| ORBIMED ADVISORS LLC | 1.03M | $8.66M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 948.2K | $7.98M | — | Held |
| FRANKLIN RESOURCES INC | 626.6K | $5.28M | — | Held |
| Woodline Partners LP | 625K | $5.26M | — | Held |
| Vanguard | 291.3K | $2.45M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 274.4K | $2.31M | — | Held |
| Prosight Management, LP | 250.2K | $2.11M | — | Held |
| Renaissance Technologies | 242.9K | $2.05M | — | Held |
| GOLDMAN SACHS GROUP INC | 234.5K | $1.97M | — | Held |
| Stonepine Capital Management, LLC | 220K | $1.85M | — | Held |
| Alyeska Investment Group, L.P. | 203.8K | $1.72M | — | Held |
| Carlyle Group Inc. | 184.3K | $1.54M | — | Held |
| NEXTBio Capital Management LP | 157.8K | $1.33M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 144.8K | $1.22M | — | Held |
| ADAR1 Capital Management, LLC | 128.6K | $1.08M | — | Held |
| TWO SIGMA ADVISERS, LP | 111.3K | $937.4K | — | Held |
| Citadel | 107.8K | $907.8K | — | Held |
| DAFNA Capital Management LLC | 93.8K | $789.9K | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 88.9K | $748.3K | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 62.5K | $526.3K | — | Held |
| REGENERON PHARMACEUTICALS, INC. | 60.5K | $509.5K | — | Held |
| LUMINUS MANAGEMENT LLC | 59.6K | $501.5K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 56.4K | $474.5K | — | Held |
| Squarepoint Ops LLC | 55.7K | $469.2K | — | Held |
| RBF Capital, LLC | 38.6K | $324.9K | — | Held |
| BlackRock, Inc. | 36.6K | $308K | — | Held |
| Maven Securities LTD | 31.3K | $263.1K | — | Held |
| State Street | 25.9K | $218K | — | Held |
| Rangeley Capital, LLC | 25K | $210.5K | — | Held |
| BARCLAYS PLC | 25K | $210.5K | $190.2K | Cut−$32.6K |
| JOHNSON & JOHNSON | 22.8K | $191.8K | $173.3K | Cut−$103.5K |
| XTX Topco Ltd | 18.6K | $156.7K | — | Held |
| NORTHERN TRUST CORP | 14.1K | $118.4K | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 6.16K | $51.9K | — | Held |
| ROYAL BANK OF CANADA | 5.45K | $46K | — | Held |
| UBS Group AG | 3.8K | $32K | — | Held |
| MORGAN STANLEY | 3.04K | $25.6K | $23.1K | Cut−$34.1K |
| BANK OF AMERICA CORP /DE/ | 1.29K | $10.8K | $9.8K | Cut−$5.85K |
| Tower Research Capital LLC (TRC) | 1.07K | $9.03K | — | Held |
| HOLLENCREST CAPITAL MANAGEMENT | 250 | $2.1K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 181.4K | $1.52K | — | Held |
| SIMPLEX TRADING, LLC | 87 | $732 | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 50 | $421 | — | Held |
| Fidelity | 34 | $286 | — | Held |
| SBI Securities Co., Ltd. | 19 | $160 | — | Held |
| GSA CAPITAL PARTNERS LLP | 17.8K | $150 | — | Held |
| JPMORGAN CHASE & CO | 12 | $101 | — | Held |
| FNY Investment Advisers, LLC | 6.1K | $51 | — | New |
| DANSKE BANK A/S | 1 | $8 | — | New |