13F

Stock

Ionis Pharmaceuticals Inc

IONS · held by 587 managers

Reported value

$14.2B

Holders

587

+10 new · −1 exited

Holders’ est. mark

$81.5M

Price effect on 8 books still in the name

Largest holder

$1.92B

Fidelity

Notable conviction

Share of each notable manager’s 13F book.

Holder count by quarter

Who holds it

Notable only
InvestorSharesValueEst. markChange
Fidelity35.8M$1.92B—Held
Capital World Investors18M$1.42B—Held
Vanguard16.4M$1.3B—Held
BlackRock, Inc.36M$880.8M—Held
Amundi3.66M$544.7M—Held
WELLINGTON MANAGEMENT GROUP LLP24.8M$524.7M—Held
Bellevue Group AG4.8M$379.9M—Held
State Street29.5M$352M—Held
TWO SIGMA INVESTMENTS, LP52.9M$285.8M—Held
DEERFIELD MANAGEMENT COMPANY, L.P.62M$251.9M—Held
GEODE CAPITAL MANAGEMENT, LLC3.15M$249.2M—Held
TWO SIGMA ADVISERS, LP3.05M$241.5M—Held
Tweedy, Browne Co LLC2.46M$195M—Held
JPMORGAN CHASE & CO3.42M$184.1M—Held
Citadel2.13M$168.9M—Held
VOYA INVESTMENT MANAGEMENT LLC96M$158.5M—Held
BAKER BROS. ADVISORS LP1.79M$141.8M—Held
Deep Track Capital, LP1.7M$134.5M—Held
AMERICAN CENTURY COMPANIES INC1.62M$127.9M—Held
CHARLES SCHWAB INVESTMENT MANAGEMENT INC1.54M$122M—Held
CAPSTONE INVESTMENT ADVISORS, LLC84.9M$116.7M—Held
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC1.46M$115.7M—Held
Pictet Asset Management Holding SA1.42M$112.5M—Held
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC1.39M$109.8M—Held
Polar Capital Holdings Plc1.33M$105.5M—Held
FRANKLIN RESOURCES INC1.32M$104.5M—Held
Invesco Ltd.2.77M$102.8M—Held
ROYAL BANK OF CANADA7.81M$99.1M—Held
Balyasny Asset Management L.P.57.6M$95.1M—Held
Artisan Partners Limited Partnership1.18M$93.5M—Held
Connor, Clark & Lunn Investment Management Ltd.1.08M$85.2M—Held
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP1.06M$84.1M—Held
BANK OF AMERICA CORP /DE/15.2M$83.3M−$41.9MAdded$24.3M
UBS Group AG1.05M$82.7M—Held
MORGAN STANLEY1.19M$80.9M$72.8MCut−$13.9M
CAMDEN ASSET MANAGEMENT L P /CA48.1M$76.3M—Held
GOLDMAN SACHS GROUP INC2.86M$70.9M—Held
DeepCurrents Investment Group LLC50.4M$69.5M—Held
BARCLAYS PLC2.45M$69.2M−$21.1MAdded$22.2M
NOMURA HOLDINGS INC871K$68.9M—Held
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.864.9K$68.4M—Held
NORTHERN TRUST CORP846.7K$67M—Held
CSS LLC/IL48.2M$67M—Held
MASSACHUSETTS FINANCIAL SERVICES CO /MA/812.7K$64.3M—Held
MILLENNIUM MANAGEMENT LLC37.3M$61.8M—Held
D. E. Shaw & Co., Inc.25.8M$61.4M—Held
TD Asset Management Inc773.2K$61.2M—Held
GROUPAMA ASSET MANAGMENT766.9K$60.7M$33.6MAdded$23.2M
Candriam S.C.A.677.6K$53.6M—Held
Nuveen, LLC660.8K$52.3M—Held
Ovata Capital Management Ltd37.7M$51.9M—Held
TENOR CAPITAL MANAGEMENT Co., L.P.35M$50.5M—Held
AMERIPRISE FINANCIAL INC598.7K$47.4M—Held
VOLORIDGE INVESTMENT MANAGEMENT, LLC585K$46.3M—Held
EVENTIDE ASSET MANAGEMENT, LLC575K$45.5M—Held
LMR Partners LLP27.3M$44.5M—Held
Tri Locum Partners LP557.2K$44.1M—Held
Bank of New York Mellon Corp753.9K$42.8M—Held
Eversept Partners, LP538.2K$42.6M—Held
DLD Asset Management, LP26.5M$42.3M—Held
FIRST TRUST ADVISORS LP525.2K$41.6M—Held
Alyeska Investment Group, L.P.481.7K$38.1M—Held
Shaolin Capital Management LLC27.5M$37.7M—Held
Hudson Bay Capital Management LP475K$37.6M$6.5MAdded$3.89M
PINNACLE ASSOCIATES LTD462K$36.5M—Held
Squarepoint Ops LLC436.3K$34.5M—Held
ARK Investment Management LLC423K$33.5M—Held
TEACHER RETIREMENT SYSTEM OF TEXAS422.9K$33.5M—Held
Linden Advisors LP21M$33.2M—Held
BOONE CAPITAL MANAGEMENT LLC417.8K$33.1M—Held
Jain Global LLC356.3K$28.2M—Held
ALLIANCEBERNSTEIN L.P.341.8K$27M—Held
BNP PARIBAS FINANCIAL MARKETS365.6K$26.5M—Held
Legal & General Group Plc325.1K$25.7M—Held
Universal- Beteiligungs- und Servicegesellschaft mbH5.37M$25.6M—Held
WELLS FARGO & COMPANY/MN2.46M$25.5M—Held
NORGES BANK320.2K$25.3M$15.7MCut−$564.9K
Calamos Advisors LLC13.3M$23.7M—Held
Swiss National Bank298.5K$23.6M—Held
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main7.67M$23.6M$15.8MAdded$15.2M
Focus Partners Wealth5.62M$22.9M—Held
CITIGROUP INC10.6M$22.6M—Held
Zurich Insurance Group Ltd/FI261.8K$20.7M—Held
MACKAY SHIELDS LLC13.2M$20.4M—Held
RAYMOND JAMES FINANCIAL INC257.2K$20.3M—Held
MARSHALL WACE, LLP256.9K$20.3M—Held
Boussard & Gavaudan Investment Management LLP12.8K$20.2M—Held
NEW YORK STATE COMMON RETIREMENT FUND241.9K$19.1M—Held
Privium Fund Management B.V.240.8K$19.1M—Held
Davern Capital Partners, LP238.5K$18.9M—Held
Orion Investment Co225.2K$17.8M—Held
Renaissance Technologies223.6K$17.7M—Held
DAVENPORT & Co LLC217.9K$17.2M—Held
Corient Private Wealth LLC216.4K$17.1M—Held
California Public Employees Retirement System213.4K$16.9M—Held
TOCQUEVILLE ASSET MANAGEMENT L.P.203.7K$16.1M—Held
Ikarian Capital, LLC202K$16M—Held
ARISTEIA CAPITAL, L.L.C.10M$15.9M—Held
STIFEL FINANCIAL CORP198.9K$15.7M—Held
SECTOR GAMMA AS185K$14.6M—Held
DIMENSIONAL FUND ADVISORS LP176K$13.9M—Held
RHUMBLINE ADVISERS175.4K$13.9M—Held
Man Group plc482K$13.6M—Held
Sicart Associates LLC163.6K$12.9M—Held
Rhenman & Partners Asset Management AB158.5K$12.5M—Held
Jefferies Financial Group Inc.5.39M$12.5M—Held
STATE OF WISCONSIN INVESTMENT BOARD3.09M$12.3M—Held
CenterBook Partners LP153.9K$12.2M—Held
MANUFACTURERS LIFE INSURANCE COMPANY, THE153.2K$12.1M—Held
DEUTSCHE BANK AG\149.4K$11.8M—Held
GREAT LAKES ADVISORS, LLC149.2K$11.8M—Held
ADAR1 Capital Management, LLC147.1K$11.6M—Held
Artia Global Partners LP144.4K$11.4M—Held
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM144.2K$11.4M—Held
Fisher Asset Management, LLC141.6K$11.2M—Held
M&G PLC6.34M$11.1M—Held
ADAGE CAPITAL PARTNERS GP, L.L.C.140K$11.1M—Held
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM135.9K$10.7M—Held
Aquatic Capital Management LLC132.8K$10.5M—Held
Trexquant Investment LP132.2K$10.5M—Held
EDMOND DE ROTHSCHILD HOLDING S.A.122.2K$9.67M—Held
FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A.121.6K$9.62M—Held
SEI INVESTMENTS CO220.9K$9.34M—Held
Exome Asset Management LLC116.5K$9.22M—Held
