| Fidelity | 2.81M | $58.6M | — | Held |
| Aberdeen Group plc | 1.14M | $23.8M | — | Held |
| BRAIDWELL LP | 927.5K | $19.3M | — | Held |
| BAKER BROS. ADVISORS LP | 903.4K | $18.8M | — | Held |
| BlackRock, Inc. | 854.4K | $17.8M | — | Held |
| 5AM Venture Management, LLC | 606.7K | $12.7M | — | Held |
| Vanguard | 599.9K | $12.5M | — | Held |
| ORBIMED ADVISORS LLC | 574.6K | $12M | — | Held |
| Point72 Asset Management, L.P. | 492.3K | $10.3M | — | Held |
| Vestal Point Capital, LP | 328K | $6.84M | — | Held |
| Citadel | 317.6K | $6.63M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 300.8K | $6.28M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 263.6K | $5.5M | — | Held |
| Pale Fire Capital SE | 261K | $5.45M | — | Held |
| Prosight Management, LP | 235K | $4.9M | — | Held |
| Opaleye Management Inc. | 214.7K | $4.48M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 209.2K | $4.36M | — | Held |
| State Street | 209.1K | $4.36M | — | Held |
| Woodline Partners LP | 200K | $4.17M | — | Held |
| Squarepoint Ops LLC | 199.6K | $4.16M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151.7K | $3.16M | — | Held |
| WELLS FARGO & COMPANY/MN | 120.4K | $2.51M | — | Held |
| D. E. Shaw & Co., Inc. | 120.3K | $2.51M | — | Held |
| ExodusPoint Capital Management, LP | 111.2K | $2.32M | — | Held |
| MORGAN STANLEY | 94.4K | $1.97M | $488.2K | Added$326.7K |
| GOLDMAN SACHS GROUP INC | 92.7K | $1.93M | — | Held |
| KOTLER KEVIN | 80K | $1.67M | — | Held |
| Knott David M Jr | 74K | $1.54M | — | Held |
| NORTHERN TRUST CORP | 72.3K | $1.51M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 71.7K | $1.49M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 54.6K | $1.14M | — | Held |
| PFM Health Sciences, LP | 42.7K | $891.2K | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 42.3K | $881.4K | — | Held |
| Jump Financial, LLC | 39.5K | $824K | — | Held |
| Schonfeld Strategic Advisors LLC | 39.1K | $815.8K | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 37.4K | $779.7K | — | Held |
| Aldebaran Capital, LLC | 37.4K | $779.2K | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32.5K | $677.1K | — | Held |
| UBS Group AG | 31.2K | $651.1K | — | Held |
| MARSHALL WACE, LLP | 30.9K | $644.9K | — | Held |
| ADAR1 Capital Management, LLC | 30K | $625.9K | — | Held |
| BIT Capital GmbH | 30K | $625.8K | — | Held |
| MONIMUS CAPITAL MANAGEMENT, LP | 26.6K | $554.8K | — | Held |
| Bank of New York Mellon Corp | 25.9K | $539.4K | — | Held |
| BARCLAYS PLC | 22.4K | $468.2K | $92.9K | Added$186.1K |
| Aquatic Capital Management LLC | 22.3K | $464.4K | — | Held |
| JANE STREET GROUP, LLC | 19.3K | $403K | — | Held |
| AlphaQuest LLC | 18.2K | $379.4K | — | Held |
| ALPS ADVISORS INC | 15.4K | $320.6K | — | Held |
| SEI INVESTMENTS CO | 15.3K | $318.1K | — | Held |
| Nuveen, LLC | 14.3K | $298.4K | — | Held |
| RHUMBLINE ADVISERS | 14.2K | $296.1K | — | Held |
| Virtus Investment Advisers, LLC | 13.5K | $280.8K | — | Held |
| Palumbo Wealth Management LLC | 13K | $272.1K | — | Held |
| Marex Group plc | 12.5K | $260.8K | — | New |
| Clarius Group, LLC | 10.1K | $211.3K | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 10.1K | $210.2K | — | Held |
| Quadrature Capital Ltd | 10K | $208.9K | — | Held |
| BANK OF AMERICA CORP /DE/ | 9.22K | $192.4K | $32.9K | Added$92.6K |
| SIMPLEX TRADING, LLC | 9.14K | $190.7K | — | Held |
| DEUTSCHE BANK AG\ | 7.59K | $158.3K | — | Held |
| MetLife Investment Management, LLC | 6.72K | $140.3K | — | Held |
| Clearstead Advisors, LLC | 6.5K | $135.6K | — | Held |
| AlphaCentric Advisors LLC | 6.48K | $135.1K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 6.3K | $131.4K | — | Held |
| China Universal Asset Management Co., Ltd. | 6.05K | $126.2K | — | Held |
| JPMORGAN CHASE & CO | 5.78K | $120.5K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 6.41K | $112.8K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5.08K | $105.9K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 5K | $104.3K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 5K | $104.3K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 2.82K | $58.8K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 2.64K | $55K | — | Held |
| Ameritas Investment Partners, Inc. | 1.12K | $23.4K | — | Held |
| Legal & General Group Plc | 1.05K | $21.9K | — | Held |
| CITIGROUP INC | 1.03K | $21.5K | — | Held |
| Russell Investments Group, Ltd. | 929 | $19.4K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 909 | $19K | — | Held |
| Tower Research Capital LLC (TRC) | 752 | $15.7K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 676 | $14.1K | — | Held |
| HighMark Wealth Management LLC | 587 | $12.2K | — | Held |
| GROUP ONE TRADING LLC | 541 | $11.3K | — | Held |
| Sterling Capital Management LLC | 537 | $11.2K | — | Held |
| Federation des caisses Desjardins du Quebec | 500 | $10.4K | — | Held |
| ROYAL BANK OF CANADA | 521 | $10K | — | Held |
| Farther Finance Advisors, LLC | 373 | $7.78K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 367 | $7.66K | — | Held |
| Bollard Group LLC | 303K | $6.32K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 173 | $3.61K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 164 | $3.42K | — | Held |
| Vermillion & White Wealth Management Group, LLC | 107 | $2.23K | — | Held |
| GSA CAPITAL PARTNERS LLP | 63.3K | $1.32K | — | Held |
| Allworth Financial LP | 62 | $1.29K | — | New |
| US BANCORP \DE\ | 37 | $772 | — | Held |
| OPTIMA CAPITAL LLC | 31 | $647 | — | Held |
| GAMMA Investing LLC | 29 | $605 | — | Held |
| Caldwell Trust Co | 20 | $417 | — | Held |
| Global Wealth Strategies & Associates | 18 | $375 | — | Held |
| True Wealth Design, LLC | 5 | $105 | — | Held |
| Sunbelt Securities, Inc. | 5 | $104 | — | Held |
| EverSource Wealth Advisors, LLC | 2 | $42 | — | Held |
| OSAIC HOLDINGS, INC. | 1 | $21 | — | Held |
| CWM, LLC | 466 | $10 | — | Held |
| AMALGAMATED BANK | 345 | $7 | — | Held |
| Daiwa Securities Group Inc. | 80 | $2 | — | Held |