13F

Stock

Ionis Pharmaceuticals Inc

IONS · held by 587 managers

Reported value

$14.2B

Holders

587

+10 new · −1 exited

Holders’ est. mark

$81.5M

Price effect on 8 books still in the name

Largest holder

$1.92B

Fidelity

Notable conviction

Share of each notable manager’s 13F book.

Holder count by quarter

Who holds it

Notable only
InvestorSharesValueEst. markChange
Fidelity35.8M$1.92BHeld
Capital World Investors18M$1.42BHeld
Vanguard16.4M$1.3BHeld
BlackRock, Inc.36M$880.8MHeld
Amundi3.66M$544.7MHeld
WELLINGTON MANAGEMENT GROUP LLP24.8M$524.7MHeld
Bellevue Group AG4.8M$379.9MHeld
State Street29.5M$352MHeld
TWO SIGMA INVESTMENTS, LP52.9M$285.8MHeld
DEERFIELD MANAGEMENT COMPANY, L.P.62M$251.9MHeld
GEODE CAPITAL MANAGEMENT, LLC3.15M$249.2MHeld
TWO SIGMA ADVISERS, LP3.05M$241.5MHeld
Tweedy, Browne Co LLC2.46M$195MHeld
JPMORGAN CHASE & CO3.42M$184.1MHeld
Citadel2.13M$168.9MHeld
VOYA INVESTMENT MANAGEMENT LLC96M$158.5MHeld
BAKER BROS. ADVISORS LP1.79M$141.8MHeld
Deep Track Capital, LP1.7M$134.5MHeld
AMERICAN CENTURY COMPANIES INC1.62M$127.9MHeld
CHARLES SCHWAB INVESTMENT MANAGEMENT INC1.54M$122MHeld
CAPSTONE INVESTMENT ADVISORS, LLC84.9M$116.7MHeld
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC1.46M$115.7MHeld
Pictet Asset Management Holding SA1.42M$112.5MHeld
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC1.39M$109.8MHeld
Polar Capital Holdings Plc1.33M$105.5MHeld
FRANKLIN RESOURCES INC1.32M$104.5MHeld
Invesco Ltd.2.77M$102.8MHeld
ROYAL BANK OF CANADA7.81M$99.1MHeld
Balyasny Asset Management L.P.57.6M$95.1MHeld
Artisan Partners Limited Partnership1.18M$93.5MHeld
Connor, Clark & Lunn Investment Management Ltd.1.08M$85.2MHeld
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP1.06M$84.1MHeld
BANK OF AMERICA CORP /DE/15.2M$83.3M−$41.9MAdded$24.3M
UBS Group AG1.05M$82.7MHeld
MORGAN STANLEY1.19M$80.9M$72.8MCut−$13.9M
CAMDEN ASSET MANAGEMENT L P /CA48.1M$76.3MHeld
GOLDMAN SACHS GROUP INC2.86M$70.9MHeld
DeepCurrents Investment Group LLC50.4M$69.5MHeld
BARCLAYS PLC2.45M$69.2M−$21.1MAdded$22.2M
NOMURA HOLDINGS INC871K$68.9MHeld
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.864.9K$68.4MHeld
NORTHERN TRUST CORP846.7K$67MHeld
CSS LLC/IL48.2M$67MHeld
MASSACHUSETTS FINANCIAL SERVICES CO /MA/812.7K$64.3MHeld
MILLENNIUM MANAGEMENT LLC37.3M$61.8MHeld
D. E. Shaw & Co., Inc.25.8M$61.4MHeld
TD Asset Management Inc773.2K$61.2MHeld
GROUPAMA ASSET MANAGMENT766.9K$60.7M$33.6MAdded$23.2M
Candriam S.C.A.677.6K$53.6MHeld
Nuveen, LLC660.8K$52.3MHeld
Ovata Capital Management Ltd37.7M$51.9MHeld
TENOR CAPITAL MANAGEMENT Co., L.P.35M$50.5MHeld
AMERIPRISE FINANCIAL INC598.7K$47.4MHeld
VOLORIDGE INVESTMENT MANAGEMENT, LLC585K$46.3MHeld
EVENTIDE ASSET MANAGEMENT, LLC575K$45.5MHeld
LMR Partners LLP27.3M$44.5MHeld
Tri Locum Partners LP557.2K$44.1MHeld
Bank of New York Mellon Corp753.9K$42.8MHeld
Eversept Partners, LP538.2K$42.6MHeld
