| Fidelity | 4.13M | $49M | — | Held |
| BVF INC/IL | 2.75M | $32.6M | — | Held |
| Fairmount Funds Management LLC | 2.75M | $32.6M | — | Held |
| VR ADVISER, LLC | 2.13M | $25.3M | — | Held |
| FCPM III SERVICES B.V. | 1.68M | $19.9M | — | Held |
| Vestal Point Capital, LP | 1.5M | $17.8M | — | Held |
| Opaleye Management Inc. | 1.18M | $14M | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 872.4K | $10.3M | — | Held |
| ADAR1 Capital Management, LLC | 606K | $7.19M | — | Held |
| Logos Global Management LP | 600K | $7.12M | — | Held |
| Vanguard | 557.5K | $6.61M | — | Held |
| Deep Track Capital, LP | 453.7K | $5.38M | — | Held |
| Boxer Capital Management, LLC | 453.7K | $5.38M | −$13.6K | Cut−$13.6K |
| PERCEPTIVE ADVISORS LLC | 453.7K | $5.38M | — | Held |
| NEXTBio Capital Management LP | 372.9K | $4.42M | — | Held |
| RTW INVESTMENTS, LP | 372.9K | $4.42M | — | Held |
| Driehaus Capital Management LLC | 302.5K | $3.59M | — | Held |
| Point72 Asset Management, L.P. | 300K | $3.56M | — | Held |
| HEIGHTS CAPITAL MANAGEMENT, INC | 264K | $3.13M | — | Held |
| Alyeska Investment Group, L.P. | 264K | $3.11M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 143.4K | $1.63M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 125.2K | $1.49M | — | Held |
| Balyasny Asset Management L.P. | 111.7K | $1.32M | — | Held |
| BlackRock, Inc. | 109.2K | $1.3M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 91.1K | $1.08M | — | Held |
| Stonepine Capital Management, LLC | 87.7K | $1.04M | — | Held |
| Blackstone Inc. | 75.6K | $896.8K | — | New |
| Woodline Partners LP | 74K | $877.6K | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 74K | $844.3K | — | Held |
| Jefferies Financial Group Inc. | 64.2K | $761.9K | — | Held |
| MILLENNIUM MANAGEMENT LLC | 61.9K | $733.9K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57K | $676.6K | — | Held |
| Renaissance Technologies | 46.7K | $553.9K | — | Held |
| TWO SIGMA ADVISERS, LP | 32.5K | $385.4K | — | Held |
| MORGAN STANLEY | 27.5K | $326.4K | −$4 | Added$324.7K |
| State Street | 26.2K | $310.9K | — | Held |
| GOLDMAN SACHS GROUP INC | 25.2K | $299.4K | — | Held |
| MOORE CAPITAL MANAGEMENT, LP | 25K | $296.5K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24.9K | $288.9K | — | Held |
| JPMORGAN CHASE & CO | 23.3K | $276.8K | — | Held |
| JANE STREET GROUP, LLC | 23K | $272.4K | — | Held |
| MARSHALL WACE, LLP | 21.8K | $258.9K | — | Held |
| NORTHERN TRUST CORP | 17.2K | $204.3K | — | Held |
| Quadrature Capital Ltd | 13.2K | $157.1K | — | Held |
| OMERS ADMINISTRATION Corp | 11.6K | $137.6K | — | Held |
| UBS Group AG | 7.13K | $84.5K | — | Held |
| BANK OF AMERICA CORP /DE/ | 5.57K | $66.1K | −$116 | Added$20.2K |
| BNP PARIBAS FINANCIAL MARKETS | 3.58K | $42.5K | — | Held |
| CITIGROUP INC | 623 | $7.39K | — | Held |
| Tower Research Capital LLC (TRC) | 409 | $4.85K | — | Held |
| Remedium Capital Partners, LLC | 361.3K | $4.28K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 338.1K | $4.01K | — | Held |
| SBI Securities Co., Ltd. | 68 | $806 | — | Held |
| OSAIC HOLDINGS, INC. | 26 | $308 | — | Held |
| HRT FINANCIAL LP | 13.1K | $155 | — | Held |
| GROUP ONE TRADING LLC | 4 | $47 | — | Held |
| ROYAL BANK OF CANADA | 20 | $0 | — | Held |
| Avion Wealth | 40 | $0 | — | Held |