K |
| China Universal Asset Management Co., Ltd. | 10.8K | $413K | $87.8K | Added$171.3K |
| CITIGROUP INC | 10.7K | $407.4K | $108.6K | Cut−$57.3K |
| VOYA INVESTMENT MANAGEMENT LLC | 10.7K | $406.4K | — | New |
| AMERICAN CENTURY COMPANIES INC | 10.4K | $394.8K | $86.9K | Added$155.6K |
| SEI INVESTMENTS CO | 10.3K | $392.1K | $104.5K | Cut−$185.6K |
| Y-Intercept (Hong Kong) Ltd | 10K | $381.4K | $101.7K | Cut−$680.1K |
| PSP Research LLC | 10K | $381.2K | $101.6K | Cut−$161.7K |
| State of New Jersey Common Pension Fund D | 9.93K | $378.5K | — | New |
| TUDOR INVESTMENT CORP ET AL | 9.65K | $367.9K | — | New |
| Verdad Advisers, LP | 9.12K | $347.5K | — | New |
| Brooklyn Investment Group | 9.09K | $346.5K | $84.6K | Added$40.3K |
| E Fund Management Co., Ltd. | 8.99K | $342.7K | — | Held |
| Creative Planning | 8.41K | $320.8K | $85.5K | Added$19.2K |
| ALLSTATE CORP | 8.41K | $320.6K | — | New |
| ProShare Advisors LLC | 8.22K | $313.2K | $83.5K | Added$80.3K |
| Vanguard Investments Australia, Ltd. | 8.2K | $312.6K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 7.98K | $304.2K | — | New |
| Quadrature Capital Ltd | 7.87K | $299.9K | — | New |
| J. Goldman & Co LP | 7.61K | $290.1K | $77.3K | Cut−$519.3K |
| Brevan Howard Capital Management LP | 6.91K | $263.4K | $70.2K | Cut−$217.7K |
| KLP KAPITALFORVALTNING AS | 6.4K | $244K | — | New |
| Cetera Investment Advisers | 5.98K | $227.8K | — | New |
| MANGROVE PARTNERS IM, LLC | 5.55K | $211.5K | — | New |
| Tower Research Capital LLC (TRC) | 5.5K | $209.6K | $4.42K | Added$197.4K |
| CWM, LLC | 3.45K | $131.5K | $119.4K | Added$131.4K |
| Mirae Asset Global Investments Co., Ltd. | 3.18K | $121.4K | $26.2K | Added$49.3K |
| STRS OHIO | 3.1K | $118.2K | $31.5K | Added$31.5K |
| Ameritas Investment Partners, Inc. | 3.1K | $118.1K | $26.1K | Added$46.3K |
| NISA INVESTMENT ADVISORS, LLC | 3.07K | $117.1K | $5.78K | Added$101.2K |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 2.86K | $109.1K | $29.1K | Cut−$121.2K |
| ROYAL BANK OF CANADA | 2.13K | $81K | $21.2K | Cut−$164K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.04M | $77.7K | $11.9K | Added$45K |
| EverSource Wealth Advisors, LLC | 1.93K | $73.5K | $10.1K | Added$45.8K |
| Sterling Capital Management LLC | 1.25K | $47.8K | $12.7K | Cut−$5.01K |
| PNC Financial Services Group, Inc. | 1.24K | $47.1K | $12.5K | Added$12.8K |
| OSAIC HOLDINGS, INC. | 1.2K | $45.7K | $12.2K | Cut−$2.29M |
| GF FUND MANAGEMENT CO. LTD. | 1.19K | $45.4K | $10.6K | Added$16.3K |
| Activest Wealth Management | 1K | $38.2K | $10.2K | Added$10.2K |
| Farther Finance Advisors, LLC | 758 | $32.5K | $11.3K | Added$659 |
| T. Rowe Price Investment Management, Inc. | 836.9K | $31.9K | $4.16K | Added$20.5K |
| GAMMA Investing LLC | 836 | $31.9K | $7.19K | Added$12.1K |
| Larson Financial Group LLC | 712 | $27.1K | — | New |
| V-Square Quantitative Management LLC | 692 | $26.4K | — | New |
| Westfuller Advisors, LLC | 692 | $26.4K | — | New |
| Spire Wealth Management | 633 | $24.1K | $6.43K | Added$6.43K |
| Physician Wealth Advisors, Inc. | 599 | $22.8K | $6.09K | Added$6.08K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 539 | $20.5K | — | New |
| POM Investment Strategies, LLC | 500 | $19.1K | $5.08K | Added$5.08K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 496 | $18.9K | — | New |
| MEEDER ASSET MANAGEMENT INC | 481 | $18.3K | — | New |
| Allworth Financial LP | 385 | $14.7K | $3.6K | Added$4.78K |
| Accent Capital Management, LLC | 230 | $8.77K | — | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 182 | $6.94K | $3.11K | Added$3.11K |
| ALGERT GLOBAL LLC | 147.9K | $5.64K | $95 | Added$5.38K |
| Quantbot Technologies LP | 124 | $4.73K | — | New |
| MAI Capital Management | 75 | $2.86K | $51 | Added$2.72K |
| MassMutual Private Wealth & Trust, FSB | 53 | $2.02K | — | New |
| Fortitude Family Office, LLC | 45 | $1.72K | — | New |
| Bare Financial Services, Inc | 44 | $1.68K | — | New |
| ROTHSCHILD INVESTMENT LLC | 37 | $1.41K | $143 | Added$1.02K |
| FINANCIAL CONSULATE, INC | 30 | $1.14K | $305 | Added$305 |
| US BANCORP \DE\ | 27 | $1.03K | $274 | Cut−$53K |
| Root Financial Partners, LLC | 19 | $724 | — | New |
| SG Americas Securities, LLC | 17.1K | $653 | $174 | Cut−$22 |
| Parkside Financial Bank & Trust | 15 | $572 | — | New |
| True Wealth Design, LLC | 13 | $496 | $132 | Added$132 |
| Virtu Financial LLC | 9.3K | $355 | — | New |
| IFP Advisors, Inc | 6 | $229 | $61 | Added$61 |
| Smartleaf Asset Management LLC | 6 | $225 | — | New |
| Cambridge Investment Research Advisors, Inc. | 5.62K | $214 | $57 | Cut−$54 |
| CANADA LIFE ASSURANCE Co | 4.95K | $189 | — | New |
| Essential Partners LLC | 4 | $152 | $40 | Added$40 |
| SBI Securities Co., Ltd. | 4 | $152 | — | New |
| KBC Group NV | 1.01K | $39 | — | New |
| Hughes Financial Services, LLC | 1 | $38 | — | New |
| Avion Wealth | 411 | $15 | $4 | Added$4 |
| Covestor Ltd | 5 | $0 | — | New |