| GENERAL ATLANTIC, L.P. | 8.03M | $222.9M | — | Held |
| Fidelity | 6.4M | $177.6M | — | Held |
| Foresite Capital Management IV, LLC | 4.78M | $132.6M | — | Held |
| venBio Partners LLC | 4.64M | $128.7M | — | Held |
| Viking Global | 3.65M | $101.4M | — | Held |
| EQT Fund Management S.a r.l. | 3.42M | $95M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3.13M | $86.7M | — | Held |
| Bain Capital Life Sciences Investors, LLC | 2.8M | $77.8M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 1.91M | $52.9M | — | Held |
| Commodore Capital LP | 1.89M | $52.4M | — | Held |
| NOVO HOLDINGS A/S | 1.75M | $48.6M | — | Held |
| Saturn V Capital Management LP | 1.14M | $31.6M | — | Held |
| Cormorant Asset Management, LP | 1.08M | $30.1M | — | Held |
| 5AM Venture Management, LLC | 797.6K | $22.1M | — | Held |
| Sofinnova Investments, Inc. | 745.2K | $20.7M | — | Held |
| Point72 Asset Management, L.P. | 711.6K | $19.7M | — | Held |
| BlackRock, Inc. | 708.6K | $19.7M | — | Held |
| Soleus Capital Management, L.P. | 702.1K | $19.5M | — | Held |
| Octagon Capital Advisors LP | 671.5K | $18.6M | — | Held |
| Kynam Capital Management, LP | 640.4K | $17.8M | — | Held |
| Rock Springs Capital Management LP | 623.4K | $17.3M | — | Held |
| Patient Square Capital LP | 542.7K | $15.1M | — | Held |
| Balyasny Asset Management L.P. | 496.3K | $13.8M | — | Held |
| Ikarian Capital, LLC | 486.9K | $13.5M | — | Held |
| Elmind Capital, LP | 475.8K | $13.2M | — | Held |
| Eversept Partners, LP | 439.2K | $12.2M | — | Held |
| BAKER BROS. ADVISORS LP | 375K | $10.4M | — | Held |
| D. E. Shaw & Co., Inc. | 260.6K | $7.23M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 248.9K | $6.91M | — | Held |
| MORGAN STANLEY | 248.3K | $6.89M | $163.1K | Added$5.44M |
| Polar Capital Holdings Plc | 238K | $6.6M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 215.2K | $5.97M | — | Held |
| ORBIMED ADVISORS LLC | 205.4K | $5.7M | — | Held |
| Kalehua Capital Management LLC | 198.8K | $5.52M | — | Held |
| Tetragon Partners GP Ltd | 194.6K | $5.4M | — | Held |
| HighVista Strategies LLC | 162.4K | $4.51M | — | Held |
| State Street | 161.5K | $4.48M | — | Held |
| GOLDMAN SACHS GROUP INC | 160.9K | $4.47M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 157.1K | $4.36M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 158K | $4.15M | — | Held |
| UBS Group AG | 137.7K | $3.82M | — | Held |
| Citadel | 135.1K | $3.75M | — | Held |
| Alyeska Investment Group, L.P. | 125K | $3.47M | — | Held |
| TD Asset Management Inc | 120.2K | $3.34M | — | Held |
| Squarepoint Ops LLC | 100.4K | $2.78M | — | Held |
| Logos Global Management LP | 100K | $2.77M | — | Held |
| TWO SIGMA ADVISERS, LP | 89.6K | $2.49M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 86.8K | $2.41M | — | Held |
| ADAR1 Capital Management, LLC | 85.5K | $2.37M | — | Held |
| Trexquant Investment LP | 84.4K | $2.34M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 83.9K | $2.33M | — | Held |
| GREAT POINT PARTNERS LLC | 82.8K | $2.3M | — | Held |
| NORTHERN TRUST CORP | 81K | $2.25M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 79.9K | $2.1M | — | Held |
| JANE STREET GROUP, LLC | 73.1K | $2.03M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 64K | $1.77M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61.6K | $1.71M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 59K | $1.64M | — | Held |
| STEMPOINT CAPITAL LP | 58.4K | $1.62M | — | Held |
| DEUTSCHE BANK AG\ | 56.4K | $1.56M | — | Held |
| Seven Fleet Capital Management LP | 55.3K | $1.54M | — | Held |
| ALPS ADVISORS INC | 52.6K | $1.46M | — | Held |
| Swiss National Bank | 44.8K | $1.24M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 32K | $888.8K | $89.7K | Cut−$1.05M |
| MARSHALL WACE, LLP | 31.8K | $883.3K | — | Held |
| Birchview Capital, LP | 29.8K | $828.3K | — | Held |
| Quadrature Capital Ltd | 28.9K | $802.5K | — | Held |
| Amundi | 27.6K | $767K | — | Held |
| Jump Financial, LLC | 26.3K | $729.8K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24K | $665.5K | — | Held |
| SummitTX Capital, L.P. | 22.9K | $634.3K | — | Held |
| Legal & General Group Plc | 22.7K | $629K | — | Held |
| JPMORGAN CHASE & CO | 21.9K | $608.9K | — | Held |
| PSP Research LLC | 20.5K | $569.2K | — | Held |
| Palumbo Wealth Management LLC | 20.2K | $560.1K | — | Held |
| BANK OF AMERICA CORP /DE/ | 19.6K | $542.7K | $52.2K | Added$77.2K |
| Vanguard | 19.3K | $535.9K | — | Held |
| XTX Topco Ltd | 18.6K | $515.3K | — | Held |
| Verition Fund Management LLC | 17.9K | $496.7K | — | Held |
| Nuveen, LLC | 17K | $471.9K | — | Held |
| Qube Research & Technologies Ltd | 14.7K | $408.1K | — | Held |
| OCCUDO QUANTITATIVE STRATEGIES LP | 12.3K | $342.7K | — | Held |
| Virtus Investment Advisers, LLC | 11K | $305.6K | — | Held |
| China Universal Asset Management Co., Ltd. | 10.4K | $289.7K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 8.98K | $249.2K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 8.91K | $247.3K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 8.24K | $228.6K | — | Held |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 7.57K | $210K | — | Held |
| KLP KAPITALFORVALTNING AS | 5.8K | $160.9K | — | Held |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 5K | $138.8K | — | Held |
| Quantbot Technologies LP | 4.26K | $118.2K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3.98K | $110.4K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.11K | $86.4K | — | Held |
| BARCLAYS PLC | 2.77K | $77K | — | New |
| CITIGROUP INC | 1.79K | $49.6K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.26K | $34.9K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 941.6K | $26.1K | — | Held |
| Tower Research Capital LLC (TRC) | 471 | $13.1K | — | Held |
| WELLS FARGO & COMPANY/MN | 450 | $12.5K | — | Held |
| ROYAL BANK OF CANADA | 80 | $2K | — | Held |
| HRT FINANCIAL LP | 14.8K | $409 | — | Held |
| Caitong International Asset Management Co., Ltd | 6 | $166 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 5.51K | $153 | — | Held |
| SBI Securities Co., Ltd. | 1 | $28 | — | Held |
| Daiwa Securities Group Inc. | 213 | $6 | — | Held |
| Centerpoint Advisors, LLC | 100 | $3 | — | Held |