DLD Asset Management, LP26.5M$42.3MHeld
FIRST TRUST ADVISORS LP525.2K$41.6MHeld
Alyeska Investment Group, L.P.481.7K$38.1MHeld
Shaolin Capital Management LLC27.5M$37.7MHeld
Hudson Bay Capital Management LP475K$37.6M$6.5MAdded$3.89M
PINNACLE ASSOCIATES LTD462K$36.5MHeld
Squarepoint Ops LLC436.3K$34.5MHeld
ARK Investment Management LLC423K$33.5MHeld
TEACHER RETIREMENT SYSTEM OF TEXAS422.9K$33.5MHeld
Linden Advisors LP21M$33.2MHeld
BOONE CAPITAL MANAGEMENT LLC417.8K$33.1MHeld
Jain Global LLC356.3K$28.2MHeld
ALLIANCEBERNSTEIN L.P.341.8K$27MHeld
BNP PARIBAS FINANCIAL MARKETS365.6K$26.5MHeld
Legal & General Group Plc325.1K$25.7MHeld
Universal- Beteiligungs- und Servicegesellschaft mbH5.37M$25.6MHeld
WELLS FARGO & COMPANY/MN2.46M$25.5MHeld
NORGES BANK320.2K$25.3M$15.7MCut−$564.9K
Calamos Advisors LLC13.3M$23.7MHeld
Swiss National Bank298.5K$23.6MHeld
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main7.67M$23.6M$15.8MAdded$15.2M
Focus Partners Wealth5.62M$22.9MHeld
CITIGROUP INC10.6M$22.6MHeld
Zurich Insurance Group Ltd/FI261.8K$20.7MHeld
MACKAY SHIELDS LLC13.2M$20.4MHeld
RAYMOND JAMES FINANCIAL INC257.2K$20.3MHeld
MARSHALL WACE, LLP256.9K$20.3MHeld
Boussard & Gavaudan Investment Management LLP12.8K$20.2MHeld
NEW YORK STATE COMMON RETIREMENT FUND241.9K$19.1MHeld
Privium Fund Management B.V.240.8K$19.1MHeld
Davern Capital Partners, LP238.5K$18.9MHeld
Orion Investment Co225.2K$17.8MHeld
Renaissance Technologies223.6K$17.7MHeld
DAVENPORT & Co LLC217.9K$17.2MHeld
Corient Private Wealth LLC216.4K$17.1MHeld
California Public Employees Retirement System213.4K$16.9MHeld
TOCQUEVILLE ASSET MANAGEMENT L.P.203.7K$16.1MHeld
Ikarian Capital, LLC202K$16MHeld
ARISTEIA CAPITAL, L.L.C.10M$15.9MHeld
STIFEL FINANCIAL CORP198.9K$15.7MHeld
SECTOR GAMMA AS185K$14.6MHeld
DIMENSIONAL FUND ADVISORS LP176K$13.9MHeld
RHUMBLINE ADVISERS175.4K$13.9MHeld
Man Group plc482K$13.6MHeld
Sicart Associates LLC163.6K$12.9MHeld
Rhenman & Partners Asset Management AB158.5K$12.5MHeld
Jefferies Financial Group Inc.5.39M$12.5MHeld
STATE OF WISCONSIN INVESTMENT BOARD3.09M$12.3MHeld
CenterBook Partners LP153.9K$12.2MHeld
MANUFACTURERS LIFE INSURANCE COMPANY, THE153.2K$12.1MHeld
DEUTSCHE BANK AG\149.4K$11.8MHeld
GREAT LAKES ADVISORS, LLC149.2K$11.8MHeld
ADAR1 Capital Management, LLC147.1K$11.6MHeld
Artia Global Partners LP144.4K$11.4MHeld
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM144.2K$11.4MHeld
Fisher Asset Management, LLC141.6K$11.2MHeld
M&G PLC6.34M$11.1MHeld
ADAGE CAPITAL PARTNERS GP, L.L.C.140K$11.1MHeld
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM135.9K$10.7MHeld
Aquatic Capital Management LLC132.8K$10.5MHeld
Trexquant Investment LP132.2K$10.5MHeld
EDMOND DE ROTHSCHILD HOLDING S.A.122.2K$9.67MHeld
FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A.121.6K$9.62MHeld
SEI INVESTMENTS CO220.9K$9.34MHeld
Exome Asset Management LLC116.5K$9.22MHeld
