| ORBIMED ADVISORS LLC | 7.96M | $312M | $189.4M | Added$189.4M |
| Fidelity | 6.83M | $267.7M | $162.5M | Added$158.2M |
| Polar Capital Holdings Plc | 5.07M | $198.6M | $83.6M | Added$144.5M |
| BlackRock, Inc. | 3.68M | $144.4M | $86M | Added$88.8M |
| Commodore Capital LP | 3.27M | $128.4M | $77.9M | Added$56.1M |
| Vestal Point Capital, LP | 3.25M | $127.4M | $77.4M | Added$68.4M |
| Bellevue Group AG | 2.32M | $91M | — | New |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.17M | $85M | — | Held |
| Fairmount Funds Management LLC | 1.86M | $72.7M | $44.2M | Added$15.6M |
| Citadel | 1.74M | $68.4M | $33.9M | Added$46.4M |
| VR ADVISER, LLC | 1.73M | $67.7M | $41.1M | Added$18M |
| NOVO HOLDINGS A/S | 1.28M | $50.2M | $30.5M | Added$27.4M |
| State Street | 1.09M | $42.8M | $25.1M | Added$26.6M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.07M | $41.8M | $25M | Added$25.7M |
| Pictet Asset Management Holding SA | 929.5K | $36.4M | $22.1M | Added$16.4M |
| BAKER BROS. ADVISORS LP | 905.2K | $35.5M | $6.46M | Added$31.3M |
| Rock Springs Capital Management LP | 826.5K | $32.4M | $19M | Added$20.1M |
| Siren, L.L.C. | 746.2K | $29.3M | — | New |
| DIMENSIONAL FUND ADVISORS LP | 681.7K | $26.7M | $9.49M | Added$20.6M |
| First Turn Management, LLC | 623.8K | $24.5M | — | New |
| Candriam S.C.A. | 594.1K | $23.3M | $10.8M | Added$16.3M |
| Jones Hill Capital LP | 593K | $23.2M | — | Held |
| Affinity Asset Advisors, LLC | 586.9K | $23M | — | New |
| Logos Global Management LP | 540K | $21.2M | $8.09M | Added$15.9M |
| MORGAN STANLEY | 518.6K | $20.3M | $9.8M | Added$14M |
| GOLDMAN SACHS GROUP INC | 473.1K | $18.5M | $5.65M | Added$14.9M |
| Avidity Partners Management LP | 400K | $15.7M | $3.34M | Added$13.5M |
| NORTHERN TRUST CORP | 372.3K | $14.6M | $8.38M | Added$9.17M |
| Caption Management, LLC | 370K | $14.5M | — | New |
| Capricorn Fund Managers Ltd | 369.4K | $14.5M | — | New |
| STEMPOINT CAPITAL LP | 363.4K | $14.2M | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 360.6K | $14.1M | $8.45M | Added$8.66M |
| MILLENNIUM MANAGEMENT LLC | 345.3K | $13.5M | $7.07M | Added$8.96M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 331K | $13M | — | Held |
| ADAR1 Capital Management, LLC | 329.5K | $12.9M | $714K | Added$12.5M |
| Spruce Street Capital LP | 329K | $12.9M | $7.83M | Added$6.03M |
| VANGUARD FIDUCIARY TRUST CO | 312.8K | $12.3M | — | Held |
| Balyasny Asset Management L.P. | 310K | $12.2M | — | New |
| JENNISON ASSOCIATES LLC | 309.2K | $12.1M | — | New |
| ALLIANCEBERNSTEIN L.P. | 771.9K | $11.9M | $0 | Added$11.3M |
| Woodline Partners LP | 301.7K | $11.8M | $7.16M | Added$7.19M |
| UBS Group AG | 283.5K | $11.1M | $1.38M | Added$10.2M |
| Seven Fleet Capital Management LP | 259.3K | $10.2M | $2.38M | Added$8.62M |
| Soleus Capital Management, L.P. | 230.9K | $9.05M | $5.49M | Cut−$6.73M |
| Exome Asset Management LLC | 220.1K | $8.63M | $5.24M | Added$5.2M |
| Schonfeld Strategic Advisors LLC | 218.9K | $8.58M | — | New |
| First Light Asset Management, LLC | 201.9K | $7.91M | — | New |
| Patient Square Capital LP | 200K | $7.84M | $4.76M | Added$3.09M |
| D. E. Shaw & Co., Inc. | 193.5K | $7.59M | — | New |
| Connor, Clark & Lunn Investment Management Ltd. | 191.3K | $7.5M | $4.55M | Added$4.5M |
| Nicholas Investment Partners, LP | 182.7K | $7.16M | — | New |
| JANE STREET GROUP, LLC | 163.5K | $6.41M | $2.43M | Added$4.84M |
| AMERIPRISE FINANCIAL INC | 160.6K | $6.29M | $451K | Added$6M |
| SPHERA FUNDS MANAGEMENT LTD. | 153.3K | $6.01M | $3.65M | Added$2.52M |
| WELLINGTON MANAGEMENT GROUP LLP | 150.1K | $5.88M | $3.09M | Added$3.88M |
| Bank of New York Mellon Corp | 120.1K | $4.71M | $2.63M | Added$3M |
| Cinctive Capital Management LP | 113.3K | $4.44M | — | New |
| Longaeva Partners L.P. | 113.1K | $4.43M | — | New |
| Nuveen, LLC | 105.9K | $4.15M | $2.51M | Added$2.53M |
| DV Trading LLC | 95.3K | $3.73M | — | New |
| Informed Momentum Co LLC | 82.8K | $3.25M | — | New |
| Trexquant Investment LP | 78.2K | $3.07M | — | New |
| Lighthouse Investment Partners, LLC | 75K | $2.94M | $1.55M | Added$1.94M |
| HighVista Strategies LLC | 73.1K | $2.87M | $1.74M | Added$1.59M |
| SummitTX Capital, L.P. | 68.7K | $2.69M | — | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 67.5K | $2.65M | $1.31M | Added$1.79M |
| PRUDENTIAL FINANCIAL INC | 66.9K | $2.62M | $846.8K | Added$2.08M |
| Swiss National Bank | 64.3K | $2.52M | $1.53M | Added$1.53M |
| AMERICAN CENTURY COMPANIES INC | 62.1K | $2.43M | $1.09M | Added$1.73M |
| Invesco Ltd. | 61.8K | $2.42M | $588.3K | Added$2.04M |
| NEUBERGER BERMAN GROUP LLC | 61.6K | $2.42M | — | New |
| PRELUDE CAPITAL MANAGEMENT, LLC | 52.6K | $2.06M | $1.25M | Added$1.25M |
| RHUMBLINE ADVISERS | 50.2K | $1.97M | $1.19M | Added$1.19M |
| Susquehanna Portfolio Strategies, LLC | 49.1K | $1.92M | $1.16M | Added$1.17M |
| Tidal Investments LLC | 47.5K | $1.86M | — | New |
| BANK OF AMERICA CORP /DE/ | 45.2K | $1.77M | $778.5K | Added$1.27M |
| TimesSquare Capital Management, LLC | 45K | $1.76M | — | New |
| TEMA ETFS LLC | 43.1K | $1.69M | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 38.6K | $1.52M | $216.5K | Added$1.37M |
| XTX Topco Ltd | 38.3K | $1.5M | $912.1K | Added$567.5K |
| Walleye Capital LLC | 37.8K | $1.48M | — | New |
| DEUTSCHE BANK AG\ | 35.3K | $1.38M | $747.8K | Added$900.6K |
| Legal & General Group Plc | 33.1K | $1.3M | $644K | Added$880.1K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31.9K | $1.25M | $759.6K | Added$755.1K |
| Legato Capital Management LLC | 31.2K | $1.22M | — | New |
| ExodusPoint Capital Management, LP | 30.1K | $1.18M | $716.4K | Added$249.6K |
