| Lynx1 Capital Management LP | 8.96M | $92.8M | — | Held |
| MPM BIOIMPACT LLC | 7.65M | $79.2M | — | Held |
| BVF INC/IL | 5.75M | $59.5M | — | Held |
| BlackRock, Inc. | 4.4M | $45.5M | — | Held |
| Vanguard | 3.3M | $34.1M | — | Held |
| Kynam Capital Management, LP | 3.11M | $32.2M | — | Held |
| Blue Owl Capital Holdings LP | 2.35M | $24.3M | — | Held |
| State Street | 2.2M | $22.7M | — | Held |
| Affinity Asset Advisors, LLC | 1.93M | $20M | — | Held |
| RTW INVESTMENTS, LP | 1.71M | $17.7M | — | Held |
| VR ADVISER, LLC | 1.38M | $14.3M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.3M | $13.5M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 1.24M | $12.8M | — | Held |
| Siren, L.L.C. | 1.19M | $12.4M | — | Held |
| Nextech Invest, Ltd. | 1.14M | $11.8M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 848.8K | $8.78M | — | Held |
| MORGAN STANLEY | 766.9K | $7.94M | $1.77M | Added$5.56M |
| GOLDMAN SACHS GROUP INC | 721.9K | $7.47M | — | Held |
| GREAT POINT PARTNERS LLC | 634K | $6.56M | — | Held |
| Renaissance Technologies | 631.7K | $6.54M | — | Held |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595.5K | $6.16M | — | Held |
| DEUTSCHE BANK AG\ | 586.6K | $6.07M | — | Held |
| Nuveen, LLC | 579.1K | $5.99M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 470.5K | $4.87M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 436.3K | $4.52M | — | Held |
| NORTHERN TRUST CORP | 421.6K | $4.36M | — | Held |
| MARSHALL WACE, LLP | 414.4K | $4.29M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 386.2K | $4M | — | Held |
| Trexquant Investment LP | 381.5K | $3.95M | — | Held |
| Jump Financial, LLC | 364.9K | $3.78M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 362.5K | $3.75M | — | Held |
| Point72 Asset Management, L.P. | 360.2K | $3.73M | — | Held |
| BANK OF AMERICA CORP /DE/ | 346.3K | $3.58M | $1.53M | Added$280.1K |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 343.7K | $3.41M | — | Held |
| Elmind Capital, LP | 310K | $3.21M | — | Held |
| Icahn Capital | 281.5K | $2.91M | — | Held |
| UBS Group AG | 271.7K | $2.81M | — | Held |
| ORBIMED ADVISORS LLC | 270K | $2.79M | — | Held |
| BARCLAYS PLC | 269.7K | $2.79M | $1.11M | Added$1.3M |
| Connor, Clark & Lunn Investment Management Ltd. | 244K | $2.53M | — | Held |
| CITIGROUP INC | 240.5K | $2.49M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 233.8K | $2.42M | — | Held |
| PFM Health Sciences, LP | 227K | $2.35M | — | Held |
| JANE STREET GROUP, LLC | 186.8K | $1.93M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 159.8K | $1.65M | — | Held |
| Assenagon Asset Management S.A. | 158.8K | $1.64M | — | Held |
| JPMORGAN CHASE & CO | 147.1K | $1.52M | — | Held |
| Bank of New York Mellon Corp | 144.9K | $1.5M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 142.8K | $1.48M | — | Held |
| Invesco Ltd. | 130.3K | $1.35M | — | Held |
| TWO SIGMA ADVISERS, LP | 129.8K | $1.34M | — | Held |
| XTX Topco Ltd | 121.3K | $1.26M | — | Held |
| Qube Research & Technologies Ltd | 119.3K | $1.23M | — | Held |
| Citadel | 110.3K | $1.14M | — | Held |
| Squarepoint Ops LLC | 75.8K | $784.7K | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 73.8K | $763.4K | — | Held |
| Engineers Gate Manager LP | 69.3K | $717.7K | — | Held |
| RHUMBLINE ADVISERS | 67.2K | $695.9K | — | Held |
| Rafferty Asset Management, LLC | 61.7K | $638.3K | — | Held |
| WELLS FARGO & COMPANY/MN | 60.5K | $626.3K | — | Held |
| Swiss National Bank | 58.3K | $603.4K | — | Held |
| ADAR1 Capital Management, LLC | 50K | $517.5K | — | Held |
| Voleon Capital Management LP | 49.7K | $514K | — | Held |
| Mariner, LLC | 49.1K | $508.2K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 48.1K | $497.3K | — | Held |
| Quantinno Capital Management LP | 48K | $496.8K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 47.6K | $493K | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 47.3K | $489.2K | — | Held |
| Creative Planning | 39.9K | $412.9K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 39.8K | $412.2K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 39.5K | $408.3K | — | Held |
| NEOS Investment Management LLC | 37.5K | $388.3K | — | Held |
| TEMA ETFS LLC | 37K | $382.6K | — | Held |
| Aquatic Capital Management LLC | 30.9K | $320.1K | — | Held |
| MetLife Investment Management, LLC | 30.8K | $318.9K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30.8K | $318.8K | — | Held |
