| GILEAD SCIENCES, INC. | 6.72M | $438.2M | — | Held |
| Paradigm Biocapital Advisors LP | 5.72M | $373.2M | — | Held |
| Vanguard | 4.08M | $266.1M | — | Held |
| Fidelity | 3.56M | $232.4M | — | Held |
| BlackRock, Inc. | 3.55M | $231.4M | — | Held |
| NEA Management Company, LLC | 3.05M | $198.6M | — | Held |
| Vestal Point Capital, LP | 2.92M | $190.7M | — | Held |
| SR One Capital Management, LP | 2.35M | $153M | — | Held |
| State Street | 2M | $130.3M | — | Held |
| Citadel | 1.5M | $97.8M | — | Held |
| PERCEPTIVE ADVISORS LLC | 1.47M | $95.6M | — | Held |
| JPMORGAN CHASE & CO | 1.45M | $94.8M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 1.27M | $82.6M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 958.1K | $62.5M | — | Held |
| JANUS HENDERSON GROUP PLC | 919.6K | $60M | — | Held |
| Woodline Partners LP | 737.8K | $48.1M | — | Held |
| GOLDMAN SACHS GROUP INC | 668.5K | $43.6M | — | Held |
| BAMCO INC /NY/ | 609.7K | $39.8M | — | Held |
| Affinity Asset Advisors, LLC | 523.7K | $34.1M | — | Held |
| MORGAN STANLEY | 518.4K | $33.8M | −$7.32M | Cut−$1.74M |
| BANK OF AMERICA CORP /DE/ | 427.8K | $27.9M | −$2.89M | Added$13.8M |
| AMERICAN CENTURY COMPANIES INC | 419.1K | $27.3M | — | Held |
| Hudson Bay Capital Management LP | 400.9K | $26.1M | — | New |
| Pictet Asset Management Holding SA | 342.6K | $22.3M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 339.8K | $22.2M | — | Held |
| Hood River Capital Management LLC | 335.5K | $21.9M | — | Held |
| STEMPOINT CAPITAL LP | 332.9K | $21.7M | — | Held |
| Fisher Asset Management, LLC | 322.9K | $21.1M | — | Held |
| NORTHERN TRUST CORP | 321.8K | $21M | — | Held |
| UBS Group AG | 316.6K | $20.6M | — | Held |
| TD Asset Management Inc | 300.9K | $19.6M | — | Held |
| DEUTSCHE BANK AG\ | 233.6K | $15.2M | — | Held |
| AJU IB Investment Co., Ltd. | 223.5K | $14.6M | — | Held |
| ExodusPoint Capital Management, LP | 217.4K | $14.2M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 214.8K | $14M | — | Held |
| Integral Health Asset Management, LLC | 200K | $13M | — | Held |
| BARCLAYS PLC | 196.8K | $12.8M | −$1.82M | Added$3.99M |
| Rock Springs Capital Management LP | 169.9K | $11.1M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 168.7K | $11M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 161K | $10.5M | — | Held |
| CITIGROUP INC | 156.5K | $10.2M | — | Held |
| Catalio Capital Management, LP | 156.1K | $10.2M | — | Held |
| Rhenman & Partners Asset Management AB | 133.5K | $8.7M | — | Held |
| Russell Investments Group, Ltd. | 130.5K | $8.51M | — | Held |
| CLOUGH CAPITAL PARTNERS L P | 129.8K | $8.46M | — | Held |
| Parkman Healthcare Partners LLC | 128.1K | $8.35M | — | Held |
| Bank of New York Mellon Corp | 123.2K | $8.03M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 122.3K | $7.79M | — | Held |
| Logos Global Management LP | 115K | $7.5M | — | Held |
| Schonfeld Strategic Advisors LLC | 99.1K | $6.46M | — | Held |
| Qube Research & Technologies Ltd | 97.9K | $6.38M | — | Held |
| Candriam S.C.A. | 96.4K | $6.29M | — | Held |
| Nuveen, LLC | 81.9K | $5.34M | — | Held |
| HighVista Strategies LLC | 75K | $4.89M | — | Held |
| XTX Topco Ltd | 72.6K | $4.73M | — | Held |
| Rafferty Asset Management, LLC | 69.5K | $4.53M | — | Held |
| AMERIPRISE FINANCIAL INC | 69.2K | $4.51M | — | Held |
| SAMSARA BIOCAPITAL, LLC | 60.9K | $3.97M | — | Held |
| Aberdeen Group plc | 60.4K | $3.94M | — | Held |
| Brevan Howard Capital Management LP | 60.2K | $3.92M | — | Held |
| Pier Capital, LLC | 59.1K | $3.85M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 57.3K | $3.67M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 54.9K | $3.58M | — | Held |
| Swiss National Bank | 54.7K | $3.57M | — | Held |
| JANE STREET GROUP, LLC | 54.7K | $3.56M | — | Held |
| WELLS FARGO & COMPANY/MN | 54.3K | $3.54M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 50.9K | $3.32M | — | Held |
| Squarepoint Ops LLC | 49.9K | $3.25M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 46K | $3M | — | New |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 45.5K | $2.97M | — | Held |
| RHUMBLINE ADVISERS | 44.4K | $2.89M | — | Held |
| Atle Fund Management AB | 41.7K | $2.72M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 42.5K | $2.7M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 40.8K | $2.66M | — | Held |
| Invesco Ltd. | 40.4K | $2.63M | — | Held |
| NEOS Investment Management LLC | 39.9K | $2.6M | — | Held |
| TEMA ETFS LLC | 39.3K | $2.56M | — | Held |
| ADAR1 Capital Management, LLC | 31.5K | $2.05M | — | Held |
| J. Goldman & Co LP | 31.2K | $2.04M | — | Held |
| Soleus Capital Management, L.P. | 30K | $1.96M | — | Held |
| Legal & General Group Plc | 29.6K | $1.93M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27.1K | $1.77M | — | Held |
| CONGRESS ASSET MANAGEMENT CO | 26K | $1.7M | — | Held |
| PROFUND ADVISORS LLC | 25.7K | $1.68M | — | Held |
| Knott David M Jr | 25.7K | $1.68M | — | Held |
| D. E. Shaw & Co., Inc. | 25.2K | $1.64M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 24.5K | $1.6M | — | Held |
| Erste Asset Management GmbH | 21K | $1.37M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 20.9K | $1.36M | — | Held |
| FIRST TRUST ADVISORS LP | 20.9K | $1.36M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20K | $1.3M | — | Held |
| MetLife Investment Management, LLC | 19.3K | $1.26M | — | Held |
| STRS OHIO | 16.9K | $1.1M | — | Held |
| PRUDENTIAL FINANCIAL INC | 16.7K | $1.09M | — | Held |
| NORGES BANK | 16.7K | $1.09M | −$4.49K | Added$353.2K |
| SEI INVESTMENTS CO | 15.7K | $1.02M | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 15K | $980K | — | Held |
| Trexquant Investment LP | 14.9K | $972.5K | — | Held |
| Jasper Ridge Partners, L.P. | 13.9K | $909.3K | — | Held |
| HighTower Advisors, LLC | 12.6K | $818.8K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 11.6K | $757.8K | — | Held |
| Shay Capital LLC | 11.4K | $743.3K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11.1K | $724.8K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 10.8K | $707.4K | — | Held |
| MARTINGALE ASSET MANAGEMENT L P | 10.6K | $692.3K | — | Held |
| T. Rowe Price Investment Management, Inc. | 10.6M | $688.5K | — | Held |
| FRANKLIN RESOURCES INC | 10.1K | $660.5K | — | Held |
| Gotham Asset Management, LLC | 9.84K | $641.7K | — | Held |
| LPL Financial LLC | 9.62K | $627.4K | — | Held |
| State of New Jersey Common Pension Fund D | 9.46K | $617.1K | — | Held |
| China Universal Asset Management Co., Ltd. | 9.42K | $614.3K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 9.07K | $591.6K | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 8.9K | $580.5K | — | Held |
| MILLENNIUM MANAGEMENT LLC | 8.82K | $575.1K | — | Held |
| ProShare Advisors LLC | 8.82K | $574.9K | — | Held |
| GUGGENHEIM CAPITAL LLC | 8.54K | $556.7K | — | Held |
| MARSHALL WACE, LLP | 8.44K | $550.4K | — | Held |
| PSP Research LLC | 8.22K | $536.2K | — | Held |
| High Net Worth Advisory Group LLC | 8K | $521.6K | — | Held |
| Icahn Capital | 7.96K | $519K | — | Held |
| ASPIRIANT, LLC | 7.91K | $515.7K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 7.61K | $496.4K | — | Held |
| Headlands Technologies LLC | 7.32K | $477.3K | — | Held |
| Creative Planning | 7.32K | $477.2K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 7.26K | $473.2K | — | Held |
| TWINBEECH CAPITAL LP | 6.95K | $453.1K | — | Held |
| Allianz Asset Management GmbH | 6.2K | $404.2K | — | Held |
| KLP KAPITALFORVALTNING AS | 5.9K | $384.7K | — | Held |
| BANQUE PICTET & CIE SA | 5.11K | $333.1K | — | Held |
| Advisors Asset Management, Inc. | 4.67K | $304.5K | — | Held |
| Marks Group Wealth Management, Inc | 4.52K | $295K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 4.14K | $270.2K | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 4.11K | $267.8K | — | Held |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 4K | $260.8K | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 4K | $260.8K | −$67.6K | Cut−$67.6K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 3.95K | $257.7K | — | Held |
| Quantinno Capital Management LP | 3.87K | $252.4K | — | Held |
| AlphaQuest LLC | 3.8K | $247.5K | — | Held |
| Harbour Capital Advisors, LLC | 3.83K | $242.3K | — | Held |
| Virtus Investment Advisers, LLC | 3.7K | $241.3K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 3.6K | $235K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 3.53K | $229.9K | — | Held |
