| BlackRock, Inc. | 7.17M | $158M | $56M | Added$113.4M |
| Deep Track Capital, LP | 6.77M | $149.2M | — | New |
| SAMSARA BIOCAPITAL, LLC | 6.35M | $139.8M | $70.6M | Added$83.6M |
| Foresite Capital Management V, LLC | 5.9M | $129.9M | $70.9M | Added$73.5M |
| venBio Partners LLC | 4.53M | $99.8M | $55.6M | Added$54.7M |
| Foresite Capital Management VI LLC | 4.25M | $93.6M | $52.1M | Added$52.1M |
| VANGUARD CAPITAL MANAGEMENT LLC | 4.03M | $88.8M | — | Held |
| Cormorant Asset Management, LP | 3.95M | $87M | $44.6M | Added$51.5M |
| Nextech Invest, Ltd. | 3.54M | $78M | $35.8M | Added$49.5M |
| Saturn V Capital Management LP | 3.2M | $70.5M | $38.5M | Added$39.9M |
| UBS Group AG | 3.05M | $67.3M | $1.4M | Added$66.2M |
| Octagon Capital Advisors LP | 2.83M | $62.4M | $31.1M | Added$37.7M |
| MPM BIOIMPACT LLC | 2.39M | $52.6M | $29.3M | Added$29.1M |
| JANUS HENDERSON GROUP PLC | 2.12M | $46.8M | — | New |
| BAKER BROS. ADVISORS LP | 2.01M | $44.3M | $19.2M | Added$29.1M |
| SR One Capital Management, LP | 1.96M | $43.2M | $24M | Added$24M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.92M | $42.3M | $18.3M | Added$27.8M |
| State Street | 1.8M | $39.7M | $15.5M | Added$27.4M |
| Invesco Ltd. | 1.51M | $33.3M | $5.18M | Added$29.2M |
| Ikarian Capital, LLC | 1.21M | $26.7M | — | New |
| MARSHALL WACE, LLP | 1.17M | $25.8M | $4.58M | Added$22.2M |
| Weiss Asset Management LP | 1.1M | $24.2M | — | New |
| PRINCIPAL FINANCIAL GROUP INC | 1.06M | $23.3M | — | New |
| Fidelity | 973.8K | $21.5M | $294.3K | Added$21.2M |
| GREAT POINT PARTNERS LLC | 856.1K | $18.9M | — | New |
| Integral Health Asset Management, LLC | 800K | $17.6M | — | New |
| JPMORGAN CHASE & CO | 861.6K | $17.4M | $3.72M | Added$13.9M |
| Yu Fan | 776.8K | $17.1M | $9.53M | Added$9.41M |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 749.1K | $16.5M | — | New |
| GOLDMAN SACHS GROUP INC | 718K | $15.8M | $5.24M | Added$11.7M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 712.6K | $15.7M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 658.1K | $14.5M | $3.66M | Added$11.6M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 635.4K | $14M | $6.19M | Added$9.08M |
| MILLENNIUM MANAGEMENT LLC | 606.3K | $13.4M | $7.44M | Added$2.12M |
| D. E. Shaw & Co., Inc. | 572.1K | $12.6M | $2.84M | Added$10.3M |
| NORTHERN TRUST CORP | 563.5K | $12.4M | $5.13M | Added$8.33M |
| Opaleye Management Inc. | 550K | $12.1M | $6.56M | Added$6.89M |
| ORBIMED ADVISORS LLC | 548.2K | $12.1M | $6.73M | Added$1.31M |
| PRUDENTIAL FINANCIAL INC | 538.7K | $11.9M | — | New |
| VANGUARD FIDUCIARY TRUST CO | 527.3K | $11.6M | — | Held |
| ROYCE & ASSOCIATES LP | 476.4K | $10.5M | — | New |
| Spruce Street Capital LP | 392.6K | $8.65M | — | New |
| Point72 Asset Management, L.P. | 363K | $8M | — | New |
| Citadel | 351.5K | $7.74M | $1.46M | Added$6.58M |
| BOOTHBAY FUND MANAGEMENT, LLC | 346.1K | $7.63M | — | New |
| Artia Global Partners LP | 325K | $7.16M | — | New |
| Nuveen, LLC | 319.2K | $7.03M | $2.08M | Added$5.38M |
| Exome Asset Management LLC | 279.2K | $6.15M | $3.43M | Added$3.3M |
| ExodusPoint Capital Management, LP | 266.2K | $5.87M | $137.4K | Added$5.76M |
| Omega Fund Management, LLC | 241.3K | $5.31M | $2.96M | Cut−$1.06M |
| WELLINGTON MANAGEMENT GROUP LLP | 239.2K | $5.27M | $2.07M | Added$3.62M |
| STEMPOINT CAPITAL LP | 229.6K | $5.06M | — | New |
| MORGAN STANLEY | 225.1K | $4.96M | $2.76M | Added$14.6K |
| BARCLAYS PLC | 222.7K | $4.91M | $1.5M | Added$3.71M |
| TOWERVIEW LLC | 222.3K | $4.9M | $2.73M | Added$65.9K |
| STIFEL FINANCIAL CORP | 209.7K | $4.62M | $2.57M | Added$2.57M |
| Bank of New York Mellon Corp | 206.7K | $4.55M | $1.96M | Added$2.99M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 194.4K | $4.28M | $2.38M | Added$2.25M |
| Hudson Bay Capital Management LP | 193.4K | $4.26M | — | New |
| Trium Capital LLP | 191.4K | $4.22M | $2.35M | Cut−$4.5M |
| TD Asset Management Inc | 191.2K | $4.21M | — | New |
| ACT CAPITAL MANAGEMENT, LLC | 174.3K | $3.84M | — | New |
| Susquehanna Portfolio Strategies, LLC | 172.8K | $3.81M | $2.12M | Added$2.12M |
| Ensign Peak Advisors, Inc | 169.5K | $3.73M | — | New |
| Ally Bridge Group (NY) LLC | 167K | $3.68M | — | New |
| BURKEHILL GLOBAL MANAGEMENT, LP | 165K | $3.63M | — | New |
| Russell Investments Group, Ltd. | 162.2K | $3.57M | $184.4K | Added$3.43M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 154.6K | $3.41M | $216.7K | Added$3.23M |
| Icahn Capital | 146.7K | $3.23M | $1.69M | Added$1.89M |
| Elmind Capital, LP | 130K | $2.86M | — | New |
| BANK OF AMERICA CORP /DE/ | 127.8K | $2.82M | $1.57M | Added$1.47M |
| Swiss National Bank | 127.8K | $2.82M | — | New |
| Quantinno Capital Management LP | 127.1K | $2.8M | $1.56M | Added$1.48M |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 137.3K | $2.78M | — | New |
| Squarepoint Ops LLC | 114.2K | $2.52M | — | New |
| HighVista Strategies LLC | 112.9K | $2.49M | — | New |
| TUDOR INVESTMENT CORP ET AL | 106.4K | $2.34M | — | New |
| AMERICAN CENTURY COMPANIES INC | 102.5K | $2.26M | $126.7K | Added$2.16M |
| Ghisallo Capital Management LLC | 100K | $2.2M | — | New |
| Harvest Investment Services, LLC | 99.8K | $2.2M | — | New |
| CITIGROUP INC | 98.9K | $2.18M | $172.6K | Added$2.04M |
| WELLS FARGO & COMPANY/MN | 86.7K | $1.91M | $1.06M | Added$647K |
| RHUMBLINE ADVISERS | 84.3K | $1.86M | $849.5K | Added$1.18M |
| Informed Momentum Co LLC | 83.2K | $1.83M | — | New |
| VICTORY CAPITAL MANAGEMENT INC | 82.7K | $1.82M | — | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 82.1K | $1.81M | — | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 80.8K | $1.78M | $42.7K | Added$1.75M |
| Renaissance Technologies | 75.2K | $1.66M | $922.3K | Added$599.9K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 74.8K | $1.65M | $917.3K | Added$789.7K |
| VOYA INVESTMENT MANAGEMENT LLC | 73.9K | $1.63M | — | New |
| Mariner, LLC | 73.1K | $1.61M | $897.3K | Added$195.2K |
| FIRST TRUST ADVISORS LP | 66.1K | $1.46M | — | New |
| DEUTSCHE BANK AG\ | 58.2K | $1.28M | $504.4K | Added$880K |
| Legal & General Group Plc | 50.6K | $1.11M | $60.8K | Added$1.07M |
| STATE OF WISCONSIN INVESTMENT BOARD | 44.5K | $980.6K | — | New |
| Vanguard Global Advisers, LLC | 42.2K | $930.6K | — | Held |
| VANGUARD ASSET MANAGEMENT, Ltd | 42.2K | $930.6K | — | Held |