Skandinaviska Enskilda Banken AB (publ)115.3K$9.12MHeld
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND110K$8.7MHeld
KENNEDY CAPITAL MANAGEMENT LLC109.3K$8.65MHeld
NEUBERGER BERMAN GROUP LLC108K$8.55MHeld
DCF Advisers, LLC103K$8.15MHeld
ADVENT CAPITAL MANAGEMENT /DE/5.06M$8.05MHeld
SIMPLEX TRADING, LLC96.6K$7.65MHeld
Susquehanna Portfolio Strategies, LLC96K$7.59MHeld
Sumitomo Mitsui Trust Group, Inc.93.8K$7.42MHeld
Amova Asset Management Americas, Inc.93.6K$7.4MHeld
Atle Fund Management AB92.4K$7.31MHeld
ENVESTNET ASSET MANAGEMENT INC89.9K$7.11MHeld
NICOLA WEALTH MANAGEMENT LTD.87K$6.88MHeld
ExodusPoint Capital Management, LP83.9K$6.64MHeld
VICTORY CAPITAL MANAGEMENT INC80.7K$6.39MHeld
BOOTHBAY FUND MANAGEMENT, LLC75.6K$5.98MHeld
EFG International AG75.3K$5.96MHeld
Rafferty Asset Management, LLC74K$5.85MHeld
Erste Asset Management GmbH71.8K$5.74MHeld
Hillsdale Investment Management Inc.70.9K$5.61MHeld
Warberg Asset Management LLC4M$5.49MHeld
JANUS HENDERSON GROUP PLC68.2K$5.4MHeld
WOLVERINE ASSET MANAGEMENT LLC1.9M$5.39MHeld
Bridgewater67.7K$5.36MHeld
J. Goldman & Co LP67.6K$5.35MHeld
Police & Firemen's Retirement System of New Jersey66.8K$5.29MHeld
BANK OF MONTREAL /CAN/1.3M$4.89MHeld
BLB&B Advisors, LLC61.5K$4.87MHeld
State of New Jersey Common Pension Fund D54.8K$4.33MHeld
Creative Planning54.8K$4.33MHeld
PDT Partners, LLC54.4K$4.3MHeld
Informed Momentum Co LLC53.9K$4.27MHeld
Ensign Peak Advisors, Inc53.7K$4.25MHeld
Alpine Global Management, LLC53.6K$4.24MHeld
LAZARD ASSET MANAGEMENT LLC25M$4.07MHeld
CAPITAL COUNSEL LLC/NY49.6K$3.92MHeld
Zurcher Kantonalbank (Zurich Cantonalbank)48.9K$3.87MHeld
Mariner, LLC47.7K$3.78MHeld
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO47.6K$3.77MHeld
Atika Capital Management LLC47.5K$3.76MHeld
Quantinno Capital Management LP47.4K$3.75MHeld
SSI INVESTMENT MANAGEMENT LLC2.34M$3.72MHeld
One Capital Management, LLC46.1K$3.65MHeld
Future Fund LLC45.9K$3.63MHeld
Russell Investments Group, Ltd.43.9K$3.47MHeld
Gotham Asset Management, LLC43.2K$3.42MHeld
ARIZONA STATE RETIREMENT SYSTEM42.4K$3.36MHeld
China Universal Asset Management Co., Ltd.42.4K$3.35MHeld
FRED ALGER MANAGEMENT, LLC38.4K$3.04MHeld
WEST MICHIGAN ADVISORS, LLC38.4K$3.04MHeld
GRANDFIELD & DODD, LLC37.8K$2.99MHeld
GUGGENHEIM CAPITAL LLC37.7K$2.98MHeld
Stanley-Laman Group, Ltd.36.5K$2.89MHeld
Ares Systematic Credit Ltd1.31M$2.86MHeld
BAMCO INC /NY/36K$2.85MHeld
Raiffeisen Bank International AG35K$2.76MHeld
Pathstone Holdings, LLC34.3K$2.71MHeld
BLAIR WILLIAM & CO/IL33.8K$2.67MHeld
KLP KAPITALFORVALTNING AS33.5K$2.65MHeld
Lisanti Capital Growth, LLC32.8K$2.59MHeld
SUSQUEHANNA INTERNATIONAL GROUP, LLP32.5K$2.57MHeld
PRELUDE CAPITAL MANAGEMENT, LLC32.5K$2.57MHeld
Twin Tree Management, LP32.5K$2.57MHeld
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC31.5K$2.49MHeld
LPL Financial LLC31.1K$2.46MHeld
PEAK6 LLC30.6K$2.42M$83.7KAdded$2.02M
JANE STREET GROUP, LLC30.5K$2.41MHeld
Assenagon Asset Management S.A.29.3K$2.32MHeld
KORNITZER CAPITAL MANAGEMENT INC /KS29.1K$2.3MHeld
Aberdeen Group plc28.9K$2.29MHeld
Qsemble Capital Management, LP27.6K$2.18MHeld
Swedbank AB27.3K$2.16MHeld
HSBC HOLDINGS PLC26.9K$2.14MHeld
PROFUND ADVISORS LLC26.7K$2.11MHeld
WESTWOOD HOLDINGS GROUP INC2M$2MHeld
Arrowpoint Investment Partners (Singapore) Pte. Ltd.25K$1.98MHeld
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.24.2K$1.91MHeld
PRUDENTIAL FINANCIAL INC24K$1.9MHeld
Cerity Partners LLC23.9K$1.89MHeld
Orion Porfolio Solutions, LLC23.6K$1.86MHeld
XPONANCE LLC22.9K$1.81MHeld
Union Bancaire Privee, UBP SA1.32M$1.8MHeld
Verition Fund Management LLC22.7K$1.79MHeld
Engineers Gate Manager LP22.2K$1.76MHeld
EXCHANGE TRADED CONCEPTS, LLC21.1K$1.67MHeld
GILDER GAGNON HOWE & CO LLC19.3K$1.52MHeld
Icahn Capital18.8K$1.48MHeld
AlphaCentric Advisors LLC18.5K$1.47MHeld
Quantedge Capital Pte Ltd18.5K$1.46MHeld
Elo Mutual Pension Insurance Co18.4K$1.46MHeld
Dana Investment Advisors, Inc.18K$1.43MHeld
Tidal Investments LLC17.9K$1.42MHeld
INCEPTIONR LLC17.9K$1.41MHeld
WORLDQUANT MILLENNIUM ADVISORS LLC17.4K$1.38MHeld
J. Safra Sarasin Holding AG17.4K$1.38MHeld
XTX Topco Ltd16.9K$1.34MHeld
Allianz Asset Management GmbH16.7K$1.32MHeld
NORTH STAR ASSET MANAGEMENT INC16.6K$1.31MHeld
Kohlberg Kravis Roberts & Co. L.P.760K$1.21MHeld
IQ EQ FUND MANAGEMENT (IRELAND) Ltd15.2K$1.2MHeld
AGF MANAGEMENT LTD750K$1.19MHeld
BROWN ADVISORY INC15K$1.18MHeld
DNB Asset Management AS14.8K$1.17MHeld
TRUIST FINANCIAL CORP85.7K$1.12MHeld
Dynasty Wealth Management, LLC14K$1.11MHeld
Bleakley Financial Group, LLC13.9K$1.1MHeld
PNC Financial Services Group, Inc.13.8K$1.09MHeld
Cinctive Capital Management LP13.7K$1.09MHeld
Friedenthal Financial13.1K$1.04MHeld
Lighthouse Investment Partners, LLC13.1K$1.03MHeld
Westmount Partners, LLC13K$1.03MHeld
OPPENHEIMER ASSET MANAGEMENT INC.106.3K$1.02MHeld
Annis Gardner Whiting Capital Advisors, LLC12.8K$1.01MHeld
SBI Okasan Asset Management Co.Ltd.12.6K$1.01MHeld
DARK FOREST CAPITAL MANAGEMENT LP12.7K$1MHeld
Federation des caisses Desjardins du Quebec12.6K$993.1KHeld
Vanguard Personalized Indexing Management, LLC12.5K$985.8KHeld
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO12K$949.2KHeld
HORIZON KINETICS ASSET MANAGEMENT LLC12K$945.5KHeld
COMMONWEALTH EQUITY SERVICES, LLC11.8K$934KHeld
OSAIC HOLDINGS, INC.11.6K$921.3KHeld
Plancorp, LLC11.2K$886.7KHeld
Baader Bank Aktiengesellschaft11.1K$865.8KHeld
Cetera Investment Advisers10.9K$858.8KHeld
SUVRETTA CAPITAL MANAGEMENT, LLC10.8K$854.4KHeld
VIRGINIA RETIREMENT SYSTEMS ET Al10.6K$838.6KHeld

Who left

Positions as of Q4 2025. 13F filings arrive up to 45 days after quarter-end and omit shorts. Values are quarter-end marks, as filed. Estimated mark is the price effect on shares still held — not realized P&L or investment advice.