| JANUS HENDERSON GROUP PLC | 32.5M | $80.9M | — | Held |
| PERCEPTIVE ADVISORS LLC | 21.8M | $53.8M | — | Held |
| BVF INC/IL | 19.5M | $48.2M | — | Held |
| MAVERICK CAPITAL LTD | 19M | $46.9M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 17.1M | $42.3M | — | Held |
| Point72 Asset Management, L.P. | 16.7M | $41.1M | — | Held |
| Driehaus Capital Management LLC | 13.1M | $32.3M | — | Held |
| Vanguard | 10.7M | $26.4M | — | Held |
| M28 Capital Management LP | 9.25M | $22.8M | — | Held |
| Saturn V Capital Management LP | 7.74M | $19.1M | — | Held |
| Soleus Capital Management, L.P. | 7.71M | $19M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 5.81M | $14.3M | — | Held |
| State Street | 5.64M | $13.9M | — | Held |
| Siren, L.L.C. | 4M | $9.88M | — | Held |
| ADAR1 Capital Management, LLC | 3.9M | $9.63M | — | Held |
| Balyasny Asset Management L.P. | 3.81M | $9.4M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3.66M | $9.04M | — | Held |
| BlackRock, Inc. | 3.55M | $8.76M | — | Held |
| 683 Capital Management, LLC | 2.9M | $7.16M | — | Held |
| Redmile Group, LLC | 2.68M | $6.62M | — | Held |
| Ikarian Capital, LLC | 2.66M | $6.56M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 2.19M | $5.41M | — | Held |
| GOLDMAN SACHS GROUP INC | 2.17M | $5.37M | — | Held |
| Eversept Partners, LP | 2.14M | $5.29M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 2.06M | $5.08M | — | Held |
| MORGAN STANLEY | 1.64M | $4.05M | $1.07M | Added$3.19M |
| Boxer Capital Management, LLC | 1.5M | $3.71M | — | New |
| MILLENNIUM MANAGEMENT LLC | 1.29M | $3.18M | — | Held |
| UBS Group AG | 1.05M | $2.6M | — | Held |
| Renaissance Technologies | 1.03M | $2.54M | — | Held |
| STEMPOINT CAPITAL LP | 989.8K | $2.44M | — | Held |
| AMERIPRISE FINANCIAL INC | 985.2K | $2.43M | — | Held |
| TWO SIGMA ADVISERS, LP | 916.6K | $2.26M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 774.6K | $1.91M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 625.8K | $1.55M | — | Held |
| DEUTSCHE BANK AG\ | 585.4K | $1.45M | — | Held |
| JANE STREET GROUP, LLC | 513.9K | $1.27M | — | Held |
| EMERALD MUTUAL FUND ADVISERS TRUST | 428.8K | $1.06M | — | Held |
| NORTHERN TRUST CORP | 392.4K | $969.3K | — | Held |
| BANK OF AMERICA CORP /DE/ | 380.6K | $940.1K | $67.5K | Added$885.9K |
| Citadel | 331.1K | $817.8K | — | Held |
| BARCLAYS PLC | 295.1K | $728.9K | $404.3K | Added$252.1K |
| Invesco Ltd. | 293.6K | $725.1K | — | Held |
| Rafferty Asset Management, LLC | 284.6K | $702.9K | — | Held |
| Qube Research & Technologies Ltd | 210.6K | $520.3K | — | Held |
| Scientech Research LLC | 209.3K | $517K | — | Held |
| Squarepoint Ops LLC | 204.6K | $505.3K | — | Held |
| XTX Topco Ltd | 147.6K | $364.7K | — | Held |
| Fidelity | 141.9K | $350.6K | — | Held |
| CITIGROUP INC | 138K | $340.8K | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117.9K | $291.3K | — | Held |
| Virtus Investment Advisers, LLC | 114.7K | $283.2K | — | Held |
| PROFUND ADVISORS LLC | 102.6K | $253.4K | — | Held |
| Knott David M Jr | 100K | $247K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 99.2K | $245K | — | Held |
| OMERS ADMINISTRATION Corp | 98.1K | $242.3K | — | Held |
| UNITED CAPITAL FINANCIAL ADVISORS, LLC | 96.5K | $238.4K | — | Held |
| Quadrature Capital Ltd | 91.2K | $225.4K | — | Held |
| EMERALD ADVISERS, LLC | 89.9K | $222.1K | — | Held |
| Jefferies Financial Group Inc. | 87.7K | $216.6K | — | Held |
| Hudson Bay Capital Management LP | 87K | $215K | — | New |
| a16z Perennial Management, L.P. | 79.9K | $197.3K | — | Held |
| Persistent Asset Partners Ltd | 68.8K | $170K | — | New |
| Lighthouse Investment Partners, LLC | 63K | $155.6K | — | Held |
| Miller Financial Services LLC | 51K | $126K | — | Held |
| GILDER GAGNON HOWE & CO LLC | 49.9K | $123.3K | — | Held |
| Jain Global LLC | 49.3K | $121.7K | — | Held |
| China Universal Asset Management Co., Ltd. | 45.2K | $111.5K | — | Held |
| MANGROVE PARTNERS IM, LLC | 42.1K | $104.1K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 39.9K | $98.6K | — | Held |
| Tower Research Capital LLC (TRC) | 39.8K | $98.3K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 38.8K | $95.8K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 26K | $64.2K | — | Held |
| FORTRESS PRIVATE LEDGER, LLC | 25K | $61.8K | — | Held |
| OXFORD FINANCIAL GROUP, LTD. LLC | 23.1K | $57K | — | Held |
| JPMORGAN CHASE & CO | 22.2K | $54.7K | — | Held |
| LAZARD ASSET MANAGEMENT LLC | 20.9K | $51.7K | — | Held |
| Bank of New York Mellon Corp | 17.6K | $43.5K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 16.8K | $41.5K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16.6K | $40.3K | — | Held |
| CIBC Asset Management Inc | 15.2K | $37.5K | — | Held |
| Schonfeld Strategic Advisors LLC | 14.5K | $35.7K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 13.5K | $33.3K | — | Held |
| Gotham Asset Management, LLC | 13.1K | $32.5K | — | Held |
| State of Wyoming | 12.3K | $30.4K | — | Held |
| ProShare Advisors LLC | 12.2K | $30.2K | — | Held |
| Ethic Inc. | 11.7K | $28.9K | — | Held |
| DGS Capital Management, LLC | 11.3K | $27.9K | $15.5K | Added$15.5K |
| DRW Securities, LLC | 11.1K | $27.5K | — | Held |
| Bronte Capital Management Pty Ltd. | 11K | $27.2K | — | Held |
| COURIER CAPITAL LLC | 10K | $24.7K | — | Held |
| NAPLES GLOBAL ADVISORS, LLC | 10K | $24.7K | — | Held |
| Sunbelt Securities, Inc. | 7.5K | $18.5K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 5.45K | $13.5K | — | Held |
| Global Retirement Partners, LLC | 2K | $4.94K | — | Held |
| SBI Securities Co., Ltd. | 1.07K | $2.64K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 950 | $2.35K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 889 | $2.2K | — | Held |
| EverSource Wealth Advisors, LLC | 514 | $1.27K | — | Held |
| PNC Financial Services Group, Inc. | 502 | $1.24K | — | Held |
| Rockefeller Capital Management L.P. | 500 | $1.24K | — | Held |
| Parallel Advisors, LLC | 496 | $1.23K | — | Held |
| ROYAL BANK OF CANADA | 246 | $1K | — | Held |
| GSA CAPITAL PARTNERS LLP | 376.6K | $930 | — | Held |
| WELLS FARGO & COMPANY/MN | 250 | $618 | — | Held |
| Virtu Financial LLC | 202.3K | $500 | — | Held |
| Rialto Wealth Management, LLC | 178 | $440 | — | Held |
| Optiver Holding B.V. | 96 | $237 | — | Held |
| SG Americas Securities, LLC | 24.1K | $60 | — | Held |
| OSAIC HOLDINGS, INC. | 19 | $45 | — | Held |
| Rachor Investment Advisory Services, LLC | 16 | $40 | — | Held |
| Cygnus Capital Advisors, LLC | 5.01K | $12 | — | Held |
| Arax Advisory Partners | 2 | $5 | — | Held |
| Farther Finance Advisors, LLC | 1 | $2 | — | Held |
| Daiwa Securities Group Inc. | 923 | $2 | — | Held |
| CWM, LLC | 645 | $2 | — | Held |