| RTW INVESTMENTS, LP | 4.54M | $106.4M | — | Held |
| Paradigm Biocapital Advisors LP | 4.47M | $104.8M | — | Held |
| BlackRock, Inc. | 2.6M | $60.9M | — | Held |
| MORGAN STANLEY | 2.56M | $60M | $8.77M | Added$9.58M |
| Jefferies Financial Group Inc. | 2.2M | $51.5M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.74M | $40.7M | — | Held |
| ACORN CAPITAL ADVISORS, LLC | 1.45M | $33.9M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 1.36M | $31.8M | — | Held |
| MENORA MIVTACHIM HOLDINGS LTD. | 1.15M | $27M | — | Held |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1.13M | $26.3M | — | Held |
| D. E. Shaw & Co., Inc. | 962.6K | $22.5M | — | Held |
| MPM BIOIMPACT LLC | 941.4K | $22M | — | Held |
| ORBIMED ADVISORS LLC | 875.5K | $20.5M | — | Held |
| State Street | 807.4K | $18.9M | — | Held |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 781.6K | $18.3M | — | Held |
| Citadel | 737.8K | $17.3M | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 718.4K | $16.8M | — | Held |
| TCG Crossover Management, LLC | 717.3K | $16.8M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 619K | $14.5M | — | Held |
| J. Goldman & Co LP | 513.3K | $12M | — | Held |
| Woodline Partners LP | 500.7K | $11.7M | — | Held |
| Boxer Capital Management, LLC | 500K | $11.7M | $1.74M | Added$238.8K |
| GEODE CAPITAL MANAGEMENT, LLC | 475.2K | $11.1M | — | Held |
| GOLDMAN SACHS GROUP INC | 459.7K | $10.8M | — | Held |
| Vanguard | 439.8K | $10.3M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 435.5K | $10.2M | — | Held |
| DEUTSCHE BANK AG\ | 366.7K | $8.59M | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 350K | $8.2M | — | Held |
| Nuveen, LLC | 302.6K | $7.09M | — | Held |
| RICE HALL JAMES & ASSOCIATES, LLC | 281.9K | $6.6M | — | Held |
| Opaleye Management Inc. | 268.4K | $6.29M | — | Held |
| Renaissance Technologies | 244.3K | $5.72M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 241.2K | $5.65M | — | Held |
| NORTHERN TRUST CORP | 237.5K | $5.56M | — | Held |
| UBS Group AG | 235K | $5.5M | — | Held |
| Atom Investors LP | 234.4K | $5.49M | — | Held |
| Privium Fund Management B.V. | 214.6K | $5.03M | — | Held |
| Parkman Healthcare Partners LLC | 168.8K | $3.95M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 162.7K | $3.81M | — | Held |
| Hennion & Walsh Asset Management, Inc. | 161.9K | $3.79M | — | Held |
| Informed Momentum Co LLC | 160.4K | $3.76M | — | Held |
| Icahn Capital | 153.4K | $3.59M | — | Held |
| Soleus Capital Management, L.P. | 150K | $3.51M | — | Held |
| JPMORGAN CHASE & CO | 146.3K | $3.43M | — | Held |
| AMERIPRISE FINANCIAL INC | 136K | $3.19M | — | Held |
| BANK OF AMERICA CORP /DE/ | 128.6K | $3.01M | $376.3K | Added$848.9K |
| WELLINGTON MANAGEMENT GROUP LLP | 126K | $2.95M | — | Held |
| ADAR1 Capital Management, LLC | 125.4K | $2.94M | — | Held |
| Fidelity | 123.6K | $2.89M | — | Held |
| ARK Investment Management LLC | 121.5K | $2.85M | — | Held |
| Aisling Capital Management LP | 108K | $2.53M | — | Held |
| Elmind Capital, LP | 100K | $2.34M | — | Held |
| Bank of New York Mellon Corp | 98.8K | $2.31M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 91K | $2.13M | — | Held |
| OAK RIDGE INVESTMENTS LLC | 85.2K | $2M | — | Held |
| WELLS FARGO & COMPANY/MN | 84.2K | $1.97M | — | Held |