| MOORE CAPITAL MANAGEMENT, LP | 41.4K | $911.4K | — | New |
| Creative Planning | 41.1K | $905.1K | $467.6K | Added$533.1K |
| MetLife Investment Management, LLC | 37.6K | $827.4K | $398.5K | Added$510.4K |
| BNP PARIBAS FINANCIAL MARKETS | 35.1K | $774.3K | $431.2K | Added$316.7K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32.2K | $708.5K | $322K | Added$452.4K |
| Walleye Capital LLC | 31.8K | $700.1K | — | New |
| ALLIANCEBERNSTEIN L.P. | 68.1K | $664.6K | −$0 | Cut−$83K |
| INTECH INVESTMENT MANAGEMENT LLC | 29.6K | $651.9K | $359.5K | Added$365.9K |
| Scientech Research LLC | 29.4K | $647.8K | — | New |
| Brevan Howard Capital Management LP | 27.6K | $607.6K | $338.4K | Added$266.8K |
| Inscription Capital, LLC | 26.2K | $577.5K | $321.6K | Added$317.2K |
| Swiss Life Asset Management Ltd | 15.8K | $574.2K | — | New |
| Virtus Investment Advisers, LLC | 23.7K | $522.8K | $284.1K | Added$296.8K |
| J. Goldman & Co LP | 23.4K | $516.6K | — | New |
| DIMENSIONAL FUND ADVISORS LP | 23.1K | $509.2K | $251.7K | Added$309K |
| China Universal Asset Management Co., Ltd. | 22.4K | $494.3K | $194.4K | Added$339.7K |
| State of New Jersey Common Pension Fund D | 22.1K | $486.6K | — | New |
| Caption Management, LLC | 20K | $440.6K | — | New |
| Caitong International Asset Management Co., Ltd | 19.7K | $434.2K | — | New |
| XTX Topco Ltd | 19.3K | $425K | $236.7K | Added$181.4K |
| Corient Private Wealth LLC | 18.7K | $411.7K | — | New |
| Police & Firemen's Retirement System of New Jersey | 18.6K | $410.6K | $188.2K | Added$260.9K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18.4K | $405K | — | New |
| Allianz Asset Management GmbH | 18.2K | $400.9K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 17.9K | $393.6K | $144.4K | Added$278.8K |
| ARIZONA STATE RETIREMENT SYSTEM | 17.8K | $391.1K | — | New |
| Vanguard Investments Australia, Ltd. | 16.3K | $358.5K | — | Held |
| ProShare Advisors LLC | 15.6K | $343.5K | $179.5K | Added$200.7K |
| Integrated Quantitative Investments LLC | 15.4K | $339.8K | — | New |
| Shay Capital LLC | 15K | $330.4K | — | New |
| OpenArc Corporate Advisory, LLC | 14.2K | $313.7K | — | New |
| KLP KAPITALFORVALTNING AS | 14.2K | $312.8K | — | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 13.6K | $299.7K | — | New |
| MERCER GLOBAL ADVISORS INC /ADV | 12.8K | $281.2K | $156.6K | Added$135.7K |
| OCCUDO QUANTITATIVE STRATEGIES LP | 11.1K | $274.7K | — | New |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 12K | $265K | — | New |
| Kera Capital Partners, Inc. | 11K | $242.4K | −$27.3K | Cut−$27.3K |
| FARALLON CAPITAL MANAGEMENT LLC | 11K | $242.3K | — | New |
| Pictet Asset Management Holding SA | 10.5K | $231.1K | — | New |
| Vanguard Personalized Indexing Management, LLC | 10.4K | $229.6K | — | New |
| CWM, LLC | 10.4K | $228.9K | $228.8K | Added$228.8K |
| PROFUND ADVISORS LLC | 10K | $220.8K | — | New |
| SmartHarvest Portfolios, LLC | 9.61K | $211.6K | — | New |
| SEI INVESTMENTS CO | 9.32K | $205.3K | — | New |
| Verdad Advisers, LP | 9.17K | $202.1K | — | New |
| Tower Research Capital LLC (TRC) | 8.88K | $195.5K | $15.9K | Added$182.8K |