| J. Goldman & Co LP | 28.7K | $1.12M | — | New |
| STATE OF WISCONSIN INVESTMENT BOARD | 28.4K | $1.11M | $485.5K | Added$799.7K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25.2K | $986.7K | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 23.4K | $918.9K | $460.2K | Added$621.1K |
| VANGUARD ASSET MANAGEMENT, Ltd | 23.1K | $903.6K | — | Held |
| Brevan Howard Capital Management LP | 22.2K | $871.5K | — | New |
| MetLife Investment Management, LLC | 22.1K | $866.1K | $525.8K | Added$487.9K |
| Artia Global Partners LP | 20.9K | $819.3K | — | New |
| FRANKLIN RESOURCES INC | 20.2K | $791.1K | $480K | Added$480.6K |
| JPMORGAN CHASE & CO | 20.8K | $761.8K | $438.7K | Added$443K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18.4K | $723.2K | $435.2K | Added$441.6K |
| Vanguard Global Advisers, LLC | 17.8K | $695.8K | — | Held |
| Virtus Investment Advisers, LLC | 16.2K | $634K | $375.5K | Added$391K |
| Scientech Research LLC | 15.8K | $620.4K | — | New |
| CANADA PENSION PLAN INVESTMENT BOARD | 15.3K | $599.8K | $257K | Added$433.4K |
| Optimize Financial Inc | 15.1K | $590.2K | — | New |
| FORA Capital, LLC | 14.7K | $577.4K | — | New |
| CITIGROUP INC | 14.7K | $576.3K | $349.9K | Added$291.5K |
| FOX RUN MANAGEMENT, L.L.C. | 15.6K | $569.8K | $263.4K | Added$378.4K |
| VOYA INVESTMENT MANAGEMENT LLC | 14.5K | $568K | — | New |
| WELLS FARGO & COMPANY/MN | 14.3K | $560.2K | $340.1K | Cut−$102.9K |
| Creative Planning | 13.7K | $535.9K | — | New |
| BARCLAYS PLC | 11.8K | $463.7K | $281.6K | Cut−$612.3K |
| Jump Financial, LLC | 11.7K | $457.1K | $277.5K | Cut−$241.3K |
| Brooklyn Investment Group | 11.7K | $457.1K | — | New |
| Police & Firemen's Retirement System of New Jersey | 11.2K | $437.6K | $265.7K | Added$265.7K |
| State of New Jersey Common Pension Fund D | 11.2K | $437.3K | — | New |
| JANUS HENDERSON GROUP PLC | 11K | $431.2K | $261.8K | Cut−$25.3M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10.9K | $428.6K | $146.7K | Added$333.7K |
| Quantbot Technologies LP | 10.7K | $419.9K | $42.1K | Added$392.6K |
| AXQ CAPITAL, LP | 10.6K | $416.8K | $253K | Added$197.4K |
| RAYMOND JAMES FINANCIAL INC | 10.6K | $416K | — | New |
| INTECH INVESTMENT MANAGEMENT LLC | 10.6K | $415.8K | $252.5K | Added$158.2K |
| China Universal Asset Management Co., Ltd. | 10.5K | $412.9K | $230.2K | Added$263.9K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 10.5K | $410.8K | $249.4K | Added$249.4K |
| OSAIC HOLDINGS, INC. | 10K | $393.3K | $1.43K | Added$392.3K |
| BNP PARIBAS FINANCIAL MARKETS | 9.63K | $377.4K | $229.1K | Added$228.4K |
| LETKO, BROSSEAU & ASSOCIATES INC | 9.6K | $376.3K | — | New |
| ARIZONA STATE RETIREMENT SYSTEM | 8.96K | $351.4K | — | New |
| TD Asset Management Inc | 8.6K | $337.1K | — | New |
| ProShare Advisors LLC | 8.36K | $327.7K | — | New |
| PROFUND ADVISORS LLC | 8.25K | $323.4K | $196.4K | Added$166.7K |
| STIFEL FINANCIAL CORP | 7.92K | $310.6K | — | New |
| SIMPLEX TRADING, LLC | 7.88K | $309K | $63K | Added$268.2K |
| Vanguard Investments Australia, Ltd. | 7.15K | $280.4K | — | Held |
| PSP Research LLC | 7K | $274.4K | — | New |
| Amundi | 6.94K | $271.9K | — | New |
| KLP KAPITALFORVALTNING AS | 6.8K | $266.6K | $161.8K | Added$161.8K |
| Persistent Asset Partners Ltd | 6.61K | $259K | — | New |
| Quantinno Capital Management LP | 6.54K | $256.3K | — | New |
| Entropy Technologies, LP | 6.1K | $239.2K | — | New |
| Bridgefront Capital, LLC | 5.8K | $227.6K | — | New |
| ROYAL BANK OF CANADA | 5.42K | $212K | $29.6K | Added$194K |
| Tower Research Capital LLC (TRC) | 3.47K | $136.1K | $54.8K | Added$100.6K |
| Ameritas Investment Partners, Inc. | 3.45K | $135.2K | $82.1K | Added$82.1K |
| Mirae Asset Global Investments Co., Ltd. | 3.1K | $121.4K | $68.6K | Added$76.9K |
| Russell Investments Group, Ltd. | 3K | $117.6K | $71.4K | Added$69.6K |
| Caitong International Asset Management Co., Ltd | 2.4K | $94.3K | $22.4K | Added$79.8K |
| Versant Capital Management, Inc | 1.57K | $61.7K | $5.05K | Added$58.5K |
| GF FUND MANAGEMENT CO. LTD. | 1.33K | $52.3K | $27.7K | Added$34.3K |
| NISA INVESTMENT ADVISORS, LLC | 1.04K | $40.9K | $14K | Added$31.9K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 844 | $33.1K | $24.9K | Added$33.1K |
| Farther Finance Advisors, LLC | 810 | $30.6K | $15.4K | Added$20K |
| Sterling Capital Management LLC | 256 | $10K | $6.09K | Added$5.74K |
| DIADEMA PARTNERS LP | 245 | $9.6K | — | New |
| SIGNATUREFD, LLC | 236 | $9.25K | $619 | Added$8.85K |
| GAMMA Investing LLC | 222 | $8.7K | $4.52K | Added$5.78K |
| MassMutual Private Wealth & Trust, FSB | 208 | $8.15K | $2.38K | Added$6.61K |
| US BANCORP \DE\ | 167 | $6.55K | — | New |
| CWM, LLC | 142 | $5.57K | $3.68K | Added$5.57K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 97.7K | $3.83K | $566 | Added$3.46K |
| Larson Financial Group LLC | 61 | $2.39K | $1.45K | Added$759 |
| Cornerstone Financial Management LLC | 42 | $1.65K | $999 | Added$999 |
| ROTHSCHILD INVESTMENT LLC | 40 | $1.57K | $476 | Added$1.26K |
| Allworth Financial LP | 39 | $1.53K | — | New |
| Rockefeller Capital Management L.P. | 25 | $980 | — | New |
| SBI Securities Co., Ltd. | 25 | $980 | $595 | Added$410 |
| Virtu Financial LLC | 24.4K | $958 | — | New |
| PNC Financial Services Group, Inc. | 22 | $862 | $523 | Added$523 |
| Parkside Financial Bank & Trust | 15 | $588 | — | New |
| MAI Capital Management | 7 | $275 | — | New |
| EverSource Wealth Advisors, LLC | 4 | $156 | — | New |
| KBC Group NV | 958 | $38 | — | New |
| Smartleaf Asset Management LLC | 1 | $37 | $21 | Added$21 |
| Covestor Ltd | 6 | $0 | $0 | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |