| Lynx1 Capital Management LP | 10.4M | $132.2M | — | Held |
| BVF INC/IL | 8.83M | $112.1M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 7.68M | $97.5M | — | Held |
| RTW INVESTMENTS, LP | 5.93M | $75.4M | — | Held |
| Fidelity | 5.14M | $65.2M | — | Held |
| Avoro Capital Advisors LLC | 1.8M | $22.9M | — | Held |
| Cormorant Asset Management, LP | 1.3M | $16.5M | — | Held |
| Jefferies Financial Group Inc. | 712.3K | $9.05M | — | Held |
| Verition Fund Management LLC | 673.7K | $8.56M | — | Held |
| 5AM Venture Management, LLC | 572.7K | $7.27M | — | Held |
| BlackRock, Inc. | 434.4K | $5.52M | — | Held |
| Troluce Capital Advisors LLC | 373.2K | $4.74M | — | Held |
| UBS Group AG | 363.4K | $4.61M | — | Held |
| Squadron Capital Management LLC | 315K | $4M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 295.9K | $3.76M | — | Held |
| CenterBook Partners LP | 283.4K | $3.6M | — | Held |
| MARSHALL WACE, LLP | 240.8K | $3.06M | — | Held |
| HighVista Strategies LLC | 240.5K | $3.05M | — | Held |
| Alyeska Investment Group, L.P. | 205K | $2.6M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 112.2K | $1.42M | — | Held |
| GOLDMAN SACHS GROUP INC | 81K | $1.03M | — | Held |
| AdvisorShares Investments LLC | 67.1K | $852.3K | — | Held |
| Trexquant Investment LP | 54.8K | $695.7K | — | Held |
| MORGAN STANLEY | 51.4K | $652.8K | −$6.79K | Added$592.2K |
| JANE STREET GROUP, LLC | 50K | $635.1K | — | Held |
| BIT Capital GmbH | 50K | $635K | — | Held |
| XTX Topco Ltd | 44.4K | $564.5K | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 35.6K | $452.7K | — | Held |
| NORTHERN TRUST CORP | 32.8K | $416.9K | — | Held |
| Citadel | 26.3K | $333.5K | — | Held |
| Virtus Investment Advisers, LLC | 20.4K | $259.2K | — | Held |
| JPMORGAN CHASE & CO | 18.9K | $239.8K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15.9K | $201.6K | — | Held |
| HighTower Advisors, LLC | 15.6K | $198.1K | — | Held |
| State Street | 10.8K | $137.4K | — | Held |
| Lion Point Capital, LP | 10.2K | $129.5K | — | Held |
| China Universal Asset Management Co., Ltd. | 10.1K | $128.4K | — | Held |
| OSAIC HOLDINGS, INC. | 10K | $127.3K | — | Held |
| BANK OF AMERICA CORP /DE/ | 4.45K | $56.5K | −$440 | Added$52.6K |
| CITIGROUP INC | 4.4K | $55.9K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.01K | $38.3K | — | Held |
| BARCLAYS PLC | 2.12K | $26.9K | −$2.07K | Added$8.37K |
| ROYAL BANK OF CANADA | 1.81K | $23K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 1.34K | $17K | — | Held |
| WELLS FARGO & COMPANY/MN | 1.25K | $15.9K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.22K | $15.5K | — | Held |
| Tower Research Capital LLC (TRC) | 770 | $9.78K | — | Held |
| Global Retirement Partners, LLC | 400 | $5.08K | — | Held |
| SIMPLEX TRADING, LLC | 48 | $609 | — | Held |
| SBI Securities Co., Ltd. | 20 | $254 | — | Held |
| GSA CAPITAL PARTNERS LLP | 18.6K | $236 | — | Held |
| HRT FINANCIAL LP | 15.9K | $202 | — | Held |
| Daiwa Securities Group Inc. | 207 | $3 | — | Held |