| Vivo Capital, LLC | 1.79M | $11.8M | $1.45M | Added$1.45M |
| MILLENNIUM MANAGEMENT LLC | 1.4M | $9.21M | $822K | Added$3.35M |
| Octagon Capital Advisors LP | 1M | $6.58M | $810K | Added$810K |
| Nantahala Capital Management, LLC | 939.2K | $6.18M | $760.8K | Added$760.8K |
| VANGUARD CAPITAL MANAGEMENT LLC | 811.4K | $5.34M | — | Held |
| GREAT POINT PARTNERS LLC | 796.6K | $5.24M | $645.2K | Added$645.2K |
| Logos Global Management LP | 473.6K | $3.12M | $383.6K | Added$383.6K |
| Citadel | 236.8K | $1.56M | $191.8K | Added$68K |
| Integral Health Asset Management, LLC | 225K | $1.48M | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 203.7K | $1.34M | $138.8K | Added$352.5K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 199.2K | $1.31M | $20.2K | Added$1.17M |
| MORGAN STANLEY | 188.2K | $1.24M | $37.7K | Added$969.4K |
| MARSHALL WACE, LLP | 154.9K | $1.02M | — | New |
| Dauntless Investment Group, LLC | 147.1K | $967.8K | $72.4K | Added$451.9K |
| DIMENSIONAL FUND ADVISORS LP | 143.1K | $940.2K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 119.5K | $786.5K | $80.8K | Added$211K |
| DIADEMA PARTNERS LP | 106.1K | $698K | — | New |
| VANGUARD FIDUCIARY TRUST CO | 101.1K | $665.1K | — | Held |
| Diametric Capital, LP | 80.4K | $528.8K | — | New |
| State Street | 80K | $526.6K | $52.8K | Added$150.2K |
| CANTOR FITZGERALD, L. P. | 75K | $493.5K | $60.8K | Cut−$660.5K |
| JANE STREET GROUP, LLC | 72.2K | $475.4K | — | New |
| ACUTA CAPITAL PARTNERS, LLC | 58K | $381.4K | $46.9K | Added$35.3K |
| Seven Fleet Capital Management LP | 55.7K | $366.5K | — | New |
| BARCLAYS PLC | 50K | $329K | $64 | Added$328.5K |
| NORTHERN TRUST CORP | 35.9K | $236.5K | $29.1K | Added$29.1K |
| BlackRock, Inc. | 35.9K | $236.2K | $29.1K | Added$26.5K |
| OMERS ADMINISTRATION Corp | 31.9K | $209.9K | $25.8K | Cut−$241.3K |
| BANK OF AMERICA CORP /DE/ | 29.5K | $194.3K | $123 | Added$193.4K |
| Quadrature Capital Ltd | 27.9K | $183.7K | $22.6K | Cut−$42K |
| GOLDMAN SACHS GROUP INC | 27.1K | $178.3K | — | New |
| Persistent Asset Partners Ltd | 26.8K | $176.5K | — | New |
| Chicago Partners Investment Group LLC | 21.8K | $167.9K | $17.2K | Added$12.8K |
| Renaissance Technologies | 24.4K | $160.6K | — | New |
| XTX Topco Ltd | 22.6K | $148.7K | $18.3K | Cut−$55.6K |
| UBS Group AG | 19.4K | $127.9K | $15.7K | Added$13.1K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12.2K | $80.5K | — | New |
| Vanguard Global Advisers, LLC | 7.87K | $51.8K | — | Held |
| SIMPLEX TRADING, LLC | 5.82K | $38.3K | — | New |
| Rockefeller Capital Management L.P. | 1.6K | $10.5K | $405 | Added$7.64K |
| SBI Securities Co., Ltd. | 557 | $3.67K | $451 | Added$445 |
| ROYAL BANK OF CANADA | 377 | $2K | — | New |
| TFC Financial Management, Inc. | 300 | $1.97K | $243 | Added$243 |
| HARBOUR INVESTMENTS, INC. | 100 | $658 | $81 | Added$81 |
| Fortitude Family Office, LLC | 75 | $494 | — | New |
| HRT FINANCIAL LP | 41.5K | $273 | — | New |
| Virtu Financial LLC | 26.3K | $173 | — | New |
| Bogart Wealth, LLC | 6 | $39 | $4 | Added$4 |
| Caitong International Asset Management Co., Ltd | 5 | $33 | — | New |
| CITIGROUP INC | 1 | $7 | $1 | Cut−$1.31K |
| DANSKE BANK A/S | 1 | $7 | $1 | Added$1 |