| SIMPLEX TRADING, LLC | 8.03K | $176.9K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 6.59K | $145.3K | $58K | Added$99.2K |
| Farther Finance Advisors, LLC | 6.01K | $136.6K | — | New |
| Ameritas Investment Partners, Inc. | 5.61K | $123.6K | $59.2K | Added$76.5K |
| ASSETMARK, INC | 4.19K | $92.3K | — | New |
| NISA INVESTMENT ADVISORS, LLC | 3.35K | $73.9K | $9.26K | Added$66.5K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.29M | $72.4K | $618 | Added$71.9K |
| EverSource Wealth Advisors, LLC | 3.13K | $69K | $5.48K | Added$64.6K |
| Essential Partners LLC | 2.89K | $63.7K | $35.5K | Added$35.5K |
| State of Wyoming | 2.59K | $57.1K | — | New |
| Sterling Capital Management LLC | 2.27K | $50K | $27.9K | Added$18.3K |
| GF FUND MANAGEMENT CO. LTD. | 2.18K | $48.1K | $23.4K | Added$29.4K |
| Parallel Advisors, LLC | 2.06K | $45.4K | $25.3K | Added$25.3K |
| STRS OHIO | 2K | $44.1K | $6.14K | Added$39.2K |
| SIGNATUREFD, LLC | 1.61K | $35.5K | $15.5K | Added$23.2K |
| GAMMA Investing LLC | 1.05K | $23.2K | $9.72K | Added$15.4K |
| Kemnay Advisory Services Inc. | 828 | $18.2K | — | New |
| JONES FINANCIAL COMPANIES LLLP | 544 | $13.5K | — | New |
| Versant Capital Management, Inc | 543 | $12K | $6.66K | Added$5.62K |
| Allworth Financial LP | 503 | $11.1K | $5.52K | Added$6.69K |
| US BANCORP \DE\ | 464 | $10.2K | $5.69K | Added$4.55K |
| PNC Financial Services Group, Inc. | 417 | $9.19K | $4.76K | Added$5.4K |
| ROTHSCHILD INVESTMENT LLC | 410 | $9.03K | $5.03K | Added$4.98K |
| Arax Advisory Partners | 366 | $8.06K | $4.49K | Cut−$2.05K |
| OSAIC HOLDINGS, INC. | 343 | $7.56K | — | New |
| MAI Capital Management | 309 | $6.81K | — | New |
| Rockefeller Capital Management L.P. | 256 | $5.64K | — | New |
| Western Wealth Management, LLC | 250 | $5.51K | — | New |
| Larson Financial Group LLC | 250 | $5.51K | $122 | Added$5.41K |
| True Wealth Design, LLC | 244 | $5.38K | $2.99K | Added$2.99K |
| Optiver Holding B.V. | 224 | $4.93K | $2.75K | Added$1.95K |
| MassMutual Private Wealth & Trust, FSB | 216 | $4.76K | — | New |
| SMA Capital LLC | 203 | $4.47K | — | New |
| BFSG, LLC | 192 | $4.23K | $2.36K | Added$2.36K |
| ALGERT GLOBAL LLC | 157.8K | $3.48K | — | New |
| Parkside Financial Bank & Trust | 150 | $3.31K | — | New |
| Transamerica Financial Advisors, LLC | 97 | $2.14K | $1.19K | Added$1.19K |
| Decker Retirement Planning Inc. | 91 | $2K | — | New |
| ROYAL BANK OF CANADA | 88 | $2K | $1.16K | Cut−$19K |
| Advisory Services Network, LLC | 55 | $1.21K | — | New |
| IFP Advisors, Inc | 55 | $1.21K | $675 | Added$675 |
| CoreCap Advisors, LLC | 26 | $573 | $319 | Added$319 |
| SALEM INVESTMENT COUNSELORS INC | 20 | $441 | — | New |
| Fortitude Family Office, LLC | 20 | $441 | — | New |
| GSA CAPITAL PARTNERS LLP | 18.4K | $406 | $226 | Added$104 |
| Virtu Financial LLC | 17.7K | $390 | $217 | Cut−$101 |
| HARBOUR INVESTMENTS, INC. | 13 | $306 | — | New |
| SG Americas Securities, LLC | 8.63K | $190 | — | New |
| Sunbelt Securities, Inc. | 7 | $154 | $86 | Added$86 |
| SBI Securities Co., Ltd. | 4 | $88 | $37 | Added$59 |
| KBC Group NV | 1.93K | $42 | — | New |
| ACADIAN ASSET MANAGEMENT LLC | 588 | $12 | — | New |
| Covestor Ltd | 5 | $0 | — | New |