| RA CAPITAL MANAGEMENT, L.P. | 6.96M | $117.1M | — | Held |
| Siren, L.L.C. | 5.22M | $87.8M | — | Held |
| Vestal Point Capital, LP | 3.58M | $60.2M | — | Held |
| Fidelity | 3.35M | $56.3M | — | Held |
| RED TREE MANAGEMENT, LLC | 3.17M | $53.4M | — | Held |
| TPG GP A, LLC | 3.01M | $50.7M | — | Held |
| Royalty Pharma Sub-Manager, LLC | 1.26M | $45.9M | — | Held |
| JANUS HENDERSON GROUP PLC | 2.65M | $44.5M | — | Held |
| Deep Track Capital, LP | 2.61M | $44M | — | Held |
| BlackRock, Inc. | 2.53M | $42.6M | — | Held |
| Omega Fund Management, LLC | 2.2M | $37.1M | — | Held |
| Vanguard | 2.19M | $36.8M | — | Held |
| State Street | 1.65M | $27.8M | — | Held |
| FRANKLIN RESOURCES INC | 1.62M | $27.3M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 811.4K | $13.7M | — | Held |
| Citadel | 772.3K | $13M | — | Held |
| FIL Ltd | 758.5K | $12.8M | — | Held |
| ACORN CAPITAL ADVISORS, LLC | 643.4K | $10.8M | — | Held |
| Aisling Capital Management LP | 568.9K | $9.57M | — | Held |
| GOLDMAN SACHS GROUP INC | 552.3K | $9.3M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 434.7K | $7.32M | — | Held |
| Rock Springs Capital Management LP | 429.1K | $7.22M | — | Held |
| Ensign Peak Advisors, Inc | 401.4K | $6.76M | — | Held |
| NAN FUNG TRINITY (HK) LTD | 372.4K | $6.27M | — | Held |
| BANK OF AMERICA CORP /DE/ | 335.7K | $5.65M | $349.1K | Cut−$1.56M |
| Clearbridge Investments, LLC | 298.8K | $5.03M | — | Held |
| Palo Alto Investors LP | 298.6K | $5.03M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 272.1K | $4.58M | — | Held |
| DAFNA Capital Management LLC | 261.6K | $4.4M | — | Held |
| TD Asset Management Inc | 244.6K | $4.12M | — | Held |
| NORTHERN TRUST CORP | 237.1K | $3.99M | — | Held |
| Woodline Partners LP | 232.7K | $3.92M | — | Held |
| ORBIMED ADVISORS LLC | 209.1K | $3.52M | — | Held |
| UBS Group AG | 192.2K | $3.23M | — | Held |
| Hudson Bay Capital Management LP | 150K | $2.52M | — | New |
| D. E. Shaw & Co., Inc. | 136.5K | $2.3M | — | Held |
| DEUTSCHE BANK AG\ | 128.6K | $2.16M | — | Held |
| Napean Trading & Investment Co (Singapore) PTE Ltd | 113.8K | $1.91M | — | Held |
| Atle Fund Management AB | 111.4K | $1.87M | — | Held |
| MORGAN STANLEY | 109.5K | $1.84M | $104K | Added$262.7K |
| BARCLAYS PLC | 103.2K | $1.74M | $50.1K | Added$977.3K |
| Soleus Capital Management, L.P. | 100K | $1.68M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 98.5K | $1.66M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 95.9K | $1.61M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 98.9K | $1.6M | — | Held |
| Bank of New York Mellon Corp | 88.7K | $1.49M | — | Held |
| JANE STREET GROUP, LLC | 85.6K | $1.44M | — | Held |
| CITIGROUP INC | 66.7K | $1.12M | — | Held |
| Mariner, LLC | 64.6K | $1.09M | — | Held |
| Shay Capital LLC | 64.3K | $1.08M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 59.9K | $1.01M | — | Held |
| Rafferty Asset Management, LLC | 59.8K | $1.01M | — | Held |
| Russell Investments Group, Ltd. | 56.6K | $952.6K | — | Held |
| SCS Capital Management LLC | 53.4K | $899.2K | — | Held |
| ALPS ADVISORS INC | 45K | $757K | — | Held |
| NORGES BANK | 42.9K | $721.8K | $163K | Added$163K |
| DIMENSIONAL FUND ADVISORS LP | 40.9K | $688.9K | — | Held |
| RHUMBLINE ADVISERS | 40.6K | $683K | — | Held |
| Nuveen, LLC | 38.8K | $653.7K | — | Held |
| DARK FOREST CAPITAL MANAGEMENT LP | 37.6K | $633.4K | — | Held |
| Trexquant Investment LP | 37.1K | $624.3K | — | Held |
| WELLS FARGO & COMPANY/MN | 35.2K | $593.1K | — | Held |
| XTX Topco Ltd | 34.1K | $573.3K | — | Held |
| Swiss National Bank | 32.3K | $543.6K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30.7K | $516.6K | — | Held |
| Bleakley Financial Group, LLC | 29.2K | $491.1K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 29.1K | $489.9K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 27.4K | $461K | $19.5K | Added$165.2K |
| AMERICAN CENTURY COMPANIES INC | 24.5K | $412.2K | — | Held |
| Caption Management, LLC | 23K | $387.1K | — | Held |
| PROFUND ADVISORS LLC | 22.2K | $373.2K | — | Held |
