| GSK plc | 18.2M | $310.2M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 18.2M | $309.5M | — | Held |
| Fidelity | 15.1M | $257.3M | — | Held |
| BlackRock, Inc. | 12.6M | $215M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9.79M | $166.4M | — | Held |
| MAVERICK CAPITAL LTD | 9.28M | $157.8M | — | Held |
| Darwin Global Management, Ltd. | 7.3M | $125.2M | — | Held |
| Driehaus Capital Management LLC | 6.58M | $111.9M | — | Held |
| M28 Capital Management LP | 5.66M | $96.3M | — | Held |
| FEDERATED HERMES, INC. | 4.74M | $80.7M | — | Held |
| PRIMECAP MANAGEMENT CO/CA/ | 4.1M | $69.6M | — | Held |
| 683 Capital Management, LLC | 4.01M | $68.3M | — | Held |
| Vanguard | 3.57M | $60.8M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 3.17M | $53.9M | — | Held |
| State Street | 3M | $50.9M | — | Held |
| GOLDMAN SACHS GROUP INC | 2.85M | $48.5M | — | Held |
| Affinity Asset Advisors, LLC | 2.7M | $45.9M | — | Held |
| EMERALD ADVISERS, LLC | 2.46M | $41.7M | — | Held |
| Siren, L.L.C. | 2.45M | $41.6M | — | Held |
| Kynam Capital Management, LP | 2.17M | $36.9M | — | Held |
| LOOMIS SAYLES & CO L P | 2.04M | $34.7M | — | Held |
| Pfizer Inc | 1.88M | $31.9M | — | Held |
| First Light Asset Management, LLC | 1.85M | $31.5M | — | Held |
| Bellevue Group AG | 1.49M | $25.3M | — | Held |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1.41M | $24M | — | Held |
| RTW INVESTMENTS, LP | 1.35M | $22.9M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.19M | $20.3M | — | Held |
| NORTHERN TRUST CORP | 1.03M | $17.6M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1.01M | $17.3M | — | Held |
| JPMORGAN CHASE & CO | 892.9K | $15.2M | — | Held |
| Squarepoint Ops LLC | 883.6K | $15M | — | Held |
| Pictet Asset Management Holding SA | 805.9K | $13.8M | — | Held |
| Citadel | 790K | $13.4M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 749.4K | $12.7M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 722.2K | $12.3M | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 600K | $10.2M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 584.6K | $9.94M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 500K | $8.5M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 492.4K | $8.37M | — | Held |
| Elmind Capital, LP | 447.8K | $7.61M | — | Held |
| Exome Asset Management LLC | 421.5K | $7.17M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 411.5K | $7M | — | Held |
| MORGAN STANLEY | 409.7K | $6.96M | $3.97M | Added$3.25M |
| SPHERA FUNDS MANAGEMENT LTD. | 408.2K | $6.94M | — | Held |
| AMERIPRISE FINANCIAL INC | 398.4K | $6.77M | — | Held |
| F/m Investments LLC | 395.9K | $6.73M | — | Held |
| Trexquant Investment LP | 391.1K | $6.65M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 379K | $6.44M | — | Held |
| Walleye Capital LLC | 378.8K | $6.44M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 365.2K | $6.21M | — | Held |
| BOONE CAPITAL MANAGEMENT LLC | 352.1K | $5.99M | — | Held |
| Woodline Partners LP | 350.5K | $5.96M | — | Held |
| BAKER BROS. ADVISORS LP | 344.1K | $5.85M | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 338.5K | $5.76M | — | Held |
| Nuveen, LLC | 332.7K | $5.66M | — | Held |
| Jain Global LLC | 328.1K | $5.58M | — | Held |
| Bank of New York Mellon Corp | 321.4K | $5.46M | — | Held |
| Jump Financial, LLC | 313.5K | $5.33M | — | Held |
| Newtyn Management, LLC | 300K | $5.1M | — | Held |
| BARCLAYS PLC | 276.8K | $4.71M | $2.64M | Added$2.71M |
| Moody Aldrich Partners LLC | 274.4K | $4.67M | — | Held |
| UBS Group AG | 268.7K | $4.57M | — | Held |
| D. E. Shaw & Co., Inc. | 266.1K | $4.52M | — | Held |
| TD Asset Management Inc | 252.2K | $4.29M | — | Held |
| Informed Momentum Co LLC | 248.8K | $4.23M | — | Held |
| Renaissance Technologies | 236.4K | $4.02M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 234.8K | $3.99M | — | Held |
| PLATINUM INVESTMENT MANAGEMENT LTD | 230.7K | $3.92M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 230.5K | $3.92M | — | Held |
| Swiss National Bank | 219.7K | $3.73M | — | Held |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 203.7K | $3.46M | — | Held |
| Icahn Capital | 202.7K | $3.45M | — | Held |
| WELLS FARGO & COMPANY/MN | 200.9K | $3.42M | — | Held |
