| Nantahala Capital Management, LLC | 5.01M | $22.5M | −$3.92M | Cut−$3.7M |
| BlackRock, Inc. | 3.2M | $14.3M | −$2.5M | Cut−$2.34M |
| AIGH Capital Management LLC | 3.1M | $13.9M | −$1.58M | Added$3.35M |
| Cable Car Capital, LP | 3.01M | $13.5M | −$1.97M | Added$297.8K |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2.68M | $12M | −$2.11M | Cut−$2.11M |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.16M | $9.7M | — | Held |
| Propel Bio Management, LLC | 1.33M | $6.01M | −$625.1K | Added$1.63M |
| KENNEDY CAPITAL MANAGEMENT LLC | 1.26M | $5.66M | −$829.6K | Added$126.5K |
| GEODE CAPITAL MANAGEMENT, LLC | 1.21M | $5.42M | −$897.3K | Cut−$571.5K |
| GOLDMAN SACHS GROUP INC | 1.13M | $5.07M | −$396.7K | Added$2.42M |
| State Street | 957.3K | $4.29M | −$709.8K | Cut−$445.9K |
| NAN FUNG TRINITY (HK) LTD | 956.8K | $4.29M | −$755.8K | Cut−$755.8K |
| AWM Investment Company, Inc. | 803.1K | $3.6M | −$611.6K | Cut−$481.6K |
| 683 Capital Management, LLC | 770K | $3.45M | −$608.3K | Cut−$608.3K |
| Stonepine Capital Management, LLC | 746.6K | $3.34M | −$560.5K | Cut−$394.4K |
| SILVERARC CAPITAL MANAGEMENT, LLC | 648.9K | $2.91M | −$495.9K | Cut−$400.9K |
| J. Goldman & Co LP | 640.5K | $2.87M | −$315.1K | Added$767.3K |
| Diametric Capital, LP | 611.5K | $2.74M | −$483.1K | Cut−$920K |
| Balyasny Asset Management L.P. | 589.8K | $2.64M | −$466K | Cut−$475.9K |
| CITIGROUP INC | 522.4K | $2.34M | −$411.7K | Cut−$405.6K |
| Simplify Asset Management Inc. | 508K | $2.28M | −$395.3K | Cut−$361K |
| NATIONAL BANK OF CANADA /FI/ | 500K | $2.24M | — | New |
| Knoll Capital Management, LLC | 485.5K | $2.18M | −$186.4K | Added$931.6K |
| NORTHERN TRUST CORP | 436K | $1.95M | −$331.3K | Cut−$256.7K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 432.4K | $1.94M | −$341.6K | Cut−$1.76M |
| MILLENNIUM MANAGEMENT LLC | 425.4K | $1.91M | −$271.4K | Added$95.3K |
| TANG CAPITAL MANAGEMENT LLC | 400K | $1.79M | −$316K | Cut−$3.48M |
| BANK OF AMERICA CORP /DE/ | 394.3K | $1.77M | −$311.5K | Cut−$908.8K |
| VANGUARD FIDUCIARY TRUST CO | 339.5K | $1.52M | — | Held |
| MORGAN STANLEY | 337.6K | $1.51M | −$266.7K | Cut−$983.9K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 271K | $1.21M | — | Held |
| JPMORGAN CHASE & CO | 266.5K | $1.13M | −$22.2K | Added$1.01M |
| UBS Group AG | 233.9K | $1.05M | −$126.7K | Added$202.7K |
| MARSHALL WACE, LLP | 216.3K | $969K | — | New |
| GROUP ONE TRADING LLC | 209.6K | $939K | −$165.6K | Cut−$768.4K |
| PANAGORA ASSET MANAGEMENT INC | 199.1K | $892.2K | −$131.7K | Added$13.6K |
| Fidelity | 194.8K | $872.8K | −$133.1K | Cut−$15K |
| Bank of New York Mellon Corp | 193.6K | $867.5K | −$153K | Cut−$156.3K |
| SEI INVESTMENTS CO | 172.5K | $772.6K | −$56.2K | Added$397.6K |
| Renaissance Technologies | 161.1K | $721.6K | −$91.8K | Added$109.3K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127.1K | $569.4K | −$100.4K | Cut−$131K |
| ExodusPoint Capital Management, LP | 122.9K | $550.8K | — | New |
| Palo Alto Investors LP | 108.9K | $487.7K | −$86K | Cut−$86K |
| Icahn Capital | 102.6K | $459.9K | −$81.1K | Cut−$143.7K |
| D. E. Shaw & Co., Inc. | 101.1K | $452.8K | −$79.8K | Cut−$105.7K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 93.1K | $417K | −$73.5K | Cut−$168.9K |
| Pale Fire Capital SE | 69.8K | $312.9K | −$55.2K | Cut−$607.8K |
| XTX Topco Ltd | 69.1K | $309.7K | −$39K | Added$49.6K |
| LPL Financial LLC | 65.1K | $291.9K | −$49.7K | Cut−$39.5K |
| Headlands Technologies LLC | 63.3K | $283.8K | — | New |
| Rangeley Capital, LLC | 60K | $268.8K | −$45.5K | Cut−$34.8K |
| Nuveen, LLC | 56.7K | $254.1K | −$44.8K | Cut−$44.8K |
| RHUMBLINE ADVISERS | 55.8K | $250.2K | −$44.1K | Cut−$44.6K |
| Citadel | 55.8K | $250.2K | −$44.1K | Cut−$422.4K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50K | $224K | — | New |
| DEUTSCHE BANK AG\ | 44.9K | $201.3K | −$31.1K | Cut−$6.2K |
| DIMENSIONAL FUND ADVISORS LP | 34.4K | $154K | — | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 33.6K | $150.4K | −$20.1K | Cut−$637K |
| SIMPLEX TRADING, LLC | 31.1K | $139.3K | −$24.6K | Cut−$378.4K |
| Brevan Howard Capital Management LP | 29.3K | $131.1K | −$17.1K | Added$16.7K |
| BARCLAYS PLC | 27.2K | $122.1K | −$21.5K | Cut−$401.3K |
| MetLife Investment Management, LLC | 23.8K | $106.5K | −$18.8K | Cut−$19.7K |
| Invesco Ltd. | 23K | $102.9K | −$18.2K | Cut−$18.6K |
| ALLIANCEBERNSTEIN L.P. | 17.9K | $94.4K | $0 | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20.8K | $93K | −$16K | Cut−$13.7K |
| Riverwater Partners LLC | 19.1K | $85.4K | −$15.1K | Cut−$16.7K |
| Vanguard Global Advisers, LLC | 18.6K | $83.4K | — | Held |
| WELLS FARGO & COMPANY/MN | 16.7K | $74.8K | −$13.2K | Cut−$177.4K |
| Cetera Investment Advisers | 15.8K | $71K | −$12.5K | Cut−$25.2K |
| Russell Investments Group, Ltd. | 14.1K | $63K | −$10.3K | Cut−$6.05K |
| STIFEL FINANCIAL CORP | 14K | $62.6K | — | New |
| ENVESTNET ASSET MANAGEMENT INC | 13.3K | $59.5K | −$10.5K | Cut−$10.6K |
| Legato Capital Management LLC | 13.2K | $59K | −$10.4K | Cut−$10.4K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12.9K | $57.8K | −$10.2K | Cut−$14.1K |
| AMERICAN CENTURY COMPANIES INC | 12.7K | $57K | — | New |
| INTECH INVESTMENT MANAGEMENT LLC | 12.2K | $54.6K | −$9.63K | Cut−$57.4K |
| Police & Firemen's Retirement System of New Jersey | 11K | $49.3K | −$8.69K | Cut−$8.69K |
| Kovack Advisors, Inc. | 10.6K | $48.4K | — | New |
| Truvestments Capital LLC | 10.3K | $46.2K | −$8.14K | Cut−$8.14K |
| BNP PARIBAS FINANCIAL MARKETS | 9.89K | $44.3K | −$7.55K | Cut−$6.05K |
| MAI Capital Management | 9.43K | $42.3K | −$4.44K | Added$12.6K |
| Tower Research Capital LLC (TRC) | 7.52K | $33.7K | −$2.89K | Added$14.4K |
| ROYAL BANK OF CANADA | 6.5K | $29K | −$2.61K | Added$7K |
| Caption Management, LLC | 4.87K | $21.8K | −$3.85K | Cut−$278.7K |
| Allworth Financial LP | 4.5K | $20.2K | −$3.55K | Cut−$3.56K |
| Ameritas Investment Partners, Inc. | 4.46K | $20K | −$3.52K | Cut−$3.52K |
| Legal & General Group Plc | 3.98K | $17.8K | −$3.14K | Cut−$6.46K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3.41K | $15.3K | −$106 | Added$14.6K |
| Federation des caisses Desjardins du Quebec | 3K | $13.4K | — | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2.36K | $10.6K | −$1.87K | Cut−$3.58K |
| NEW YORK STATE COMMON RETIREMENT FUND | 1.7K | $7.53K | −$1.56K | Cut−$1.56K |
| SHP Wealth Management | 1.67K | $7.47K | −$1.32K | Cut−$1.32K |
| OSAIC HOLDINGS, INC. | 1.43K | $6.41K | −$1.13K | Cut−$3.61K |
| Rockefeller Capital Management L.P. | 1.25K | $5.6K | −$988 | Cut−$988 |
| JONES FINANCIAL COMPANIES LLLP | 1K | $4.29K | −$980 | Cut−$980 |
| GAMMA Investing LLC | 909 | $4.07K | −$71 | Added$3.6K |
| Farther Finance Advisors, LLC | 618 | $2.83K | −$427 | Cut−$8.36K |
| Parallel Advisors, LLC | 400 | $1.79K | −$316 | Cut−$316 |
| Sterling Capital Management LLC | 346 | $1.55K | −$273 | Cut−$700 |
| BEACON INVESTMENT ADVISORY SERVICES, INC. | 240 | $1.08K | — | New |
| EverSource Wealth Advisors, LLC | 136 | $609 | — | New |
| PNC Financial Services Group, Inc. | 86 | $385 | −$4 | Added$359 |
| CWM, LLC | 75 | $336 | $246 | Added$336 |
| SBI Securities Co., Ltd. | 74 | $332 | −$58 | Cut−$79 |
| HARBOR CAPITAL ADVISORS, INC. | 35.1K | $157 | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31K | $139 | −$20 | Added$11 |
| Darwin Wealth Management, LLC | 26 | $116 | −$21 | Cut−$21 |