| Darwin Global Management, Ltd. | 3.03M | $486.9M | — | Held |
| RTW INVESTMENTS, LP | 715.3K | $114.4M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 558.9K | $89.4M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 432.5K | $69.2M | — | Held |
| PERCEPTIVE ADVISORS LLC | 414.2K | $66.3M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 383.1K | $61.3M | — | Held |
| Point72 Asset Management, L.P. | 284.4K | $45.5M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 233.8K | $37.4M | — | Held |
| MARSHALL WACE, LLP | 192.7K | $30.8M | — | Held |
| UBS Group AG | 128.8K | $20.6M | — | Held |
| MPM BIOIMPACT LLC | 87.8K | $14M | — | Held |
| Holocene Advisors, LP | 84.1K | $13.4M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 79.4K | $12.7M | — | Held |
| Western Standard LLC | 60K | $9.6M | — | Held |
| GOLDMAN SACHS GROUP INC | 44.6K | $7.13M | — | Held |
| Soleus Capital Management, L.P. | 40.4K | $6.46M | — | Held |
| ADAR1 Capital Management, LLC | 39.8K | $6.37M | — | Held |
| JANE STREET GROUP, LLC | 32.3K | $5.17M | — | Held |
| MORGAN STANLEY | 28K | $4.48M | $449.6K | Added$4.09M |
| Squadron Capital Management LLC | 26K | $4.16M | — | Held |
| Quadrature Capital Ltd | 24.8K | $3.97M | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 24.7K | $3.95M | — | Held |
| Affinity Asset Advisors, LLC | 20K | $3.2M | — | Held |
| PFM Health Sciences, LP | 19.8K | $3.17M | — | Held |
| Woodline Partners LP | 18K | $2.89M | — | Held |
| Artia Global Partners LP | 18K | $2.88M | — | Held |
| State Street | 15.7K | $2.52M | — | Held |
| BANK OF MONTREAL /CAN/ | 15.5K | $2.5M | — | Held |
| Exome Asset Management LLC | 14.3K | $2.29M | — | Held |
| AMERIPRISE FINANCIAL INC | 13.2K | $2.11M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 11.9K | $1.9M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 10.4K | $1.67M | — | Held |
| STEMPOINT CAPITAL LP | 9.16K | $1.47M | — | Held |
| Seven Fleet Capital Management LP | 9.16K | $1.47M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 6.2K | $991.4K | — | Held |
| Citadel | 5.05K | $808.6K | — | Held |
| SmartHarvest Portfolios, LLC | 4.18K | $669.3K | — | Held |
| BARCLAYS PLC | 4.18K | $668K | — | New |
| High Net Worth Advisory Group LLC | 3.5K | $559.9K | — | Held |
| PSP Research LLC | 3.44K | $550.7K | — | Held |
| Y-Intercept (Hong Kong) Ltd | 3.15K | $504.2K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 3.12K | $498.9K | — | Held |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 3.05K | $487.7K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 2.45K | $391.6K | — | Held |
| Yeomans Consulting Group, Inc. | 2.4K | $383.7K | — | Held |
| CITIGROUP INC | 2.14K | $341.8K | — | Held |
| ROYAL BANK OF CANADA | 2.09K | $334K | — | Held |
| INDEPENDENT FINANCIAL GROUP, LLC | 2K | $319.9K | — | New |
| Virtus Investment Advisers, LLC | 1.88K | $301K | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.85K | $296.2K | $100.7K | Added$209.6K |
| Brooklyn Investment Group | 1.74K | $287.4K | — | Held |
| GAMMA Investing LLC | 1.78K | $284.6K | — | Held |
| EverSource Wealth Advisors, LLC | 1.6K | $255.6K | — | Held |
| Independent Advisor Alliance | 1.32K | $211K | — | Held |
| Persistent Asset Partners Ltd | 673 | $107.7K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 645 | $103.2K | — | Held |
| Caitong International Asset Management Co., Ltd | 549 | $87.8K | — | Held |
| China Universal Asset Management Co., Ltd. | 500 | $80K | — | Held |
| OSAIC HOLDINGS, INC. | 195 | $31.2K | — | Held |
| Farther Finance Advisors, LLC | 101 | $16.2K | — | Held |
| WELLS FARGO & COMPANY/MN | 100 | $16K | — | Held |
| TD Waterhouse Canada Inc. | 70 | $11.2K | — | Held |
| SBI Securities Co., Ltd. | 50 | $8K | — | Held |
| Rossby Financial, LCC | 13 | $2.08K | — | Held |
| HRT FINANCIAL LP | 8.16K | $1.3K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 6 | $960 | — | Held |
| JPMORGAN CHASE & CO | 3 | $480 | — | Held |
| SG Americas Securities, LLC | 2.75K | $441 | — | Held |
| GSA CAPITAL PARTNERS LLP | 1.46K | $234 | — | Held |