| ORBIMED ADVISORS LLC | 7.96M | $122.6M | — | Held |
| Fidelity | 7.11M | $109.5M | — | Held |
| Commodore Capital LP | 4.69M | $72.3M | — | Held |
| Vestal Point Capital, LP | 3.83M | $59M | — | Held |
| Fairmount Funds Management LLC | 3.71M | $57.2M | — | Held |
| BlackRock, Inc. | 3.61M | $55.6M | — | Held |
| Polar Capital Holdings Plc | 3.51M | $54.1M | — | Held |
| VR ADVISER, LLC | 3.23M | $49.7M | — | Held |
| Vanguard | 2.8M | $43.1M | — | Held |
| JANUS HENDERSON GROUP PLC | 1.67M | $25.7M | — | Held |
| Point72 Asset Management, L.P. | 1.5M | $23.2M | — | Held |
| NOVO HOLDINGS A/S | 1.48M | $22.8M | — | Held |
| Citadel | 1.42M | $21.9M | — | Held |
| Capital Research Global Investors | 1.3M | $20.1M | — | Held |
| Pictet Asset Management Holding SA | 1.3M | $20.1M | — | Held |
| State Street | 1.05M | $16.2M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.05M | $16.2M | — | Held |
| Soleus Capital Management, L.P. | 1.02M | $15.8M | — | Held |
| Blackstone Inc. | 954.9K | $14.7M | — | New |
| Rock Springs Capital Management LP | 798.4K | $12.3M | — | Held |
| 5AM Venture Management, LLC | 772.5K | $11.9M | — | Held |
| Candriam S.C.A. | 453K | $6.98M | — | Held |
| Spruce Street Capital LP | 446.1K | $6.87M | — | Held |
| MORGAN STANLEY | 411.8K | $6.34M | −$1.31M | Added$1.05M |
| DIMENSIONAL FUND ADVISORS LP | 398.9K | $6.14M | — | Held |
| MARSHALL WACE, LLP | 371.9K | $5.73M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 355.2K | $5.47M | — | Held |
| NORTHERN TRUST CORP | 352.2K | $5.42M | — | Held |
| Logos Global Management LP | 340K | $5.24M | — | Held |
| Patient Square Capital LP | 308.1K | $4.75M | — | Held |
| Woodline Partners LP | 301K | $4.64M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 296.9K | $4.57M | — | Held |
| BAKER BROS. ADVISORS LP | 271.4K | $4.18M | — | Held |
| GOLDMAN SACHS GROUP INC | 237.2K | $3.65M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 226.8K | $3.49M | — | Held |
| Exome Asset Management LLC | 222.3K | $3.42M | — | Held |
| Trails Edge Capital Partners, LP | 199.3K | $3.07M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 194.7K | $3M | — | Held |
| Avidity Partners Management LP | 140.3K | $2.16M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 129.9K | $2M | — | Held |
| Bank of New York Mellon Corp | 110.6K | $1.7M | — | Held |
| Nuveen, LLC | 105.4K | $1.62M | — | Held |
| JANE STREET GROUP, LLC | 102K | $1.57M | — | Held |
| Seven Fleet Capital Management LP | 100K | $1.54M | — | Held |
| HighVista Strategies LLC | 82.5K | $1.27M | — | Held |
| BARCLAYS PLC | 69.9K | $1.08M | −$354.3K | Cut−$370.9K |
| Lighthouse Investment Partners, LLC | 65K | $1M | — | Held |
| Swiss National Bank | 64.3K | $989.8K | — | Held |
| XTX Topco Ltd | 60.7K | $934.8K | — | Held |
| ExodusPoint Capital Management, LP | 60.4K | $930.4K | — | Held |
| UBS Group AG | 57.9K | $891.2K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 55.2K | $850.2K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 52.6K | $809.7K | — | Held |
| RHUMBLINE ADVISERS | 50.5K | $777.8K | — | Held |
| Susquehanna Portfolio Strategies, LLC | 48.7K | $750.6K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 45.8K | $705.2K | — | Held |
| Jump Financial, LLC | 45.4K | $698.5K | — | Held |
| WELLS FARGO & COMPANY/MN | 43.1K | $663.1K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 36.8K | $567.3K | — | Held |
| PRUDENTIAL FINANCIAL INC | 35.6K | $547.9K | — | Held |
| BANK OF AMERICA CORP /DE/ | 32.7K | $503.7K | −$119.4K | Added$21.8K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32.2K | $496K | — | Held |
| DEUTSCHE BANK AG\ | 31.4K | $483.9K | — | Held |
| ADAR1 Capital Management, LLC | 30K | $462K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 29.7K | $457K | −$82.7K | Added$123.2K |
| Aquatic Capital Management LLC | 28K | $430.5K | — | Held |
| Legal & General Group Plc | 27.1K | $416.7K | — | Held |
| Invesco Ltd. | 24.7K | $380.7K | — | Held |
| MetLife Investment Management, LLC | 24.6K | $378.2K | — | Held |
| Squarepoint Ops LLC | 20.8K | $319.8K | — | Held |
| JPMORGAN CHASE & CO | 20.7K | $318.8K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 20.4K | $314.1K | — | Held |
| FRANKLIN RESOURCES INC | 20.2K | $310.6K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19.3K | $297.8K | — | Held |
| AMERIPRISE FINANCIAL INC | 18.9K | $291.8K | — | Held |
| CITIGROUP INC | 18.5K | $284.7K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18.3K | $281.6K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 16.7K | $257.6K | — | Held |
| Virtus Investment Advisers, LLC | 15.8K | $243K | — | Held |
| AXQ CAPITAL, LP | 14.2K | $219.4K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 12.4K | $191.5K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 11.2K | $171.9K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 10.8K | $166.3K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 10.5K | $161.4K | — | Held |
| AlphaQuest LLC | 10.3K | $159.2K | — | Held |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10.3K | $158.6K | — | Held |
| PROFUND ADVISORS LLC | 10.2K | $156.8K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 9.67K | $148.9K | — | Held |
| China Universal Asset Management Co., Ltd. | 9.67K | $148.9K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 9.1K | $140.1K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 5.41K | $129.7K | — | Held |
| KLP KAPITALFORVALTNING AS | 6.8K | $104.7K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6.16K | $94.9K | — | Held |
| Ameritas Investment Partners, Inc. | 3.45K | $53.1K | — | Held |
| Russell Investments Group, Ltd. | 3.12K | $48.1K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.88K | $44.4K | — | Held |
| SIMPLEX TRADING, LLC | 2.65K | $40.8K | — | Held |
| Tower Research Capital LLC (TRC) | 2.3K | $35.5K | — | Held |
| Quantbot Technologies LP | 1.77K | $27.3K | — | Held |
| ROYAL BANK OF CANADA | 1.22K | $18K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.17K | $17.9K | — | Held |
| Caitong International Asset Management Co., Ltd | 940 | $14.5K | — | Held |
| Farther Finance Advisors, LLC | 688 | $10.6K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 589 | $9.07K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 295 | $4.54K | — | Held |
| Sterling Capital Management LLC | 279 | $4.3K | — | Held |
| Versant Capital Management, Inc | 212 | $3.27K | — | Held |
| GAMMA Investing LLC | 190 | $2.93K | — | Held |
| Arax Advisory Partners | 137 | $2.11K | — | Held |
| Larson Financial Group LLC | 106 | $1.63K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 100 | $1.54K | — | Held |
| Optiver Holding B.V. | 64 | $986 | — | Held |
| OSAIC HOLDINGS, INC. | 60 | $924 | — | Held |
| Cornerstone Financial Management LLC | 42 | $647 | — | Held |
| SBI Securities Co., Ltd. | 37 | $570 | — | Held |
| SIGNATUREFD, LLC | 26 | $400 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23.8K | $367 | — | Held |
| PNC Financial Services Group, Inc. | 22 | $339 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 20 | $308 | — | Held |
| SG Americas Securities, LLC | 14K | $216 | — | Held |
| AMALGAMATED BANK | 1.24K | $19 | — | Held |
| Smartleaf Asset Management LLC | 1 | $16 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 635 | $10 | — | Held |
| Daiwa Securities Group Inc. | 152 | $2 | — | Held |
| CWM, LLC | 94 | $1 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |
| Covestor Ltd | 6 | $0 | — | Held |
| BESSEMER GROUP INC | 0 | $0 | — | Held |