| JPMORGAN CHASE & CO | 23.2M | $4.04B | — | Held |
| Vanguard | 21.1M | $3.67B | — | Held |
| Darwin Global Management, Ltd. | 20.9M | $3.64B | — | Held |
| BlackRock, Inc. | 15.1M | $2.62B | — | Held |
| Fidelity | 9.93M | $1.73B | — | Held |
| BAKER BROS. ADVISORS LP | 6.59M | $1.15B | — | Held |
| State Street | 5.2M | $905.3M | — | Held |
| Capital International Investors | 5.15M | $896.6M | — | Held |
| Artisan Partners Limited Partnership | 4.84M | $843M | — | Held |
| RTW INVESTMENTS, LP | 4.84M | $842.9M | — | Held |
| D. E. Shaw & Co., Inc. | 4.35M | $757.2M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 4.3M | $751.9M | — | Held |
| Orbis Allan Gray Ltd | 4.18M | $727.5M | — | Held |
| NORGES BANK | 2.91M | $506.6M | $170.4M | Added$373.7M |
| FRANKLIN RESOURCES INC | 2.76M | $479.6M | — | Held |
| Invesco Ltd. | 2.73M | $474.6M | — | Held |
| AMERIPRISE FINANCIAL INC | 1.97M | $342.7M | — | Held |
| UBS Group AG | 1.87M | $325M | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.73M | $300.3M | $48.1M | Added$69.7M |
| MORGAN STANLEY | 1.63M | $284M | $28.9M | Added$145.2M |
| Bank of New York Mellon Corp | 1.39M | $241.9M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 1.31M | $228.3M | — | Held |
| Castle Hook Partners LP | 1.25M | $218.2M | — | Held |
| Integral Health Asset Management, LLC | 1.25M | $217.6M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.24M | $216.7M | — | Held |
| NORTHERN TRUST CORP | 1.24M | $215.5M | — | Held |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1.22M | $212.5M | — | Held |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 1.18M | $205.9M | — | Held |
| Citadel | 1.16M | $201.4M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.03M | $178.8M | — | Held |
| Fiera Capital Corp | 992.9K | $172.8M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 962.2K | $167.5M | — | Held |
| Pictet Asset Management Holding SA | 959K | $167.3M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 943.3K | $164.2M | — | Held |
| Jefferies Financial Group Inc. | 926.3K | $161.2M | — | Held |
| Amundi | 917K | $159.6M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 915.4K | $159.3M | — | Held |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 909.1K | $158.2M | — | Held |
| SEI INVESTMENTS CO | 890.2K | $154.9M | — | Held |
| FIL Ltd | 838.5K | $145.9M | — | Held |
| Clearbridge Investments, LLC | 819K | $142.5M | — | Held |
| Holocene Advisors, LP | 801.2K | $139.4M | — | Held |
| JANUS HENDERSON GROUP PLC | 800.6K | $139.3M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 779.3K | $135.6M | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 771.4K | $134.2M | — | Held |
| Artia Global Partners LP | 682.2K | $118.7M | — | Held |
| Nuveen, LLC | 650.4K | $113.2M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 646.7K | $112.6M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 642.7K | $111.9M | — | Held |
| Hood River Capital Management LLC | 637.6K | $111M | — | Held |
| FEDERATED HERMES, INC. | 632.3K | $110M | — | Held |
| DEUTSCHE BANK AG\ | 590K | $102.7M | — | Held |
| WELLS FARGO & COMPANY/MN | 586.7K | $102.1M | — | Held |
| Swiss National Bank | 579.1K | $100.8M | — | Held |
| JENNISON ASSOCIATES LLC | 562.3K | $97.9M | — | Held |
| Legal & General Group Plc | 540.3K | $94M | — | Held |
| ROYAL BANK OF CANADA | 506.8K | $88.2M | — | Held |
| Nearwater Capital Markets, Ltd | 500K | $87M | — | Held |
| TimesSquare Capital Management, LLC | 490.5K | $85.4M | — | Held |
| Palo Alto Investors LP | 489.5K | $85.2M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 486.1K | $84.6M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 483.6K | $84.2M | — | Held |
| Icahn Capital | 468.3K | $81.5M | — | Held |
| Affinity Asset Advisors, LLC | 450K | $78.3M | — | Held |
| BARCLAYS PLC | 444.7K | $77.4M | $3.43M | Added$61M |
| Sumitomo Mitsui Trust Group, Inc. | 435.4K | $75.8M | — | Held |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 432.5K | $75.3M | — | Held |
| Candriam S.C.A. | 401K | $69.8M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 399.1K | $69.5M | — | Held |
| TWO SIGMA ADVISERS, LP | 395K | $68.7M | — | Held |
| MARSHALL WACE, LLP | 389.9K | $67.9M | — | Held |
| Ensign Peak Advisors, Inc | 382.2K | $66.5M | — | Held |
| Balyasny Asset Management L.P. | 380.6K | $66.2M | — | Held |
| SAMLYN CAPITAL, LLC | 369.6K | $64.3M | — | Held |
| GATEWAY INVESTMENT ADVISERS LLC | 365K | $63.5M | — | Held |
| California Public Employees Retirement System | 354.9K | $61.8M | — | Held |
| Polar Capital Holdings Plc | 344.2K | $59.9M | — | Held |
| ProShare Advisors LLC | 340.7K | $59.3M | — | Held |
| Rock Springs Capital Management LP | 319.3K | $55.6M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 310.3K | $54M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300K | $52.2M | — | Held |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 284.8K | $49.6M | — | Held |
| Zurich Insurance Group Ltd/FI | 281.1K | $48.9M | — | Held |
| National Pension Service | 280.4K | $48.8M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 276.3K | $48.1M | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 276.1K | $48.1M | — | Held |
| Cormorant Asset Management, LP | 275K | $47.9M | — | Held |
| RHUMBLINE ADVISERS | 268.3K | $46.7M | — | Held |
| Patient Square Capital LP | 267K | $46.5M | — | Held |
| First Turn Management, LLC | 264.3K | $46M | — | Held |
| TD Asset Management Inc | 262.5K | $45.7M | — | Held |
| AXIOM INVESTORS LLC /DE | 255.8K | $44.5M | — | Held |
| Aberdeen Group plc | 253.1K | $44.1M | — | Held |
| FIRST TRUST ADVISORS LP | 247.9K | $43.2M | — | Held |
| CITIGROUP INC | 237.9K | $41.4M | — | Held |
| Mitsubishi UFJ Asset Management Co., Ltd. | 222.3K | $39.4M | — | Held |
| Allspring Global Investments Holdings, LLC | 220.1K | $39M | — | Held |
| Eagle Health Investments LP | 210.9K | $36.7M | — | Held |
| NEUBERGER BERMAN GROUP LLC | 207.9K | $36.2M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 207.5K | $36.1M | — | Held |
| Alberta Investment Management Corp | 206.5K | $35.9M | — | New |
| VOYA INVESTMENT MANAGEMENT LLC | 201K | $35M | — | Held |
| NOVO HOLDINGS A/S | 200K | $34.8M | — | Held |
| LOOMIS SAYLES & CO L P | 200K | $34.8M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 188.6K | $32.8M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 185.1K | $32.2M | — | Held |
| Nicholas Investment Partners, LP | 180.4K | $31.4M | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 180.3K | $31.4M | — | Held |
| TREMBLANT CAPITAL GROUP | 175.7K | $30.6M | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 161.8K | $28.2M | — | Held |
| Sofinnova Investments, Inc. | 156.8K | $27.3M | — | Held |
| Russell Investments Group, Ltd. | 145.1K | $25.3M | — | Held |
| Perpetual Ltd | 141.5K | $24.6M | — | Held |
| LPL Financial LLC | 132.8K | $23.1M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 131.6K | $22.9M | — | Held |
| Woodline Partners LP | 130.2K | $22.7M | — | Held |
| Caption Management, LLC | 130K | $22.6M | — | Held |
| Long Focus Capital Management, LLC | 125K | $21.8M | — | Held |
| HSBC HOLDINGS PLC | 123.3K | $21.5M | — | Held |
| ING GROEP NV | 122.9K | $21.4M | — | Held |
| Evergreen Quality Fund GP, Ltd. | 120.5K | $21M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 120.4K | $21M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 118.8K | $20.7M | — | Held |
| Man Group plc | 118.4K | $20.6M | — | Held |
| Rhenman & Partners Asset Management AB | 113.6K | $19.8M | — | Held |
| DANSKE BANK A/S | 110.3K | $19.2M | $176.2K | Added$18.9M |
| AVIVA PLC | 109.4K | $19M | — | Held |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 109.3K | $19M | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 108.7K | $18.9M | — | Held |
| LMR Partners LLP | 107.5K | $18.7M | — | Held |
| Assenagon Asset Management S.A. | 106.8K | $18.6M | — | Held |
| Driehaus Capital Management LLC | 105.6K | $18.4M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 103.3K | $18M | — | Held |
| Rafferty Asset Management, LLC | 100.8K | $17.5M | — | Held |
| Skandinaviska Enskilda Banken AB (publ) | 96.4K | $16.8M | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 82.4K | $16M | — | Held |
| Police & Firemen's Retirement System of New Jersey | 89.1K | $15.5M | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 83.5K | $14.5M | — | Held |
| Mitsubishi UFJ Trust & Banking Corp | 83K | $14.5M | — | Held |
| GUGGENHEIM CAPITAL LLC | 82.3K | $14.3M | — | Held |
| Asset Management One Co., Ltd. | 80.9K | $14.3M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 81.3K | $14.2M | — | Held |
| EULAV Asset Management | 81K | $14.1M | — | Held |
| ExodusPoint Capital Management, LP | 80.1K | $13.9M | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 78.5K | $13.7M | — | Held |
| Atika Capital Management LLC | 77.2K | $13.4M | — | Held |
| KLP KAPITALFORVALTNING AS | 74K | $12.9M | — | Held |
| Korea Investment CORP | 72.6K | $12.6M | — | Held |
| State of New Jersey Common Pension Fund D | 72.1K | $12.6M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 71.3K | $12.4M | — | Held |
| Creative Planning | 70.5K | $12.3M | — | Held |
| STIFEL FINANCIAL CORP | 69.2K | $12.1M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 67.4K | $11.7M | — | Held |
| Squarepoint Ops LLC | 66.4K | $11.6M | — | Held |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 65.3K | $11.4M | — | Held |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 63K | $11M | — | Held |
| BANK OF MONTREAL /CAN/ | 62.8K | $10.9M | — | Held |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 62.4K | $10.9M | — | Held |
| BANK OF NOVA SCOTIA | 60.8K | $10.6M | — | Held |
| Resona Asset Management Co.,Ltd. | 60.4K | $10.5M | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 60K | $10.4M | — | Held |
| Alyeska Investment Group, L.P. | 60K | $10.4M | — | Held |
| ROYCE & ASSOCIATES LP | 59.7K | $10.4M | — | Held |
| Swedbank AB | 59.6K | $10.4M | — | Held |
| AGF MANAGEMENT LTD | 58.8K | $10.2M | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 57.9K | $10.1M | — | Held |
| NISSAY ASSET MANAGEMENT CORP /JAPAN | 57.7K | $10M | — | Held |
| PICTON MAHONEY ASSET MANAGEMENT | 57.3K | $9.97M | — | Held |
| Engineers Gate Manager LP | 54.8K | $9.53M | — | Held |
| STRS OHIO | 52K | $9.05M | — | Held |
| PARNASSUS INVESTMENTS, LLC | 51.6K | $8.99M | — | Held |
| OP Asset Management Ltd | 50.5K | $8.8M | — | New |
| FJARDE AP-FONDEN /FOURTH SWEDISH NATIONAL PENSION FUND | 50.5K | $8.79M | — | Held |
| Erste Asset Management GmbH | 49.6K | $8.75M | — | Held |
| Monashee Investment Management LLC | 50K | $8.7M | — | Held |
| Defilade Capital Management, L.P. | 50K | $8.7M | — | Held |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 49.1K | $8.54M | — | Held |
| Soleus Capital Management, L.P. | 48.5K | $8.44M | — | Held |
| CIBC Asset Management Inc | 48.5K | $8.43M | — | Held |
| PFA Pension, Forsikringsaktieselskab | 48.3K | $8.41M | — | Held |
| NEOS Investment Management LLC | 48K | $8.35M | — | Held |
| FORSTA AP-FONDEN | 45.1K | $7.85M | — | Held |
| TWINBEECH CAPITAL LP | 44K | $7.66M | — | Held |
| XPONANCE LLC | 43K | $7.49M | — | Held |
| Allianz Asset Management GmbH | 42.6K | $7.42M | — | Held |
| China Universal Asset Management Co., Ltd. | 42.4K | $7.38M | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 42.2K | $7.35M | — | Held |
| DNB Asset Management AS | 40.9K | $7.12M | — | Held |
| Legato Capital Management LLC | 40K | $6.96M | — | Held |
| ASSETMARK, INC | 39.7K | $6.91M | — | Held |
| HighVista Strategies LLC | 39.4K | $6.86M | — | Held |
| Cetera Investment Advisers | 38.4K | $6.69M | — | Held |
| BAMCO INC /NY/ | 38.2K | $6.65M | — | Held |
| THORNBURG INVESTMENT MANAGEMENT INC | 38K | $6.61M | — | Held |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 37.5K | $6.53M | — | Held |
| Simplify Asset Management Inc. | 36.9K | $6.42M | — | Held |
| Orion Porfolio Solutions, LLC | 36.6K | $6.37M | — | Held |
| TORONTO DOMINION BANK | 36.3K | $6.32M | — | Held |
| Andra AP-fonden | 36.3K | $6.32M | — | Held |
| Freestone Grove Partners LP | 36.2K | $6.3M | — | Held |
| NWAM LLC | 39K | $6.23M | −$319.3K | Cut−$2.09M |
| Mariner, LLC | 35.3K | $6.14M | — | Held |
| MML INVESTORS SERVICES, LLC | 34.2K | $5.95M | — | Held |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 33.8K | $5.88M | — | New |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 33.2K | $5.78M | — | Held |
| Calamos Advisors LLC | 32.2K | $5.6M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 32K | $5.58M | — | Held |
| Utah Retirement Systems | 32K | $5.57M | — | Held |
| NOMURA HOLDINGS INC | 30.5K | $5.31M | — | Held |
| Caisse de depot et placement du Quebec | 29.5K | $5.13M | — | Held |
| GordonMD Global Investments LP | 28.6K | $4.98M | — | Held |
| KVP Capital Advisors, LP | 28.5K | $4.96M | — | Held |
| Atle Fund Management AB | 27.9K | $4.85M | — | Held |
| PROFUND ADVISORS LLC | 27.8K | $4.85M | — | Held |
| Compound Planning, Inc. | 27.7K | $4.81M | — | Held |
| Pathstone Holdings, LLC | 27K | $4.69M | — | Held |
| MCRAE CAPITAL MANAGEMENT INC | 26.7K | $4.64M | — | Held |
| SummitTX Capital, L.P. | 26K | $4.52M | — | Held |
| Renaissance Technologies | 25.9K | $4.51M | — | Held |
| ACUTA CAPITAL PARTNERS, LLC | 25.9K | $4.5M | — | Held |
| ORBIMED ADVISORS LLC | 25.4K | $4.42M | — | Held |
| SHELTON CAPITAL MANAGEMENT | 24.3K | $4.23M | — | Held |
| Sumitomo Mitsui DS Asset Management Company, Ltd | 22.3K | $3.88M | — | Held |
| PEAK6 LLC | 22.2K | $3.86M | — | New |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 21.9K | $3.82M | — | Held |
| Campbell & CO Investment Adviser LLC | 21.9K | $3.81M | — | Held |
| EFG International AG | 21.9K | $3.81M | — | Held |
| Gotham Asset Management, LLC | 21.8K | $3.79M | — | Held |
| MACKENZIE FINANCIAL CORP | 21.6K | $3.76M | — | Held |
| Sanctuary Advisors, LLC | 21.3K | $3.71M | $586.6K | Added$900.2K |
| Tidal Investments LLC | 21.3K | $3.71M | — | Held |
| ASR Vermogensbeheer N.V. | 21.1K | $3.67M | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 21K | $3.65M | — | Held |
| Corient Private Wealth LLC | 20.9K | $3.63M | — | Held |
| Rakuten Investment Management, Inc. | 20.5K | $3.61M | — | Held |
| STOREBRAND ASSET MANAGEMENT AS | 20.6K | $3.59M | — | Held |
| SBI Okasan Asset Management Co.Ltd. | 20.2K | $3.56M | — | Held |
| Atria Investments, Inc | 20.4K | $3.55M | — | Held |
| NEXT CENTURY GROWTH INVESTORS LLC | 20.3K | $3.53M | — | Held |
| NORDEA INVESTMENT MANAGEMENT AB | 20K | $3.49M | — | Held |
| BROWN ADVISORY INC | 20K | $3.48M | — | Held |
| Baird Financial Group, Inc. | 19.7K | $3.43M | — | Held |
| Silvant Capital Management LLC | 19.6K | $3.41M | — | Held |
| Quantinno Capital Management LP | 19.5K | $3.4M | — | Held |
| Cerity Partners LLC | 19.4K | $3.38M | — | Held |
| OSAIC HOLDINGS, INC. | 19.3K | $3.35M | — | Held |
| Cinctive Capital Management LP | 17.9K | $3.12M | — | Held |
| Avidity Partners Management LP | 17.7K | $3.08M | — | Held |
| CIBC WORLD MARKETS CORP | 17.7K | $3.08M | — | Held |
| Walleye Trading LLC | 17.7K | $3.07M | — | Held |