| Point72 Asset Management, L.P. | 4.43M | $36.3M | — | Held |
| ORBIMED ADVISORS LLC | 3.84M | $31.4M | — | Held |
| VR ADVISER, LLC | 3.84M | $31.4M | — | Held |
| Deep Track Capital, LP | 1.85M | $15.2M | — | Held |
| Rosalind Advisors, Inc. | 1.66M | $13.6M | — | Held |
| ACORN CAPITAL ADVISORS, LLC | 1.57M | $12.9M | — | Held |
| MORGAN STANLEY | 1.3M | $10.6M | $521.3K | Added$9.29M |
| EVENTIDE ASSET MANAGEMENT, LLC | 1.26M | $10.3M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 1.03M | $8.41M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 825.6K | $6.75M | — | Held |
| Citadel | 805.4K | $6.59M | — | Held |
| DCF Advisers, LLC | 775.6K | $6.34M | — | Held |
| Spruce Street Capital LP | 770K | $6.3M | — | Held |
| Boxer Capital Management, LLC | 715K | $5.85M | — | New |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 700K | $5.73M | — | Held |
| ArrowMark Colorado Holdings LLC | 598.4K | $4.9M | — | Held |
| Squadron Capital Management LLC | 525K | $4.29M | — | Held |
| Nan Fung Group Holdings Ltd | 460K | $3.76M | — | Held |
| DAFNA Capital Management LLC | 455K | $3.72M | — | Held |
| Stonepine Capital Management, LLC | 339.9K | $2.78M | — | Held |
| PEAK6 LLC | 283.5K | $2.78M | $322.7K | Added$2.29M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 300.2K | $2.46M | — | Held |
| Knott David M Jr | 285.2K | $2.33M | — | Held |
| ADAR1 Capital Management, LLC | 238.4K | $1.95M | — | Held |
| UBS Group AG | 233.7K | $1.91M | — | Held |
| Pale Fire Capital SE | 153.5K | $1.26M | — | Held |
| Ikarian Capital, LLC | 132.2K | $1.08M | — | Held |
| JANE STREET GROUP, LLC | 99K | $810.1K | — | Held |
| AdvisorShares Investments LLC | 98.1K | $802.1K | — | Held |
| Quadrature Capital Ltd | 79.7K | $651.9K | — | Held |
| Fore Capital, LLC | 66.4K | $543.3K | — | Held |
| ROYAL BANK OF CANADA | 51.1K | $418K | — | Held |
| GOLDMAN SACHS GROUP INC | 47.9K | $392.1K | — | Held |
| Graham Capital Management, L.P. | 35.5K | $290.5K | — | Held |
| PDS Planning, Inc | 30.3K | $248.2K | — | Held |
| MYDA Advisors LLC | 30K | $245.4K | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 29.4K | $240.5K | — | Held |
| BlackRock, Inc. | 25.4K | $207.8K | — | Held |
| JPMORGAN CHASE & CO | 22.4K | $183.6K | — | Held |
| LPL Financial LLC | 18.1K | $148.3K | — | Held |
| Diametric Capital, LP | 17.8K | $145.3K | — | Held |
| PNC Financial Services Group, Inc. | 11K | $90.1K | — | Held |
| GROUP ONE TRADING LLC | 10.7K | $87.7K | — | Held |
| BANK OF AMERICA CORP /DE/ | 4.25K | $34.7K | $9.73K | Cut−$336.7K |
| NATIONAL BANK OF CANADA /FI/ | 5.41K | $32.5K | — | Held |
| Global Retirement Partners, LLC | 3.1K | $25.4K | — | Held |
| Federation des caisses Desjardins du Quebec | 3.12K | $25.3K | — | Held |
| OSAIC HOLDINGS, INC. | 2.93K | $24K | — | Held |
| IAG Wealth Partners, LLC | 2.75K | $22.5K | — | Held |
| Tower Research Capital LLC (TRC) | 2.56K | $20.9K | — | Held |
| North Star Investment Management Corp. | 2.5K | $20.4K | — | Held |
| TD Waterhouse Canada Inc. | 2.03K | $16.4K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 925 | $7.57K | — | Held |
| BARCLAYS PLC | 862 | $7.05K | $1.97K | Added$1.97K |
| Global Wealth Strategies & Associates | 526 | $4.3K | — | Held |
| HARBOUR INVESTMENTS, INC. | 250 | $2.04K | — | Held |
| Farther Finance Advisors, LLC | 247 | $2.02K | — | Held |
| IFP Advisors, Inc | 200 | $1.64K | $458 | Added$458 |
| Avalon Trust Co | 197 | $1.61K | — | Held |
| Atlantic Edge Private Wealth Management, LLC | 137 | $1.12K | — | Held |
| AMERIFLEX GROUP, INC. | 131 | $1.07K | — | Held |
| Tidemark, LLC | 131 | $1.07K | — | Held |
| Hilton Head Capital Partners, LLC | 117 | $957 | — | Held |
| FLAGSHIP HARBOR ADVISORS, LLC | 105 | $859 | — | New |
| NewEdge Advisors, LLC | 95 | $777 | — | Held |
| Root Financial Partners, LLC | 65 | $532 | — | Held |
| NVWM, LLC | 59 | $483 | — | Held |
| Westside Investment Management, Inc. | 26 | $213 | — | Held |
| CENTRAL TRUST Co | 26 | $213 | — | Held |
| City State Bank | 25 | $205 | — | Held |
| Larson Financial Group LLC | 21 | $172 | — | Held |
| Allworth Financial LP | 20 | $164 | $46 | Cut−$107 |
| Arax Advisory Partners | 13 | $106 | — | Held |
| McIlrath & Eck, LLC | 10 | $82 | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 7 | $57 | — | Held |
| CNB Bank | 4 | $33 | — | Held |
| CoreCap Advisors, LLC | 3 | $25 | — | Held |
| MCGUIRE CAPITAL ADVISORS INC | 1 | $8 | — | Held |
| TSFG, LLC | 2 | $0 | — | Held |
| FNY Investment Advisers, LLC | 100 | $0 | −$1 | Cut−$300 |