| Fidelity | 2.82M | $87.1M | $28.2M | Added$28.5M |
| TCG Crossover Management, LLC | 1.2M | $37.2M | — | New |
| Aberdeen Group plc | 1.14M | $35.3M | $11.5M | Added$11.5M |
| BlackRock, Inc. | 860.4K | $26.6M | $8.59M | Added$8.77M |
| BRAIDWELL LP | 847.2K | $26.2M | $8.51M | Added$6.84M |
| First Light Asset Management, LLC | 647.7K | $20M | — | New |
| BAKER BROS. ADVISORS LP | 607.8K | $18.8M | $6.11M | Cut−$58.2K |
| 5AM Venture Management, LLC | 606.7K | $18.8M | $6.1M | Added$6.1M |
| VANGUARD CAPITAL MANAGEMENT LLC | 473.5K | $14.6M | — | Held |
| Vestal Point Capital, LP | 328K | $10.1M | $3.3M | Added$3.3M |
| KENNEDY CAPITAL MANAGEMENT LLC | 286.7K | $8.86M | $2.1M | Added$4.5M |
| GEODE CAPITAL MANAGEMENT, LLC | 268.3K | $8.29M | $2.65M | Added$2.8M |
| MARSHALL WACE, LLP | 229.6K | $7.1M | $310.7K | Added$6.45M |
| ORBIMED ADVISORS LLC | 226.6K | $7M | $2.28M | Cut−$4.98M |
| State Street | 213.5K | $6.6M | $2.1M | Added$2.24M |
| Squarepoint Ops LLC | 164.4K | $5.08M | $1.65M | Added$917.6K |
| Ikarian Capital, LLC | 157.5K | $4.87M | — | New |
| AMERIPRISE FINANCIAL INC | 143.4K | $4.43M | — | New |
| Opaleye Management Inc. | 123K | $3.8M | $1.24M | Cut−$677.7K |
| Soleus Capital Management, L.P. | 121.7K | $3.76M | — | New |
| D. E. Shaw & Co., Inc. | 116.1K | $3.59M | $1.17M | Added$1.08M |
| WELLS FARGO & COMPANY/MN | 112.7K | $3.48M | $1.13M | Added$970.7K |
| Woodline Partners LP | 100K | $3.09M | $1.01M | Cut−$1.08M |
| ExodusPoint Capital Management, LP | 83.7K | $2.59M | $841K | Added$267.1K |
| Prosight Management, LP | 79.9K | $2.47M | $802.7K | Cut−$2.43M |
| NORTHERN TRUST CORP | 78.4K | $2.42M | $726.2K | Added$914.7K |
| Point72 Asset Management, L.P. | 68.6K | $2.12M | $689.4K | Cut−$8.15M |
| VANGUARD FIDUCIARY TRUST CO | 67.9K | $2.1M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 67K | $2.07M | $673.3K | Added$576K |
| MORGAN STANLEY | 64.8K | $2M | $651.7K | Added$34.5K |
| RAYMOND JAMES FINANCIAL INC | 64.2K | $1.98M | $548.7K | Added$845.3K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 63.6K | $1.97M | — | Held |
| GOLDMAN SACHS GROUP INC | 62.4K | $1.93M | $627.4K | Cut−$4.2K |
| MILLENNIUM MANAGEMENT LLC | 58.3K | $1.8M | $586.4K | Cut−$4.47M |
| JPMORGAN CHASE & CO | 58.9K | $1.7M | $46.3K | Added$1.58M |
| BOOTHBAY FUND MANAGEMENT, LLC | 46.1K | $1.43M | — | New |
| PFM Health Sciences, LP | 46.1K | $1.43M | $429.4K | Added$534.6K |
| Jump Financial, LLC | 43.1K | $1.33M | $397K | Added$508.2K |
| Tetragon Partners GP Ltd | 37.6K | $1.16M | — | New |
| Aldebaran Capital, LLC | 37.2K | $1.15M | $373.7K | Added$370.2K |
| SEI INVESTMENTS CO | 36.9K | $1.14M | $153.3K | Added$821.5K |
| UBS Group AG | 30K | $926.9K | $301.4K | Added$275.8K |
| WELLINGTON MANAGEMENT GROUP LLP | 29.2K | $903.8K | $293.9K | Added$124.1K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29.1K | $899.8K | $292.6K | Added$222.7K |
| Clearstead Advisors, LLC | 26.8K | $827.2K | $65.3K | Added$691.6K |
| MONIMUS CAPITAL MANAGEMENT, LP | 26.8K | $826.9K | $267.3K | Added$272.2K |
| Bank of New York Mellon Corp | 24.8K | $765.3K | $248.8K | Added$225.9K |
| TD Asset Management Inc | 20.4K | $630.6K | — | New |
| SECTORAL ASSET MANAGEMENT INC | 19.1K | $628.2K | $230.6K | Cut−$253.2K |
| Icahn Capital | 16.9K | $523.4K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16.2K | $500K | $162.6K | Cut−$2.66M |
| ALPS ADVISORS INC | 15.3K | $472.5K | $153.6K | Added$151.9K |
| RHUMBLINE ADVISERS | 14K | $433.6K | $141K | Added$137.4K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13.9K | $430.5K | — | New |
| Virtus Investment Advisers, LLC | 13.8K | $426.5K | $135.3K | Added$145.7K |
