| RA CAPITAL MANAGEMENT, L.P. | 12.2M | $320.7M | — | Held |
| Nextech Invest, Ltd. | 4.06M | $106.6M | — | Held |
| Alta Partners Management Company, L.P. | 3.82M | $100.5M | — | Held |
| Commodore Capital LP | 3.38M | $88.7M | — | Held |
| Canaan Partners XI LLC | 3.37M | $88.7M | — | Held |
| JANUS HENDERSON GROUP PLC | 2.94M | $77.1M | — | Held |
| TCG Crossover Management, LLC | 2.9M | $76.2M | — | Held |
| Vestal Point Capital, LP | 2.42M | $63.8M | — | Held |
| BVF INC/IL | 2.13M | $55.9M | — | Held |
| BlackRock, Inc. | 2.09M | $54.9M | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 2.07M | $54.3M | $14.1M | Added$38.3M |
| Vanguard | 1.57M | $41.3M | — | Held |
| Kynam Capital Management, LP | 1.56M | $41.1M | — | Held |
| 5AM Venture Management, LLC | 1.03M | $27.1M | — | Held |
| Caligan Partners LP | 944.3K | $24.8M | — | Held |
| Point72 Asset Management, L.P. | 874.2K | $23M | — | Held |
| Balyasny Asset Management L.P. | 818.3K | $21.5M | — | Held |
| State Street | 749.5K | $19.7M | — | Held |
| MARSHALL WACE, LLP | 711.9K | $18.7M | — | Held |
| Trails Edge Capital Partners, LP | 700K | $18.4M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 657.8K | $17.3M | — | Held |
| Sio Capital Management, LLC | 526K | $13.8M | — | Held |
| BOONE CAPITAL MANAGEMENT LLC | 398.5K | $10.5M | — | Held |
| Elmind Capital, LP | 350K | $9.2M | — | Held |
| Eversept Partners, LP | 278.6K | $7.32M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 221.2K | $5.81M | — | Held |
| Logos Global Management LP | 210K | $5.52M | — | Held |
| NORTHERN TRUST CORP | 201K | $5.28M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 199.4K | $5.24M | — | Held |
| GOLDMAN SACHS GROUP INC | 182.4K | $4.79M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 170K | $4.47M | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 129.8K | $3.41M | — | Held |
| Invesco Ltd. | 129.4K | $3.4M | — | Held |
| Soleus Capital Management, L.P. | 125K | $3.29M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 120.3K | $3.16M | — | Held |
| MORGAN STANLEY | 118.9K | $3.13M | $1.46M | Cut−$1.38M |
| MILLENNIUM MANAGEMENT LLC | 114.4K | $3.01M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 107K | $2.81M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 104.3K | $2.74M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 95.6K | $2.51M | — | Held |
| INVESTMENT COUNSEL CO OF NEVADA | 85K | $2.24M | — | Held |
| OPPENHEIMER & CO INC | 84.7K | $2.23M | — | Held |
| Seven Fleet Capital Management LP | 79.6K | $2.09M | — | Held |
| BARCLAYS PLC | 76.3K | $2.01M | $702.6K | Added$1.21M |
| Kalehua Capital Management LLC | 74.5K | $1.96M | — | Held |
| JPMORGAN CHASE & CO | 71.2K | $1.87M | — | Held |
| Bank of New York Mellon Corp | 60.9K | $1.6M | — | Held |
| TWO SIGMA ADVISERS, LP | 58.9K | $1.55M | — | Held |
| UBS Group AG | 58.9K | $1.55M | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 58.7K | $1.54M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55.1K | $1.45M | — | Held |
| AMERIPRISE FINANCIAL INC | 54.6K | $1.44M | — | Held |
| Squarepoint Ops LLC | 54.4K | $1.43M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 48.6K | $1.28M | — | Held |
| Nuveen, LLC | 47.3K | $1.24M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 46.2K | $1.22M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 45.9K | $1.21M | — | Held |
| ALPS ADVISORS INC | 43.8K | $1.15M | — | Held |
| ExodusPoint Capital Management, LP | 42.8K | $1.12M | — | Held |
| PDT Partners, LLC | 42.3K | $1.11M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 39K | $1.03M | — | Held |
| RHUMBLINE ADVISERS | 38.8K | $1.02M | — | Held |
| BANK OF AMERICA CORP /DE/ | 38.3K | $1.01M | $471.2K | Cut−$872K |
| HighVista Strategies LLC | 35.1K | $922.4K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 32K | $841K | — | Held |
| XTX Topco Ltd | 30.4K | $799.6K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 29.9K | $785.7K | — | Held |
| WELLS FARGO & COMPANY/MN | 29K | $763.7K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 28.9K | $759.8K | — | Held |
| Fisher Asset Management, LLC | 28.8K | $757.2K | — | Held |
| Icahn Capital | 28.6K | $752.7K | — | Held |
| PSP Research LLC | 21.9K | $574.5K | — | Held |
| Auour Investments LLC | 21K | $552.6K | — | Held |
| Creative Planning | 19.6K | $515.4K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 18.8K | $494K | — | Held |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 18.5K | $487.5K | — | Held |
| DEUTSCHE BANK AG\ | 16.4K | $430.6K | — | Held |
| Rafferty Asset Management, LLC | 15.5K | $406.3K | — | Held |
| MetLife Investment Management, LLC | 15.4K | $403.7K | — | Held |
| Russell Investments Group, Ltd. | 13K | $341.7K | — | Held |
| FRANKLIN RESOURCES INC | 13K | $341K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12.9K | $338.6K | — | Held |
| Fidelity | 12.6K | $330.3K | — | Held |
| Virtus Investment Advisers, LLC | 11.8K | $309.1K | — | Held |
| BANK OF NOVA SCOTIA | 11.1K | $291.8K | — | Held |
| BAKER BROS. ADVISORS LP | 10.6K | $278.9K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 9.8K | $257.7K | — | Held |
| VARCOV Co. | 9.71K | $255.2K | — | Held |
| China Universal Asset Management Co., Ltd. | 8.7K | $228.6K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8.36K | $219.7K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 7.42K | $195.2K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 6.44K | $169.3K | — | Held |
| CITIGROUP INC | 3.82K | $100.3K | — | Held |
| Bellevue Group AG | 3.14K | $82.6K | — | Held |
| Caitong International Asset Management Co., Ltd | 3K | $78.8K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.59K | $68.2K | — | Held |
| Legal & General Group Plc | 2.37K | $62.2K | — | Held |
| AlphaQuest LLC | 2.14K | $56.2K | — | Held |
| Chung Wu Investment Group, LLC | 2K | $52.6K | — | Held |
| Ameritas Investment Partners, Inc. | 1.99K | $52.3K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.59K | $41.9K | — | Held |
| Sterling Capital Management LLC | 1.49K | $39.1K | — | Held |
| FEDERATED HERMES, INC. | 1.3K | $34.1K | — | Held |
| OSAIC HOLDINGS, INC. | 1.19K | $31.2K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.05K | $27.6K | — | Held |
| Versant Capital Management, Inc | 819 | $21.5K | — | Held |
| ROYAL BANK OF CANADA | 742 | $19K | — | Held |
| STRS OHIO | 700 | $18.4K | — | Held |
| GAMMA Investing LLC | 472 | $12.4K | — | Held |
| Tower Research Capital LLC (TRC) | 331 | $8.7K | — | Held |
| PNC Financial Services Group, Inc. | 208 | $5.47K | — | Held |
| Larson Financial Group LLC | 146 | $3.84K | — | Held |
| True Wealth Design, LLC | 142 | $3.73K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 129.8K | $3.41K | — | Held |
| Optiver Holding B.V. | 128 | $3.37K | — | Held |
| Smartleaf Asset Management LLC | 127 | $3.23K | — | Held |
| Allworth Financial LP | 100 | $2.63K | $1.23K | Added$1.23K |
| NISA INVESTMENT ADVISORS, LLC | 86 | $2.26K | — | Held |
| Rockefeller Capital Management L.P. | 84 | $2.21K | — | Held |
| Steward Partners Investment Advisory, LLC | 77 | $2.02K | — | Held |
| Farther Finance Advisors, LLC | 60 | $1.58K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 55 | $1.45K | — | Held |
| ALGERT GLOBAL LLC | 46.9K | $1.23K | — | Held |
| SIGNATUREFD, LLC | 43 | $1.13K | — | Held |
| EverSource Wealth Advisors, LLC | 42 | $1.1K | — | Held |
| Clearstead Advisors, LLC | 29 | $759 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14.4K | $380 | — | Held |
| SBI Securities Co., Ltd. | 4 | $105 | — | Held |
| Arax Advisory Partners | 3 | $79 | — | Held |
| CWM, LLC | 1.55K | $41 | — | Held |
| AMALGAMATED BANK | 814 | $21 | — | Held |
| Daiwa Securities Group Inc. | 173 | $5 | — | Held |
| Covestor Ltd | 6 | $0 | — | Held |