| RTW INVESTMENTS, LP | 4.54M | $81.7M | −$24.7M | Cut−$24.7M |
| BlackRock, Inc. | 2.85M | $51.2M | −$14.1M | Cut−$9.75M |
| TORONTO DOMINION BANK | 2.62M | $47M | — | New |
| MORGAN STANLEY | 2.56M | $46M | −$13.9M | Cut−$14M |
| Kynam Capital Management, LP | 2.25M | $40.4M | — | New |
| Jefferies Financial Group Inc. | 2.2M | $39.5M | −$12M | Cut−$12M |
| Paradigm Biocapital Advisors LP | 1.7M | $30.6M | −$9.27M | Cut−$74.1M |
| ACORN CAPITAL ADVISORS, LLC | 1.67M | $30.1M | −$7.88M | Cut−$3.83M |
| AMERICAN CENTURY COMPANIES INC | 1.64M | $29.4M | −$7.39M | Cut−$2.38M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.5M | $27M | −$8.18M | Cut−$13.7M |
| Opaleye Management Inc. | 1.43M | $25.7M | −$1.46M | Added$19.4M |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1.31M | $23.6M | −$4.25M | Added$5.32M |
| MENORA MIVTACHIM HOLDINGS LTD. | 1.15M | $20.7M | −$6.27M | Cut−$6.27M |
| D. E. Shaw & Co., Inc. | 1.02M | $18.4M | −$5.24M | Cut−$4.15M |
| MPM BIOIMPACT LLC | 943.8K | $17M | −$5.12M | Cut−$5.08M |
| J. Goldman & Co LP | 938.9K | $16.9M | −$2.79M | Added$4.86M |
| ORBIMED ADVISORS LLC | 875.5K | $15.7M | −$4.76M | Cut−$4.76M |
| State Street | 874.2K | $15.7M | −$4.39M | Cut−$3.19M |
| Migdal Insurance & Financial Holdings Ltd. | 770.9K | $13.9M | $13.8M | Added$13.8M |
| Soleus Capital Management, L.P. | 727K | $13.1M | −$816K | Added$9.56M |
| GOLDMAN SACHS GROUP INC | 598.5K | $10.8M | −$2.5M | Cut−$5.16K |
| GEODE CAPITAL MANAGEMENT, LLC | 523.8K | $9.42M | −$2.59M | Cut−$1.71M |
| Woodline Partners LP | 500.7K | $9M | −$2.72M | Cut−$2.72M |
| Boxer Capital Management, LLC | 500K | $8.99M | −$2.72M | Cut−$2.72M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 409.6K | $7.36M | — | Held |
| TCG Crossover Management, LLC | 405.4K | $7.29M | −$2.21M | Cut−$9.51M |
| ADAR1 Capital Management, LLC | 395.5K | $7.11M | −$682K | Added$4.17M |
| SUPERSTRING CAPITAL MANAGEMENT LP | 387.4K | $6.96M | −$2.11M | Cut−$9.86M |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 387.1K | $6.96M | −$2.11M | Cut−$19.4M |
| MILLENNIUM MANAGEMENT LLC | 370.9K | $6.67M | −$2.02M | Cut−$7.83M |
| TANG CAPITAL MANAGEMENT LLC | 350K | $6.29M | −$1.9M | Cut−$1.9M |
| RICE HALL JAMES & ASSOCIATES, LLC | 285.8K | $5.14M | −$1.53M | Cut−$1.46M |
| NORTHERN TRUST CORP | 275.9K | $4.96M | −$1.29M | Cut−$599.9K |
| Parkman Healthcare Partners LLC | 275K | $4.94M | −$918.1K | Added$992K |
| Citadel | 268K | $4.82M | −$1.46M | Cut−$12.5M |
| Privium Fund Management B.V. | 238.1K | $4.28M | −$1.17M | Cut−$745K |
| DEUTSCHE BANK AG\ | 236.2K | $4.25M | −$1.28M | Cut−$4.34M |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 230.6K | $4.15M | −$1.25M | Cut−$6.05M |
| Elmind Capital, LP | 220K | $3.96M | −$544K | Added$1.61M |
| Ally Bridge Group (NY) LLC | 202.1K | $3.63M | — | New |
| Hennion & Walsh Asset Management, Inc. | 183.5K | $3.3M | −$880.9K | Cut−$492.9K |
| TWO SIGMA INVESTMENTS, LP | 177.9K | $3.2M | −$967.8K | Cut−$2.45M |
| UBS Group AG | 159.7K | $2.87M | −$868.5K | Cut−$2.63M |
| Schonfeld Strategic Advisors LLC | 158.1K | $2.84M | — | New |
| Atom Investors LP | 145.3K | $2.61M | −$790.7K | Cut−$2.88M |
| Fidelity | 145K | $2.61M | −$672.2K | Cut−$287.5K |
| Icahn Capital | 144.1K | $2.59M | −$783.7K | Cut−$1M |
| Vestal Point Capital, LP | 139.1K | $2.5M | — | New |
| BANK OF AMERICA CORP /DE/ | 126.8K | $2.28M | −$689.7K | Cut−$733K |
| ARK Investment Management LLC | 115.5K | $2.08M | −$628.6K | Cut−$767.7K |
| Aisling Capital Management LP | 108K | $1.94M | −$587.5K | Cut−$587.5K |
| Tidal Investments LLC | 102.9K | $1.85M | −$146.7K | Added$1.22M |
| WELLINGTON MANAGEMENT GROUP LLP | 100.2K | $1.8M | −$545.2K | Cut−$1.15M |
| Bank of New York Mellon Corp | 98.9K | $1.78M | −$537.6K | Cut−$535.6K |
| PANAGORA ASSET MANAGEMENT INC | 98.1K | $1.76M | −$402.9K | Added$28.7K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 88.5K | $1.59M | −$481.3K | Cut−$540.3K |
| Nuveen, LLC | 87.5K | $1.57M | −$476.1K | Cut−$5.51M |
| OAK RIDGE INVESTMENTS LLC | 86.4K | $1.55M | −$463.7K | Cut−$442.6K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 83.6K | $1.5M | −$454.9K | Cut−$2.31M |
| Swiss National Bank | 77.8K | $1.4M | — | New |
| Trexquant Investment LP | 73.9K | $1.33M | — | New |
| TRUIST FINANCIAL CORP | 72.3K | $1.3M | −$393.2K | Cut−$393.2K |
| ExodusPoint Capital Management, LP | 70.2K | $1.26M | −$192.5K | Added$434K |
| Russell Investments Group, Ltd. | 63.2K | $1.14M | −$257.1K | Added$30.4K |
| WELLS FARGO & COMPANY/MN | 55.8K | $1M | −$303.3K | Cut−$968.5K |
| RHUMBLINE ADVISERS | 49.4K | $888.3K | −$248.9K | Cut−$183.4K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47.4K | $852.6K | −$2.19K | Added$843.2K |
| ALLIANCEBERNSTEIN L.P. | 35K | $820.6K | $0 | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 43.5K | $782.1K | −$236.6K | Cut−$1.02M |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38.8K | $696.7K | −$12.4K | Added$643.5K |
| Coastal Bridge Advisors, LLC | 37K | $665.3K | −$201.3K | Cut−$201.3K |
| BENDER ROBERT & ASSOCIATES | 34.7K | $623.9K | — | New |
| Focus Partners Wealth | 34K | $612K | −$185.2K | Cut−$214.2K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 32.5K | $584.5K | −$176.8K | Cut−$337.8K |
| STATE OF WISCONSIN INVESTMENT BOARD | 32.1K | $577.4K | — | New |
| VANGUARD FIDUCIARY TRUST CO | 31.6K | $567.4K | — | Held |
| AMERIPRISE FINANCIAL INC | 30.2K | $542.4K | −$164.1K | Cut−$2.64M |
| Cetera Investment Advisers | 29.1K | $523.1K | −$158.3K | Cut−$181.7K |
| Invesco Ltd. | 28.1K | $504.9K | −$147.2K | Cut−$129K |
| HighVista Strategies LLC | 26.5K | $476.6K | −$144.2K | Cut−$179.2K |
| VANGUARD ASSET MANAGEMENT, Ltd | 26K | $467.6K | — | Held |
| Man Group plc | 25.4K | $456.6K | — | New |
| Legal & General Group Plc | 25.2K | $452.6K | −$19.8K | Added$367.3K |
| Palo Alto Investors LP | 24.5K | $440.5K | −$133.3K | Cut−$133.3K |
| FOX RUN MANAGEMENT, L.L.C. | 25.7K | $436.4K | — | New |
| MetLife Investment Management, LLC | 23.3K | $419.4K | −$122.1K | Cut−$106.3K |
| DIADEMA PARTNERS LP | 23.2K | $416.3K | −$118.6K | Cut−$94.5K |
| MEITAV INVESTMENT HOUSE LTD | 22.2K | $399.5K | −$120.9K | Cut−$432.2K |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21.8K | $392.4K | −$118.7K | Cut−$118.7K |
| MML INVESTORS SERVICES, LLC | 20.8K | $374K | −$113.2K | Cut−$196.6K |
| Quantinno Capital Management LP | 20.2K | $362.8K | −$109.8K | Cut−$187.9K |
| JPMORGAN CHASE & CO | 21.1K | $359.1K | −$135.6K | Cut−$3.07M |
| Susquehanna Portfolio Strategies, LLC | 19.4K | $348.9K | −$105.6K | Cut−$292.4K |
| JANUS HENDERSON GROUP PLC | 19.1K | $343.1K | — | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18.9K | $339.2K | −$93.3K | Cut−$62.5K |
| FRANKLIN RESOURCES INC | 16.7K | $301.1K | −$91.1K | Cut−$91.1K |
| Vivaldi Capital Management LP | 15.7K | $281.6K | −$85.2K | Cut−$85.2K |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 15.4K | $276.6K | −$83.7K | Cut−$83.7K |
| KLP KAPITALFORVALTNING AS | 14.3K | $257.1K | — | New |
| MAI Capital Management | 14K | $251.8K | −$11 | Added$251.8K |
| DNB Asset Management AS | 13.5K | $242.3K | −$73.3K | Cut−$155K |
| State of New Jersey Common Pension Fund D | 13.4K | $241.6K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 12.7K | $229K | −$69.3K | Cut−$69.3K |
| Integrated Wealth Concepts LLC | 12.6K | $227.3K | — | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12.5K | $225K | — | New |
| FARALLON CAPITAL MANAGEMENT LLC | 11K | $197.8K | −$59.8K | Cut−$59.8K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10.9K | $196.1K | −$57.2K | Cut−$1.1M |
| Vanguard Investments Australia, Ltd. | 10.8K | $194.5K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 10.8K | $194.2K | — | New |
| Creative Planning | 10.7K | $192K | −$57.5K | Cut−$55.7K |
| GLENMEDE TRUST CO NA | 10.5K | $189.1K | — | New |
| Police & Firemen's Retirement System of New Jersey | 10.5K | $188.2K | −$57K | Cut−$57K |
| Allianz Asset Management GmbH | 10.1K | $181.6K | −$54.9K | Cut−$333.6K |
| BARCLAYS PLC | 9.63K | $173.2K | −$52.4K | Cut−$1.18M |
| BNP PARIBAS FINANCIAL MARKETS | 9.52K | $171.2K | −$50.3K | Cut−$45.4K |
| ROYAL BANK OF CANADA | 8.55K | $154K | −$44.8K | Cut−$42K |
| Vanguard Global Advisers, LLC | 8.47K | $152.3K | — | Held |
| China Universal Asset Management Co., Ltd. | 8.31K | $149.4K | −$41.5K | Cut−$29.3K |
| SIMPLEX TRADING, LLC | 8.07K | $145K | −$43.9K | Cut−$372.8K |
| Persistent Asset Partners Ltd | 5.82K | $104.7K | −$31.7K | Cut−$195.2K |
| CITIGROUP INC | 4.94K | $88.9K | −$18.5K | Added$9.2K |
| GROUP ONE TRADING LLC | 4.67K | $83.9K | — | New |
| Caption Management, LLC | 4.12K | $74.2K | — | New |
| CWM, LLC | 3.89K | $70K | $69.8K | Added$69.9K |
| Ameritas Investment Partners, Inc. | 3.08K | $55.4K | −$16.8K | Cut−$16.8K |
| Tower Research Capital LLC (TRC) | 3.07K | $55.2K | −$7.99K | Added$20.8K |
| OSAIC HOLDINGS, INC. | 2.92K | $52.4K | −$15.9K | Cut−$15.8K |
| Mirae Asset Global Investments Co., Ltd. | 2.44K | $43.9K | −$12.4K | Cut−$9.37K |
| SG Americas Securities, LLC | 1.66M | $29.8K | −$7.49K | Cut−$2.46K |
| GF FUND MANAGEMENT CO. LTD. | 1.04K | $18.8K | −$5K | Cut−$2.73K |
| Activest Wealth Management | 1K | $18K | −$5.45K | Cut−$5.45K |
| Newbridge Financial Services Group, Inc. | 1K | $18K | −$5.44K | Cut−$5.44K |
| JONES FINANCIAL COMPANIES LLLP | 1K | $17.2K | −$6.25K | Cut−$6.25K |
| Rossby Financial, LCC | 770 | $14.6K | −$3.45K | Cut−$3.45K |
| QUADRANT CAPITAL GROUP LLC | 688 | $12.4K | −$3.74K | Cut−$3.74K |
| Pinnacle Wealth Planning Services, Inc. | 688 | $12.4K | −$3.74K | Cut−$3.74K |
| EverSource Wealth Advisors, LLC | 596 | $10.7K | −$3.18K | Cut−$2.96K |
| Advisory Services Network, LLC | 553 | $9.94K | — | New |
| NISA INVESTMENT ADVISORS, LLC | 464 | $8.34K | −$2.52K | Cut−$2.52K |
| Sterling Capital Management LLC | 455 | $8.18K | −$2.47K | Cut−$5.5K |
| GAMMA Investing LLC | 439 | $7.89K | −$1.92K | Cut−$351 |
| Sound Income Strategies, LLC | 388 | $7.35K | $55 | Cut−$1.82K |
| Napier Financial, LLC | 400 | $7.19K | — | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 325 | $5.84K | −$607 | Cut−$620.8K |
| Larson Financial Group LLC | 244 | $4.39K | −$762 | Added$1.11K |
| Costello Asset Management, INC | 200 | $3.6K | −$1.09K | Cut−$1.09K |
| Optiver Holding B.V. | 152 | $2.73K | −$827 | Cut−$2.49K |
| TWIN PEAKS WEALTH ADVISORS, LLC | 120 | $2.16K | — | New |
| Essential Partners LLC | 118 | $2.12K | −$642 | Cut−$642 |
| Rockefeller Capital Management L.P. | 112 | $2.01K | −$609 | Cut−$609 |
| Smartleaf Asset Management LLC | 72 | $1.22K | −$444 | Cut−$444 |
| ROTHSCHILD INVESTMENT LLC | 64 | $1.15K | −$272 | Cut−$20 |
| PNC Financial Services Group, Inc. | 63 | $1.13K | −$342 | Cut−$342 |
| Annandale Capital, LLC | 58.6K | $1.05K | −$318 | Cut−$365 |
| HRT FINANCIAL LP | 49.4K | $887 | −$269 | Cut−$2.18K |
| Allworth Financial LP | 45 | $810 | −$190 | Cut−$10 |
| Parkside Financial Bank & Trust | 45 | $810 | −$244 | Cut−$244 |
| IFP Advisors, Inc | 31 | $557 | −$169 | Cut−$169 |
| Root Financial Partners, LLC | 30 | $539 | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28.5K | $512 | −$154 | Cut−$13.9K |
| Farther Finance Advisors, LLC | 24 | $455 | −$107 | Cut−$5.54K |
| DecisionPoint Financial, LLC | 22 | $396 | −$120 | Cut−$120 |
| SBI Securities Co., Ltd. | 20 | $360 | −$98 | Cut−$62 |
| ALGERT GLOBAL LLC | 19K | $341 | −$104 | Cut−$1.2K |
| True Wealth Design, LLC | 16 | $288 | −$87 | Cut−$87 |
| SHIKIAR ASSET MANAGEMENT INC | 10.8K | $193 | −$59 | Cut−$59 |
| SIGNATUREFD, LLC | 10 | $180 | −$54 | Cut−$54 |
| Hughes Financial Services, LLC | 3 | $54 | — | New |
| KBC Group NV | 1.34K | $24 | — | New |
| JPL Wealth Management, LLC | 1 | $18 | — | New |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |
| Covestor Ltd | 6 | $0 | — | New |