| TD Asset Management Inc | 80.2K | $1.88M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 76.8K | $1.8M | — | Held |
| PANAGORA ASSET MANAGEMENT INC | 74.1K | $1.73M | — | Held |
| TRUIST FINANCIAL CORP | 72.3K | $1.69M | — | Held |
| BARCLAYS PLC | 57.7K | $1.35M | $193K | Added$242.8K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55.7K | $1.29M | — | Held |
| NEOS Investment Management LLC | 53.6K | $1.25M | — | Held |
| Russell Investments Group, Ltd. | 47.3K | $1.11M | — | Held |
| RHUMBLINE ADVISERS | 45.8K | $1.07M | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 39.4K | $922.4K | — | Held |
| Coastal Bridge Advisors, LLC | 37K | $866.5K | — | Held |
| MEITAV INVESTMENT HOUSE LTD | 35.5K | $831.7K | — | Held |
| ExodusPoint Capital Management, LP | 35.4K | $828.9K | — | Held |
| Focus Partners Wealth | 35.3K | $826.2K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 35K | $820.6K | — | Held |
| DARK FOREST CAPITAL MANAGEMENT LP | 31.5K | $738.1K | — | Held |
| Cetera Investment Advisers | 30.1K | $704.8K | — | Held |
| HighVista Strategies LLC | 28K | $655.9K | — | Held |
| Susquehanna Portfolio Strategies, LLC | 27.4K | $641.2K | — | Held |
| Invesco Ltd. | 27.1K | $633.9K | — | Held |
| Tidal Investments LLC | 27K | $631.7K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 31.6K | $626.6K | — | Held |
| Palo Alto Investors LP | 24.5K | $573.8K | — | Held |
| MML INVESTORS SERVICES, LLC | 24.4K | $570.6K | — | Held |
| Quantinno Capital Management LP | 23.5K | $550.7K | — | Held |
| Squarepoint Ops LLC | 22.8K | $534.7K | — | Held |
| XTX Topco Ltd | 22.5K | $526.7K | — | Held |
| MetLife Investment Management, LLC | 22.4K | $525.7K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 22.2K | $520.2K | — | Held |
| SIMPLEX TRADING, LLC | 22.1K | $517.8K | — | Held |
| Allianz Asset Management GmbH | 22K | $515.2K | — | Held |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21.8K | $511.1K | — | Held |
| DIADEMA PARTNERS LP | 21.8K | $510.8K | — | Held |
| Main Street Financial Solutions, LLC | 21K | $491.6K | — | Held |
| Jump Financial, LLC | 17.9K | $419.2K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17.2K | $401.7K | — | Held |
| Cinctive Capital Management LP | 17K | $397.9K | — | Held |
| OPPENHEIMER & CO INC | 17K | $397.3K | — | Held |
| DNB Asset Management AS | 17K | $397.2K | — | Held |
| FRANKLIN RESOURCES INC | 16.7K | $392.2K | — | Held |
| MARSHALL WACE, LLP | 16.3K | $381.7K | — | Held |
| Vivaldi Capital Management LP | 15.7K | $366.8K | — | Held |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 15.4K | $360.3K | — | Held |
| WINTON GROUP Ltd | 13.2K | $308.9K | — | Held |
| Persistent Asset Partners Ltd | 12.8K | $299.9K | $44.4K | Cut−$113.6K |
| NEW YORK STATE COMMON RETIREMENT FUND | 12.7K | $298.3K | — | Held |
| Cresset Asset Management, LLC | 11.2K | $262.7K | $38.9K | Cut−$70.8K |
| FARALLON CAPITAL MANAGEMENT LLC | 11K | $257.6K | $38.2K | Added$38.2K |
| Creative Planning | 10.6K | $247.7K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 10.5K | $245.2K | — | Held |
| HSBC HOLDINGS PLC | 10.3K | $235.9K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 9.25K | $216.5K | — | Held |
| Orion Porfolio Solutions, LLC | 9.01K | $211K | — | Held |
| ProShare Advisors LLC | 8.81K | $206.4K | — | Held |
