| Lynx1 Capital Management LP | 1.54M | $17.4M | $2.24M | Added$12M |
| NEA Management Company, LLC | 1.3M | $14.7M | $3.61M | Added$5.95M |
| Atlas Venture Life Science Advisors, LLC | 1.14M | $12.9M | $3.76M | Added$3.76M |
| Balyasny Asset Management L.P. | 1.04M | $11.8M | — | New |
| VR ADVISER, LLC | 1.01M | $11.4M | — | New |
| Affinity Asset Advisors, LLC | 706.9K | $8M | — | New |
| Nantahala Capital Management, LLC | 660K | $7.47M | $1.99M | Added$2.67M |
| ADAR1 Capital Management, LLC | 540.1K | $6.11M | — | New |
| BlackRock, Inc. | 460K | $5.21M | $1.51M | Added$1.54M |
| Driehaus Capital Management LLC | 450K | $5.09M | — | New |
| TCG Crossover Management, LLC | 416.3K | $4.71M | $1.38M | Added$1.38M |
| Siren, L.L.C. | 347.7K | $3.94M | $1.15M | Added$1.15M |
| VANGUARD CAPITAL MANAGEMENT LLC | 310.9K | $3.52M | — | Held |
| 72 Investment Holdings, LLC | 276.8K | $3.13M | $916.3K | Added$916.3K |
| Icahn Capital | 267.8K | $3.03M | $134.5K | Added$2.71M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 228.4K | $2.59M | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 173.6K | $1.97M | $538.8K | Added$662K |
| TWO SIGMA INVESTMENTS, LP | 165.5K | $1.87M | $261.4K | Added$1.24M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 148.6K | $1.68M | — | Held |
| State Street | 140.3K | $1.59M | $464.5K | Added$417.4K |
| Renaissance Technologies | 136.2K | $1.54M | $247.9K | Added$942.1K |
| JANE STREET GROUP, LLC | 115.7K | $1.31M | $383K | Cut−$1M |
| Kalehua Capital Management LLC | 109.4K | $1.24M | — | New |
| MILLENNIUM MANAGEMENT LLC | 63.6K | $720K | $210.5K | Cut−$570.3K |
| EMERALD MUTUAL FUND ADVISERS TRUST | 62.9K | $711.5K | $208.1K | Added$186.5K |
| F/m Investments LLC | 62.9K | $711.5K | $208.1K | Added$186.5K |
| JPMORGAN CHASE & CO | 68.5K | $704.2K | $6.44K | Added$681.4K |
| XTX Topco Ltd | 60.5K | $684.5K | $188.9K | Added$227.4K |
| NORTHERN TRUST CORP | 57.7K | $653.2K | $184.2K | Added$207.5K |
| Trexquant Investment LP | 56.2K | $636.3K | — | New |
| GOLDMAN SACHS GROUP INC | 50.5K | $572.1K | $167.3K | Added$156K |
| RAYMOND JAMES FINANCIAL INC | 42.8K | $484.9K | $76.2K | Added$300.4K |
| BOOTHBAY FUND MANAGEMENT, LLC | 42K | $475.4K | — | New |
| VANGUARD FIDUCIARY TRUST CO | 41.5K | $470.2K | — | Held |
| MORGAN STANLEY | 41.1K | $465.5K | $136.1K | Cut−$93K |
| Fidelity | 38.9K | $440.3K | $125.3K | Added$137.1K |
| Quantinno Capital Management LP | 36K | $407.3K | $91.3K | Added$186.2K |
| MARSHALL WACE, LLP | 34.3K | $388.8K | $65.4K | Added$230.4K |
| Citadel | 30.9K | $349.9K | $102.3K | Cut−$117.3K |
| AIHC Capital Management Ltd | 30.3K | $342.6K | $100.2K | Added$100.2K |
| Mariner, LLC | 25.8K | $292.1K | — | New |
| Engineers Gate Manager LP | 23.7K | $268.3K | $78.5K | Added$53K |
| Bank of New York Mellon Corp | 21.7K | $246K | $62.4K | Added$95K |
| UBS Group AG | 21.7K | $245.4K | $66.2K | Added$85.2K |
| Quadrature Capital Ltd | 20.4K | $230.4K | $67.4K | Added$13.6K |
| Susquehanna Portfolio Strategies, LLC | 19.1K | $216.5K | — | New |
| GUGGENHEIM CAPITAL LLC | 14.1K | $159.6K | $34.6K | Added$76K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13.4K | $151.6K | $44.3K | Added$20.8K |
| IEQ CAPITAL, LLC | 12.8K | $144.6K | — | New |
| DEUTSCHE BANK AG\ | 10.5K | $119.4K | $34.9K | Added$17.2K |
| RHUMBLINE ADVISERS | 9.85K | $111.5K | $32.6K | Added$29.4K |
| CWM, LLC | 9.77K | $110.6K | $3.26K | Added$110.6K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3.21K | $36.4K | $10.4K | Added$11.2K |
| NEW YORK STATE COMMON RETIREMENT FUND | 3K | $34K | $9.93K | Added$9.93K |
| WELLS FARGO & COMPANY/MN | 2.59K | $29.3K | $8.57K | Cut−$30.9K |
| BNP PARIBAS FINANCIAL MARKETS | 2.35K | $26.6K | $4.92K | Added$14.7K |
| Russell Investments Group, Ltd. | 2.12K | $23.9K | $6.39K | Added$8.48K |
| Vanguard Global Advisers, LLC | 1.93K | $21.8K | — | Held |
| North Star Investment Management Corp. | 1.8K | $20.4K | $5.96K | Added$5.96K |
| Tower Research Capital LLC (TRC) | 1.64K | $18.6K | $4.6K | Added$7.47K |
| Police & Firemen's Retirement System of New Jersey | 1.37K | $15.5K | $4.54K | Added$4.54K |
| Essential Partners LLC | 1.32K | $15K | — | New |
| TD Waterhouse Canada Inc. | 808 | $10.1K | $3.63K | Added$3.73K |
| PNC Financial Services Group, Inc. | 830 | $9.4K | $2.45K | Added$3.47K |
| GAMMA Investing LLC | 737 | $8.34K | $338 | Added$7.53K |
| Versant Capital Management, Inc | 691 | $7.82K | — | New |
| MAI Capital Management | 606 | $6.86K | $16 | Added$6.82K |
| Ameritas Investment Partners, Inc. | 598 | $6.77K | $1.98K | Added$1.98K |
| Legal & General Group Plc | 526 | $5.95K | $1.74K | Added$1.74K |
| DUNCKER STREETT & CO INC | 437 | $4.95K | $1.45K | Added$1.45K |
| EverSource Wealth Advisors, LLC | 379 | $4.29K | — | New |
| CITIGROUP INC | 308 | $3.49K | $1.02K | Cut−$1.38K |
| Allworth Financial LP | 291 | $3.29K | $2 | Added$3.29K |
| Advisory Services Network, LLC | 245 | $2.77K | — | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 225 | $2.55K | $301 | Added$1.82K |
| Sterling Capital Management LLC | 220 | $2.49K | $728 | Cut−$1.18K |
| OSAIC HOLDINGS, INC. | 135 | $1.53K | $447 | Cut−$9.82K |
| True Wealth Design, LLC | 99 | $1.12K | — | New |
| ROYAL BANK OF CANADA | 104 | $1K | $71 | Cut−$1K |
| Arax Advisory Partners | 86 | $974 | — | New |
| ROTHSCHILD INVESTMENT LLC | 72 | $815 | $20 | Added$767 |
| Root Financial Partners, LLC | 63 | $713 | — | New |
| Keating Financial Advisory Services, Inc. | 63 | $713 | $208 | Added$208 |
| Farther Finance Advisors, LLC | 54 | $683 | — | New |
| Optiver Holding B.V. | 60 | $679 | $198 | Cut−$250 |
| IFP Advisors, Inc | 45 | $509 | $132 | Added$189 |
| Wealth Preservation Advisors, LLC | 44 | $498 | — | New |
| Bare Financial Services, Inc | 44 | $498 | — | New |
| ACADIAN ASSET MANAGEMENT LLC | 41.8K | $471 | $111 | Added$201 |
| NISA INVESTMENT ADVISORS, LLC | 40 | $453 | — | New |
| Fortitude Family Office, LLC | 39 | $441 | — | New |
| SJS Investment Consulting Inc. | 22 | $250 | — | New |
| ALGERT GLOBAL LLC | 19.2K | $217 | $63 | Held |
| Sunbelt Securities, Inc. | 17 | $192 | $3 | Added$184 |
| FIFTH THIRD BANCORP | 11 | $125 | — | New |
| HRT FINANCIAL LP | 10.8K | $122 | — | New |
| JPL Wealth Management, LLC | 2 | $23 | — | New |
| SBI Securities Co., Ltd. | 1 | $11 | $3 | Added$3 |