| BAKER BROS. ADVISORS LP | 38.7M | $856.1M | — | Held |
| NEA Management Company, LLC | 3.54M | $352.6M | — | Held |
| PERCEPTIVE ADVISORS LLC | 9.66M | $329.3M | — | Held |
| Avoro Capital Advisors LLC | 3.11M | $310.3M | — | Held |
| BlackRock, Inc. | 2.54M | $253.4M | — | Held |
| Vanguard | 2.28M | $227.4M | — | Held |
| Linden Advisors LP | 93.4M | $202.5M | — | Held |
| Soleus Capital Management, L.P. | 1.81M | $180.4M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1.71M | $171M | — | Held |
| State Street | 1.64M | $163.3M | — | Held |
| MORGAN STANLEY | 1.4M | $139.5M | $70.4M | Added$64.8M |
| TANG CAPITAL MANAGEMENT LLC | 1.05M | $104.7M | — | Held |
| BANK OF AMERICA CORP /DE/ | 977.1K | $97.5M | $27.2M | Added$70.8M |
| GEODE CAPITAL MANAGEMENT, LLC | 830.7K | $82.9M | — | Held |
| Holocene Advisors, LP | 695.3K | $69.4M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.06M | $66M | — | Held |
| Apis Capital Advisors, LLC | 602K | $60M | — | Held |
| RTW INVESTMENTS, LP | 550.2K | $54.9M | — | Held |
| Artisan Partners Limited Partnership | 546.6K | $54.5M | — | Held |
| Nearwater Capital Markets, Ltd | 520.2K | $51.9M | — | Held |
| Sio Capital Management, LLC | 477.1K | $47.6M | — | Held |
| Candriam S.C.A. | 476.4K | $47.5M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 472.9K | $47.2M | — | Held |
| Context Capital Management, LLC | 17.5M | $37.9M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 375.1K | $37.4M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 371.1K | $37M | — | Held |
| Capitolis Liquid Global Markets LLC | 355.2K | $35.4M | — | Held |
| Pfizer Inc | 349.4K | $34.8M | — | Held |
| Saturn V Capital Management LP | 317.1K | $31.6M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 313.7K | $31.3M | — | Held |
| Sofinnova Investments, Inc. | 299.4K | $29.9M | — | Held |
| Jump Financial, LLC | 13.8M | $29.8M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 292.3K | $29.2M | — | Held |
| NORTHERN TRUST CORP | 287.7K | $28.7M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 7.6M | $26.8M | — | Held |
| Driehaus Capital Management LLC | 250.1K | $24.9M | — | Held |
| Focus Partners Wealth | 234.8K | $23.4M | — | Held |
| JENNISON ASSOCIATES LLC | 229.7K | $22.9M | — | Held |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 226.5K | $22.6M | — | Held |
| Boxer Capital Management, LLC | 225K | $22.4M | $4.53M | Added$18M |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 221.6K | $22.1M | — | Held |
| Qube Research & Technologies Ltd | 208.5K | $20.8M | — | Held |
| Hennion & Walsh Asset Management, Inc. | 190.9K | $19M | — | Held |
| AMERIPRISE FINANCIAL INC | 3.12M | $18.8M | — | Held |
| Walleye Capital LLC | 153.3K | $15.3M | — | Held |
| Ensign Peak Advisors, Inc | 149K | $14.9M | — | Held |
| Invesco Ltd. | 147.9K | $14.8M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 142.2K | $14.2M | — | Held |
| WELLS FARGO & COMPANY/MN | 138.4K | $13.8M | — | Held |
| Woodline Partners LP | 130.9K | $13.1M | — | Held |
| BARCLAYS PLC | 122.9K | $12.3M | $2.61M | Added$9.69M |
| Acasta Partners UK LLP | 5.55M | $12.1M | — | Held |
| Patient Square Capital LP | 120K | $12M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 119.6K | $11.9M | — | Held |
| STEMPOINT CAPITAL LP | 118.3K | $11.8M | — | Held |
| Clearbridge Investments, LLC | 106.9K | $10.7M | — | Held |
| Ikarian Capital, LLC | 105.5K | $10.5M | — | Held |
| TD Asset Management Inc | 97.5K | $9.73M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91.9K | $9.17M | — | Held |
| CSS LLC/IL | 4.21M | $9.15M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 432.2K | $8.96M | — | Held |
| Bank of New York Mellon Corp | 88.6K | $8.84M | — | Held |
| Granahan Investment Management, LLC | 87K | $8.68M | — | Held |
| Russell Investments Group, Ltd. | 85.8K | $8.56M | — | Held |
| ORBIMED ADVISORS LLC | 85.7K | $8.54M | — | Held |
| Atom Investors LP | 85.6K | $8.54M | — | Held |
| Nuveen, LLC | 85.3K | $8.51M | — | Held |
| UBS Group AG | 81.6K | $8.14M | — | Held |
| NAN FUNG TRINITY (HK) LTD | 80.8K | $8.06M | — | Held |
| Integral Health Asset Management, LLC | 80K | $7.98M | — | Held |
| Fidelity | 2.29M | $7.57M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71.7K | $7.16M | — | Held |
| JPMORGAN CHASE & CO | 954.1K | $7.05M | — | Held |
| SSI INVESTMENT MANAGEMENT LLC | 3.21M | $6.95M | — | Held |
| Affinity Asset Advisors, LLC | 3M | $6.52M | — | Held |
| ACT CAPITAL MANAGEMENT, LLC | 63.4K | $6.33M | — | Held |
| Man Group plc | 62.5K | $6.23M | — | Held |
| CAPTRUST FINANCIAL ADVISORS | 61.5K | $6.14M | — | Held |
| D. E. Shaw & Co., Inc. | 57.7K | $5.75M | — | Held |
| Rafferty Asset Management, LLC | 57.1K | $5.7M | — | Held |
| Squarepoint Ops LLC | 57.1K | $5.69M | — | Held |
| GAGNON SECURITIES LLC | 53.4K | $5.33M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 48.7K | $4.86M | — | Held |
| Informed Momentum Co LLC | 48K | $4.79M | — | Held |
| Citadel | 47K | $4.69M | — | Held |
| Aquatic Capital Management LLC | 45.7K | $4.56M | — | Held |
| Harvest Investment Services, LLC | 42.5K | $4.24M | — | Held |
| Atle Fund Management AB | 41.8K | $4.17M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 41.5K | $4.14M | — | Held |
| ExodusPoint Capital Management, LP | 40K | $3.99M | — | Held |
| PRUDENTIAL FINANCIAL INC | 38.7K | $3.86M | — | Held |
| RHUMBLINE ADVISERS | 38.1K | $3.8M | — | Held |
| ALPS ADVISORS INC | 37.9K | $3.78M | — | Held |
| JNBA Financial Advisors | 36.8K | $3.67M | — | Held |
| Exome Asset Management LLC | 34.3K | $3.42M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 30.3K | $3.03M | — | Held |
| NEOS Investment Management LLC | 28.2K | $2.82M | — | Held |
| TEMA ETFS LLC | 27.8K | $2.77M | — | Held |
| Accredited Investors Inc. | 27.1K | $2.7M | — | Held |
| Swiss National Bank | 25.1K | $2.5M | — | Held |
| DEUTSCHE BANK AG\ | 23.5K | $2.35M | — | Held |
| ADVENT CAPITAL MANAGEMENT /DE/ | 980K | $2.14M | — | Held |
| PROFUND ADVISORS LLC | 21.2K | $2.12M | — | Held |
| SEI INVESTMENTS CO | 21.2K | $2.11M | — | Held |
| Creative Planning | 21K | $2.09M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 21K | $2.09M | — | Held |
| Quantinno Capital Management LP | 20.6K | $2.05M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 19.3K | $1.93M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 18.9K | $1.89M | $953K | Added$537.7K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18.3K | $1.82M | — | Held |
| MetLife Investment Management, LLC | 17.7K | $1.77M | — | Held |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 15.8K | $1.66M | — | Held |
| HighVista Strategies LLC | 16.5K | $1.65M | — | Held |
| Polar Capital Holdings Plc | 750K | $1.63M | — | Held |
| LPL Financial LLC | 15.4K | $1.53M | — | Held |
| Aristides Capital LLC | 15.3K | $1.53M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15.3K | $1.52M | — | Held |
| OAKTREE CAPITAL MANAGEMENT LP | 700K | $1.52M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 15K | $1.49M | — | Held |
| FRANKLIN RESOURCES INC | 14.4K | $1.43M | — | Held |
| DARK FOREST CAPITAL MANAGEMENT LP | 13.7K | $1.37M | — | Held |
| SummitTX Capital, L.P. | 13.4K | $1.34M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13.4K | $1.33M | — | Held |
| XTX Topco Ltd | 13.3K | $1.32M | — | Held |