| Creative Planning | 21.8K | $367.5K | — | Held |
| MetLife Investment Management, LLC | 21.5K | $362.2K | — | Held |
| Invesco Ltd. | 21K | $353.5K | — | Held |
| Jump Financial, LLC | 21K | $353.2K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 18.2K | $306.2K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18.1K | $302.8K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17.2K | $288.8K | — | Held |
| GROUP ONE TRADING LLC | 16.9K | $284.7K | — | Held |
| JPMORGAN CHASE & CO | 16.8K | $283.5K | — | Held |
| AMERIPRISE FINANCIAL INC | 16K | $269.8K | — | Held |
| Legal & General Group Plc | 16K | $268.6K | — | Held |
| VARCOV Co. | 15.7K | $263.4K | — | Held |
| Quantinno Capital Management LP | 15.2K | $255.2K | — | Held |
| Virtus Investment Advisers, LLC | 14.4K | $242.3K | — | Held |
| LPL Financial LLC | 14.3K | $240.4K | — | Held |
| Ascent Group, LLC | 14.2K | $238.2K | — | Held |
| Brevan Howard Capital Management LP | 14.1K | $237.6K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 14.1K | $237.4K | — | Held |
| ADAR1 Capital Management, LLC | 13.7K | $230.7K | — | Held |
| Graham Capital Management, L.P. | 13.1K | $220.7K | — | Held |
| Orion Porfolio Solutions, LLC | 11.3K | $189.8K | — | Held |
| LETKO, BROSSEAU & ASSOCIATES INC | 11.2K | $188.1K | — | Held |
| Aquatic Capital Management LLC | 11.1K | $187.3K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 10.1K | $169.5K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 9.84K | $165.5K | — | Held |
| China Universal Asset Management Co., Ltd. | 8.93K | $150.2K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 7.5K | $126.2K | — | Held |
| Caitong International Asset Management Co., Ltd | 5.78K | $97.2K | — | Held |
| Avanza Fonder AB | 5.04K | $84.8K | — | Held |
| OSAIC HOLDINGS, INC. | 4.49K | $75.6K | — | Held |
| SIMPLEX TRADING, LLC | 4.17K | $70.1K | — | Held |
| Larson Financial Group LLC | 3.56K | $59.9K | — | Held |
| KLP KAPITALFORVALTNING AS | 3.5K | $58.9K | — | Held |
| T. Rowe Price Investment Management, Inc. | 3.24M | $54.5K | — | Held |
| Ameritas Investment Partners, Inc. | 2.89K | $48.7K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.66K | $44.8K | — | Held |
| Sterling Capital Management LLC | 1.72K | $28.9K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.56M | $26.2K | — | Held |
| GAMMA Investing LLC | 1.13K | $18.9K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.08K | $18.1K | — | Held |
| ROYAL BANK OF CANADA | 1.08K | $18K | — | Held |
| Tower Research Capital LLC (TRC) | 684 | $11.5K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 570 | $9.59K | — | Held |
| PNC Financial Services Group, Inc. | 319 | $5.37K | — | Held |
| ALGERT GLOBAL LLC | 318.3K | $5.36K | — | Held |
| EverSource Wealth Advisors, LLC | 309 | $5.2K | — | Held |
| Smartleaf Asset Management LLC | 274 | $4.42K | — | Held |
| US BANCORP \DE\ | 234 | $3.94K | — | Held |
| PRIVATE TRUST CO NA | 225 | $3.79K | — | Held |
| Rockefeller Capital Management L.P. | 121 | $2.04K | — | Held |
| Global Retirement Partners, LLC | 118 | $1.99K | — | Held |
| Versant Capital Management, Inc | 108 | $1.82K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 76 | $1.28K | — | Held |
| Farther Finance Advisors, LLC | 67 | $1.13K | — | Held |
| BELLEVUE ASSET MANAGEMENT, LLC | 61 | $1.03K | — | Held |
| Allworth Financial LP | 53 | $892 | $43 | Added$228 |
| HRT FINANCIAL LP | 50.1K | $843 | — | Held |
| MAI Capital Management | 45 | $758 | — | Held |
| CoreCap Advisors, LLC | 32 | $539 | — | Held |
| WPG Advisers, LLC | 26 | $438 | — | Held |
| True Wealth Design, LLC | 23 | $388 | — | Held |
| COMERICA BANK | 12 | $202 | — | Held |
| SG Americas Securities, LLC | 11.1K | $187 | — | Held |
| Stone House Investment Management, LLC | 10 | $168 | — | Held |
| Essential Partners LLC | 9 | $151 | $9 | Added$9 |
| Arax Advisory Partners | 3 | $50 | — | Held |
| CWM, LLC | 1.16K | $19 | — | Held |
| Aster Capital Management (DIFC) Ltd | 1 | $17 | — | Held |
| AMALGAMATED BANK | 989 | $17 | — | Held |
| Daiwa Securities Group Inc. | 182 | $3 | — | Held |