| AyurMaya Capital Management Company, LP | 15.1M | $147.8M | — | Held |
| Foresite Capital Management V, LLC | 5.78M | $56.4M | — | Held |
| SAMSARA BIOCAPITAL, LLC | 5.76M | $56.2M | — | Held |
| venBio Partners LLC | 4.62M | $45.1M | — | Held |
| BlackRock, Inc. | 4.57M | $44.6M | — | Held |
| Foresite Capital Management VI LLC | 4.25M | $41.5M | — | Held |
| Vanguard | 4.1M | $40M | — | Held |
| Cormorant Asset Management, LP | 3.64M | $35.5M | — | Held |
| Saturn V Capital Management LP | 3.14M | $30.6M | — | Held |
| Nextech Invest, Ltd. | 2.92M | $28.5M | — | Held |
| Octagon Capital Advisors LP | 2.53M | $24.7M | — | Held |
| MPM BIOIMPACT LLC | 2.4M | $23.4M | — | Held |
| SR One Capital Management, LP | 1.96M | $19.1M | — | Held |
| BAKER BROS. ADVISORS LP | 1.56M | $15.3M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.49M | $14.5M | — | Held |
| State Street | 1.26M | $12.3M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 1.15M | $11.2M | — | Held |
| ORBIMED ADVISORS LLC | 1.1M | $10.8M | — | Held |
| Trium Capital LLP | 893.1K | $8.72M | — | Held |
| Yu Fan | 789.6K | $7.71M | — | Held |
| Omega Fund Management, LLC | 653.2K | $6.38M | — | Held |
| Opaleye Management Inc. | 535K | $5.22M | — | Held |
| MORGAN STANLEY | 506.5K | $4.94M | $1.92M | Added$3.62M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 504.1K | $4.92M | — | Held |
| Siren, L.L.C. | 500K | $4.88M | — | Held |
| TOWERVIEW LLC | 495K | $4.83M | — | Held |
| GOLDMAN SACHS GROUP INC | 427.1K | $4.17M | — | Held |
| Invesco Ltd. | 421.8K | $4.12M | — | Held |
| NORTHERN TRUST CORP | 418.2K | $4.08M | — | Held |
| MARSHALL WACE, LLP | 372.9K | $3.64M | — | Held |
| JPMORGAN CHASE & CO | 356.3K | $3.48M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 298.2K | $2.91M | — | Held |
| Exome Asset Management LLC | 292.3K | $2.85M | — | Held |
| D. E. Shaw & Co., Inc. | 231.7K | $2.26M | — | Held |
| STIFEL FINANCIAL CORP | 209.7K | $2.05M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 208.1K | $2.03M | — | Held |
| JANE STREET GROUP, LLC | 173.8K | $1.7M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 172.8K | $1.69M | — | Held |
| Nuveen, LLC | 169.5K | $1.65M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 169.1K | $1.65M | — | Held |
| Bank of New York Mellon Corp | 160.1K | $1.56M | — | Held |
| Mariner, LLC | 145K | $1.42M | — | Held |
| BANK OF AMERICA CORP /DE/ | 138.3K | $1.35M | $798.2K | Added$297.2K |
| Icahn Capital | 137.8K | $1.34M | — | Held |
| Quantinno Capital Management LP | 135.4K | $1.32M | — | Held |
| WELLS FARGO & COMPANY/MN | 129.4K | $1.26M | — | Held |
| BARCLAYS PLC | 122.2K | $1.19M | $481K | Added$860.1K |
| Citadel | 119.3K | $1.16M | — | Held |
| UBS Group AG | 114K | $1.11M | — | Held |
| Renaissance Technologies | 108.2K | $1.06M | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 87.8K | $857.2K | — | Held |
| Verition Fund Management LLC | 80.1K | $781.4K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 163.1K | $760K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 76.6K | $747.6K | — | Held |
| RHUMBLINE ADVISERS | 69.2K | $675.7K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 56.7K | $553.7K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 46.9K | $457.6K | — | Held |
| PSP Research LLC | 43.8K | $427.2K | — | Held |
| DEUTSCHE BANK AG\ | 41.1K | $401.3K | — | Held |
| LMR Partners LLP | 40K | $390.4K | — | Held |
| Creative Planning | 38.1K | $372K | — | Held |
| TWO SIGMA ADVISERS, LP | 38.1K | $371.6K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 37.7K | $368K | — | Held |
| Brevan Howard Capital Management LP | 34.9K | $340.8K | — | Held |
| MetLife Investment Management, LLC | 32.5K | $317K | — | Held |
| Grange Capital, LLC | 32K | $312.3K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 29.3K | $286K | — | Held |
