| RA CAPITAL MANAGEMENT, L.P. | 11.2M | $154.4M | — | Held |
| JANUS HENDERSON GROUP PLC | 5.35M | $73.9M | — | Held |
| BlackRock, Inc. | 4.08M | $56.3M | — | Held |
| State Street | 3.85M | $53.2M | — | Held |
| Fidelity | 3.51M | $48.5M | — | Held |
| Vanguard | 2.91M | $40.1M | — | Held |
| Prosight Management, LP | 2.39M | $33M | — | Held |
| ORBIMED ADVISORS LLC | 1.95M | $27M | — | Held |
| TCG Crossover Management, LLC | 1.79M | $24.7M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 1.61M | $22.2M | — | Held |
| Alyeska Investment Group, L.P. | 1.3M | $18M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.11M | $15.4M | — | Held |
| Citadel | 1.1M | $15.2M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.07M | $14.8M | — | Held |
| Woodline Partners LP | 1.03M | $14.2M | — | Held |
| Logos Global Management LP | 1M | $13.8M | — | Held |
| Point72 Asset Management, L.P. | 961.8K | $13.3M | — | Held |
| READYSTATE ASSET MANAGEMENT LP | 885.9K | $12.2M | — | Held |
| Balyasny Asset Management L.P. | 885.6K | $12.2M | — | Held |
| BANK OF AMERICA CORP /DE/ | 738.3K | $10.2M | −$5.25M | Cut−$1.87M |
| Cormorant Asset Management, LP | 650K | $8.97M | — | Held |
| MORGAN STANLEY | 618.4K | $8.53M | −$5.27M | Cut−$3.58M |
| UBS Group AG | 590.1K | $8.14M | — | Held |
| JANE STREET GROUP, LLC | 540.2K | $7.46M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 471K | $6.5M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400K | $5.52M | — | Held |
| Squarepoint Ops LLC | 391K | $5.4M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 390.5K | $5.39M | — | Held |
| FRANKLIN RESOURCES INC | 385.3K | $5.32M | — | Held |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 376.5K | $5.2M | — | Held |
| University of Wisconsin Foundation | 362K | $5M | — | Held |
| Rock Springs Capital Management LP | 358.8K | $4.95M | — | Held |
| NORTHERN TRUST CORP | 340.4K | $4.7M | — | Held |
| Walleye Capital LLC | 323K | $4.46M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 289.8K | $4M | — | Held |
| Caption Management, LLC | 272.5K | $3.76M | — | Held |
| Pictet Asset Management Holding SA | 272.3K | $3.76M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 267.1K | $3.69M | — | Held |
| ADAR1 Capital Management, LLC | 245.5K | $3.39M | — | Held |
| Rhenman & Partners Asset Management AB | 225.4K | $3.11M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 224.3K | $3.1M | — | Held |
| BARCLAYS PLC | 221.2K | $3.05M | −$1.53M | Cut−$466.9K |
| Qube Research & Technologies Ltd | 216K | $2.98M | — | Held |
| Rafferty Asset Management, LLC | 175.2K | $2.42M | — | Held |
| JPMORGAN CHASE & CO | 170.5K | $2.35M | — | Held |
| Trexquant Investment LP | 170.5K | $2.35M | — | Held |
| ExodusPoint Capital Management, LP | 161.5K | $2.23M | — | Held |
| XTX Topco Ltd | 161.4K | $2.23M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 157.8K | $2.18M | — | Held |
| Bank of New York Mellon Corp | 122.1K | $1.68M | — | Held |
| Hudson Bay Capital Management LP | 110K | $1.52M | −$532K | Added$296K |
| TWO SIGMA ADVISERS, LP | 104.1K | $1.44M | — | Held |
| Blue Owl Capital Holdings LP | 100K | $1.38M | — | Held |
| Jump Financial, LLC | 96.7K | $1.33M | — | Held |
| Nuveen, LLC | 96.4K | $1.33M | — | Held |
| Deep Track Capital, LP | 89.6K | $1.24M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 79.2K | $1.09M | −$842.2K | Cut−$1.32M |
| Swiss National Bank | 77.1K | $1.06M | — | Held |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 76.6K | $1.06M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 75.5K | $1.04M | — | Held |
| Man Group plc | 64.5K | $890.3K | — | Held |
| PROFUND ADVISORS LLC | 64K | $883.5K | — | Held |
| TWINBEECH CAPITAL LP | 58.8K | $811.6K | — | Held |
| DARK FOREST CAPITAL MANAGEMENT LP | 57.4K | $791.6K | — | Held |
| CONGRESS ASSET MANAGEMENT CO | 57.3K | $791.3K | — | Held |
| Headlands Technologies LLC | 56.5K | $779.7K | — | Held |
| Aquatic Capital Management LLC | 52.4K | $723.4K | — | Held |
| RHUMBLINE ADVISERS | 52.4K | $722.6K | — | Held |
| WELLS FARGO & COMPANY/MN | 47.9K | $661.3K | — | Held |
| Raiffeisen Bank International AG | 46K | $636.2K | — | Held |
| Schonfeld Strategic Advisors LLC | 45.5K | $627.3K | — | Held |
| Legal & General Group Plc | 43.5K | $599.8K | — | Held |
| Freestone Grove Partners LP | 41.8K | $576.9K | — | Held |
| HighVista Strategies LLC | 41.4K | $571.9K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 38.5K | $531.1K | — | Held |
| NEOS Investment Management LLC | 37.6K | $519.5K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37.3K | $515K | — | Held |
| TEMA ETFS LLC | 37.1K | $511.9K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36.6K | $505K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 35.6K | $491.1K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35.2K | $486.3K | — | Held |
| Quadrature Capital Ltd | 33K | $455.4K | — | Held |
| D. E. Shaw & Co., Inc. | 32.7K | $451.4K | — | Held |
| DEUTSCHE BANK AG\ | 32.2K | $443.9K | — | Held |
| WINTON GROUP Ltd | 31.8K | $438.8K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30.1K | $416.3K | — | Held |
| Invesco Ltd. | 28.3K | $390.8K | — | Held |
| Atom Investors LP | 27.9K | $385.6K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 27.7K | $382.1K | — | Held |
| Rangeley Capital, LLC | 25.4K | $350.7K | — | Held |
| CITIGROUP INC | 24.2K | $334.2K | — | Held |
| Quantinno Capital Management LP | 24.2K | $334.2K | — | Held |
| MetLife Investment Management, LLC | 23.9K | $329.5K | — | Held |
| OXFORD ASSET MANAGEMENT LLP | 22.8K | $314.8K | — | New |
| Russell Investments Group, Ltd. | 21.1K | $290.7K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 9.96K | $283.8K | — | Held |
| Stonepine Capital Management, LLC | 20K | $276K | — | Held |
| CAPSTONE INVESTMENT ADVISORS, LLC | 19.5K | $269.2K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19.3K | $266.8K | — | Held |
| Lion Point Capital, LP | 19K | $262.2K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 18.2K | $250.8K | — | Held |
| SIMPLEX TRADING, LLC | 17.6K | $242.4K | — | Held |
| Virtus Investment Advisers, LLC | 17.4K | $240K | — | Held |
| DNB Asset Management AS | 17.3K | $238.4K | — | Held |
| TD Asset Management Inc | 17K | $234.7K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 16.7K | $231.1K | — | Held |
| Entropy Technologies, LP | 16.1K | $222.3K | — | Held |
| Quantbot Technologies LP | 15.3K | $211.8K | — | Held |
| Brevan Howard Capital Management LP | 14.8K | $203.6K | — | Held |
| Engineers Gate Manager LP | 13.1K | $181.4K | — | Held |
| Aristides Capital LLC | 13.1K | $180.8K | — | Held |
| AlphaQuest LLC | 12.9K | $177.4K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12.5K | $173K | — | Held |
| FEDERATED HERMES, INC. | 11.9K | $164.2K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 11.7K | $162.1K | — | Held |
| MARTINGALE ASSET MANAGEMENT L P | 11.2K | $155.1K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 10.9K | $150.4K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 10.9K | $150.2K | — | Held |
| ProShare Advisors LLC | 10.5K | $144.8K | — | Held |
| Walleye Trading LLC | 10.4K | $144.2K | — | Held |
| China Universal Asset Management Co., Ltd. | 9.8K | $135.3K | — | Held |
| KLP KAPITALFORVALTNING AS | 8.4K | $115.9K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 5.95K | $82.2K | — | Held |
| Ensign Peak Advisors, Inc | 4.75K | $65.5K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 4.23K | $58.3K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 3.95K | $54.5K | — | Held |
| Caitong International Asset Management Co., Ltd | 3.71K | $51.2K | — | Held |
| Ameritas Investment Partners, Inc. | 3.29K | $45.4K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.92K | $40.3K | — | Held |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 2.5K | $34.5K | — | Held |
| Sterling Capital Management LLC | 1.76K | $24.3K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 1.42K | $19.6K | — | Held |
| ROYAL BANK OF CANADA | 1.23K | $17K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.18K | $16.3K | — | Held |
| SageView Advisory Group, LLC | 950 | $13.1K | — | Held |
| Tower Research Capital LLC (TRC) | 909 | $12.5K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 744.5K | $10.3K | — | Held |
| ANTIPODES PARTNERS Ltd | 720 | $9.94K | — | Held |
| Smartleaf Asset Management LLC | 692 | $9.57K | — | Held |
| Parallel Advisors, LLC | 386 | $5.33K | — | Held |
| SIGNATUREFD, LLC | 360 | $4.97K | — | Held |
| Aster Capital Management (DIFC) Ltd | 314 | $4.33K | — | Held |
| Fourth Dimension Wealth, LLC | 300 | $4.14K | — | Held |
| OSAIC HOLDINGS, INC. | 278 | $3.84K | — | Held |
| Larson Financial Group LLC | 244 | $3.37K | — | Held |
| Fortitude Family Office, LLC | 207 | $2.86K | — | Held |
| ALGERT GLOBAL LLC | 183.4K | $2.53K | — | Held |
| CIBC Private Wealth Group LLC | 171 | $2.36K | — | Held |
| DekaBank Deutsche Girozentrale | 49.5K | $2.04K | — | Held |
| Optiver Holding B.V. | 102 | $1.41K | — | Held |
| BFSG, LLC | 100 | $1.38K | — | Held |
| Aventura Private Wealth, LLC | 88 | $1.21K | −$937 | Cut−$937 |
| SG Americas Securities, LLC | 79.8K | $1.1K | — | Held |
| Rockefeller Capital Management L.P. | 68 | $938 | — | Held |
| HRT FINANCIAL LP | 63.5K | $876 | — | Held |
| THURSTON, SPRINGER, MILLER, HERD & TITAK, INC. | 60 | $828 | — | Held |
| EverSource Wealth Advisors, LLC | 56 | $773 | — | Held |
| SBI Securities Co., Ltd. | 41 | $566 | — | Held |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 38.9K | $536 | — | Held |
| COMERICA BANK | 28 | $386 | — | Held |
| Lester Murray Antman dba SimplyRich | 24.3K | $335 | — | Held |
| Parkside Financial Bank & Trust | 20 | $276 | — | Held |
| Handelsbanken Fonder AB | 17.8K | $246 | — | Held |
| GAMMA Investing LLC | 16 | $221 | — | Held |
| FNY Investment Advisers, LLC | 10.3K | $142 | −$55 | Added$15 |
| Allworth Financial LP | 7 | $97 | −$75 | Cut−$99 |
| PNC Financial Services Group, Inc. | 5 | $69 | — | Held |
| T. Rowe Price Investment Management, Inc. | 1.73K | $24 | — | Held |
| AMALGAMATED BANK | 1.35K | $19 | — | Held |
| KBC Group NV | 1.39K | $19 | −$15 | Cut−$15 |
| HUNTINGTON NATIONAL BANK | 1 | $14 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 508 | $7 | — | Held |
| Daiwa Securities Group Inc. | 187 | $3 | — | Held |
| Covestor Ltd | 3 | $0 | — | Held |
| CWM, LLC | 29 | $0 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |