| GENERAL ATLANTIC, L.P. | 8.03M | $226.9M | $4.02M | Added$4.02M |
| Fidelity | 6.28M | $177.5M | $3.14M | Cut−$40.3K |
| Foresite Capital Management IV, LLC | 4.78M | $135M | $2.39M | Added$2.39M |
| venBio Partners LLC | 4.64M | $131.1M | $2.32M | Added$2.32M |
| Viking Global | 3.65M | $103.2M | $1.83M | Added$1.83M |
| EQT Fund Management S.a r.l. | 3.42M | $96.7M | $1.71M | Added$1.71M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3.13M | $88.3M | $1.56M | Added$1.56M |
| Bain Capital Life Sciences Investors, LLC | 2.68M | $75.6M | $1.34M | Cut−$2.17M |
| WELLINGTON MANAGEMENT GROUP LLP | 2.12M | $59.9M | $952.9K | Added$6.97M |
| Commodore Capital LP | 1.92M | $54.2M | $944.7K | Added$1.78M |
| NOVO HOLDINGS A/S | 1.75M | $49.4M | $875K | Added$875K |
| Saturn V Capital Management LP | 1.2M | $33.9M | $570K | Added$2.3M |
| Point72 Asset Management, L.P. | 1.01M | $28.4M | $355.8K | Added$8.7M |
| Cormorant Asset Management, LP | 1M | $28.3M | $500K | Cut−$1.8M |
| Sofinnova Investments, Inc. | 818.3K | $23.1M | $372.6K | Added$2.44M |
| 5AM Venture Management, LLC | 797.6K | $22.5M | $398.8K | Added$398.8K |
| Polar Capital Holdings Plc | 781K | $22.1M | $119K | Added$15.5M |
| BlackRock, Inc. | 757.2K | $21.4M | $354.3K | Added$1.73M |
| Soleus Capital Management, L.P. | 702.1K | $19.8M | $351K | Added$351K |
| Rock Springs Capital Management LP | 645.5K | $18.2M | $311.7K | Added$936.9K |
| Kynam Capital Management, LP | 640.4K | $18.1M | $320.2K | Added$320.2K |
| Patient Square Capital LP | 493K | $13.9M | $246.5K | Cut−$1.13M |
| Ikarian Capital, LLC | 486.9K | $13.8M | $243.4K | Added$243.4K |
| Elmind Capital, LP | 475.8K | $13.4M | $237.9K | Added$237.9K |
| Balyasny Asset Management L.P. | 462.3K | $13.1M | $231.1K | Cut−$712.6K |
| Eversept Partners, LP | 407K | $11.5M | $203.5K | Cut−$690.5K |
| BAKER BROS. ADVISORS LP | 375K | $10.6M | $187.5K | Added$187.5K |
| D. E. Shaw & Co., Inc. | 321.2K | $9.07M | $130.3K | Added$1.84M |
| Seven Fleet Capital Management LP | 316.7K | $8.95M | $27.7K | Added$7.41M |
| Tetragon Partners GP Ltd | 221.6K | $6.26M | $97.3K | Added$860K |
| ORBIMED ADVISORS LLC | 205.4K | $5.8M | $102.7K | Added$102.7K |
| Kalehua Capital Management LLC | 198.8K | $5.62M | $99.4K | Added$99.4K |
| Foresite Capital Management V, LLC | 194.1K | $5.48M | — | New |
| MILLENNIUM MANAGEMENT LLC | 181.9K | $5.14M | $91K | Cut−$1.77M |
| Citadel | 168.6K | $4.76M | $67.5K | Added$1.02M |
| Jones Hill Capital LP | 167K | $4.72M | — | Held |
| Octagon Capital Advisors LP | 165K | $4.66M | $82.5K | Cut−$14M |
| MORGAN STANLEY | 164.3K | $4.64M | $82.2K | Cut−$2.25M |
| BOOTHBAY FUND MANAGEMENT, LLC | 157.1K | $4.44M | $78.6K | Added$78.6K |
| State Street | 152.9K | $4.32M | $76.5K | Cut−$160.9K |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 158K | $4.31M | $164.3K | Added$164.3K |
| DV Trading LLC | 144K | $4.07M | — | New |
| GOLDMAN SACHS GROUP INC | 142.9K | $4.04M | $71.5K | Cut−$427.5K |
| TWO SIGMA INVESTMENTS, LP | 126.1K | $3.56M | $63K | Cut−$2.41M |
| Alyeska Investment Group, L.P. | 125K | $3.53M | $62.5K | Added$62.5K |
| ADAR1 Capital Management, LLC | 105.5K | $2.98M | $42.8K | Added$607.8K |
| HighVista Strategies LLC | 97.9K | $2.76M | $48.9K | Cut−$1.74M |
| Squarepoint Ops LLC | 96.4K | $2.72M | $48.2K | Cut−$62.1K |
| GEODE CAPITAL MANAGEMENT, LLC | 89.1K | $2.52M | $43.4K | Added$109.2K |
| STEMPOINT CAPITAL LP | 86.6K | $2.45M | $29.2K | Added$827.2K |
| NORTHERN TRUST CORP | 83.5K | $2.36M | $40.5K | Added$109.3K |
| GREAT POINT PARTNERS LLC | 82.8K | $2.34M | $41.4K | Added$41.4K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 77.6K | $2.19M | $38.8K | Cut−$136K |
| UBS Group AG | 71.9K | $2.03M | $36K | Cut−$1.79M |
| Qube Research & Technologies Ltd | 71.2K | $2.01M | $7.35K | Added$1.6M |
| Trexquant Investment LP | 66.1K | $1.87M | $33.1K | Cut−$472.9K |
| Logos Global Management LP | 65K | $1.84M | $32.5K | Cut−$938.8K |
| XTX Topco Ltd | 54.9K | $1.55M | $9.28K | Added$1.04M |
| TD Asset Management Inc | 54.8K | $1.55M | $27.4K | Cut−$1.79M |
| DEUTSCHE BANK AG\ | 53.7K | $1.52M | $26.9K | Cut−$47.1K |
| ALPS ADVISORS INC | 52.1K | $1.47M | $26.1K | Added$13.8K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 45K | $1.27M | $22.5K | Cut−$439.6K |
| Swiss National Bank | 44.8K | $1.26M | $22.4K | Added$22.4K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 44.2K | $1.25M | $88.4K | Cut−$848.6K |
| Amundi | 31K | $874.4K | $13.8K | Added$107.4K |
| TUDOR INVESTMENT CORP ET AL | 30.9K | $873K | $15.5K | Cut−$15.8K |
| Birchview Capital, LP | 29.8K | $843.2K | $14.9K | Added$14.9K |
| DIADEMA PARTNERS LP | 29.3K | $828.3K | — | New |
| SummitTX Capital, L.P. | 29.2K | $824.4K | $11.4K | Added$190.1K |
| Legal & General Group Plc | 26.8K | $756.4K | $11.3K | Added$127.4K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24.2K | $682.3K | $12K | Added$16.8K |
| Palumbo Wealth Management LLC | 20.6K | $582.2K | $10.1K | Added$22.1K |
| PSP Research LLC | 20K | $565K | $10K | Cut−$4.18K |
| Jump Financial, LLC | 19.5K | $550.9K | $9.75K | Cut−$178.9K |
| JPMORGAN CHASE & CO | 20K | $545.9K | −$9.2K | Cut−$63K |
| Nuveen, LLC | 17K | $480.4K | $8.5K | Added$8.5K |
| BANK OF AMERICA CORP /DE/ | 15.6K | $442K | $7.82K | Cut−$100.7K |
| VANGUARD ASSET MANAGEMENT, Ltd | 15.1K | $425.4K | — | Held |
| Quadrature Capital Ltd | 13.7K | $387.7K | $6.86K | Cut−$414.9K |
| ExodusPoint Capital Management, LP | 13.5K | $380.5K | — | New |
| OCCUDO QUANTITATIVE STRATEGIES LP | 11.4K | $352.4K | $37K | Added$9.71K |
| China Universal Asset Management Co., Ltd. | 11.4K | $321.1K | $5.22K | Added$31.5K |
| Virtus Investment Advisers, LLC | 11.3K | $318.8K | $5.51K | Added$13.3K |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 10K | $282.5K | $2.5K | Added$143.8K |
| Atom Investors LP | 9.1K | $257.1K | — | New |
| ALLIANCEBERNSTEIN L.P. | 8.98K | $249.2K | $0 | Held |
| Police & Firemen's Retirement System of New Jersey | 8.24K | $232.8K | $4.12K | Added$4.12K |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 8.18K | $231K | $4.09K | Cut−$16.3K |
| Persistent Asset Partners Ltd | 7.9K | $223.3K | — | New |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 7.57K | $213.8K | $3.78K | Added$3.78K |
| Vanguard Investments Australia, Ltd. | 6.09K | $172K | — | Held |
| KLP KAPITALFORVALTNING AS | 5.8K | $163.8K | $2.9K | Added$2.9K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 5.72K | $161.7K | $155.5K | Added$161.6K |
| BARCLAYS PLC | 4.37K | $123.4K | $1.39K | Added$46.4K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3.98K | $112.4K | $1.99K | Added$1.99K |
| Mirae Asset Global Investments Co., Ltd. | 3.34K | $94.4K | $1.56K | Added$8K |
| CITIGROUP INC | 2.44K | $69K | $894 | Added$19.4K |
| Quantbot Technologies LP | 2.39K | $67.5K | $1.2K | Cut−$50.7K |
| SIMPLEX TRADING, LLC | 2.17K | $61.4K | — | New |
| GF FUND MANAGEMENT CO. LTD. | 1.44K | $40.7K | $629 | Added$5.74K |
| BNP PARIBAS FINANCIAL MARKETS | 1.39K | $39.2K | $694 | Cut−$1.6M |
| WELLS FARGO & COMPANY/MN | 450 | $12.7K | $225 | Added$225 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 442.3K | $12.5K | $221 | Cut−$13.6K |
| Tower Research Capital LLC (TRC) | 238 | $6.72K | $120 | Cut−$6.35K |
| ROYAL BANK OF CANADA | 81 | $2K | −$25 | Held |
| HRT FINANCIAL LP | 27.6K | $780 | $8 | Added$371 |
| Caitong International Asset Management Co., Ltd | 18 | $508 | $3 | Added$342 |
| Bare Financial Services, Inc | 6 | $170 | — | New |
| SBI Securities Co., Ltd. | 1 | $28 | $0 | Held |
| Centerpoint Advisors, LLC | 100 | $3 | $0 | Held |