| ROYAL BANK OF CANADA | 8.39K | $196K | — | Held |
| China Universal Asset Management Co., Ltd. | 7.63K | $178.6K | — | Held |
| STRS OHIO | 3.8K | $89K | — | Held |
| Legal & General Group Plc | 3.64K | $85.3K | — | Held |
| CITIGROUP INC | 3.4K | $79.7K | — | Held |
| Ameritas Investment Partners, Inc. | 3.08K | $72.2K | — | Held |
| OSAIC HOLDINGS, INC. | 2.92K | $68.3K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.27K | $53.3K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2.27K | $53.2K | — | Held |
| Tower Research Capital LLC (TRC) | 1.47K | $34.4K | — | Held |
| SG Americas Securities, LLC | 1.38M | $32.3K | — | Held |
| Activest Wealth Management | 1K | $23.4K | — | Held |
| Newbridge Financial Services Group, Inc. | 1K | $23.4K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 1K | $23.4K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 919 | $21.5K | — | Held |
| Migdal Insurance & Financial Holdings Ltd. | 770.9K | $18.1K | — | Held |
| Rossby Financial, LCC | 770 | $18K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 688 | $16.1K | — | Held |
| Pinnacle Wealth Planning Services, Inc. | 688 | $16.1K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 616.6K | $14.4K | — | Held |
| EverSource Wealth Advisors, LLC | 584 | $13.7K | — | Held |
| Sterling Capital Management LLC | 584 | $13.7K | — | Held |
| CIBC Private Wealth Group LLC | 575 | $13.5K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 464 | $10.9K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 403 | $9.44K | — | Held |
| Sound Income Strategies, LLC | 488 | $9.17K | — | Held |
| GAMMA Investing LLC | 352 | $8.24K | — | Held |
| Aster Capital Management (DIFC) Ltd | 298 | $6.98K | — | Held |
| Farther Finance Advisors, LLC | 256 | $6K | — | Held |
| Optiver Holding B.V. | 223 | $5.22K | — | Held |
| Costello Asset Management, INC | 200 | $4.68K | — | Held |
| Quantbot Technologies LP | 200 | $4.68K | — | Held |
| FEDERATED HERMES, INC. | 196 | $4.59K | — | Held |
| Larson Financial Group LLC | 140 | $3.28K | — | Held |
| HRT FINANCIAL LP | 130.9K | $3.06K | — | Held |
| Essential Partners LLC | 118 | $2.76K | $400 | Added$470 |
| Rockefeller Capital Management L.P. | 112 | $2.62K | — | Held |
| NewEdge Advisors, LLC | 100 | $2.34K | — | Held |
| Smartleaf Asset Management LLC | 72 | $1.67K | — | Held |
| ALGERT GLOBAL LLC | 65.9K | $1.54K | — | Held |
| PNC Financial Services Group, Inc. | 63 | $1.48K | — | Held |
| Annandale Capital, LLC | 60.6K | $1.42K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 50 | $1.17K | — | Held |
| Parkside Financial Bank & Trust | 45 | $1.05K | — | Held |
| Allworth Financial LP | 35 | $820 | $122 | Cut−$2.15K |
| IFP Advisors, Inc | 31 | $726 | $108 | Added$48 |
| DecisionPoint Financial, LLC | 22 | $516 | — | Held |
| SBI Securities Co., Ltd. | 18 | $422 | — | Held |
| US BANCORP \DE\ | 17 | $398 | — | Held |
| True Wealth Design, LLC | 16 | $375 | — | Held |
| Arax Advisory Partners | 14 | $328 | — | Held |
| SHIKIAR ASSET MANAGEMENT INC | 10.8K | $252 | — | Held |
| SIGNATUREFD, LLC | 10 | $234 | — | Held |
| CWM, LLC | 3.89K | $91 | — | Held |
| MAI Capital Management | 2 | $47 | — | Held |
| AMALGAMATED BANK | 1.16K | $27 | — | Held |
| Daiwa Securities Group Inc. | 160 | $4 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |