| RA CAPITAL MANAGEMENT, L.P. | 12.2M | $467.2M | $146.5M | Added$146.5M |
| Fidelity | 7.75M | $296.7M | $150.9K | Added$296.4M |
| Nextech Invest, Ltd. | 4.06M | $155.3M | $48.7M | Added$48.7M |
| JANUS HENDERSON GROUP PLC | 3.89M | $148.9M | $35.2M | Added$71.8M |
| Alta Partners Management Company, L.P. | 3.82M | $146.4M | $45.9M | Added$45.9M |
| FARALLON CAPITAL MANAGEMENT LLC | 3.58M | $137.1M | $24.8M | Added$82.8M |
| TCG Crossover Management, LLC | 3.25M | $124.4M | $34.8M | Added$48.2M |
| Commodore Capital LP | 2.48M | $94.8M | $29.7M | Added$6.06M |
| BlackRock, Inc. | 2.22M | $84.9M | $25.1M | Added$30.1M |
| Paradigm Biocapital Advisors LP | 2.05M | $78.7M | — | New |
| BVF INC/IL | 1.98M | $75.7M | $23.7M | Added$19.8M |
| Caligan Partners LP | 1.28M | $48.9M | $11.3M | Added$24.1M |
| State Street | 1.22M | $46.6M | $9M | Added$26.9M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.13M | $43.1M | — | Held |
| 5AM Venture Management, LLC | 1.03M | $39.4M | $12.4M | Added$12.4M |
| Logos Global Management LP | 850K | $32.6M | $2.52M | Added$27M |
| BARCLAYS PLC | 833.4K | $31.9M | $916.5K | Added$29.9M |
| Canaan Partners XI LLC | 750K | $28.7M | $9.01M | Cut−$60M |
| GEODE CAPITAL MANAGEMENT, LLC | 658.5K | $25.2M | $7.9M | Added$7.93M |
| JENNISON ASSOCIATES LLC | 632.4K | $24.2M | — | New |
| Sio Capital Management, LLC | 605.4K | $23.2M | $6.32M | Added$9.36M |
| GOLDMAN SACHS GROUP INC | 550.3K | $21.1M | $2.19M | Added$16.3M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 549K | $21M | — | New |
| Balyasny Asset Management L.P. | 351.5K | $13.5M | $4.22M | Cut−$8.05M |
| Elmind Capital, LP | 350K | $13.4M | $4.2M | Added$4.2M |
| Woodline Partners LP | 301K | $11.5M | — | New |
| BOOTHBAY FUND MANAGEMENT, LLC | 273.3K | $10.5M | $2.66M | Added$4.65M |
| Affinity Asset Advisors, LLC | 257.5K | $9.86M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 247.3K | $9.47M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 247.1K | $9.46M | $2.04M | Added$4.99M |
| MILLENNIUM MANAGEMENT LLC | 221.6K | $8.49M | $1.37M | Added$5.48M |
| NORTHERN TRUST CORP | 218.5K | $8.37M | $2.41M | Added$3.09M |
| BANK OF AMERICA CORP /DE/ | 209.9K | $8.04M | $460.1K | Added$7.03M |
| Sofinnova Investments, Inc. | 204K | $7.81M | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 199.1K | $7.63M | $2.39M | Added$2.38M |
| Seven Fleet Capital Management LP | 198.6K | $7.61M | $955.5K | Added$5.51M |
| MARSHALL WACE, LLP | 197.7K | $7.57M | $2.37M | Cut−$11.1M |
| STEMPOINT CAPITAL LP | 193.2K | $7.4M | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 190K | $7.28M | $1.44M | Added$4.12M |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 162.2K | $6.21M | $1.56M | Added$2.8M |
| VANGUARD FIDUCIARY TRUST CO | 157.8K | $6.04M | — | Held |
| Trexquant Investment LP | 147.3K | $5.64M | — | New |
| AMERIPRISE FINANCIAL INC | 144.9K | $5.55M | $656K | Added$4.11M |
| HighVista Strategies LLC | 131.3K | $5.03M | $421.4K | Added$4.11M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 128.9K | $4.94M | $4.93M | Added$4.93M |
| MORGAN STANLEY | 120.5K | $4.61M | $1.43M | Added$1.49M |
| Invesco Ltd. | 109.1K | $4.18M | $1.31M | Added$773.8K |
| TWO SIGMA INVESTMENTS, LP | 101.6K | $3.89M | $1.22M | Added$1.08M |
| DIMENSIONAL FUND ADVISORS LP | 91.8K | $3.52M | $1.1M | Added$1M |
| OPPENHEIMER & CO INC | 84.2K | $3.22M | $1.01M | Added$997.1K |
| XTX Topco Ltd | 83.9K | $3.21M | $365.3K | Added$2.41M |
| Schonfeld Strategic Advisors LLC | 79.6K | $3.05M | — | New |
| Cinctive Capital Management LP | 78K | $2.99M | — | New |
| WELLINGTON MANAGEMENT GROUP LLP | 77.2K | $2.96M | $926.8K | Added$213.4K |