| ADAR1 Capital Management, LLC | 13K | $401.9K | $130.7K | Cut−$224.1K |
| AMERICAN CENTURY COMPANIES INC | 12.5K | $387.4K | — | New |
| Creative Planning | 12.4K | $384.7K | — | New |
| Nuveen, LLC | 12K | $371.9K | $120.9K | Added$73.6K |
| XTX Topco Ltd | 11.6K | $359.2K | — | New |
| BANK OF AMERICA CORP /DE/ | 11.5K | $354.4K | $92.7K | Added$162K |
| DIMENSIONAL FUND ADVISORS LP | 10.1K | $311.5K | $101.3K | Added$101.3K |
| DEUTSCHE BANK AG\ | 9.35K | $288.9K | $76.3K | Added$130.5K |
| Invesco Ltd. | 7.67K | $237.2K | — | New |
| AlphaCentric Advisors LLC | 6.85K | $211.7K | $65.1K | Added$76.6K |
| MetLife Investment Management, LLC | 6.72K | $207.8K | $67.6K | Added$67.6K |
| BARCLAYS PLC | 6.71K | $207.3K | $67.4K | Cut−$260.9K |
| China Universal Asset Management Co., Ltd. | 6.33K | $195.7K | $60.8K | Added$69.5K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5.21K | $161.2K | $51K | Added$55.2K |
| NISA INVESTMENT ADVISORS, LLC | 5K | $154.6K | $50.3K | Added$50.3K |
| NEW YORK STATE COMMON RETIREMENT FUND | 4.6K | $142.2K | $46.2K | Added$37.9K |
| Vanguard Global Advisers, LLC | 3.96K | $122.5K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 2.82K | $87K | $28.3K | Added$28.2K |
| Police & Firemen's Retirement System of New Jersey | 2.64K | $81.5K | $26.5K | Added$26.5K |
| CWM, LLC | 1.83K | $56.5K | $14.4K | Added$56.5K |
| Caption Management, LLC | 1.45K | $44.8K | — | New |
| SIMPLEX TRADING, LLC | 1.35K | $41.8K | $13.6K | Cut−$148.9K |
| CITIGROUP INC | 1.15K | $35.5K | $10.4K | Added$13.9K |
| US BANCORP \DE\ | 1.14K | $35.1K | $372 | Added$34.3K |
| Ameritas Investment Partners, Inc. | 1.12K | $34.7K | $11.3K | Added$11.3K |
| Legal & General Group Plc | 1K | $30.9K | $10.1K | Added$9.01K |
| Mirae Asset Global Investments Co., Ltd. | 979 | $30.3K | $9.14K | Added$11.3K |
| Tower Research Capital LLC (TRC) | 914 | $28.3K | $7.56K | Added$12.6K |
| Russell Investments Group, Ltd. | 851 | $26.3K | $8.55K | Added$6.93K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 595 | $18.4K | $5.98K | Added$4.29K |
| HighMark Wealth Management LLC | 587 | $18.1K | $5.89K | Added$5.89K |
| Federation des caisses Desjardins du Quebec | 500 | $15.5K | $5.03K | Added$5.03K |
| GF FUND MANAGEMENT CO. LTD. | 415 | $12.8K | $3.69K | Added$5.17K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 382 | $11.8K | $1.74K | Added$8.2K |
| Rockefeller Capital Management L.P. | 370 | $11.4K | — | New |
| GAMMA Investing LLC | 330 | $10.2K | $291 | Added$9.6K |
| Sterling Capital Management LLC | 313 | $9.68K | $3.15K | Cut−$1.53K |
| Bollard Group LLC | 303K | $9.36K | $3.04K | Added$3.04K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 164.1K | $5.07K | — | New |
| Farther Finance Advisors, LLC | 102 | $3.14K | $1.01K | Cut−$4.64K |
| Allworth Financial LP | 65 | $2.01K | $623 | Added$716 |
| Marshall & Sterling Wealth Advisors Inc. | 50 | $1.55K | — | New |
| Essential Partners LLC | 37 | $1.14K | — | New |
| PNC Financial Services Group, Inc. | 26 | $804 | — | New |
| Caldwell Trust Co | 20 | $618 | $201 | Added$201 |
| EverSource Wealth Advisors, LLC | 19 | $588 | $20 | Added$546 |
| GSA CAPITAL PARTNERS LLP | 18.9K | $583 | $189 | Cut−$737 |
| Global Wealth Strategies & Associates | 18 | $556 | $181 | Added$181 |
| Fortitude Family Office, LLC | 15 | $464 | — | New |
| HUNTINGTON NATIONAL BANK | 13 | $402 | — | New |
| ROTHSCHILD INVESTMENT LLC | 11 | $340 | — | New |
| Sunbelt Securities, Inc. | 8 | $247 | $50 | Added$143 |
| MAI Capital Management | 7 | $217 | — | New |
| True Wealth Design, LLC | 7 | $217 | $50 | Added$112 |
| Root Financial Partners, LLC | 5 | $155 | — | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3 | $93 | $30 | Cut−$3.33K |