Skandinaviska Enskilda Banken AB (publ)115.3K$9.12M—Held
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND110K$8.7M—Held
KENNEDY CAPITAL MANAGEMENT LLC109.3K$8.65M—Held
NEUBERGER BERMAN GROUP LLC108K$8.55M—Held
DCF Advisers, LLC103K$8.15M—Held
ADVENT CAPITAL MANAGEMENT /DE/5.06M$8.05M—Held
SIMPLEX TRADING, LLC96.6K$7.65M—Held
Susquehanna Portfolio Strategies, LLC96K$7.59M—Held
Sumitomo Mitsui Trust Group, Inc.93.8K$7.42M—Held
Amova Asset Management Americas, Inc.93.6K$7.4M—Held
Atle Fund Management AB92.4K$7.31M—Held
ENVESTNET ASSET MANAGEMENT INC89.9K$7.11M—Held
NICOLA WEALTH MANAGEMENT LTD.87K$6.88M—Held
ExodusPoint Capital Management, LP83.9K$6.64M—Held
VICTORY CAPITAL MANAGEMENT INC80.7K$6.39M—Held
BOOTHBAY FUND MANAGEMENT, LLC75.6K$5.98M—Held
EFG International AG75.3K$5.96M—Held
Rafferty Asset Management, LLC74K$5.85M—Held
Erste Asset Management GmbH71.8K$5.74M—Held
Hillsdale Investment Management Inc.70.9K$5.61M—Held
Warberg Asset Management LLC4M$5.49M—Held
JANUS HENDERSON GROUP PLC68.2K$5.4M—Held
WOLVERINE ASSET MANAGEMENT LLC1.9M$5.39M—Held
Bridgewater67.7K$5.36M—Held
J. Goldman & Co LP67.6K$5.35M—Held
Police & Firemen's Retirement System of New Jersey66.8K$5.29M—Held
BANK OF MONTREAL /CAN/1.3M$4.89M—Held
BLB&B Advisors, LLC61.5K$4.87M—Held
State of New Jersey Common Pension Fund D54.8K$4.33M—Held
Creative Planning54.8K$4.33M—Held
PDT Partners, LLC54.4K$4.3M—Held
Informed Momentum Co LLC53.9K$4.27M—Held
Ensign Peak Advisors, Inc53.7K$4.25M—Held
Alpine Global Management, LLC53.6K$4.24M—Held
LAZARD ASSET MANAGEMENT LLC25M$4.07M—Held
CAPITAL COUNSEL LLC/NY49.6K$3.92M—Held
Zurcher Kantonalbank (Zurich Cantonalbank)48.9K$3.87M—Held
Mariner, LLC47.7K$3.78M—Held
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO47.6K$3.77M—Held
Atika Capital Management LLC47.5K$3.76M—Held
Quantinno Capital Management LP47.4K$3.75M—Held
SSI INVESTMENT MANAGEMENT LLC2.34M$3.72M—Held
One Capital Management, LLC46.1K$3.65M—Held
Future Fund LLC45.9K$3.63M—Held
Russell Investments Group, Ltd.43.9K$3.47M—Held
Gotham Asset Management, LLC43.2K$3.42M—Held
ARIZONA STATE RETIREMENT SYSTEM42.4K$3.36M—Held
China Universal Asset Management Co., Ltd.42.4K$3.35M—Held
FRED ALGER MANAGEMENT, LLC38.4K$3.04M—Held
WEST MICHIGAN ADVISORS, LLC38.4K$3.04M—Held
GRANDFIELD & DODD, LLC37.8K$2.99M—Held
GUGGENHEIM CAPITAL LLC37.7K$2.98M—Held
Stanley-Laman Group, Ltd.36.5K$2.89M—Held
Ares Systematic Credit Ltd1.31M$2.86M—Held
BAMCO INC /NY/36K$2.85M—Held
Raiffeisen Bank International AG35K$2.76M—Held
Pathstone Holdings, LLC34.3K$2.71M—Held
BLAIR WILLIAM & CO/IL33.8K$2.67M—Held
KLP KAPITALFORVALTNING AS33.5K$2.65M—Held
Lisanti Capital Growth, LLC32.8K$2.59M—Held
SUSQUEHANNA INTERNATIONAL GROUP, LLP32.5K$2.57M—Held
PRELUDE CAPITAL MANAGEMENT, LLC32.5K$2.57M—Held
Twin Tree Management, LP32.5K$2.57M—Held
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC31.5K$2.49M—Held
LPL Financial LLC31.1K$2.46M—Held
PEAK6 LLC30.6K$2.42M$83.7KAdded$2.02M
JANE STREET GROUP, LLC30.5K$2.41M—Held
Assenagon Asset Management S.A.29.3K$2.32M—Held
KORNITZER CAPITAL MANAGEMENT INC /KS29.1K$2.3M—Held
Aberdeen Group plc28.9K$2.29M—Held
Qsemble Capital Management, LP27.6K$2.18M—Held
Swedbank AB27.3K$2.16M—Held
HSBC HOLDINGS PLC26.9K$2.14M—Held
PROFUND ADVISORS LLC26.7K$2.11M—Held
WESTWOOD HOLDINGS GROUP INC2M$2M—Held
Arrowpoint Investment Partners (Singapore) Pte. Ltd.25K$1.98M—Held
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.24.2K$1.91M—Held
PRUDENTIAL FINANCIAL INC24K$1.9M—Held
Cerity Partners LLC23.9K$1.89M—Held
Orion Porfolio Solutions, LLC23.6K$1.86M—Held
XPONANCE LLC22.9K$1.81M—Held
Union Bancaire Privee, UBP SA1.32M$1.8M—Held
Verition Fund Management LLC22.7K$1.79M—Held
Engineers Gate Manager LP22.2K$1.76M—Held
EXCHANGE TRADED CONCEPTS, LLC21.1K$1.67M—Held
GILDER GAGNON HOWE & CO LLC19.3K$1.52M—Held
Icahn Capital18.8K$1.48M—Held
AlphaCentric Advisors LLC18.5K$1.47M—Held
Quantedge Capital Pte Ltd18.5K$1.46M—Held
Elo Mutual Pension Insurance Co18.4K$1.46M—Held
Dana Investment Advisors, Inc.18K$1.43M—Held
Tidal Investments LLC17.9K$1.42M—Held
INCEPTIONR LLC17.9K$1.41M—Held
WORLDQUANT MILLENNIUM ADVISORS LLC17.4K$1.38M—Held
J. Safra Sarasin Holding AG17.4K$1.38M—Held
XTX Topco Ltd16.9K$1.34M—Held
Allianz Asset Management GmbH16.7K$1.32M—Held
NORTH STAR ASSET MANAGEMENT INC16.6K$1.31M—Held
Kohlberg Kravis Roberts & Co. L.P.760K$1.21M—Held
IQ EQ FUND MANAGEMENT (IRELAND) Ltd15.2K$1.2M—Held
AGF MANAGEMENT LTD750K$1.19M—Held
BROWN ADVISORY INC15K$1.18M—Held
DNB Asset Management AS14.8K$1.17M—Held
TRUIST FINANCIAL CORP85.7K$1.12M—Held
Dynasty Wealth Management, LLC14K$1.11M—Held
Bleakley Financial Group, LLC13.9K$1.1M—Held
PNC Financial Services Group, Inc.13.8K$1.09M—Held
Cinctive Capital Management LP13.7K$1.09M—Held
Friedenthal Financial13.1K$1.04M—Held
Lighthouse Investment Partners, LLC13.1K$1.03M—Held
Westmount Partners, LLC13K$1.03M—Held
OPPENHEIMER ASSET MANAGEMENT INC.106.3K$1.02M—Held
Annis Gardner Whiting Capital Advisors, LLC12.8K$1.01M—Held
SBI Okasan Asset Management Co.Ltd.12.6K$1.01M—Held
DARK FOREST CAPITAL MANAGEMENT LP12.7K$1M—Held
Federation des caisses Desjardins du Quebec12.6K$993.1K—Held
Vanguard Personalized Indexing Management, LLC12.5K$985.8K—Held
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO12K$949.2K—Held
HORIZON KINETICS ASSET MANAGEMENT LLC12K$945.5K—Held
COMMONWEALTH EQUITY SERVICES, LLC11.8K$934K—Held
OSAIC HOLDINGS, INC.11.6K$921.3K—Held
Plancorp, LLC11.2K$886.7K—Held
Baader Bank Aktiengesellschaft11.1K$865.8K—Held
Cetera Investment Advisers10.9K$858.8K—Held
SUVRETTA CAPITAL MANAGEMENT, LLC10.8K$854.4K—Held
VIRGINIA RETIREMENT SYSTEMS ET Al10.6K$838.6K—Held

Who left

Positions as of Q4 2025. 13F filings arrive up to 45 days after quarter-end and omit shorts. Values are quarter-end marks, as filed. Estimated mark is the price effect on shares still held — not realized P&L or investment advice.