| Privium Fund Management B.V. | 193K | $3.28M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 182.7K | $3.13M | — | Held |
| BANK OF AMERICA CORP /DE/ | 182.9K | $3.11M | $1.77M | Cut−$1.76M |
| Invesco Ltd. | 179.9K | $3.06M | — | Held |
| Squadron Capital Management LLC | 175K | $2.98M | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 170.2K | $2.89M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 165K | $2.8M | — | Held |
| Sofinnova Investments, Inc. | 158.2K | $2.69M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 150K | $2.55M | — | Held |
| RHUMBLINE ADVISERS | 141.9K | $2.41M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 134.6K | $2.29M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 112.9K | $1.92M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 112K | $1.9M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 111.2K | $1.89M | — | Held |
| JANE STREET GROUP, LLC | 110.9K | $1.89M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 107.7K | $1.83M | — | Held |
| James J. Burns & Company, LLC | 105.8K | $1.8M | — | Held |
| Itau Unibanco Holding S.A. | 102K | $1.75M | — | Held |
| LMR Partners LLP | 100K | $1.7M | — | Held |
| SEVEN GRAND MANAGERS, LLC | 100K | $1.7M | — | Held |
| DEUTSCHE BANK AG\ | 95.7K | $1.63M | — | Held |
| DARK FOREST CAPITAL MANAGEMENT LP | 95.1K | $1.62M | — | Held |
| Legal & General Group Plc | 94K | $1.6M | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 93.2K | $1.58M | — | Held |
| Prescott Group Capital Management, L.L.C. | 90K | $1.53M | — | Held |
| Knott David M Jr | 90K | $1.53M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 87.1K | $1.48M | — | Held |
| Ikarian Capital, LLC | 85.3K | $1.45M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 82K | $1.39M | — | Held |
| a16z Perennial Management, L.P. | 77.6K | $1.32M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 69.1K | $1.17M | — | Held |
| GROUP ONE TRADING LLC | 68K | $1.16M | — | Held |
| MetLife Investment Management, LLC | 64.8K | $1.1M | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 62.7K | $1.07M | — | Held |
| Cinctive Capital Management LP | 61.8K | $1.05M | — | Held |
| SEI INVESTMENTS CO | 54.5K | $925.8K | — | Held |
| J. Goldman & Co LP | 53.8K | $914K | — | Held |
| JANUS HENDERSON GROUP PLC | 51.7K | $877.6K | — | Held |
| Russell Investments Group, Ltd. | 49.9K | $848.4K | — | Held |
| SIG BROKERAGE, LP | 48.4K | $822.5K | — | Held |
| CITIGROUP INC | 46.8K | $794.9K | — | Held |
| GLENMEDE TRUST CO NA | 42.7K | $726.4K | — | Held |
| Matisse Capital | 42.2K | $717.3K | — | Held |
| Gainplan LLC | 40K | $679.5K | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 39.8K | $676.9K | — | Held |
| China Universal Asset Management Co., Ltd. | 39.7K | $675.6K | — | Held |
| Quantinno Capital Management LP | 38.9K | $661.7K | — | Held |
| State of New Jersey Common Pension Fund D | 38K | $646.4K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 35.9K | $610.6K | — | Held |
| Walleye Trading LLC | 33.2K | $565.1K | — | Held |
| Mitsubishi UFJ Asset Management Co., Ltd. | 33.8K | $539.7K | — | Held |
| Man Group plc | 31.4K | $534.1K | — | Held |
| PSP Research LLC | 31K | $527.7K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 31K | $527.6K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 30.7K | $521.3K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 30.6K | $521K | — | Held |
| Entropy Technologies, LP | 30.6K | $520.4K | — | Held |
| Vestmark Advisory Solutions, Inc. | 30.4K | $517.2K | — | Held |
| ProShare Advisors LLC | 28.5K | $485.1K | — | Held |
| AlphaCentric Advisors LLC | 27.6K | $469K | — | Held |
| EXCHANGE TRADED CONCEPTS, LLC | 25.6K | $435.5K | — | Held |
| Orion Porfolio Solutions, LLC | 25K | $425.5K | — | Held |
| KLP KAPITALFORVALTNING AS | 24K | $408K | — | Held |
| ROYAL BANK OF CANADA | 23.2K | $396K | — | Held |
| HighTower Advisors, LLC | 22.8K | $388.1K | — | Held |
| Allianz Asset Management GmbH | 22K | $374K | — | Held |
| SIMPLEX TRADING, LLC | 21.1K | $359.1K | — | Held |
| Advisory Services Network, LLC | 20.9K | $355.3K | — | Held |
| Persistent Asset Partners Ltd | 19.8K | $337.1K | — | New |
| FORA Capital, LLC | 19.2K | $326.3K | — | Held |
| Creative Planning | 18.1K | $308.1K | — | Held |
| Cresset Asset Management, LLC | 17.9K | $304.8K | $145.4K | Added$194.8K |