| NORGES BANK | 13.2K | $1.32M | — | New |
| AGF MANAGEMENT LTD | 600K | $1.3M | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 13K | $1.29M | — | Held |
| Artia Global Partners LP | 12.9K | $1.29M | — | Held |
| Legal & General Group Plc | 12.8K | $1.28M | — | Held |
| COFG Advisors, LLC | 12.3K | $1.23M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 11.8K | $1.17M | — | Held |
| Blackstone Inc. | 11.7K | $1.16M | — | New |
| FOCUSED ALPHA, LLC | 11K | $1.1M | — | Held |
| Icahn Capital | 10.6K | $1.06M | — | Held |
| HSBC HOLDINGS PLC | 10.6K | $1.06M | — | Held |
| GABELLI FUNDS LLC | 456K | $989.1K | — | Held |
| LEVEL FOUR ADVISORY SERVICES, LLC | 9.8K | $977.7K | — | Held |
| Focus Financial Network, Inc. | 9.33K | $931K | — | Held |
| Allianz Asset Management GmbH | 9K | $897.7K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 8.93K | $890.8K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 8.64K | $861.5K | — | Held |
| Seven Fleet Capital Management LP | 8.34K | $831.6K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 8.12K | $809.7K | — | Held |
| CITIGROUP INC | 8.05K | $803.4K | — | Held |
| GUGGENHEIM CAPITAL LLC | 7.71K | $768.8K | — | Held |
| WINTON GROUP Ltd | 7.65K | $763.4K | — | Held |
| Cresset Asset Management, LLC | 7.4K | $737.8K | $266.1K | Added$476.6K |
| Jefferies Financial Group Inc. | 7.05K | $703.3K | — | Held |
| ROYAL BANK OF CANADA | 6.96K | $695K | — | Held |
| Persistent Asset Partners Ltd | 6.72K | $670.2K | — | New |
| SBI Okasan Asset Management Co.Ltd. | 6.5K | $660.1K | — | Held |
| Murphy Pohlad Asset Management LLC | 6.6K | $658.3K | — | Held |
| Trexquant Investment LP | 6.46K | $644.2K | — | Held |
| PERKINS CAPITAL MANAGEMENT INC | 6.4K | $638.3K | — | Held |
| Kohlberg Kravis Roberts & Co. L.P. | 285K | $619K | — | Held |
| JANUS HENDERSON GROUP PLC | 6.2K | $617.9K | — | Held |
| Polymer Capital Management (US) LLC | 6.14K | $612.6K | — | Held |
| ProShare Advisors LLC | 5.9K | $588.7K | — | Held |
| Simplicity Wealth,LLC | 5.82K | $580.3K | — | Held |
| SCHWARZ DYGOS WHEELER INVESTMENT ADVISORS LLC | 5.7K | $568.5K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5.52K | $550.7K | — | Held |
| AlTi Global, Inc. | 5.29K | $527.3K | — | Held |
| PSP Research LLC | 5.24K | $523K | — | Held |
| GREAT VALLEY ADVISOR GROUP, INC. | 5.23K | $521.9K | — | Held |
| Odyssean, LLC | 5.23K | $521.5K | — | Held |
| Red Door Wealth Management, LLC | 5.17K | $516.2K | — | Held |
| NorthRock Partners, LLC | 4.85K | $484.1K | — | Held |
| CHOREO, LLC | 4.83K | $482.6K | — | Held |
| Inscription Capital, LLC | 4.72K | $470.5K | — | Held |
| M&T Bank Corp | 4.67K | $465.5K | — | Held |
| POLEN CAPITAL MANAGEMENT LLC | 4.66K | $464.8K | — | Held |
| J. Goldman & Co LP | 4.64K | $463K | — | Held |
| INTEGRITY ALLIANCE, LLC. | 4.52K | $451K | — | Held |
| State of New Jersey Common Pension Fund D | 4.34K | $433.3K | — | Held |
| Sequoia Financial Advisors, LLC | 4.26K | $425.4K | — | Held |
| AlphaQuest LLC | 4.19K | $418.3K | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 4K | $399K | — | New |
| KVP Capital Advisors, LP | 4K | $399K | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 3.77K | $376.3K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 3.6K | $359.5K | — | Held |
| Aigen Investment Management, LP | 3.56K | $354.8K | — | Held |
| Balyasny Asset Management L.P. | 3.5K | $349.5K | — | Held |
| OSAIC HOLDINGS, INC. | 3.36K | $335.1K | — | Held |
| Central Pacific Bank - Trust Division | 153K | $331.5K | — | Held |
| GROUP ONE TRADING LLC | 3.11K | $309.9K | — | Held |
| TRUIST FINANCIAL CORP | 3K | $299.2K | — | Held |
| Graham Capital Management, L.P. | 2.96K | $295.1K | — | Held |