| SBI Securities Co., Ltd. | 3.52K | $229.2K | — | Held |
| SIMPLEX TRADING, LLC | 3.41K | $222.6K | — | Held |
| Man Group plc | 3.32K | $216.6K | — | Held |
| Advisory Alpha, LLC | 3.31K | $216K | — | Held |
| Mariner, LLC | 3.11K | $205.8K | — | Held |
| Ameritas Investment Partners, Inc. | 2.86K | $186.5K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.81K | $183.2K | — | Held |
| Avanza Fonder AB | 2K | $130.6K | — | Held |
| GROUP ONE TRADING LLC | 1.97K | $128.4K | — | Held |
| Caption Management, LLC | 1.82K | $119K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.61M | $105K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.14K | $74.1K | — | Held |
| ROYAL BANK OF CANADA | 1.01K | $66K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 967 | $63K | — | Held |
| US BANCORP \DE\ | 948 | $61.8K | — | Held |
| FEDERATED HERMES, INC. | 697 | $45.4K | — | Held |
| State of Wyoming | 537 | $35K | — | Held |
| Ramirez Asset Management, Inc. | 500 | $32.6K | — | Held |
| LORD, ABBETT & CO. LLC | 449.6K | $29.3K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 429 | $28K | — | Held |
| Tower Research Capital LLC (TRC) | 427 | $27.8K | — | Held |
| PNC Financial Services Group, Inc. | 425 | $27.7K | — | Held |
| GAMMA Investing LLC | 334 | $21.8K | — | Held |
| Smartleaf Asset Management LLC | 317 | $20.2K | — | Held |
| Versant Capital Management, Inc | 243 | $15.8K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 176 | $15.4K | — | Held |
| Sterling Capital Management LLC | 229 | $14.9K | — | Held |
| Keating Financial Advisory Services, Inc. | 210 | $13.7K | — | Held |
| Kemnay Advisory Services Inc. | 179 | $11.7K | — | Held |
| Pinnacle Wealth Planning Services, Inc. | 160 | $10.4K | — | Held |
| Arax Advisory Partners | 151 | $9.85K | — | Held |
| EverSource Wealth Advisors, LLC | 110 | $7.17K | — | Held |
| Rockefeller Capital Management L.P. | 97 | $6.32K | — | Held |
| OSAIC HOLDINGS, INC. | 94 | $6.13K | — | Held |
| Larson Financial Group LLC | 79 | $5.15K | — | Held |
| COMERICA BANK | 61 | $3.98K | — | Held |
| Parallel Advisors, LLC | 55 | $3.59K | — | Held |
| ASSETMARK, INC | 50 | $3.26K | — | Held |
| Aventura Private Wealth, LLC | 45 | $2.93K | −$761 | Cut−$761 |
| Optiver Holding B.V. | 44 | $2.87K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 40 | $2.61K | — | Held |
| SIGNATUREFD, LLC | 36 | $2.35K | — | Held |
| DekaBank Deutsche Girozentrale | 30K | $2.3K | — | Held |
| HUNTINGTON NATIONAL BANK | 32 | $2.09K | — | Held |
| Parkside Financial Bank & Trust | 29 | $1.89K | — | Held |
| Farther Finance Advisors, LLC | 27 | $1.76K | — | Held |
| Fortitude Family Office, LLC | 26 | $1.7K | — | Held |
| Bare Financial Services, Inc | 25 | $1.63K | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 25 | $1.63K | — | Held |
| HARBOR CAPITAL ADVISORS, INC. | 24.1K | $1.57K | — | Held |
| Allworth Financial LP | 24 | $1.56K | −$406 | Cut−$734 |
| FIRST HORIZON CORP | 23 | $1.5K | — | Held |
| IFP Advisors, Inc | 20 | $1.3K | −$67 | Added$976 |
| Cornerstone Financial Management LLC | 15 | $978 | — | Held |
| QUADRANT CAPITAL GROUP LLC | 14 | $913 | — | Held |
| Handelsbanken Fonder AB | 13K | $848 | — | Held |
| SG Americas Securities, LLC | 12K | $785 | — | Held |
| Blue Trust, Inc. | 8 | $522 | — | Held |
| Bell Investment Advisors, Inc | 7 | $457 | — | Held |
| Steward Partners Investment Advisory, LLC | 7 | $456 | — | Held |
| TD Capital Management LLC | 5 | $326 | — | Held |
| Global Retirement Partners, LLC | 5 | $326 | — | Held |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 3.22K | $210 | — | Held |
| TD PRIVATE CLIENT WEALTH LLC | 2 | $130 | — | Held |
| Hughes Financial Services, LLC | 2 | $130 | — | Held |
| AMALGAMATED BANK | 1.08K | $70 | — | Held |
| KBC Group NV | 1.06K | $69 | −$18 | Cut−$18 |
| TFC Financial Management, Inc. | 1 | $66 | — | Held |
| MassMutual Private Wealth & Trust, FSB | 1 | $65 | — | Held |
| Dunhill Financial, LLC | 1 | $44 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 366 | $24 | — | Held |
| Covestor Ltd | 225 | $15 | — | Held |
| CWM, LLC | 201 | $13 | — | Held |
| Daiwa Securities Group Inc. | 174 | $11 | — | Held |
| BESSEMER GROUP INC | 30 | $2 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |