| Lynx1 Capital Management LP | 8.96M | $127.4M | $34.6M | Added$34.6M |
| MPM BIOIMPACT LLC | 7.65M | $108.7M | $29.5M | Added$29.5M |
| BVF INC/IL | 5.75M | $81.7M | $22.2M | Added$22.2M |
| BlackRock, Inc. | 4.45M | $63.2M | $17M | Added$17.7M |
| Kynam Capital Management, LP | 3.11M | $44.3M | $12M | Added$12M |
| State Street | 2.54M | $36.2M | $8.48M | Added$13.4M |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.48M | $35.3M | — | Held |
| Blue Owl Capital Holdings LP | 1.91M | $27.1M | $7.37M | Added$2.81M |
| RTW INVESTMENTS, LP | 1.71M | $24.2M | $6.59M | Added$6.59M |
| VR ADVISER, LLC | 1.38M | $19.6M | $5.33M | Added$5.33M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.37M | $19.4M | $5.03M | Added$5.97M |
| Siren, L.L.C. | 1.19M | $17M | $4.61M | Added$4.61M |
| Nextech Invest, Ltd. | 1.14M | $16.2M | $4.4M | Added$4.4M |
| BOOTHBAY FUND MANAGEMENT, LLC | 1.11M | $15.8M | $4.3M | Added$3.01M |
| MARSHALL WACE, LLP | 1.05M | $14.9M | $1.6M | Added$10.6M |
| DIMENSIONAL FUND ADVISORS LP | 906K | $12.9M | $3.27M | Added$4.09M |
| Point72 Asset Management, L.P. | 905.4K | $12.9M | $1.39M | Added$9.14M |
| Nuveen, LLC | 805.7K | $11.4M | $2.24M | Added$5.46M |
| Affinity Asset Advisors, LLC | 781.3K | $11.1M | $3.02M | Cut−$8.9M |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595.5K | $8.46M | $2.3M | Added$2.3M |
| MORGAN STANLEY | 589.5K | $8.38M | $2.28M | Added$438.8K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 552.6K | $7.85M | — | Held |
| Elmind Capital, LP | 530K | $7.53M | $1.2M | Added$4.32M |
| TWO SIGMA INVESTMENTS, LP | 522K | $7.42M | $1.82M | Added$2.55M |
| BANK OF AMERICA CORP /DE/ | 516.7K | $7.34M | $1.34M | Added$3.76M |
| GOLDMAN SACHS GROUP INC | 455.4K | $6.47M | $1.76M | Cut−$999.4K |
| NORTHERN TRUST CORP | 449.3K | $6.38M | $1.63M | Added$2.02M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 432.9K | $6.15M | $1.67M | Added$1.64M |
| Soleus Capital Management, L.P. | 410.2K | $5.83M | — | New |
| TCG Crossover Management, LLC | 406.8K | $5.78M | — | New |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 386.2K | $5.49M | $1.49M | Added$1.49M |
| DEUTSCHE BANK AG\ | 367.9K | $5.23M | $1.42M | Cut−$843.7K |
| Icahn Capital | 360.9K | $5.13M | $1.09M | Added$2.21M |
| MILLENNIUM MANAGEMENT LLC | 346.6K | $4.92M | $1.34M | Added$1.17M |
| VANGUARD FIDUCIARY TRUST CO | 342.9K | $4.87M | — | Held |
| Renaissance Technologies | 324.1K | $4.61M | $1.25M | Cut−$1.93M |
| GREAT POINT PARTNERS LLC | 300K | $4.26M | $1.16M | Cut−$2.3M |
| Connor, Clark & Lunn Investment Management Ltd. | 289.1K | $4.11M | $941.9K | Added$1.58M |
| JPMORGAN CHASE & CO | 297.2K | $3.99M | $451.5K | Added$2.47M |
| Citadel | 252.8K | $3.59M | $425.8K | Added$2.45M |
| Invesco Ltd. | 244.2K | $3.47M | $503K | Added$2.12M |
| ORBIMED ADVISORS LLC | 243K | $3.45M | $938K | Added$658.6K |
| Susquehanna Portfolio Strategies, LLC | 233.8K | $3.32M | $902.6K | Added$902.6K |
| PFM Health Sciences, LP | 227.4K | $3.23M | $876.2K | Added$882K |
| UBS Group AG | 202.4K | $2.88M | $781.2K | Added$63.4K |
| Jump Financial, LLC | 193.8K | $2.75M | $748.1K | Cut−$1.02M |
| Longaeva Partners L.P. | 183.7K | $2.61M | — | New |
| Trexquant Investment LP | 168.5K | $2.39M | $650.3K | Cut−$1.55M |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 173.7K | $2.33M | $608.1K | Cut−$1.08M |
| WELLINGTON MANAGEMENT GROUP LLP | 149.6K | $2.13M | $577.6K | Added$472.8K |
| PRUDENTIAL FINANCIAL INC | 149.4K | $2.12M | — | New |
| CITIGROUP INC | 144.1K | $2.05M | $556.3K | Cut−$440.9K |
| AMERICAN CENTURY COMPANIES INC | 144.1K | $2.05M | $551.1K | Added$570.2K |
| Bank of New York Mellon Corp | 143.7K | $2.04M | $554.7K | Added$542.1K |
| BARCLAYS PLC | 140.3K | $1.99M | $541.5K | Cut−$797.3K |
| Assenagon Asset Management S.A. | 138.7K | $1.97M | $535.4K | Added$327.9K |
| TD Asset Management Inc | 114.4K | $1.63M | — | New |
| MOORE CAPITAL MANAGEMENT, LP | 106K | $1.51M | — | New |
| Bleichroeder LP | 100K | $1.42M | — | New |
| Y-Intercept (Hong Kong) Ltd | 95.4K | $1.36M | — | New |
| Cinctive Capital Management LP | 94.4K | $1.34M | — | New |
| Qube Research & Technologies Ltd | 90.3K | $1.28M | $348.6K | Added$48.7K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 75.3K | $1.07M | $64.9K | Added$896K |
| Quantinno Capital Management LP | 72.3K | $1.03M | $185.3K | Added$530.3K |
| Rafferty Asset Management, LLC | 69.5K | $987.4K | $238.1K | Added$349.1K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 67.7K | $961.4K | $185.5K | Added$464.1K |
| RHUMBLINE ADVISERS | 67.5K | $959.4K | $259.5K | Added$263.5K |
| Engineers Gate Manager LP | 66.3K | $942K | $255.9K | Added$224.3K |
| Mariner, LLC | 62.7K | $891.1K | $189.8K | Added$382.9K |
| Tidal Investments LLC | 62.4K | $887K | — | New |
| TEMA ETFS LLC | 62.4K | $887K | $142.7K | Added$504.4K |
| Apis Capital Advisors, LLC | 60K | $852.6K | — | New |
| Creative Planning | 60K | $852.2K | $154K | Added$439.4K |
| SUPERSTRING CAPITAL MANAGEMENT LP | 59.5K | $845.3K | — | New |
| Swiss National Bank | 58.3K | $828.4K | $225K | Added$225K |
| KENNEDY CAPITAL MANAGEMENT LLC | 51.5K | $731.7K | $182.4K | Added$242.5K |
| ADAR1 Capital Management, LLC | 50K | $710.5K | $193K | Added$193K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47.4K | $673.2K | $153.7K | Added$261.1K |
| ALLIANCEBERNSTEIN L.P. | 47.6K | $493K | $0 | Held |
| PROFUND ADVISORS LLC | 31.3K | $444.1K | $89.9K | Added$203.1K |
| MetLife Investment Management, LLC | 30.8K | $437.9K | $118.9K | Added$118.9K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30.4K | $431.9K | $117.3K | Added$113.2K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30.2K | $424.6K | $108.5K | Added$129.6K |
| BNP PARIBAS FINANCIAL MARKETS | 29.5K | $419.8K | $114K | Added$11.5K |
| TUDOR INVESTMENT CORP ET AL | 29K | $411.9K | $39.1K | Added$307.1K |
| Optimize Financial Inc | 28.2K | $400.1K | — | New |
| Corient Private Wealth LLC | 27.9K | $396.2K | — | New |
| IEQ CAPITAL, LLC | 27.7K | $394.1K | — | New |
| Vanguard Global Advisers, LLC | 27.1K | $384.6K | — | Held |
| XTX Topco Ltd | 26.3K | $374.1K | $101.6K | Cut−$880.9K |
| Knott David M Jr | 24.2K | $343.9K | — | New |
| Voleon Capital Management LP | 24.1K | $342.3K | $93K | Cut−$171.7K |
| Brevan Howard Capital Management LP | 24.1K | $342.1K | $42.3K | Added$228.6K |
| Virtus Investment Advisers, LLC | 22.9K | $325.1K | $86.1K | Added$94.1K |
| JANE STREET GROUP, LLC | 22.8K | $324.2K | $88.1K | Cut−$1.61M |
| WELLS FARGO & COMPANY/MN | 20.9K | $297.5K | $80.8K | Cut−$328.8K |
| AlphaCentric Advisors LLC | 20.1K | $286.1K | $73.5K | Added$89K |
| VANGUARD ASSET MANAGEMENT, Ltd | 20K | $284.8K | — | Held |
| Birchview Capital, LP | 20K | $284.2K | $77.2K | Added$77.2K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19.1K | $270.9K | $38.2K | Added$168.4K |
| Legal & General Group Plc | 18.7K | $265.7K | $72.2K | Cut−$30.6K |
| JANUS HENDERSON GROUP PLC | 18.5K | $263.2K | $71.8K | Added$71.8K |
| SIMPLEX TRADING, LLC | 17.6K | $250.5K | $51.2K | Added$113.4K |
| Police & Firemen's Retirement System of New Jersey | 15K | $213.1K | $57.9K | Added$57.9K |
| INTECH INVESTMENT MANAGEMENT LLC | 14.9K | $211.9K | $57.6K | Cut−$77.2K |
| Pale Fire Capital SE | 14.2K | $202K | $54.9K | Added$2.1K |
| MERCER GLOBAL ADVISORS INC /ADV | 14.1K | $200.5K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 12.9K | $183.6K | $49.9K | Added$49.9K |
| Verdad Advisers, LP | 12.6K | $179.1K | — | New |
| CWM, LLC | 12.2K | $173.3K | $55K | Added$173.3K |
| GREAT LAKES ADVISORS, LLC | 11.8K | $167.8K | $45.6K | Added$39.4K |
| Inscription Capital, LLC | 11.7K | $165.7K | $45K | Added$45K |
| Quadrature Capital Ltd | 10.6K | $150.3K | — | New |
| China Universal Asset Management Co., Ltd. | 10.5K | $149K | $37.2K | Added$49.3K |
| ProShare Advisors LLC | 10.5K | $148.7K | $40.4K | Added$19.4K |
| State of New Jersey Common Pension Fund D | 10.1K | $143.4K | — | New |
| Leonteq Securities AG | 10K | $142.1K | — | New |
| Quarry LP | 9.6K | $136.4K | $37.1K | Added$37.1K |
| GROUP ONE TRADING LLC | 8.86K | $125.8K | — | New |
| Vanguard Investments Australia, Ltd. | 7.27K | $103.3K | — | Held |
| Fidelity | 7.23K | $102.8K | $17.8K | Added$55.2K |
| KLP KAPITALFORVALTNING AS | 6.8K | $96.6K | $26.2K | Added$26.2K |
| NISA INVESTMENT ADVISORS, LLC | 5.8K | $82.4K | $1.16K | Added$79.3K |
| SIGNATUREFD, LLC | 5.55K | $78.9K | $15.9K | Added$36.1K |
| Ameritas Investment Partners, Inc. | 4.3K | $61.2K | $16.6K | Added$16.6K |
| Russell Investments Group, Ltd. | 4.27K | $60.7K | $16.5K | Cut−$191.9K |
| Tower Research Capital LLC (TRC) | 4.13K | $58.7K | $3.5K | Added$49.3K |
| ROYAL BANK OF CANADA | 4.04K | $58K | $6.26K | Added$42K |
| Mirae Asset Global Investments Co., Ltd. | 3.08K | $43.8K | $11.1K | Added$14.1K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.03M | $28.8K | $182 | Added$28.4K |
| Federation des caisses Desjardins du Quebec | 2K | $28.4K | — | New |
| Parallel Advisors, LLC | 1.9K | $26.9K | $7.32K | Added$7.32K |
| Seven Fleet Capital Management LP | 1.84K | $26.2K | $7.12K | Cut−$4.85K |
| Sterling Capital Management LLC | 1.8K | $25.6K | $6.94K | Cut−$6.22K |
| GAMMA Investing LLC | 1.76K | $25K | $3.78K | Added$14.9K |
| GF FUND MANAGEMENT CO. LTD. | 1.32K | $18.7K | $4.48K | Added$6.72K |
| Allworth Financial LP | 1.15K | $16.3K | $2.49K | Added$9.61K |
| EverSource Wealth Advisors, LLC | 1.1K | $15.6K | $4.24K | Added$2.37K |
| MAI Capital Management | 938 | $13.3K | $69 | Added$13.1K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 922 | $13.1K | — | New |
| Bangor Savings Bank | 842 | $12K | — | New |
| Essential Partners LLC | 800 | $11.4K | $3.05K | Added$3.18K |
| QUADRANT CAPITAL GROUP LLC | 761 | $10.8K | $2.94K | Added$2.94K |
| UMB Bank, n.a. | 685 | $9.73K | $2.64K | Added$2.64K |
| Rockefeller Capital Management L.P. | 649 | $9.22K | — | New |
| Farther Finance Advisors, LLC | 605 | $8.43K | $2.01K | Added$2.64K |
| FEDERATED HERMES, INC. | 516 | $7.33K | — | New |
| US BANCORP \DE\ | 502 | $7.13K | $1.86K | Added$2.13K |
| Optiver Holding B.V. | 404 | $5.74K | $772 | Added$3.67K |
| OSAIC HOLDINGS, INC. | 384 | $5.46K | $938 | Added$2.94K |
| Larson Financial Group LLC | 354 | $5.03K | $154 | Added$4.62K |
| Arax Advisory Partners | 350 | $4.97K | $663 | Added$3.19K |
| IFP Advisors, Inc | 313 | $4.45K | $1.21K | Added$1.21K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 306 | $4.35K | $2.03K | Cut−$3.82K |
| Fortitude Family Office, LLC | 192 | $2.73K | $224 | Added$2.13K |
| ROTHSCHILD INVESTMENT LLC | 189 | $2.69K | $127 | Added$2.34K |
| Quantbot Technologies LP | 122 | $1.73K | — | New |
| ALGERT GLOBAL LLC | 109.7K | $1.56K | $423 | Cut−$123 |
| Wealth Preservation Advisors, LLC | 84 | $1.19K | — | New |
| FIFTH THIRD BANCORP | 63 | $895 | — | New |
| Root Financial Partners, LLC | 62 | $881 | — | New |
| True Wealth Design, LLC | 54 | $768 | — | New |
| GSA CAPITAL PARTNERS LLP | 43.3K | $616 | $105 | Added$333 |
| SJS Investment Consulting Inc. | 43 | $612 | $78 | Added$405 |
| HRT FINANCIAL LP | 38.6K | $548 | $149 | Cut−$322 |
| MassMutual Private Wealth & Trust, FSB | 27 | $384 | $105 | Added$105 |
| Smartleaf Asset Management LLC | 26 | $349 | $91 | Added$91 |
| PNC Financial Services Group, Inc. | 18 | $256 | $19 | Added$204 |
| SG Americas Securities, LLC | 15.5K | $220 | $60 | Added$58 |
| Capital Advisors, Ltd. LLC | 1.6K | $23 | — | New |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1.15K | $16 | $4 | Added$4 |
| SBI Securities Co., Ltd. | 1 | $14 | $4 | Added$4 |
| Covestor Ltd | 10 | $0 | $0 | Held |