| MPM BIOIMPACT LLC | 4.84M | $86.5M | — | New |
| EcoR1 Capital, LLC | 4.82M | $86.3M | — | New |
| Blue Owl Capital Holdings LP | 3.16M | $56.6M | — | New |
| WELLINGTON MANAGEMENT GROUP LLP | 2.32M | $41.5M | — | New |
| BlackRock, Inc. | 2.11M | $37.8M | — | New |
| RTW INVESTMENTS, LP | 1.59M | $28.5M | — | New |
| RA CAPITAL MANAGEMENT, L.P. | 1.5M | $26.9M | — | New |
| JANUS HENDERSON GROUP PLC | 1.45M | $26M | — | New |
| BAKER BROS. ADVISORS LP | 996.4K | $17.8M | — | New |
| Octagon Capital Advisors LP | 960.8K | $17.2M | — | New |
| Merck & Co., Inc. | 952.8K | $17M | — | New |
| VANGUARD CAPITAL MANAGEMENT LLC | 833.9K | $14.9M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 507K | $9.07M | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 491.9K | $8.8M | — | New |
| Avidity Partners Management LP | 468.6K | $8.38M | — | New |
| State Street | 428.3K | $7.66M | — | New |
| a16z Capital Management, L.L.C. | 415K | $7.42M | — | New |
| Fidelity | 386.4K | $6.91M | — | New |
| UBS Group AG | 353.3K | $6.32M | — | New |
| ArrowMark Colorado Holdings LLC | 329.5K | $5.89M | — | New |
| Alyeska Investment Group, L.P. | 290K | $5.19M | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 162K | $2.9M | — | New |
| Driehaus Capital Management LLC | 150K | $2.68M | — | New |
| NORTHERN TRUST CORP | 149.5K | $2.67M | — | New |
| VANGUARD FIDUCIARY TRUST CO | 127.4K | $2.28M | — | Held |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 120.3K | $2.15M | — | Held |
| AMERIPRISE FINANCIAL INC | 102.9K | $1.84M | — | New |
| TD Asset Management Inc | 101K | $1.81M | — | New |
| Soros Fund Management | 100K | $1.79M | — | New |
| Laurion Capital Management LP | 100K | $1.79M | — | New |
| Woodline Partners LP | 100K | $1.79M | — | New |
| Citadel | 75K | $1.34M | — | New |
| BANK OF AMERICA CORP /DE/ | 69.9K | $1.25M | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47K | $840.7K | — | New |
| Bank of New York Mellon Corp | 42.9K | $767.5K | — | New |
| MORGAN STANLEY | 30.7K | $549.6K | — | New |
| GOLDMAN SACHS GROUP INC | 30.2K | $539.6K | — | New |
| READYSTATE ASSET MANAGEMENT LP | 30K | $536.7K | — | New |
| Ghisallo Capital Management LLC | 25K | $447.3K | — | New |
| SEVEN GRAND MANAGERS, LLC | 25K | $447.3K | — | New |
| Nuveen, LLC | 24.5K | $437.7K | — | New |
| RHUMBLINE ADVISERS | 21K | $376.3K | — | New |
| D. E. Shaw & Co., Inc. | 17.1K | $305.2K | — | New |
| Zimmer Partners, LP | 15K | $268.4K | — | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 14.2K | $253.8K | — | New |
| DEUTSCHE BANK AG\ | 14.1K | $251.9K | — | New |
| XTX Topco Ltd | 14K | $250.3K | — | New |
| Invesco Ltd. | 12.1K | $216.7K | — | New |
| MetLife Investment Management, LLC | 11.6K | $208.2K | — | New |
| BARCLAYS PLC | 9.72K | $174K | — | New |
| Vanguard Global Advisers, LLC | 9.69K | $173.3K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9.65K | $172.7K | — | New |
| JPMORGAN CHASE & CO | 8.36K | $138.2K | — | New |
| WELLS FARGO & COMPANY/MN | 7.61K | $136.2K | — | New |
| PNC Financial Services Group, Inc. | 6.95K | $124.3K | — | New |
| Police & Firemen's Retirement System of New Jersey | 5.53K | $98.9K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 4.48K | $80.1K | — | New |
| STRS OHIO | 3.6K | $64.4K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 3.2K | $57.2K | — | New |
| T. Rowe Price Investment Management, Inc. | 2.12M | $38K | — | New |
| Legal & General Group Plc | 1.83K | $32.7K | — | New |
| Ameritas Investment Partners, Inc. | 1.68K | $30.1K | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.56M | $28K | — | New |
| Russell Investments Group, Ltd. | 1.55K | $27.7K | — | New |
| CITIGROUP INC | 1.02K | $18.2K | — | New |
| Tower Research Capital LLC (TRC) | 1.01K | $18.1K | — | New |
| SALEM INVESTMENT COUNSELORS INC | 1K | $17.9K | — | New |
| Sterling Capital Management LLC | 393 | $7.03K | — | New |
| CWM, LLC | 21 | $376 | — | New |