| Flagship Pioneering, LLC | 12.7M | $68.4M | — | Held |
| Fidelity | 5.4M | $29.1M | — | Held |
| BVF INC/IL | 5.3M | $28.6M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3.65M | $19.7M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 2.51M | $13.5M | — | Held |
| BlackRock, Inc. | 2.35M | $12.7M | — | Held |
| Vanguard | 1.93M | $10.4M | — | Held |
| Euclidean Capital LLC | 1.57M | $8.5M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 795K | $4.29M | — | Held |
| Siren, L.L.C. | 720.7K | $3.89M | — | Held |
| State Street | 618.7K | $3.34M | — | Held |
| AMERIPRISE FINANCIAL INC | 607.7K | $3.28M | — | Held |
| Renaissance Technologies | 297.7K | $1.61M | — | Held |
| Birchview Capital, LP | 281.7K | $1.52M | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 269.2K | $1.45M | — | Held |
| NORTHERN TRUST CORP | 262.4K | $1.42M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 208.6K | $1.13M | — | Held |
| Citadel | 182.3K | $984.3K | — | Held |
| Squarepoint Ops LLC | 141.6K | $764.5K | — | Held |
| JANE STREET GROUP, LLC | 132.5K | $715.5K | — | Held |
| DAFNA Capital Management LLC | 126.9K | $685K | — | Held |
| Sio Capital Management, LLC | 122.9K | $663.6K | — | Held |
| MORGAN STANLEY | 121.7K | $657.3K | $32.5K | Added$346K |
| GOLDMAN SACHS GROUP INC | 118.7K | $641K | — | Held |
| SCS Capital Management LLC | 107K | $577.7K | — | Held |
| PANAGORA ASSET MANAGEMENT INC | 89.3K | $482.2K | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 82.4K | $444.8K | — | Held |
| Walleye Capital LLC | 81.3K | $439.3K | — | Held |
| Bank of New York Mellon Corp | 78.9K | $426K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 74.6K | $402.8K | — | Held |
| BANK OF AMERICA CORP /DE/ | 73.9K | $398.8K | $15.3K | Added$251.8K |
| BARCLAYS PLC | 63.2K | $341.2K | $29.8K | Added$55.2K |
| Point72 Asset Management, L.P. | 62K | $334.6K | — | Held |
| Qube Research & Technologies Ltd | 53.3K | $287.6K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 53.1K | $287K | — | Held |
| Nuveen, LLC | 50.1K | $270.7K | — | Held |
| Persistent Asset Partners Ltd | 47.1K | $254.4K | $5.84K | Added$198.4K |
| RHUMBLINE ADVISERS | 40.1K | $216.6K | — | Held |
| WELLS FARGO & COMPANY/MN | 38.8K | $209.3K | — | Held |
| DIADEMA PARTNERS LP | 30.6K | $165.4K | — | Held |
| MARSHALL WACE, LLP | 28.9K | $156K | — | Held |
| DEUTSCHE BANK AG\ | 27.4K | $148.1K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 26.7K | $144K | — | Held |
| UBS Group AG | 24.5K | $132.3K | — | Held |
| Jump Financial, LLC | 24.1K | $130.3K | — | Held |
| Woodline Partners LP | 21.5K | $116.2K | — | Held |
| MetLife Investment Management, LLC | 19.1K | $103.4K | — | Held |
| JPMORGAN CHASE & CO | 17.2K | $93K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 16.6K | $89.6K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15.9K | $85.7K | — | Held |
| XTX Topco Ltd | 15.7K | $84.6K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 14.6K | $78.7K | — | Held |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 14.3K | $77.1K | — | Held |
| Icahn Capital | 13.6K | $73.2K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 12.8K | $69.1K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 11.3K | $61.2K | — | Held |
| Fiduciary Trust Co | 10.9K | $58.7K | — | Held |
| Invesco Ltd. | 10.8K | $58.2K | — | Held |
| Brevan Howard Capital Management LP | 10.5K | $56.6K | — | Held |
| TWO SIGMA ADVISERS, LP | 10.4K | $56.2K | — | Held |
| China Universal Asset Management Co., Ltd. | 9.21K | $49.8K | — | Held |
| STRS OHIO | 8.6K | $46.4K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 8.27K | $44.7K | — | Held |
| Evelyn Partners Asset Management Ltd | 7.1K | $38.3K | $12.4K | Added$12.4K |
| Russell Investments Group, Ltd. | 5.94K | $32.1K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 5.24K | $28.3K | — | Held |
| Brummer Multi-Strategy AB | 4.71K | $25.4K | — | Held |
| Legal & General Group Plc | 3.38K | $18.2K | — | Held |
| Ameritas Investment Partners, Inc. | 3.34K | $18.1K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.75K | $14.8K | — | Held |
| CITIGROUP INC | 2.33K | $12.6K | — | Held |
| Tower Research Capital LLC (TRC) | 2.07K | $11.2K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2.05K | $11.1K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 1.87K | $10.1K | — | Held |
| ROYAL BANK OF CANADA | 1K | $6K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.11K | $6K | — | Held |
| OSAIC HOLDINGS, INC. | 1.03K | $5.56K | — | Held |
| Sunbelt Securities, Inc. | 1K | $5.4K | — | Held |
| Sterling Capital Management LLC | 847 | $4.57K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 374 | $2.02K | — | Held |
| GAMMA Investing LLC | 364 | $1.97K | — | Held |
| Optiver Holding B.V. | 310 | $1.67K | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 200 | $1.08K | — | Held |
| TFC Financial Management, Inc. | 123 | $665 | — | Held |
| SBI Securities Co., Ltd. | 100 | $540 | — | Held |
| PNC Financial Services Group, Inc. | 84 | $454 | — | Held |
| EverSource Wealth Advisors, LLC | 75 | $405 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16.4K | $89 | — | Held |
| ALGERT GLOBAL LLC | 13.9K | $75 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 7.73K | $41 | — | Held |
| True Wealth Design, LLC | 5 | $27 | — | Held |
| CWM, LLC | 1.35K | $7 | — | Held |
| AMALGAMATED BANK | 1.05K | $6 | — | Held |