| ExodusPoint Capital Management, LP | 30.5K | $315.5K | — | Held |
| AlphaQuest LLC | 28.9K | $299.6K | — | Held |
| Legal & General Group Plc | 28.6K | $296.3K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 28.7K | $295.1K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 27.9K | $289.1K | — | Held |
| Russell Investments Group, Ltd. | 24.4K | $252.6K | — | Held |
| EntryPoint Capital, LLC | 23.8K | $246.2K | — | Held |
| PROFUND ADVISORS LLC | 23.3K | $241K | — | Held |
| Virtus Investment Advisers, LLC | 22.3K | $231K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 21.2K | $219.5K | — | Held |
| Birchview Capital, LP | 20K | $207K | — | Held |
| Pale Fire Capital SE | 19.3K | $199.9K | — | Held |
| AlphaCentric Advisors LLC | 19K | $197.1K | — | Held |
| JANUS HENDERSON GROUP PLC | 18.5K | $191.4K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16.8K | $174.1K | — | Held |
| Schonfeld Strategic Advisors LLC | 16.6K | $172.2K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 15K | $155.2K | — | Held |
| D. E. Shaw & Co., Inc. | 14.4K | $148.7K | — | Held |
| Compass Ion Advisors, LLC | 13.9K | $143.9K | — | Held |
| SIMPLEX TRADING, LLC | 13.3K | $137.2K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 12.9K | $133.7K | — | Held |
| ProShare Advisors LLC | 12.5K | $129.3K | — | Held |
| GREAT LAKES ADVISORS, LLC | 12.4K | $128.4K | — | Held |
| Inscription Capital, LLC | 11.7K | $120.7K | — | Held |
| Brevan Howard Capital Management LP | 11K | $113.5K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 10.1K | $104.8K | $44.8K | Cut−$67.1K |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 10K | $103.5K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9.91K | $102.6K | — | Held |
| China Universal Asset Management Co., Ltd. | 9.63K | $99.6K | — | Held |
| Quarry LP | 9.6K | $99.4K | — | Held |
| KLP KAPITALFORVALTNING AS | 6.8K | $70.4K | — | Held |
| Caitong International Asset Management Co., Ltd | 4.68K | $48.4K | — | Held |
| Fidelity | 4.6K | $47.6K | — | Held |
| Ameritas Investment Partners, Inc. | 4.3K | $44.6K | — | Held |
| SIGNATUREFD, LLC | 4.13K | $42.7K | — | Held |
| Sterling Capital Management LLC | 3.07K | $31.8K | — | Held |
| Seven Fleet Capital Management LP | 3K | $31.1K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.87K | $29.7K | — | Held |
| Parallel Advisors, LLC | 1.9K | $19.6K | — | Held |
| ROYAL BANK OF CANADA | 1.55K | $16K | — | Held |
| EverSource Wealth Advisors, LLC | 1.28K | $13.2K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.16K | $12K | — | Held |
| GAMMA Investing LLC | 980 | $10.1K | — | Held |
| Tower Research Capital LLC (TRC) | 906 | $9.38K | — | Held |
| Essential Partners LLC | 791 | $8.19K | $1.46K | Added$6.22K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 1.08K | $8.17K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 761 | $7.88K | — | Held |
| UMB Bank, n.a. | 685 | $7.09K | — | Held |
| Allworth Financial LP | 645 | $6.68K | $2.46K | Added$3.38K |
| Farther Finance Advisors, LLC | 560 | $5.8K | — | Held |
| US BANCORP \DE\ | 483 | $5K | — | Held |
| IFP Advisors, Inc | 313 | $3.24K | $650 | Added$2.37K |
| NISA INVESTMENT ADVISORS, LLC | 300 | $3.1K | — | Held |
| OSAIC HOLDINGS, INC. | 243 | $2.52K | — | Held |
| Optiver Holding B.V. | 200 | $2.07K | — | Held |
| Arax Advisory Partners | 172 | $1.78K | — | Held |
| ALGERT GLOBAL LLC | 162.5K | $1.68K | — | Held |
| HRT FINANCIAL LP | 84.1K | $870 | — | Held |
| COMERICA BANK | 66 | $683 | — | Held |
| Fortitude Family Office, LLC | 58 | $600 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 47.2K | $489 | — | Held |
| Larson Financial Group LLC | 40 | $414 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 33 | $342 | — | Held |
| GSA CAPITAL PARTNERS LLP | 27.3K | $283 | — | Held |
| MassMutual Private Wealth & Trust, FSB | 27 | $279 | — | Held |
| Smartleaf Asset Management LLC | 26 | $258 | — | Held |
| SJS Investment Consulting Inc. | 20 | $207 | — | Held |
| MAI Capital Management | 18 | $187 | — | Held |
| SG Americas Securities, LLC | 15.6K | $162 | — | Held |
| PNC Financial Services Group, Inc. | 5 | $52 | — | Held |
| Clearstead Advisors, LLC | 4 | $42 | — | Held |
| CWM, LLC | 3.88K | $40 | — | Held |
| AMALGAMATED BANK | 1.7K | $18 | — | Held |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1.15K | $12 | — | Held |
| SBI Securities Co., Ltd. | 1 | $10 | — | Held |
| Daiwa Securities Group Inc. | 218 | $2 | — | Held |
| Covestor Ltd | 43 | $0 | — | Held |