| HSBC HOLDINGS PLC | 17K | $290.9K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16.9K | $288.1K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 16.4K | $279.5K | — | Held |
| Virtus Investment Advisers, LLC | 16.1K | $273.1K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 15.7K | $267.3K | — | Held |
| Scientech Research LLC | 15.6K | $264.7K | — | Held |
| WINTON GROUP Ltd | 14.7K | $249.9K | — | Held |
| PROFUND ADVISORS LLC | 14.6K | $247.9K | — | Held |
| Savant Capital, LLC | 13K | $220.2K | — | New |
| FIRST TRUST ADVISORS LP | 11.7K | $198.7K | — | Held |
| Rafferty Asset Management, LLC | 11.6K | $196.5K | — | Held |
| Palumbo Wealth Management LLC | 11.4K | $193.1K | — | Held |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 10.7K | $181.9K | — | Held |
| INCEPTIONR LLC | 10.6K | $180.8K | — | Held |
| Caitong International Asset Management Co., Ltd | 10.4K | $176.1K | — | Held |
| Tower Research Capital LLC (TRC) | 9.53K | $162K | — | Held |
| Ameritas Investment Partners, Inc. | 9.36K | $159.2K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 8.12K | $138.1K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 7.41M | $125.9K | — | Held |
| US BANCORP \DE\ | 6.26K | $106.5K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 3.29K | $55.8K | — | Held |
| Ancora Advisors LLC | 3K | $51K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 2.4K | $40.7K | — | Held |
| Smartleaf Asset Management LLC | 2.24K | $38.5K | — | Held |
| Farther Finance Advisors, LLC | 1.95K | $33.1K | — | Held |
| Sterling Capital Management LLC | 1.42K | $24.2K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 1.31K | $22.2K | — | Held |
| OSAIC HOLDINGS, INC. | 1.18K | $20K | — | Held |
| Rockefeller Capital Management L.P. | 861 | $14.6K | — | Held |
| Larson Financial Group LLC | 842 | $14.3K | — | Held |
| GAMMA Investing LLC | 692 | $11.8K | — | Held |
| Wilmington Savings Fund Society, FSB | 580 | $9.86K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 500 | $8.5K | — | Held |
| Global Retirement Partners, LLC | 500 | $8.5K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 429 | $7.29K | — | Held |
| Steward Partners Investment Advisory, LLC | 400 | $6.8K | — | Held |
| ENTRUST FINANCIAL LLC | 345 | $5.87K | — | Held |
| SIGNATUREFD, LLC | 310 | $5.27K | — | Held |
| HRT FINANCIAL LP | 299.7K | $5.09K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 292 | $4.96K | — | Held |
| J.Safra Asset Management Corp | 262 | $4.45K | — | Held |
| Optiver Holding B.V. | 258 | $4.39K | — | Held |
| Aster Capital Management (DIFC) Ltd | 248 | $4.22K | — | Held |
| EverSource Wealth Advisors, LLC | 224 | $3.81K | — | Held |
| ORG Partners LLC | 200 | $3.4K | — | Held |
| Duquesne Family Office | 173K | $2.94K | — | Held |
| Fourth Dimension Wealth, LLC | 150 | $2.55K | — | Held |
| Allworth Financial LP | 129 | $2.19K | $1.2K | Added$1.28K |
| CVA Family Office, LLC | 128 | $2.18K | — | Held |
| ALGERT GLOBAL LLC | 122.5K | $2.08K | — | Held |
| Parallel Advisors, LLC | 95 | $1.61K | — | Held |
| Cornerstone Financial Management LLC | 86 | $1.46K | — | Held |
| Parkside Financial Bank & Trust | 72 | $1.22K | — | Held |
| SG Americas Securities, LLC | 67K | $1.14K | — | Held |
| SBI Securities Co., Ltd. | 60 | $1.02K | — | Held |
| Truvestments Capital LLC | 57 | $966 | — | Held |
| Handelsbanken Fonder AB | 54.7K | $930 | — | Held |
| True Wealth Design, LLC | 37 | $629 | — | Held |
| Essential Partners LLC | 36 | $612 | — | New |
| Virtu Financial LLC | 26.9K | $457 | — | Held |
| SJS Investment Consulting Inc. | 17 | $289 | — | Held |
| Arax Advisory Partners | 14 | $238 | — | Held |
| MAI Capital Management | 11 | $187 | — | Held |
| BESSEMER GROUP INC | 9.96K | $170 | — | Held |
| PNC Financial Services Group, Inc. | 10 | $170 | — | Held |
| IFP Advisors, Inc | 9 | $153 | — | New |
| ACADIAN ASSET MANAGEMENT LLC | 5.82K | $98 | — | Held |
| AMALGAMATED BANK | 3.64K | $62 | — | Held |
| CWM, LLC | 2.12K | $36 | — | Held |
| Hughes Financial Services, LLC | 1 | $17 | — | Held |
| Daiwa Securities Group Inc. | 503 | $9 | — | Held |
| Cygnus Capital Advisors, LLC | 271 | $5 | — | Held |
| Covestor Ltd | 13 | $0 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |