| SUVRETTA CAPITAL MANAGEMENT, LLC | 4.4M | $101.5M | $12.1M | Added$18.9M |
| INFINITUM ASSET MANAGEMENT, LLC | 4.15M | $95.7M | $12.2M | Added$12.7M |
| HHLR ADVISORS, LTD. | 3.93M | $90.6M | $11.6M | Added$11.6M |
| ORBIMED ADVISORS LLC | 3.03M | $69.8M | $8.93M | Added$8.93M |
| Fidelity | 3.02M | $69.6M | $8.9M | Cut−$4.93M |
| BlackRock, Inc. | 2.53M | $58.4M | $7M | Added$10.6M |
| Octagon Capital Advisors LP | 1.97M | $45.5M | $5.81M | Added$5.81M |
| NOVO HOLDINGS A/S | 1.94M | $44.8M | $5.73M | Added$5.73M |
| Sofinnova Investments, Inc. | 1.7M | $39.1M | $5.01M | Added$5.01M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.53M | $35.3M | — | Held |
| General Catalyst Group Management, LLC | 1.49M | $34.5M | $4.41M | Added$4.41M |
| State Street | 1.42M | $32.8M | $3.22M | Added$10.8M |
| Vivo Capital, LLC | 885.9K | $20.4M | — | New |
| GOLDMAN SACHS GROUP INC | 853.4K | $19.7M | $2.19M | Added$4.75M |
| GEODE CAPITAL MANAGEMENT, LLC | 803.7K | $18.5M | $2.22M | Added$3.38M |
| Point72 Asset Management, L.P. | 748.2K | $17.3M | $639.1K | Added$12.9M |
| HSG Holding Ltd | 663.3K | $14M | −$2.73M | Cut−$2.73M |
| Fund 1 Investments, LLC | 500K | $11.5M | $1.47M | Added$149.8K |
| UBS Group AG | 486.3K | $11.2M | $1.33M | Added$2.15M |
| Balyasny Asset Management L.P. | 426.3K | $9.83M | $126.9K | Added$8.97M |
| MILLENNIUM MANAGEMENT LLC | 425.9K | $9.83M | $831.8K | Added$4.15M |
| D. E. Shaw & Co., Inc. | 368.8K | $8.51M | $688.3K | Added$3.81M |
| Logos Global Management LP | 350K | $8.07M | — | New |
| NORTHERN TRUST CORP | 268.8K | $6.2M | $724.5K | Added$1.26M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 258.8K | $5.97M | $739.2K | Added$928K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 253.9K | $5.86M | — | Held |
| NOMURA HOLDINGS INC | 242.1K | $5.58M | — | New |
| VANGUARD FIDUCIARY TRUST CO | 217.1K | $5.01M | — | Held |
| AMERIPRISE FINANCIAL INC | 180K | $4.15M | $349.5K | Added$1.77M |
| Affinity Asset Advisors, LLC | 175K | $4.04M | $442.5K | Added$1.02M |
| Citadel | 166.2K | $3.83M | $490.2K | Cut−$5.39M |
| Woodline Partners LP | 147.6K | $3.41M | $434.8K | Added$440.6K |
| ADAR1 Capital Management, LLC | 141.8K | $3.27M | — | New |
| MORGAN STANLEY | 128.5K | $2.97M | $287.9K | Added$1M |
| DIMENSIONAL FUND ADVISORS LP | 126.5K | $2.92M | $43.4K | Added$2.62M |
| Polymer Capital Management (HK) LTD | 122.3K | $2.82M | — | New |
| BURKEHILL GLOBAL MANAGEMENT, LP | 100K | $2.31M | $295K | Added$295K |
| E Fund Management Co., Ltd. | 94K | $2.17M | — | Held |
| BANK OF AMERICA CORP /DE/ | 80.2K | $1.85M | $166.7K | Added$713.2K |
| WELLINGTON MANAGEMENT GROUP LLP | 78.2K | $1.8M | $230.7K | Added$148.9K |
| Bank of New York Mellon Corp | 75.4K | $1.74M | $215.7K | Added$269.6K |
| Qube Research & Technologies Ltd | 70.3K | $1.62M | — | New |
| BARCLAYS PLC | 65.4K | $1.51M | $193K | Cut−$1.09M |
| XTX Topco Ltd | 63K | $1.45M | $77.4K | Added$925.2K |
| JPMORGAN CHASE & CO | 65.9K | $1.38M | $58.6K | Cut−$12.1K |
| Nuveen, LLC | 56.8K | $1.31M | $158.2K | Added$232.5K |
| Moody Aldrich Partners LLC | 56.1K | $1.29M | $165.5K | Added$154K |
| Squarepoint Ops LLC | 55.4K | $1.28M | $163.5K | Cut−$2.47M |
| Seven Fleet Capital Management LP | 50.3K | $1.16M | — | New |
| TWO SIGMA INVESTMENTS, LP | 48.7K | $1.12M | $143.6K | Cut−$435.8K |
| Jones Hill Capital LP | 45.8K | $1.06M | — | Held |
| Swiss National Bank | 40K | $922.8K | $118K | Added$118K |
| Rafferty Asset Management, LLC | 37.3K | $859.4K | $85.2K | Added$278.4K |
| ALPS ADVISORS INC | 36K | $830.2K | $100K | Added$148.2K |
| MARSHALL WACE, LLP | 35.2K | $811.3K | $103.7K | Cut−$1.18M |
| RHUMBLINE ADVISERS | 35.1K | $810.9K | $92.8K | Added$178K |
| SECTORAL ASSET MANAGEMENT INC | 30K | $720.4K | $116.6K | Cut−$49.3K |
| Quantinno Capital Management LP | 31K | $715.1K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30.9K | $712.8K | $91.1K | Cut−$4.17M |
| DEUTSCHE BANK AG\ | 28K | $645.5K | $63.5K | Added$212.3K |
| Corient Private Wealth LLC | 27.2K | $607.8K | — | New |
| ALLIANCEBERNSTEIN L.P. | 28.2K | $567.4K | $0 | Held |
| Invesco Ltd. | 23.9K | $552.3K | $49.8K | Added$212.5K |
| TUDOR INVESTMENT CORP ET AL | 22.1K | $509.9K | — | New |
| Jump Financial, LLC | 21.9K | $505.2K | $64.6K | Added$17.9K |
| Man Group plc | 20.7K | $478.2K | — | New |
| AMERICAN CENTURY COMPANIES INC | 19.5K | $450.2K | — | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19.4K | $446.8K | $57.1K | Added$10.6K |
| ExodusPoint Capital Management, LP | 19K | $438.9K | $56.1K | Cut−$770.9K |
| Optimize Financial Inc | 18.9K | $436.4K | — | New |
| JANE STREET GROUP, LLC | 17.7K | $407.4K | $52.1K | Cut−$1.67M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17.7K | $403.6K | $39.7K | Added$93.2K |
| MetLife Investment Management, LLC | 17.3K | $399.7K | $49.1K | Added$64.5K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 17.3K | $399.3K | $79.6K | Cut−$345K |
| PROFUND ADVISORS LLC | 16.8K | $387.9K | $32.4K | Added$166.9K |
| IvyRock Asset Management (HK) Ltd | 16K | $369.1K | — | New |
| Caption Management, LLC | 16K | $368.4K | — | New |
| Icahn Capital | 15.9K | $367.3K | $33.9K | Added$136.5K |
| VOYA INVESTMENT MANAGEMENT LLC | 15.3K | $353.7K | — | New |
| VANGUARD ASSET MANAGEMENT, Ltd | 14.9K | $343.6K | — | Held |
| Legal & General Group Plc | 14.7K | $338.6K | $43.3K | Added$31.2K |
| Brooklyn Investment Group | 14.1K | $325.9K | — | New |
| Quadrature Capital Ltd | 13.3K | $307K | $37.6K | Added$50.2K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13.1K | $302.4K | $14K | Added$206.9K |
| Susquehanna Portfolio Strategies, LLC | 12.3K | $282.7K | — | New |
| WELLS FARGO & COMPANY/MN | 12.1K | $279.7K | $35.8K | Cut−$369.8K |
| INTECH INVESTMENT MANAGEMENT LLC | 11.8K | $272.7K | $32.5K | Added$51.2K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 11.4K | $262K | $32.5K | Added$40.5K |
| Virtus Investment Advisers, LLC | 11.2K | $257.6K | $32.1K | Added$38.4K |
| Vanguard Global Advisers, LLC | 10.8K | $248.3K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 9.58K | $220.9K | $16.1K | Added$110.8K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 9.07K | $209.2K | — | New |
| GLENMEDE TRUST CO NA | 9.06K | $209K | — | New |
| AXQ CAPITAL, LP | 8.94K | $206.1K | — | New |
| Persistent Asset Partners Ltd | 8.11K | $187.1K | $23.5K | Added$26.8K |
| Police & Firemen's Retirement System of New Jersey | 7.88K | $181.8K | $23.2K | Added$23.2K |
| NEW YORK STATE COMMON RETIREMENT FUND | 7.78K | $179.6K | $23K | Added$23K |
| CITIGROUP INC | 7.43K | $171.5K | $21.9K | Added$8.69K |
| China Universal Asset Management Co., Ltd. | 7.33K | $169K | $19.8K | Added$33.7K |
| Vanguard Investments Australia, Ltd. | 6.08K | $140.2K | — | Held |
| KLP KAPITALFORVALTNING AS | 4.3K | $99.2K | $12.7K | Added$12.7K |
| Tower Research Capital LLC (TRC) | 2.5K | $57.7K | $6.99K | Added$9.99K |
| Ameritas Investment Partners, Inc. | 2.35K | $54.3K | $6.94K | Added$6.94K |
| Mirae Asset Global Investments Co., Ltd. | 2.15K | $49.7K | $5.92K | Added$9.31K |
| Russell Investments Group, Ltd. | 2.07K | $47.7K | $6.1K | Added$6.1K |
| US BANCORP \DE\ | 1.22K | $28.2K | $3.28K | Added$5.84K |
| GF FUND MANAGEMENT CO. LTD. | 919 | $21.2K | $2.39K | Added$4.88K |
| Farther Finance Advisors, LLC | 671 | $16.3K | $1.37K | Added$9.51K |
| OSAIC HOLDINGS, INC. | 702 | $16.2K | $1.76K | Added$4.2K |
| Quantbot Technologies LP | 534 | $12.3K | — | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 494 | $11.4K | — | New |
| Aquatic Capital Management LLC | 460 | $10.6K | $1.36K | Cut−$236.9K |
| Versant Capital Management, Inc | 423 | $9.76K | $1.22K | Added$1.45K |
| CWM, LLC | 392 | $9.04K | $4.19K | Added$9.04K |
| SIGNATUREFD, LLC | 368 | $8.49K | $1.09K | Added$1.09K |
| GAMMA Investing LLC | 359 | $8.28K | $428 | Added$5.37K |
| Arax Advisory Partners | 330 | $7.61K | $564 | Added$3.77K |
| PNC Financial Services Group, Inc. | 326 | $7.52K | $405 | Added$4.76K |
| NISA INVESTMENT ADVISORS, LLC | 313 | $7.22K | $923 | Added$923 |
| Larson Financial Group LLC | 277 | $6.39K | $817 | Cut−$3.03K |
| Optiver Holding B.V. | 258 | $5.95K | $395 | Added$3.26K |
| Sterling Capital Management LLC | 209 | $4.82K | $552 | Added$1.06K |
| SG Americas Securities, LLC | 48.7K | $1.12K | $144 | Added$89 |
| HRT FINANCIAL LP | 47.1K | $1.08K | $139 | Added$11 |
| Allworth Financial LP | 45 | $1.04K | $53 | Added$676 |
| ROYAL BANK OF CANADA | 44 | $1K | $58 | Cut−$20K |
| Torren Management, LLC | 33 | $761 | $97 | Added$97 |
| Caitong International Asset Management Co., Ltd | 31 | $715 | $91 | Cut−$15.5K |
| EverSource Wealth Advisors, LLC | 27 | $623 | $33 | Added$402 |
| SBI Securities Co., Ltd. | 26 | $600 | $77 | Cut−$326 |
| Parallel Advisors, LLC | 24 | $554 | — | New |
| ROTHSCHILD INVESTMENT LLC | 23 | $531 | $60 | Added$129 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22.6K | $522 | $47 | Added$197 |
| MAI Capital Management | 19 | $439 | — | New |
| Root Financial Partners, LLC | 18 | $415 | — | New |
| Essential Partners LLC | 8 | $185 | $3 | Added$165 |
| True Wealth Design, LLC | 6 | $139 | $12 | Added$58 |
| Keating Financial Advisory Services, Inc. | 1 | $23 | — | New |
| Covestor Ltd | 9 | $0 | $0 | Held |