| Kalehua Capital Management LLC | 74.5K | $2.85M | $894.3K | Added$894.3K |
| Ensign Peak Advisors, Inc | 74.1K | $2.84M | — | New |
| Bank of New York Mellon Corp | 72.2K | $2.77M | $731.4K | Added$1.16M |
| Russell Investments Group, Ltd. | 70.4K | $2.7M | $156.1K | Added$2.36M |
| Catalio Capital Management, LP | 67.3K | $2.58M | — | New |
| UBS Group AG | 61.6K | $2.36M | $706.9K | Added$810.5K |
| JPMORGAN CHASE & CO | 66.8K | $2.31M | $555K | Added$439.7K |
| Vestal Point Capital, LP | 54K | $2.07M | $648.5K | Cut−$61.7M |
| Nuveen, LLC | 50.8K | $1.95M | $568.7K | Added$702.4K |
| TD Asset Management Inc | 50K | $1.92M | — | New |
| AMERICAN CENTURY COMPANIES INC | 47.9K | $1.84M | $555.2K | Added$620.4K |
| Arkadios Wealth Advisors | 47.6K | $1.82M | — | New |
| Susquehanna Portfolio Strategies, LLC | 47K | $1.8M | $564.8K | Added$522.2K |
| ALPS ADVISORS INC | 43.9K | $1.68M | $526.4K | Added$527.5K |
| PDT Partners, LLC | 42.3K | $1.62M | $507.8K | Added$507.8K |
| Jump Financial, LLC | 41.4K | $1.58M | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40.2K | $1.54M | $100.4K | Added$1.32M |
| RHUMBLINE ADVISERS | 39.7K | $1.52M | $465.9K | Added$499.2K |
| Point72 Asset Management, L.P. | 38.9K | $1.49M | $466.6K | Cut−$21.5M |
| VOYA INVESTMENT MANAGEMENT LLC | 38.4K | $1.47M | $358.9K | Added$683.4K |
| Brevan Howard Capital Management LP | 38.6K | $1.46M | — | New |
| Rafferty Asset Management, LLC | 34.9K | $1.33M | $185.6K | Added$928.7K |
| STATE OF WISCONSIN INVESTMENT BOARD | 33.3K | $1.27M | $399.4K | Added$247.9K |
| Icahn Capital | 29.4K | $1.13M | $343.9K | Added$374.2K |
| Fisher Asset Management, LLC | 28.8K | $1.1M | $345.9K | Added$345.9K |
| Eversept Partners, LP | 27.1K | $1.04M | $324.9K | Cut−$6.29M |
| Swiss National Bank | 26.4K | $1.01M | — | New |
| Creative Planning | 23.9K | $917.2K | $235.4K | Added$401.8K |
| ALLIANCEBERNSTEIN L.P. | 32K | $841K | $0 | Held |
| Auour Investments LLC | 21K | $805.1K | $252.4K | Added$252.4K |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 20.5K | $786K | $222.7K | Added$298.5K |
| DEUTSCHE BANK AG\ | 20.5K | $785K | $196.7K | Added$354.4K |
| Squarepoint Ops LLC | 20.5K | $784.9K | $246.1K | Cut−$645.9K |
| Walleye Capital LLC | 18.7K | $716.8K | — | New |
| Quadrature Capital Ltd | 18.2K | $697.2K | — | New |
| STRS OHIO | 18.1K | $693.2K | $8.41K | Added$674.8K |
| TUDOR INVESTMENT CORP ET AL | 16.3K | $623.7K | — | New |
| PSP Research LLC | 16K | $612.8K | $192.2K | Added$38.3K |
| PROFUND ADVISORS LLC | 15.7K | $599.6K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15.5K | $595.3K | $186.7K | Cut−$854.2K |
| Vanguard Global Advisers, LLC | 15.5K | $592.9K | — | Held |
| Citadel | 15.4K | $589.7K | — | New |
| VICTORY CAPITAL MANAGEMENT INC | 15.2K | $583.3K | $182.9K | Added$89.3K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14.6K | $551K | $147.7K | Added$212.5K |
| CANADA PENSION PLAN INVESTMENT BOARD | 14.3K | $547.7K | $171.7K | Cut−$212.1K |
| ExodusPoint Capital Management, LP | 14.1K | $538.7K | $168.9K | Cut−$586.2K |
| MetLife Investment Management, LLC | 14K | $535.9K | $168.1K | Added$132.2K |
| FRANKLIN RESOURCES INC | 13K | $496.8K | $155.8K | Added$155.8K |
| Virtus Investment Advisers, LLC | 12K | $461.5K | $141.2K | Added$152.4K |
| WELLS FARGO & COMPANY/MN | 11.7K | $447K | $140.2K | Cut−$316.7K |
| BAKER BROS. ADVISORS LP | 10.6K | $406.2K | $127.4K | Added$127.4K |
| JANE STREET GROUP, LLC | 10.2K | $389.5K | — | New |
| Soleus Capital Management, L.P. | 10K | $383K | $120.1K | Cut−$2.9M |
| Legal & General Group Plc | 9.54K | $364.8K | $28.3K | Added$302.6K |
| China Universal Asset Management Co., Ltd. | 9.47K | $362.7K | $104.5K | Added$134.1K |
| VANGUARD ASSET MANAGEMENT, Ltd | 8.99K | $344.4K | — | Held |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 8.07K | $309.3K | — | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8.04K | $307.9K | — | New |
| Bridgefront Capital, LLC | 7.91K | $303K | — | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 7.83K | $300K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 7.42K | $284.3K | $89.2K | Added$89.2K |
| Allianz Asset Management GmbH | 7K | $268.1K | — | New |
| Police & Firemen's Retirement System of New Jersey | 6.44K | $246.7K | $77.3K | Added$77.3K |
| INTECH INVESTMENT MANAGEMENT LLC | 6.34K | $243K | $76.2K | Cut−$14.7K |
| ProShare Advisors LLC | 6.14K | $235.2K | — | New |
| CITIGROUP INC | 5.99K | $229.5K | $45.8K | Added$129.1K |
| Graham Capital Management, L.P. | 5.76K | $220.5K | — | New |
| Persistent Asset Partners Ltd | 4.52K | $173K | — | New |
| Tower Research Capital LLC (TRC) | 3K | $115.1K | $3.98K | Added$106.4K |
| Vanguard Investments Australia, Ltd. | 2.93K | $112.1K | — | Held |
| KLP KAPITALFORVALTNING AS | 2.9K | $111.1K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 2.78K | $106.6K | $31.2K | Added$38.4K |
| Chung Wu Investment Group, LLC | 2K | $76.6K | $24K | Added$24K |
| Ameritas Investment Partners, Inc. | 1.99K | $76.3K | $23.9K | Added$23.9K |
| Caitong International Asset Management Co., Ltd | 1.89K | $72.4K | $22.7K | Cut−$6.37K |
| Steward Partners Investment Advisory, LLC | 1.58K | $60.4K | $925 | Added$58.4K |
| CWM, LLC | 1.57K | $60K | $59.2K | Added$59.9K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.4K | $53.7K | $16.8K | Added$11.8K |
| GF FUND MANAGEMENT CO. LTD. | 1.2K | $45.9K | $12.6K | Added$18.3K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 986.1K | $37.8K | $173 | Added$37.4K |
| Sterling Capital Management LLC | 858 | $32.9K | $10.3K | Cut−$6.26K |
| Versant Capital Management, Inc | 819 | $31.4K | $9.84K | Added$9.84K |
| Hilton Head Capital Partners, LLC | 772 | $29.6K | — | New |
| FEDERATED HERMES, INC. | 714 | $27.3K | $8.58K | Cut−$6.75K |
| OSAIC HOLDINGS, INC. | 551 | $21.1K | $6.62K | Cut−$10.1K |
| GAMMA Investing LLC | 506 | $19.4K | $5.67K | Added$6.97K |
| Rockefeller Capital Management L.P. | 421 | $16.1K | $1.01K | Added$13.9K |
| Larson Financial Group LLC | 295 | $11.3K | $1.75K | Added$7.46K |
| Quantbot Technologies LP | 243 | $9.31K | — | New |
| PNC Financial Services Group, Inc. | 223 | $8.54K | $2.5K | Added$3.07K |
| ALGERT GLOBAL LLC | 188K | $7.2K | $563 | Added$5.97K |
| True Wealth Design, LLC | 142 | $5.44K | $1.7K | Added$1.71K |
| EverSource Wealth Advisors, LLC | 128 | $4.9K | $504 | Added$3.8K |
| Smartleaf Asset Management LLC | 127 | $4.39K | $1.16K | Added$1.16K |
| Optiver Holding B.V. | 106 | $4.06K | $1.27K | Added$695 |
| Allworth Financial LP | 104 | $3.98K | $1.2K | Added$1.35K |
| Atlantic Union Bankshares Corp | 100 | $3.83K | — | New |
| NISA INVESTMENT ADVISORS, LLC | 88 | $3.37K | $1.03K | Added$1.11K |
| ROYAL BANK OF CANADA | 88 | $3K | $747 | Cut−$16K |
| ROTHSCHILD INVESTMENT LLC | 70 | $2.68K | $660 | Added$1.24K |
| Farther Finance Advisors, LLC | 60 | $2.3K | $720 | Added$720 |
| SIGNATUREFD, LLC | 43 | $1.65K | $517 | Added$517 |
| Clearstead Advisors, LLC | 29 | $1.1K | $346 | Added$346 |
| US BANCORP \DE\ | 11 | $421 | — | New |
| SG Americas Securities, LLC | 7.21K | $276 | — | New |
| TWIN PEAKS WEALTH ADVISORS, LLC | 7 | $268 | — | New |
| MAI Capital Management | 4 | $154 | — | New |
| SBI Securities Co., Ltd. | 4 | $153 | $48 | Added$48 |
| TFC Financial Management, Inc. | 1 | $39 | — | New |
| Covestor Ltd | 6 | $0 | $0 | Held |