| Roundview Capital LLC | 2.78K | $277.1K | — | Held |
| KLP KAPITALFORVALTNING AS | 2.7K | $269.3K | — | Held |
| Magnus Financial Group LLC | 2.64K | $263.2K | — | Held |
| Ameritas Investment Partners, Inc. | 2.61K | $260.5K | — | Held |
| Virtus Investment Advisers, LLC | 2.53K | $252.1K | — | Held |
| Saxony Capital Management, LLC | 2.52K | $251.3K | — | Held |
| XPONANCE LLC | 2.51K | $250.5K | — | Held |
| Keystone Wealth Services, LLC | 2.48K | $246.9K | — | Held |
| STRS OHIO | 2.4K | $239.4K | — | Held |
| CIBC WORLD MARKETS CORP | 2.13K | $212.3K | — | Held |
| Everhart Financial Group, Inc. | 2.1K | $209.5K | — | Held |
| Tradition Wealth Management, LLC | 2.04K | $203.6K | — | Held |
| CIBC Private Wealth Group LLC | 2.03K | $202.1K | — | Held |
| Versant Capital Management, Inc | 1.59K | $158.9K | — | Held |
| Avanza Fonder AB | 1.53K | $152.8K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.24M | $123.7K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 1.44K | $113.6K | — | Held |
| Kemnay Advisory Services Inc. | 1.01K | $100.6K | — | Held |
| GAMMA Investing LLC | 995 | $99.2K | — | Held |
| NBC SECURITIES, INC. | 994 | $99.1K | — | Held |
| US BANCORP \DE\ | 728 | $72.6K | — | Held |
| Pinnacle Wealth Planning Services, Inc. | 654 | $65.2K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 508 | $50.7K | — | Held |
| PNC Financial Services Group, Inc. | 428 | $42.7K | — | Held |
| MEEDER ASSET MANAGEMENT INC | 421 | $42K | — | Held |
| EverSource Wealth Advisors, LLC | 343 | $34.2K | — | Held |
| Sterling Capital Management LLC | 303 | $30.2K | — | Held |
| LORD, ABBETT & CO. LLC | 5.3M | $29.2K | — | Held |
| Tower Research Capital LLC (TRC) | 250 | $24.9K | — | Held |
| Optiver Holding B.V. | 224 | $22.3K | — | Held |
| Arax Advisory Partners | 214 | $21.3K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 206 | $20.5K | — | Held |
| SIGNATUREFD, LLC | 189 | $18.9K | — | Held |
| Financial Perspectives, Inc | 150 | $15K | — | Held |
| Rockefeller Capital Management L.P. | 120 | $12K | — | Held |
| True Wealth Design, LLC | 115 | $11.5K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 3.25K | $10.4K | — | Held |
| DV Trading LLC | 100 | $9.97K | — | Held |
| PRIVATE TRUST CO NA | 91 | $9.08K | — | Held |
| Quantbot Technologies LP | 85 | $8.48K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 82 | $8.18K | — | Held |
| Global Retirement Partners, LLC | 67 | $6.68K | — | Held |
| BI Asset Management Fondsmaeglerselskab A/S | 51.2K | $5.1K | — | Held |
| Larson Financial Group LLC | 50 | $4.99K | — | Held |
| COMERICA BANK | 37 | $3.7K | — | Held |
| HRT FINANCIAL LP | 25K | $2.49K | — | Held |
| SG Americas Securities, LLC | 18.4K | $2.33K | — | Held |
| Vermillion Wealth Management, Inc. | 20 | $2K | — | Held |
| Steward Partners Investment Advisory, LLC | 19 | $1.9K | — | Held |
| WPG Advisers, LLC | 15 | $1.5K | — | Held |
| Smartleaf Asset Management LLC | 12 | $1.2K | — | Held |
| HARBOR CAPITAL ADVISORS, INC. | 6.29K | $628 | — | Held |
| WoodTrust Financial Corp | 6.21K | $619 | — | Held |
| Parkside Financial Bank & Trust | 5 | $499 | — | Held |
| Farther Finance Advisors, LLC | 5 | $499 | — | Held |
| Bare Financial Services, Inc | 5 | $499 | — | Held |
| GSA CAPITAL PARTNERS LLP | 4.04K | $403 | — | Held |
| Cambridge Investment Research Advisors, Inc. | 3.26K | $325 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 2.04K | $203 | — | Held |
| Allworth Financial LP | 2 | $200 | $50 | Added$150 |
| AMALGAMATED BANK | 1.01K | $101 | — | Held |
| MAI Capital Management | 1 | $100 | — | Held |
| OGOREK ANTHONY JOSEPH /NY/ /ADV | 662 | $66 | — | Held |