| Kera Capital Partners, Inc. | 11K | $269.7K | — | Held |
| Inscription Capital, LLC | 26.7K | $260.3K | — | Held |
| Dynamic Technology Lab Private Ltd | 26.6K | $259K | — | Held |
| AXQ CAPITAL, LP | 26.4K | $257.8K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26.2K | $256.1K | — | Held |
| XTX Topco Ltd | 25K | $243.6K | — | Held |
| Balyasny Asset Management L.P. | 24.8K | $241.7K | — | Held |
| Fidelity | 24K | $234.1K | — | Held |
| Virtus Investment Advisers, LLC | 23.2K | $226K | — | Held |
| Schonfeld Strategic Advisors LLC | 23K | $224.8K | — | Held |
| BANK OF NOVA SCOTIA | 20.9K | $204K | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 20.5K | $200.2K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17.7K | $172.4K | — | Held |
| IEQ CAPITAL, LLC | 17.4K | $170K | — | Held |
| China Universal Asset Management Co., Ltd. | 15.8K | $154.6K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 15.3K | $149.7K | — | Held |
| Russell Investments Group, Ltd. | 15K | $146.7K | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 14.9K | $145.5K | — | Held |
| ProShare Advisors LLC | 14.6K | $142.8K | — | Held |
| PDT Partners, LLC | 14.6K | $142.1K | — | Held |
| Banco BTG Pactual S.A. | 14.3K | $139.6K | — | Held |
| CITIGROUP INC | 14.1K | $137.3K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 11.8K | $114.8K | — | Held |
| ExodusPoint Capital Management, LP | 11.2K | $109.3K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 10.3K | $100.7K | — | Held |
| Birchview Capital, LP | 10K | $97.6K | — | Held |
| Legal & General Group Plc | 4.95K | $48.4K | — | Held |
| Ameritas Investment Partners, Inc. | 4.83K | $47.1K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 4.72K | $46.1K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.48K | $34K | — | Held |
| Sterling Capital Management LLC | 3.25K | $31.7K | — | Held |
| Essential Partners LLC | 2.89K | $28.2K | $16.7K | Added$16.7K |
| ROYAL BANK OF CANADA | 2.2K | $21K | — | Held |
| Parallel Advisors, LLC | 2.06K | $20.1K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.91K | $18.6K | — | Held |
| GROUP ONE TRADING LLC | 1.41K | $13.7K | — | Held |
| Tower Research Capital LLC (TRC) | 1.3K | $12.7K | — | Held |
| SIGNATUREFD, LLC | 1.27K | $12.4K | — | Held |
| Arax Advisory Partners | 1.04K | $10.1K | — | Held |
| COMERICA BANK | 932 | $9.1K | — | Held |
| GAMMA Investing LLC | 792 | $7.73K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 755 | $7.37K | — | Held |
| Aster Capital Management (DIFC) Ltd | 728 | $7.11K | — | Held |
| Versant Capital Management, Inc | 650 | $6.34K | — | Held |
| US BANCORP \DE\ | 581 | $5.67K | — | Held |
| STRS OHIO | 500 | $4.88K | — | Held |
| Allworth Financial LP | 450 | $4.39K | $2.6K | Added$2.19K |
| EverSource Wealth Advisors, LLC | 447 | $4.36K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 415 | $4.05K | — | Held |
| PNC Financial Services Group, Inc. | 388 | $3.79K | — | Held |
| Optiver Holding B.V. | 306 | $2.99K | — | Held |
| True Wealth Design, LLC | 244 | $2.38K | — | Held |
| BFSG, LLC | 192 | $1.87K | — | Held |
| Transamerica Financial Advisors, LLC | 97 | $947 | — | Held |
| Global Retirement Partners, LLC | 65 | $634 | — | Held |
| IFP Advisors, Inc | 55 | $537 | $318 | Added$318 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 50.4K | $493 | — | Held |
| Virtu Financial LLC | 50.3K | $491 | — | Held |
| GSA CAPITAL PARTNERS LLP | 30.9K | $302 | — | Held |
| CoreCap Advisors, LLC | 26 | $254 | — | Held |
| Torren Management, LLC | 14 | $137 | — | Held |
| CWM, LLC | 10.4K | $102 | — | Held |
| Larson Financial Group LLC | 10 | $98 | — | Held |
| Sunbelt Securities, Inc. | 7 | $68 | — | Held |
| SBI Securities Co., Ltd. | 3 | $29 | — | Held |
| AMALGAMATED BANK | 1.78K | $17 | — | Held |
| Daiwa Securities Group Inc. | 347 | $3 | — | Held |